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HRH The Princess Royal opens Cardiometabolic Phenotyping Unit Use SHIFT+ENTER to open the menu (new window).New
A centre for groundbreaking research into cardiometabolic diseases was officially opened today (15 April) at University College London (UCL) by HRH The Princess Royal.

The royal visit marks the start of an exciting new opportunity to research adult conditions such as heart disease, vascular disease and metabolic disorders such as diabetes.

The unit was set up by the UCL Institute of Cardiovascular Science in collaboration with the NIHR University College London Hospitals Biomedical Research Centre (BRC).

The unit focuses on phenotyping, which involves detailed studies of the function of the heart and blood vessels to understand why disease develops and identify ways to treat both rare and common cardiovascular diseases.

Professor Bryan Williams, Director of the NIHR UCL Hospitals BRC said: 'This cardiometabolic phenotype unit is an important addition to the world class research infrastructure here at UCL and UCL Hospitals, supported by our NIHR BRC. This is great news for our patients who will benefit from the medical advances that will flow from leading edge medical research at UCL and UCL Hospitals.'
News Link: Read the news release
News Date: 15/04/2014
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Date Created: 15/04/2014 17:45
Date Modified: 15/04/2014 17:45
The April e-newsletter from the NIHR Central Commissioning Facility is available to view nowUse SHIFT+ENTER to open the menu (new window).
Including:

- the new NIHR Research Design Service website
- the new issue of Faculty World out now
- NIHR Senior Investigators 2014 results.

Plus more!
News Link: Read the April e-newsletter
News Date: 11/04/2014
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The latest NIHR Collaborations for Leadership in Applied Health Research and Care (CLAHRC) e-newsletter explores their work into the delivery of high quality care/patient centred careUse SHIFT+ENTER to open the menu (new window).
Bringing you the latest news and interesting developments from across the thirteen collaborations and the health service research community.
News Link: Read the full e-newsletter
News Date: 11/04/2014
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World's largest ever Parkinson's disease study supported by NIHR Sheffield Clinical Research FacilityUse SHIFT+ENTER to open the menu (new window).
Each day, 80 people are newly diagnosed with Parkinson's disease (PD) in the UK and one in 20 will be under the age of 40.

Professor Oliver Bandmann, Professor of Movement Disorders Neurology at the University of Sheffield and Consultant at the Royal Hallamshire Hospital, said: "Parkinson's is not just a movement disorder but can also cause other problems such as depression and memory problems."

He added: "Basic scientists and clinician scientists at our University benefit from excellent facilities at the Sheffield Institute for Translational Neuroscience (SITraN), the Bateson Centre in the Faculty of Basic Sciences and the NIHR Clinical Research Facility"
News Link: Read the full press release
News Date: 09/04/2014
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NIHR Programme Grants and Biomedical Research Centre funded study suggests small cash incentives improve hep B vaccination rates among injecting drug usersUse SHIFT+ENTER to open the menu (new window).
Small financial incentives, totalling as little as £30, can dramatically increase the likelihood of people who inject drugs completing a course of hepatitis B virus (HBV) vaccination, according to new research led by King's College London, published today in The Lancet. 

The study was funded by NIHR Programme Grants for Applied Research Programme (PGfAR) with additional funding from the NIHR Biomedical Research Centre (BRC) at the South London and Maudsley NHS Foundation Trust and King's College London. 
News Link: Read the full press release
News Date: 09/04/2014
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NIHR PHR Programme funded project on environmental influences on the fear of crime publishes in NIHR Journals LibraryUse SHIFT+ENTER to open the menu (new window).
Research funded by the NIHR reviewing existing evidence on fear of crime and the environment has published its findings in Public Health Research this week.

Being afraid of crime can lead to anxiety, depression and insecurity. It can also affect our behaviour, for example, people who are afraid of crime may not go out as much or trust others.

Researchers, led by Professor Mark Petticrew of the London School of Hygiene and Tropical Medicine, conducted a systematic review of the existing evidence and also held focus groups in London, Liverpool and Glasgow. Overall, the team found that fear of crime can have an effect on health and wellbeing, and can reduce physical activity for example.
News Link: Read more
News Date: 04/04/2014
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Three new NIHR-funded projects focusing on organising and delivering 24/7 careUse SHIFT+ENTER to open the menu (new window).
Three new projects funded by the NIHR are examining the organisation and delivery of 24/7 healthcare.

The call is a response to increasing pressure in the NHS to make services available to patients outside normal working hours. Research shows that hospital care may be of poorer quality at night and weekends, while there is increasing demand for greater flexibility and efficiency in public services. The NHS is already making changes to meet this demand.
News Link: Read more
News Date: 04/04/2014
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NIHR HTA study evaluating different forms of knee replacements publishes in the NIHR Journals LibraryUse SHIFT+ENTER to open the menu (new window).
An NIHR HTA-funded study looking at the effectiveness of different forms of knee replacements has just published in the NIHR Journals Library.

Knee replacements are a common procedure with nearly 100,000 taking place each year in the UK. Most of these are in the over 65s. Knee replacements are usually used to treat knee arthritis. Even though this is a successful procedure, between 10 and 20 percent of patients are not satisfied with their outcome. There is therefore a need to know which types of knee replacement work best in different circumstances. The researcher was led by Professor David Murray from the University of Oxford.
News Link: Read more
News Date: 04/04/2014
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NIHR Research for Patient Benefit funded study carries out first UK study of the use ketamine in people with treatment-resistant depressionUse SHIFT+ENTER to open the menu (new window).
Researchers confirmed that ketamine has a rapid antidepressant effect in some patients with severe depression who have not responded to other treatments. These are patients suffering from severe depression which may have lasted years despite multiple antidepressants and talking therapies.
News Link: Read the full press release
News Date: 04/04/2014
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NIHR School for Primary Care Research funded study, OxWATCH, which is focusing on women's health gets BBC Oxford media coverageUse SHIFT+ENTER to open the menu (new window).
The OxWATCH study looks at how the lifestyle and well-being of young Oxfordshire women affects their health later in life, particularly after the birth of their first child. The study is part of the Oxford Safer Pregnancy Research Alliance (Osprea), a collaboration between Oxford University Hospitals NHS Trust and the University of Oxford.
News Link: Read more
News Date: 04/04/2014
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MRC-NIHR EME Programme Focus4 colorectal cancer study recruits first patientUse SHIFT+ENTER to open the menu (new window).
The Focus4 trial, jointly funded by the MRC-NIHR Efficacy & Mechanism Evaluation (EME) programme and Cancer Research UK, has registered its first patient.

The study is will use mollecular selection of therapy to test new cancer drugs in patients with different subtypes of advanced and incurable bowel cancer.
News Link: Read more
News Date: 03/04/2014
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New structure for NIHR Clinical Research NetworkUse SHIFT+ENTER to open the menu (new window).
The National Institute for Health Research (NIHR) Clinical Research Network, which provides more than £284m a year to support the delivery of clinical research studies in the NHS, has reconfigured and will be operating in a new streamlined structure from this week (1 April 2014).
 
Until this point, the Network has comprised 102 overlapping local networks, each supporting clinical research studies in different therapy areas or parts of the service. From April 2014, this has been rationalized into 15 local Clinical Research Networks across England, which will deliver studies across all therapy areas. The geographical boundaries of the Networks correlate with those of the Academic Health Science Networks, although the remits of the two organisations remain separate.
 
Dr Jonathan Sheffield, chief executive of the NIHR Clinical Research Network, explained:
“The ability to conduct clinical research is hugely important to the future of the NHS because it is the way we gather evidence to improve the quality of care for patients. Over the last year we have seen significant changes in both the NHS environment, and in the nature of research studies. It was important for the Network to evolve, so we can continue to provide the flexible infrastructure the research community needs to conduct clinical studies efficiently in the NHS.”
News Link: Read more
News Date: 03/04/2014
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3rd NIHR Invention for Innovation (i4i) Challenge Awards call in the area of regenerative medicine or biological therapeutics for cancer NOW OPEN Use SHIFT+ENTER to open the menu (new window).
The NIHR i4i Challenge Awards addresses particular ‘challenges’ that are a priorities for the NHS.

The programme will seek to identify those medical technologies with the greatest potential clinical benefit, along with how they might be integrated into clinical decision and treatment pathways and how they might be implemented on a large scale.

The Challenge Awards will seek to support a team capable in developing and supporting a programme of work for the further development of the technology's clinical utility, including its broader applicability.

Deadline: 21 May 2014
News Link: Find out more and apply
News Date: 03/04/2014
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NIHR Health Technology Assessment Programme - March 2014 Bulletin availableUse SHIFT+ENTER to open the menu (new window).
The March 2014 Bulletin from the NIHR Health Technology Assessment Programme is available to read.
News Link: Read more
News Date: 02/04/2014
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NIHR implements “Gold” approach to Open AccessUse SHIFT+ENTER to open the menu (new window).
Any peer-reviewed research articles supported in whole or in part by NIHR funding, that are submitted for publication and published  from 1st April 2014 should be made available under the “Gold” approach to Open Access – which means the report is free at the time of publication. This includes review articles not commissioned by publishers, final reports or executive summaries.  The NIHR recognises that there will be progressive implementation, but expects full compliance in four years. NIHR Programmes will monitor compliance with this policy and will be providing further guidance on how to comply with the policy over the summer. Full details on the revised policy will be made available shortly, in the meantime, the existing policycan be found at  http://www.nihr.ac.uk/research/Pages/Research_Open_Access_Policy_Statement.aspx
 
The NIHR, alongside the other main biomedical research funders, has committed  to the principal of Open Access to the outputs of its research. As a publically funded research body, the NIHR is subject to the requirement to make the outputs from its research freely and publicly available – not just to other researchers, but also to potential users in business, charitable and public sectors, and to the general tax-paying public. The 2012 Finch Report (http://www.researchinfonet.org/wp-content/uploads/2012/06/Finch-Group-report-FINAL-VERSION.pdf) recommended this and the approach was accepted by the Government.
News Link: Read more
News Date: 01/04/2014
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NIHR Clinical Lecturer 2014 (Medical) - recruitment is now openUse SHIFT+ENTER to open the menu (new window).
The 2014 NIHR Clinical Lectureship recruitment round is now open and will end on 31st March 2015.

• Prospective applicants should note that they must contact the relevant LETB/Deanery in the first instance for further information on post availability and the recruitment process.  This includes dates for when the posts will be advertised and the associated closing dates. Take up of posts will start from 1st April 2014.

• Please note that successful applicants must be in post before 31st March 2015, therefore LETBs/Deaneries need to allow enough time to advertise, shortlist, interview and where required, allow for notice periods to be given.
News Link: read more
News Date: 01/04/2014
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NIHR Collaboration for Leadership in Applied Health Research and Care South West Peninsula (NIHR PenCLAHRC) supported systematic review discovers that doctors raise blood pressure in patientsUse SHIFT+ENTER to open the menu (new window).
Doctors routinely record blood pressure levels that are significantly higher than levels recorded by nurses, the first thorough analysis of scientific data has revealed.
News Link: Read more
News Date: 01/04/2014
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NIHR Health Technology Assessment Programme and Biomedical Research Centre funded study finds that breathing support for premature babies could mean better lung function laterUse SHIFT+ENTER to open the menu (new window).
A new study led by researchers at King’s College London has found that premature babies supported immediately after birth by high-frequency oscillation - a type of breathing support - had better lung function as adolescents than those who received conventional ventilation. The children ventilated with the high frequency method also showed higher academic achievement in three of eight school subjects.

The findings of the research, funded by the NIHR, could change the use of ventilation in neonatal units across the UK, where around 60,000 babies are born prematurely each year.
News Link: Read the full press release
News Date: 01/04/2014
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New study run by NIHR Collaboration for Leadership in Applied Health Research and Care (CLAHRC) Wessex to begin in West Hampshire to help identify and treat silent diseaseUse SHIFT+ENTER to open the menu (new window).
The new pilot study will see specific breathing tests which reveal chronic obstructive pulmonary disease (COPD) characteristics take place in GP surgeries in Totton, instead of hospitals. The aim is to identify, diagnose and treat COPD earlier.

The study is run by NIHR CLAHRC Wessex, a group of researchers from the University of Southampton and University Hospital Southampton NHS Foundation Trust, the Wessex Academic Health Science Network and other local NHS partners.

NIHR CLAHRC Wessex, which formally launched on Wednesday 12 March, aims to tackle some of the most pressing health problems in the South.
News Link: Read the full press release
News Date: 01/04/2014
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NIHR Clinical Research Network achieves two more first global patientsUse SHIFT+ENTER to open the menu (new window).
The NIHR Clinical Research Network: Cancer has achieved first global patient in Follicular Lymphoma. This was achieved on Tuesday 25 March at University of Southampton NHS Trust.

The NIHR Clinical Research Network: Children has achieved first global patient in Hunter Syndrome and Early Cognitive Impairment. This was achieved on Monday 24 March at Royal Manchester Children's Hospital.

This takes the running total of first global patients achieved by the NIHR Clinical Research Network since April 2013 to 29.
News Date: 01/04/2014
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DH approves HRA business plan to deliver a single approval system for all health research studies in EnglandUse SHIFT+ENTER to open the menu (new window).
The HRA welcomes the announcement of funding for our plans for HRA Assessment and Approval. This funding means that the HRA will be able to reduce duplication and bureaucracy by incorporating assessments by NHS staff alongside the independent Research Ethics Committee opinion, which will result in one application, one assessment and one approval for research in the NHS in England.

These proposals will build on recent improvements in timelines for approvals, will radically simplify the regulation of research and will remove complexity for researchers and industry.
News Link: Read more
News Date: 31/03/2014
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NIHR School for Primary Care Research March NewsUse SHIFT+ENTER to open the menu (new window).
The March newsletter from the NIHR School for Primary Care Research is available to read.
News Link: Read more
News Date: 31/03/2014
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NIHR Biomedical Research Centre funded study shows people with serious mental illness have lower cancer survival ratesUse SHIFT+ENTER to open the menu (new window).
People with serious mental illness have lower cancer survival rates than the general population, according to a new study by King’s College London's Institute of Psychiatry (IoP) published in BMJ Open.

The study suggests that problems arise during care, rather than being associated with late diagnosis or screening, and highlights the health inequalities faced by people with mental illness. 

The study was funded by the NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College London.
News Link: Read more
News Date: 28/03/2014
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New treatment discovered that improves lives for patients with hyperinsulinemic hypoglycemiaUse SHIFT+ENTER to open the menu (new window).
Hyperinsulinemic hypoglycemia (HH) is a condition causing low blood glucose levels through the excessive production of insulin. HH is the most common cause of severe, persistent neonatal hypoglycaemia and in its’ most severe form the condition can be life-threatening. If severely affected patients do not respond to the standard mediciation (diazoxide), often the removal of the pancreas is the only treatment. Removal of the pancreas would result in the life-long need for insulin injections and pancreatic enzyme replacement therapy necessary to enable the supply of enzymes responsible for digestion.

NIHR Great Ormond Street Biomedical Research Centre supported clinician Dr Khalid Hussain has saved four patients at Great Ormond Street Hospital (GOSH) from having their pancreases removed through the discovery of a new treatment which is an insulin production inhibitor called sirolimus.

For more information on this story, please read the GOSH press release. Dr Khalid Hussain has published the study in the New England Journal of Medicine.
News Link: GOSH press release
News Date: 28/03/2014
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The March edition of the NIHR School for Primary Care Research’s e-newsletter is out nowUse SHIFT+ENTER to open the menu (new window).
Including details about a call for abstracts for the 2014 School for Primary Care Research (SPCR) Showcase in Oxford, news about a significant SPCR milestone that has been reached plus more.
News Link: Read the March e-newsletter
News Date: 28/03/2014
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New collaboration site for all NIHR-related work and staffUse SHIFT+ENTER to open the menu (new window).
The Department of Health has recently contracted for the development of a new collaboration site for the National Institute for Health Research (NIHR). This new site – the “NIHR Hub” – will replace the NIHR Portal and provide an integrated platform to enable NIHR researchers and staff to create, develop, share and collaborate on NIHR-related work across a simple, secure, reliable and accessible environment.

The NIHR Hub is being built and hosted on Google technology, which is in line with Government Digital Strategy; the attached letter contains information to pass onto to your local IT support teams to ensure you will have full access.
News Link: Letter from the Department of Health
News Date: 27/03/2014
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Winners of the 'Access to Understanding' science writing awards 2014 are announcedUse SHIFT+ENTER to open the menu (new window).
The announcement of the winners of the Europe PubMed Central (Europe PMC) and the British Library’s science writing competition, Access to Understanding was made on 24 March.

Entrants to the competition were challenged to summarise a cutting-edge research article, communicating what the research is, and why it matters, for a non-specialist audience. The project, which is run by Europe PubMed Central in partnership with the science team at the British Library, aims to demonstrate the increasing importance of effectively communicating the results of publicly funded research.

The overall winner, Elizabeth Kirkham, a PhD student in the Psychology Department at the University of Sheffield, was selected from nearly 300 applicants from around the world for her entry explaining research that investigated the brain structure involved in the prediction of musical beats.
News Link: Read the full press release
News Date: 27/03/2014
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NIHR Imperial Biomedical Research Centre part funded study suggests climate change will cause more deaths in London and Southeast EnglandUse SHIFT+ENTER to open the menu (new window).
Warmer summers brought on by climate change will cause more deaths in London and southeast England than the rest of the country, scientists predict.

Writing in Nature Climate Change, the researchers say local variations in climate change vulnerability should be taken into account when assessing the risks and choosing policy responses.

The researchers received funding from the Medical Research Council, Public Health England, and the NIHR Imperial Biomedical Research Centre.
News Link: Read the full press release
News Date: 25/03/2014
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Three NIHR Biomedical Research Centre (BRC) funded projects move to Stevenage Bioscience Catalyst lab to fast track the development of new treatmentsUse SHIFT+ENTER to open the menu (new window).
The Stevenage Bioscience Catalyst is the UK’s first open innovation bioscience campus, located next to GlaxoSmithKline (GSK) and BRC funding has meant that UCL industry-reading projects will be able to take up lab space on the campus and access drug development expertise and facilities.
News Link: Read more
News Date: 25/03/2014
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NIHR Biomedical Research Centre supported Professor and research team discover gene mutations in rare cancerUse SHIFT+ENTER to open the menu (new window).
An international team of researchers have identified mutations in two genes linked to a rare cancer of the inner lining of blood vessels.

News Link: Read more
News Date: 24/03/2014
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NIHR Biomedical Research Centre supported researchers’ breakthrough suggests statins could help progressive Multiple Sclerosis patientsUse SHIFT+ENTER to open the menu (new window).
NIHR Biomedical Research Centre supported researchers at UCL and UCLH, with colleagues from Imperial College, have found that a high dose of the drug simvastatin significantly reduces brain shrinkage in people with secondary progressive multiple sclerosis (SPMS).

This research is an exciting breakthrough and is having a lot of media coverage, as up until now successful clinical trials have mainly focused on treatments for the relapsing-remitting form of multiple sclerosis (MS).
News Link: Read the full news article
News Date: 24/03/2014
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NIHR Research for Patient Benefit funded research shows humour helps penile cancer patients to copeUse SHIFT+ENTER to open the menu (new window).
New research by our University, published in the Journal of Advanced Nursing, reveals that the use of humour can help men undergoing treatment for penile cancer to stay positive and that this is an effective way for health professionals to build rapport.
News Link: Read more
News Date: 24/03/2014
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NIHR Programme Grants for Applied Research funded study finds that third of women at risk of developing cancer may benefit from more frequent mammogramsUse SHIFT+ENTER to open the menu (new window).
A study of over 50,000 women participating in the UK NHS Breast Screening Programme has found that, while three-yearly screening intervals are appropriate for the majority of women, approximately one third of women are at higher risk of developing cancer and might benefit from more frequent mammograms.
News Link: Read the full press release
News Date: 24/03/2014
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NIHR Collaboration for Leadership in Applied Health Research and Care North West London (CLAHRC NWL) funds three Improvement Leader FellowshipsUse SHIFT+ENTER to open the menu (new window).
A PhD graduate, an Associate Lecturer and a Service User in mental health who are all affiliated to Buckinghamshire New University have been awarded Improvement Leader Fellowships by the NIHR CLAHRC NWL and will now undertake research projects for the fellowship spanning twelve months.
News Link: Read more
News Date: 24/03/2014
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NIHR HTA Programme is accepting applications for research using efficient study designs and hosting Webinar Use SHIFT+ENTER to open the menu (new window).
The focus of this call is for research that will demonstrate particular design features to allow more rapid conduct and/or lower costs, when benchmarked against conventional pragmatic multicentre trials, while still providing data sufficiently robust to guide NHS or patient decisions.
Proposals can be in any specialty area provided they are within the remit of the programme. The closing date for applications is 16 July 2014, by 1pm. 

You can also sign up to a webinar about the call with Dr Peter Davidson, Director of NETSCC, HTA. The webinar will be held on 4 April 2014, 1-2pm.
For full details and to apply, please visit the HTA researcher-led webpage.
News Link: Read more
News Date: 21/03/2014
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Northwest London CLAHRC Spring Collaborative Learning Event - 29 April 2014 Use SHIFT+ENTER to open the menu (new window).
After the popular Launch Event on 4th March, a number of projects and activities are now in preparation and the next event will focus on sharing experiences on research and quality improvement projects, including:
- Planning early for long-term success
- Identifying how data can tell your story and evaluate impact
- Involvement- how to work together, learning from the National Involvement Partnership
Whether you are participating in any of the CLAHRC themes, are a CLAHRC Fellow or Alumni, or whether you are interested and involved in other quality improvement and research projects in Northwest London, please register.
News Link: Read more and register
News Date: 20/03/2014
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NIHR Diabetes Research Network achieves first global patient at Ipswich HospitalUse SHIFT+ENTER to open the menu (new window).
The NIHR Diabetes Research Network has achieved first global patient for DRN2849 in Type 2 Diabetes. This was achieved on Thursday 13 March at Ipswich Hospital.

This takes the running total of first global patients achieved by the NIHR Clinical Research Network since April 2013 to 27.
News Link: Read more
News Date: 20/03/2014
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NIHR study finds breathing support for premature babies could lead to better lung function in later lifeUse SHIFT+ENTER to open the menu (new window).
A new NIHR-funded study has found that premature babies supported immediately after birth by high-frequency oscillation - a type of breathing support - had better lung function as adolescents than those who received conventional ventilation. The children ventilated with the high frequency method also showed higher academic achievement in three of eight school subjects.

The findings of the research, funded by the NIHR HTA Programme and the NIHR Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, could change the use of ventilation in neonatal units across the UK, where around 60,000 babies are born prematurely each year.
News Link: Read more
News Date: 20/03/2014
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NIHR Clinical Research Network’s Fast Facts newsletter - March issue availableUse SHIFT+ENTER to open the menu (new window).
The March 2014 issue of the Fast Facts newsletter from the NIHR Clinical Research Network is available to read.
News Link: Read more
News Date: 19/03/2014
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NIHR 2014 Senior Investigators competition results announced including first NIHR Senior Investigators EmeritusUse SHIFT+ENTER to open the menu (new window).
Fifty-four Senior Investigators have been appointed - 16 new appointees, and 38 current or previous holders of the award. The total college now stands at 201 NIHR Senior Investigators.

An independent expert panel Chaired by Professor Sir Alex Markham advised on the appointments. These are made according to criteria of quality and volume of internationally excellent research; its relevance to patients; and the public; impact on improvements in healthcare and public health; research leadership including contribution to NIHR; engagement of patients and the public and engagement of healthcare policy makers and planners with their research.

The first NIHR Senior Investigators Emeritus are created this year. Senior Investigators are able to occupy their positions for no more two terms, in order to ensure turnover. This creates opportunities for new researchers to participate in NIHR at this level, incentivising the research community whilst maintaining the College of Senior Investigators at a manageable size. The new Emeritus status applies only whilst the holders remain in substantive employment. It is a considerable achievement to attain Emeritus status, holders having succeeded twice in open competition and completed two terms as a Senior Investigator.

NIHR Senior Investigators and Senior Investigators Emeritus are listed below. Their full details will be available from 1st April 2014 on the NIHR Senior Investigators Directory - http://www.nihr.ac.uk/faculty/Pages/faculty_senior_investigators_directory.aspx
News Link: Read more and see the list
News Date: 19/03/2014
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NIHR Dementia Biomedical Research Unit researcher to investigate nerve cell changes prior to dementiaUse SHIFT+ENTER to open the menu (new window).
A researcher from NIHR Queen’s Square Dementia Biomedical Research Unit is to investigate biological changes that occur in nerve cells prior to their demise as a way to help develop treatments for dementia.

Dr Selina Wray, based in UCL’s Department of Molecular Neuroscience, aims to develop cell models that can be used in the laboratory to study the changes in cells that lead to cell death.
News Link: Read the full news item
News Date: 17/03/2014
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Launch of the NIHR BioResourceUse SHIFT+ENTER to open the menu (new window).
On Friday 14 March 2014 the Secretary of State for Health, Jeremy Hunt, announced the launch of the NIHR BioResource.  

Funded by the National Institute for Health Research (NIHR) and led from the NIHR Cambridge Biomedical Research Centre (BRC), the NIHR BioResource is a bank of nearly 75,000 medical research volunteers, available to make it much easier for researchers to recruit people with specific conditions and a family history of conditions into research and trials. The focus will include heart disease, dementia, infections and rare diseases, and could speed-up the development of new treatments. 

It provides a national recallable resource of volunteers of patients, their families and from general population who wish to participate in clinical research across a wide range of studies. Volunteers provide clinical information and samples that allow them to be recalled by their genotype and phenotype (their physical characteristics) for experimental medicine studies and early phase trials.

The creation of the NIHR BioResource was a commitment in the Government’s Strategy for UK Life Sciences. It will support life sciences industry research by supporting companies to have access to a growing bank of tens of thousands of volunteers from across the country who are keen to help medical research.  The NIHR BioResource is part of the NIHR-funded research infrastructure which is designed to make the country the best possible place in which to carry out public, charity and industry funded health research. 

Health Secretary Jeremy Hunt said:
“Most people are only too happy to altruistically volunteer for medical research if it helps saves lives, and by linking them with researchers faster, NIHR BioResource will help increase the number of discoveries about diseases and how we can treat them.”

Lord Howe, Parliamentary Under Secretary for Quality, said:
“We are determined to make the UK the best place in the world for health research, development and innovation, which is why we are so proud to be launching the NIHR BioResource. It will become an incredible, world-leading resource for health researchers.
There’s no doubt that medical research helps save lives, and volunteers on this scheme will make a real difference to the health of the nation.”

Professor Dame Sally C. Davies, Chief Medical Officer and Chief Scientific Adviser at the Department of Health, said:
“The NIHR BioResource provides a unique capacity to undertake research that would either not be possible - or at best difficult - to conduct without access to patients, their families and members of the public that agree to participate. The BioResource is focusing on some of the most significant challenges to health which include cardiovascular, infectious, immunological and inflammatory disease, neuro-degeneration and rare diseases.”

The NIHR BioResource has been established around NIHR Biomedical Research Centres (BRCs) at Cambridge, Imperial, Guy’s and St Thomas’/King’s, South London and the Maudsley/King’s, Oxford, Newcastle and UCLH/UCL, and the NIHR Cardiovascular Biomedical Research Unit (BRU) in Leicester.

Total NIHR funding being invested in the NIHR BioResource is £36.89 million. 

The announcement of the launch of the NIHR BioResource coincided with the announcement of a new Early Access to Medicines scheme.  This new scheme will enable promising new medicines will be fast-tracked to patients with life-threatening and seriously debilitating conditions who have run out of treatments that work. One of the first schemes of its kind in Europe, this contributes to making the UK a more attractive country in which to do research.

Mr Hunt added:
 “Running out of treatments when you’re severely ill can leave you feeling distressed and in despair, and by providing cutting-edge medicines earlier this ground-breaking scheme will offer hope and even save lives.
“Encouraging innovation, investment and economic growth, it will keep the UK’s life sciences industry as a world-leader in experimental medicine.”

Read the Department of Health Press Release - https://www.gov.uk/government/news/cutting-edge-drugs-to-be-fast-tracked-to-patients
News Link: Read more
News Date: 14/03/2014
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Global pharmaceutical company, Teva, announces an investment of US$20 million in UK clinical trials and US$1 million into UK dementia research through collaboration with the NIHRUse SHIFT+ENTER to open the menu (new window).
Announced on 12 March, during Prime Minister David Cameron's visit to Israel, the Israeli pharmaceutical company Teva is due to invest US$20 million (£12 million) into UK clinical trials and US$1 million (£600,000) into UK dementia research. This enables Teva to benefit from the NIHR's translational research infrastructure and its ability to efficiently set-up and deliver world-leading health research studies.

As part of the announcement Teva intends to invest in a three-year dementia research program, providing funding of up to US$1 million for early stage work in UK academic and medical centres. This work will be focused on understanding targets, mechanisms and new approaches to treatment of different causes and types of dementia. The NIHR Office for Clinical Research Infrastructure (NOCRI) will facilitate Teva's access to the NIHR Biomedical Research Centres and Units in Dementia and the NIHR Translational Research Collaboration in Dementia.
News Link: Read more
News Date: 14/03/2014
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NIHR HTA Programme Smoking cessation trial published in Mental Health PracticeUse SHIFT+ENTER to open the menu (new window).
Research evaluating a new intervention that helps people with serious mental illness cut down on smoking has just published in Mental Health Practice. The research has been funded by the NIHR HTA Programme.

According to research by the Disability Rights Commission, people who have a mental illness such as schizophrenia are more likely to smoke than the general population. This means that many die prematurely from smoking-related diseases and so there is a need to develop smoking cessation services for this group.
 
Researchers, led by Professor Gilbody of the University of York, are carrying out a pilot randomised controlled trial to evaluate an intervention which has been designed specifically for people with a serious mental illness.
News Link: Read more
News Date: 14/03/2014
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EME Programme Study - Improving the diagnosis of TuberculosisUse SHIFT+ENTER to open the menu (new window).
A new project funded by the  Efficacy and Mechanism (EME) Programme is looking at whether new tests will diagnose Tuberculosis (TB) quickly and accurately.

Researchers, led by Professor Ajit Lalvani of Imperial College London, are testing four new technologies to see whether they are better and more cost-effective than the current tests for diagnosing TB.
News Link: Read more
News Date: 14/03/2014
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NIHR Health Services and Delivery Research (HS&DR) Programme - Spring Bulletin 2014 availableUse SHIFT+ENTER to open the menu (new window).
The Spring Bulletin from the NIHR Health Services and Delivery Research (HS&DR) Programme is available to read.
News Link: Read more
News Date: 14/03/2014
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NIHR Collaboration for Leadership in Applied Health Research and Care Oxford awarded £9 million funding to develop innovative new treatments and techniques for patient benefitUse SHIFT+ENTER to open the menu (new window).
The NIHR CLAHRC Oxford is led by Professor Richard Hobbs, Head of Oxford University’s Nuffield Department of Primary Care Health Sciences with colleagues from the University’s Medical Sciences Division, in particular researchers at the Department of Psychiatry. The collaboration will work closely with the users of research, including clinicians, patients, commissioners, and the public.
News Link: Read more
News Date: 14/03/2014
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NIHR HS&DR and SPCR nationwide multi-morbidity research study Use SHIFT+ENTER to open the menu (new window).
Following a series of successful NIHR School for Primary Care Research (SPCR) studies into multi-morbidity by researchers at the universities of Bristol and Manchester, funding has been granted for a new nationwide study by the NIHR.

The three year study will investigate ways to improve the quality of life for patients suffering with multiple long-term conditions and the project is funded by the NIHR Health Services and Delivery Research (NIHR HS&DR).
News Link: Read more
News Date: 13/03/2014
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NIHR Diabetes Research Network - First global patient at Manchester Royal InfirmaryUse SHIFT+ENTER to open the menu (new window).
The NIHR Diabetes Research Network has achieved first global patient for DRN3057 in Diabetic foot ulcer. This was achieved on Thursday 6 March at Manchester Royal Infirmary.

This takes the running total of first global patients achieved by the NIHR Clinical Research Network since April 2013 to 26.

The NIHR Diabetes Research Network has achieved first European patient for DRN2373 in Diabetes. This was achieved on Tuesday 10 December 2013 at St Bartholomew’s Hospital.

This takes the running total of first European patients achieved by the NIHR Clinical Research Network since April 2013 to six.
News Link: Read more
News Date: 13/03/2014
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NIHR School for Primary Care Research (SPCR) - Over £2 million awarded to 51 primary care projectsUse SHIFT+ENTER to open the menu (new window).
Following the completion of two successful funding rounds, the National Institute for Health Research (NIHR) School for Primary Care Research (SPCR) is pleased to announce the award of over £2 million to 51 primary care studies in the past year.

News Link: Read more
News Date: 12/03/2014
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Putting patients, carers and clinicians at the heart of palliative and end of life care researchUse SHIFT+ENTER to open the menu (new window).
A ground breaking partnership, of which the NIHR is a co-funding partner, has been launched to find out what palliative and end of life care research is important to people who are likely to be within the last years of life, their families, and the professionals who work with them.

Initiated by Marie Curie Cancer Care, a large number of organisations have come together to form “the Palliative and end of life care Priority Setting Partnership” (PeolcPSP) with the James Lind Alliance. This means that for the first time, people directly affected will get the chance to have their say in setting research priorities for palliative and end of life care. They are particularly seeking to hear from people who are likely to be in the last years of life, current and bereaved carers and families, and frontline social and healthcare professionals.

Palliative and end of life care is an under-researched area and requires greater attention and focus.  The aim of the partnership is to ensure that future research brings the greatest possible benefit to people at the end of life, and their carers and families, by identifying what questions are of the greatest importance to them.
News Link: Read more and take the survey
News Date: 07/03/2014
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NIHR/HEE Healthcare Science Research Fellowship Programme - Round 5Use SHIFT+ENTER to open the menu (new window).
Healthcare Scientists are invited to apply to Round 5 of the Healthcare Science Research Fellowship Programme.
 
The National Institute for Health Research (NIHR) and Health Education England (HEE) currently work in partnership to provide dedicated research training awards for Healthcare Scientists through the NIHR / HEE Healthcare Science Research Fellowship (HCS) Programme. The programme has been designed to support the development of healthcare science research capacity and capability, and comprises three schemes that serve as ‘career steps’ for Healthcare Scientists with aspirations for academic leadership:

• The HCS Doctoral Research Fellowship Scheme
• The HCS Post Doctoral Fellowship Scheme
• The HCS Senior Clinical Lectureship Scheme
 
These three schemes should be of interest to members of the English NHS Healthcare Science workforce who already have some research experience and wish to develop research capability and activity alongside their clinical / service careers.
News Link: Read more
News Date: 07/03/2014
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NIHR sponsored Nursing Times Clinical Research Nurse award - entries invitedUse SHIFT+ENTER to open the menu (new window).
This year, the NIHR for the first time will sponsor a Nursing Times Clinical Research Nurse Award.  This award aims to increase wider understanding of clinical research nursing and recognise initiatives that contribute to achieving the NIHR’s strategic priorities for the specialty. If your work is enhancing the experience of patients participating in clinical research, improving the standards of research delivery and practice, embedding the principles of Compassion in Practice into clinical research or improving awareness of the specialty and of how clinical research leads to improved care, practice and skills, then do enter for the award.

The deadline for entries is 28 April 2014.
News Link: Read more and Enter
News Date: 07/03/2014
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Issue 4 of Faculty World now publishedUse SHIFT+ENTER to open the menu (new window).
Read this issue to find out more about the NIHR Journals Library, the James Lind Alliance Priority Setting Partnerships and read the news from around the NIHR including an interview with Professor Tom Walley, CBE.
News Link: Read more
News Date: 07/03/2014
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NIHR School for Primary Care Research funded study finds that working pressures increase children attending nursery with respiratory tract infectionsUse SHIFT+ENTER to open the menu (new window).
Working parents are often caught between the needs of their sick child and their job, which can lead to continued day care use even when their child is ill. New research has found children going to nursery when they are unwell with respiratory tract infections (RTIs) may be an important factor in the spread of these illnesses in the community.

The findings, to be presented today [Thursday 6 March] at the South West Society for Academic Primary Care (SW SPAC) meeting, explored why parents send their children to nursery when they are unwell.

The Parents’ Choices About Daycare (PiCArD) study was funded by the NIHR School for Primary Care Research (SPCR).
News Link: Read the full press release
News Date: 07/03/2014
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Call for applications for a UK Clinical Research Collaboration Joint Funders Tissue Directory and Co-ordination CentreUse SHIFT+ENTER to open the menu (new window).
The Medical Research Council has issued a call on behalf of funders, including the NIHR, for applications for a UK Clinical Research Collaboration Joint Funders Tissue Directory and Co-ordination Centre.
News Link: Read more
News Date: 06/03/2014
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The latest edition of the NIHR Collaborations for Leadership in Applied Health Research and Care (CLAHRC) community e-newsletter focusing on behaviour change is available to view nowUse SHIFT+ENTER to open the menu (new window).
Promoting healthy behaviours and informed personal choice through targeted public health interventions is central to improving population health.

This newsletter explores how the NIHR CLAHRCs will continue to contribute to the growing evidence base on what works to support behaviour change over the next five years. They will do this by working with their local populations to develop and evaluate health improvement interventions.
News Link: View the e-newsletter
News Date: 06/03/2014
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New Programme Grants for Applied Health Research report has published in the NIHR Journals Library: a programme of research to facilitate recognition of stroke by emergency medical dispatchersUse SHIFT+ENTER to open the menu (new window).
Findings from an NIHR-funded Programme Grant for Applied Research (PGfAR) show that online stroke-specific training has the potential to contribute to a reduction in pre-hospital delays, as well as improving the recognition of stroke. If stroke is suspected, use of the word stroke by the public during the call to the emergency medical service (EMS) should increase the likelihood that an immediate and appropriate response is initiated.
News Link: Read the full news item
News Date: 05/03/2014
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A leaflet has been produced about the thirteen NIHR Collaborations for Leadership in Applied Health Research and Care (CLAHRCs) funded from January 2014 to carry out world-class applied health researchUse SHIFT+ENTER to open the menu (new window).
Thirteen NIHR CLAHRCs have been funded from January 2014 to carry out world-class applied health research focused on the needs of patients and to translate research evidence into practice in the NHS.

CLAHRCs are partnerships set up between health and social care organisations, universities and other relevant bodies to improve patient and population outcomes through the conduct and application of applied health research.
News Link: View online leaflet
News Date: 05/03/2014
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NIHR Health Technology Assessment (HTA) Programme - February 2014 BulletinUse SHIFT+ENTER to open the menu (new window).
The February 2014 bulletin from the NIHR Health Technology Assessment (HTA) Programme is available to read
News Link: Read more
News Date: 04/03/2014
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Chief Medical Officer appoints NIHR National Director for Dementia ResearchUse SHIFT+ENTER to open the menu (new window).
Dame Sally Davies, the Chief Medical Officer, has appointed Professor Martin Rossor (Clinical Neurology, UCL) as the new NIHR National Director for Dementia Research.

This new post will provide the leadership needed to facilitate and support the Department of Health’s research response to commitments under the Prime Minister’s Dementia Challenge and the G8 Dementia Summit. This will involve activity across NIHR activity as well as work with single components of NIHR. Other work will involve engagement with external stakeholders, such as NHS England, research charities and other research funders, including industry. Martin will draw on the expertise of the Evington Group, and work with the Dementia Innovation Envoy.

Professor Rossor will work closely with staff in the DH R&D Directorate, with the NIHR Clinical Research Network, particularly Jonathan Sheffield and Ian McKeith, and with other NIHR research infrastructure, especially Simon Lovestone and the NIHR Dementia Translational Research Collaboration, as well as Alistair Burns, NHS England’s National Clinical Director for Dementia.


When the new structure for the NIHR Clinical Research Network comes into place in April, Martin will step back from his current role as Director of DeNDRoN, but will continue to work closely with the Dementias and Neurodegeneration (DeNDRoN) and Neurological Disorders specialties.

The initial focus of effort will be on:

1. International Action Plan: Contributing to the development of an international action plan for research, which will account for the current state of science and promote global efforts to maintain brain health and find therapies for dementia.

2. Championing research: Working with clinical academics and the NHS.

3. Patients and their data: Improving recruitment of patients into research through building on the NHS Constitution pledge to inform patients about opportunities to participate in research and engaging the NHS in the implementation of ‘Join Dementia Research’ (formerly known as RAFT - the Recruitment & Feasibility Tool – a database for patients to register their interest in dementia research).

4. Facilitating clinical research: Working with the Translational Research Collaboration and the NIHR Clinical Research Network towards achieving common research platforms; working within current frameworks for consent and use of data to promote sharing of data from existing research.

5. Living Well with Dementia:  Facilitating research to support living well with dementia initiatives and identifying effective interventions, in the clinic, in the nursing home, and in everyday life.

6. Building research capacity and addressing other barriers to research progress.

The responsibility for the research and infrastructure funded by NIHR will remain with individuals leading the research and the relevant NIHR initiatives.

Martin will be supported by a small staff.
News Date: 03/03/2014
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Nations publish first stage plans for Rare Diseases Strategy implementationUse SHIFT+ENTER to open the menu (new window).
To coincide with Rare Diseases Day, a new GOV.UK webpage has been launched as a resource space for the implementation of the UK Strategy for Rare Diseases. The UK Strategy for Rare Diseases was published in November 2013 and sets out a shared vision for improving the lives of all those with rare diseases in the UK by 2020. The NIHR will play a key role in the delivery of commitments related to rare diseases research, including through its research programmes, the world-class NIHR research infrastructure of Biomedical Research Centres, Biomedical Research Units and the NIHR Rare Diseases Translational Research Collaboration which was announced by the Government alongside the publication of the UK Strategy.
News Link: Read more
News Date: 03/03/2014
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NIHR School for Primary Care Research February 2014 news updateUse SHIFT+ENTER to open the menu (new window).
The February 2014 news update from the NIHR School for Primary Care Research (SPCR) is available to read
News Link: Read the Feb 2014 NIHR SPCR news update
News Date: 28/02/2014
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NIHR Oxford Biomedical Research Centre funded study suggests surgery offers better survival rates for most men with localised prostate cancerUse SHIFT+ENTER to open the menu (new window).
The study, led by an Oxford University researcher, found that surgery as the first-line treatment offered greatest benefits for younger men in good general health.

It is hoped the findings, published online in the British Medical Journal, could help inform treatment choice.

The study was funded by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre and the Swedish Research Council.
News Link: Read the full press release
News Date: 28/02/2014
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NIHR Programme Grants for Applied Research funded study finds that mental health stigma is 'key deterrent' in accessing careUse SHIFT+ENTER to open the menu (new window).
Mental health stigma is a key factor preventing people from accessing the care they need, according to new research from King’s College London.

The new study, published today in Psychological Medicine, brings together data from 144 studies, including over 90,000 participants worldwide.

The research was funded by the NIHR under its Programme Grants for Applied Research (PGfAR) Programme.
News Link: Read the full press release
News Date: 27/02/2014
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New Funding for Research into SurgeryUse SHIFT+ENTER to open the menu (new window).
Following an NIHR Themed Call in surgery £20 million is being invested into research projects that address important issues around surgery.
The funding from the NIHR will mean researchers can look at new, cutting edge surgery and tools to see how well they work and how they could be used to help patients across the NHS. The call was launched in recognition of the fact that more high-quality research is needed into surgery. It focused on the evaluation of technology-driven implanted or implantable medical devices, surgical procedures or surgical services.
Projects that have been given money for research include a study looking at how surgical teams can best use high-tech ‘da Vinci’ robots – devices controlled by a surgeon from a computer console - as a matter of routine. Other projects range from looking at the long term benefits of gastric band surgery to assessing different pain relief techniques following joint replacement surgery. Studies also include examining the effectiveness of different kinds of prostate surgery across six hospitals.

Professor Dame Sally C. Davies, Chief Medical Officer and Chief Scientific Adviser at the Department of Health said:
“Surgery is fundamental to our healthcare with most of us needing some form of surgery during our lifetime. Common practice today was unimaginable only 20 years ago. It is vital we continue to provide new evidence on the application of new technology in this area in order to generate further and better developments for patients.”

President of the Royal College of Surgeons Professor Norman Williams said: “Investment in surgical techniques can revolutionise care for patients.  We are delighted that the government is investing £20 million in a range of surgical research projects - from using robotics – to examining how we can improve treatment for breast cancer.  These projects will help lead to the type of medical breakthroughs which save lives.”

So far, the NIHR has funded 22 projects from this call, with a total contracted value of £20 million. Further projects are expected to be funded during 2014.

Funding opportunities are available for researchers wishing to make bids for surgical research projects across NIHR programmes - http://www.nihr.ac.uk/proposals
News Link: View a summary of surgery research projects
News Date: 24/02/2014
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NIHR Clinical Research Network Achieves 25 First Global Patients In One YearUse SHIFT+ENTER to open the menu (new window).
The NIHR Clinical Research Network has reached a milestone in study set up achievements by recruiting 25 first global patients in commercial studies in the 2013/14 financial year.

The 25th study to make this highly sought after achievement was at Manchester Royal Eye Hospital, a site of the Central Manchester University Hospitals NHS Foundation Trust. It aims to build on existing safety and effectiveness data for ocriplasmin, a treatment for some people with the rare eye condition, vitreomacular traction.

Recruiting a first global patient is a key performance indicator for the life-sciences industry in clinical research delivery as it shows the Network can support the rapid set-up of studies.

Since the Network started to record first global patients, it has achieved 42 in total. But it is during the past financial year that it has seen a rapid upturn in the number of studies to make the achievement. This is down to the reduction of study set-up times.

Professor Dame Sally C. Davies, Chief Medical Officer and Chief Scientific Adviser at the Department of Health said:
“Rapid study set-up is integral to attracting new studies and companies to the UK. This is a key aim of the NIHR and plays an important role in the Government’s Strategy for UK Life Sciences.”
News Link: Read more and see a full list of the studies
News Date: 24/02/2014
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BBC Radio 4 Today programme features NIHR Biomedical Research Centre’s “Clinical Record Interactive Search” (CRIS) system Use SHIFT+ENTER to open the menu (new window).
On Friday 21 February, the BBC Radio 4 Today programme featured the NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust’s “Clinical Record Interactive Search” (CRIS).

CRIS is a secure database of anonymised mental health records from 250,000 people (and growing!) CRIS is a tool that securely uses the Trust’s electronic patient records, robustly anonymises them, and allows them to be used, en masse, inside the Trust’s firewall, by carefully vetted health researchers, to advance knowledge about mental health and ill health.
News Link: Read more
News Date: 24/02/2014
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80% of ‘A’ level students from underprivileged backgrounds attending NIHR Biomedical Research Centre funded summer school go on to UniversityUse SHIFT+ENTER to open the menu (new window).
Nearly 80% of ‘A’ level students from underprivileged backgrounds attending the NIHR Biomedical Research Centre (BRC) summer school go on to university, a third of which are prestigious ‘Russell Group’ universities, according to a report out this month.

Gifted ‘A’ level students who attended NIHR BRC-supported laboratory placements said the scheme helped them choose universities and degrees, gave them greater insight into what science can offer and increased their awareness of career options.
News Link: Read more
News Date: 24/02/2014
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NIHR Biomedical Research Centre-supported Professor to examine effects of novel drug that modulates communication between nerve cells in brainUse SHIFT+ENTER to open the menu (new window).
A group of UCL researchers is beginning a £500,000 clinical trial to examine the effects of a novel drug that modulates communication between nerve cells in the brain.
News Link: Read full press release
News Date: 24/02/2014
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Medical records from Clinical Record Interactive Search (CRIS) system at NIHR Biomedical Research Centre for mental health to be used to identify how online rumours affect healthUse SHIFT+ENTER to open the menu (new window).
In the digital age, rumours – both true and false - spread fast, often with far reaching consequences. Online reviews of drugs, access to advice or diagnostic information have changed the relationship between patients and their doctors. 

In order to map how rumours spread through social media translate into patient behaviour, researchers at King’s College London are part of a new EU project.

The case studies carried out at King’s will use anonymised electronic medical records from the CRIS system at the NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King’s College London. 
News Link: Read more
News Date: 24/02/2014
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NIHR launches "Focus on Stroke" as ground-breaking stroke trial opens in the UKUse SHIFT+ENTER to open the menu (new window).
EuroHYP-1, the largest worldwide clinical trial of a new revolutionary stroke treatment called Therapeutic Hypothermia, is due to open in the UK. The study is just one of those featured on “Focus on Stroke”, a new online resource from the National Institute for Health Research (NIHR) aimed at raising public awareness of the exciting developments happening in stroke research.

Speaking about the launch of the trial, Dr Jonathan Sheffield, CEO at the NIHR Clinical Research Network said:
“This trial means that we will be able to give even more patients the opportunity to help doctors and researchers to get an even deeper insight into stroke, and gather evidence needed to drive better treatments.

“Thanks to facilities like the Hyper-acute Stroke Research centres, England has the infrastructure to lead the way in stroke research and offer more effective treatments to stroke patients across the country.”

EuroHYP-1 is just one study featured on a new NIHR online resource showcasing the pioneering work top researchers are doing to tackle stroke, with examples of treatments that are being researched in order to improve patient care in this area as well as resources for patients on how to get involved.
News Link: Read more
News Date: 20/02/2014
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NIHR PHR programme study published - The impact of free bus travel on public healthUse SHIFT+ENTER to open the menu (new window).
Free bus travel can result in a greater sense of wellbeing among young people, according to a NIHR Public Health Research (PHR) Programme-funded study published in Public Health Research this week.

The research team, led by Professor Judith Green from the London School of Hygiene and Tropical Medicine, evaluated the impact of free bus travel on public health in London. The researchers employed a number of methods including interviews and focus groups, travel diaries and a systematic review.
News Link: Read more
News Date: 20/02/2014
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NIHR Collaborations for Leadership in Applied Health Research and Care Greater Manchester (CLAHRC GM) to roll out new model of working to improve physical health of people with mental illnessUse SHIFT+ENTER to open the menu (new window).
CLAHRC Greater Manchester has been working in collaboration with the Manchester Mental Health and Social Care Trust to develop a new model of working to improve the physical health of people with severe mental illness.

They now plan to roll-out the new model to every Community Mental Health Team (CMHT) across the Trust, spanning North, Central and South Manchester Clinical Commissioning Groups.
News Link: Read more
News Date: 20/02/2014
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A Collaborations for Leadership in Applied Health Research and Care (CLAHRC) community e-newsletter, focusing on stroke research, is published to support the Focus on Stroke launchUse SHIFT+ENTER to open the menu (new window).
Eight of the nine pilot NIHR CLAHRCs had stroke research or implementation projects within their portfolio ranging from initiatives to improve early detection of stroke risk to improvements in secondary prevention.
News Link: Read more
News Date: 20/02/2014
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NIHR Collaboration for Leadership in Applied Health Research and Care East Midlands (NIHR CLAHRC EM) officially launched to drive forward improvement and innovation in local health priorities Use SHIFT+ENTER to open the menu (new window).
With life expectancy in the East Midlands lower than the England average and prevalence of long term conditions, such as diabetes, chronic obstructive pulmonary disease and poor mental health, being much higher in some inner city areas, it is vital to find new ways of tackling these issues. The NIHR CLAHRC EM brings together all the people involved in health care and research in the region and provides a unique framework in which to carry out and implement studies that will mean a real difference to local people.
News Link: Read more
News Date: 19/02/2014
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New survey launches to help identify mesothelioma treatment uncertaintiesUse SHIFT+ENTER to open the menu (new window).
An important survey launched on 17 February 2014 will help to inform future research into mesothelioma diagnosis, treatments and care. The survey is now available at www.psp.nihr.ac.uk/mesothelioma/survey, and will remain open for a few months to collect data from patients, carers and clinicians.

This is part of a project being carried out by a National Institute for Health Research (NIHR)-funded ‘Priority Setting Partnership’ (PSP) recently set up by the James Lind Alliance (JLA). The survey gives patients, carers and family members affected by the disease an opportunity to identify and prioritise unanswered questions about mesothelioma. The results of the survey will be published later this year and will be used to inform the ‘top ten’ priorities for clinical research, as determined by patients, carers and clinicians.

Professor Dame Sally C. Davies, Chief Medical Officer and Chief Scientific Adviser at the Department of Health, said:
“It is vital that we gather and listen to the views of as many people as possible so everyone knows the topics that are a priority for clinical research. Mesothelioma research has been identified as an important area and everyone needs to hear what patients, carers, families and healthcare professionals believe are the most important unanswered questions around the diagnosis, treatment and care of mesothelioma.”

Videos about the PSP are available to watch at: www.psp.nihr.ac.uk/mesothelioma/videos
News Link: Read more
News Date: 17/02/2014
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NIHR Blood & Transplant Research Units competition 2014Use SHIFT+ENTER to open the menu (new window).
A new, open competition to fund a number of NIHR Blood & Transplant Research Units (NIHR BTRUs) has now opened. NIHR BTRUs will be partnerships between universities and NHS Blood & Transplant (NHSBT), in a range of priority areas. The NIHR BTRUs will act as centres of excellence in multidisciplinary research in support of NHSBT.

From 1 October 2015, research funding of £15m over five years will be awarded through open competition to universities in England in partnership with NHSBT, to form NIHR BTRUs.

The closing date for submission of applications by universities in England that are interested in being considered for NIHR BTRU award is 17 April 2014 at 1.00pm.
News Link: Read more
News Date: 17/02/2014
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NIHR CRN first European patient in Respiratory COPD at Bradford Royal InfirmaryUse SHIFT+ENTER to open the menu (new window).
The NIHR Comprehensive Clinical Research Network has achieved first European patient for CCRN2590 in Respiratory COPD. This was achieved on Thursday 13 February at Bradford Royal Infirmary.

This takes the running total of first European patients achieved for 2013/14 to five.
News Link: Read more
News Date: 17/02/2014
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NIHR Respiratory Biomedical Research Unit part-funded study finds that passive smoking impairs children's responses to asthma treatmentUse SHIFT+ENTER to open the menu (new window).
Children exposed to cigarette smoke at home have lower levels of an enzyme that helps them respond to asthma treatment, a study has found.

The findings are reported in the journal Chest.

The study was funded by the Wellcome Trust and the NIHR Respiratory Biomedical Research Unit at Royal Brompton & Harefield NHS Foundation Trust and Imperial College London.
News Link: Read the full press release
News Date: 14/02/2014
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Queen Alexandra Hospital to host prestigious event celebrating research nursesUse SHIFT+ENTER to open the menu (new window).
Clinical research nurses are to be celebrated at a prestigious regional event being hosted at Portsmouth’s Queen Alexandra Hospital.

Around 100 research nurses, some from as far away as Cornwall, are to descend on the hospital next week for the Celebrating Clinical Research Nurses event being held as part of a programme organised by the National Institute for Health Research (NIHR) and Department of Health.

The event is one of four regional meetings organised following the success of the first NIHR national meeting held last May to celebrate International Nurses Day 2013.

Being hosted on Tuesday February 18, the event will celebrate the care nurses bring to the patient experience of participating in research; celebrate the leadership nurses bring to the delivery of research; and celebrate the innovation nurses bring to the clinical research field.
News Link: Read more
News Date: 13/02/2014
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NIHR Biomedical Research Centre supported study discovers new gene target for psoriasis treatmentUse SHIFT+ENTER to open the menu (new window).
Researchers at King’s College London have identified a new gene (PIM1), which could be an effective target for innovative treatments and therapies for the human autoimmune disease, psoriasis.

The study, published today in Science Translational Medicine highlights for the first time the role of PIM1 and the IL-22 cytokine – a protein that sends messages between cells – in skin inflammation such as that seen in psoriasis patients. 

The study was supported by the Medical Research Council, Wellcome Trust and the NIHR Biomedical Research Centre (NIHR BRC) at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London.
News Link: Read the full press release
News Date: 13/02/2014
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A new video on respiratory research at Imperial College promotes the NIHR Respiratory Biomedical Research Unit Use SHIFT+ENTER to open the menu (new window).
Imperial College London host a National Institute of Health Research (NIHR) Respiratory Biomedical Research Unit which focuses on chronic lung disease and has a long term aim to increase the number of new therapeutic agents, devices or biomarkers entering phase I and II clinical trials.
News Link: Read more and watch the video
News Date: 12/02/2014
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Results from trial led by NIHR Biomedical Research Centre faculty member finds promising new treatment for respiratory syndromeUse SHIFT+ENTER to open the menu (new window).
A new treatment for patients with acute respiratory distress syndrome (ARDS) has demonstrated an astonishing 81% reduction in mortality.

Approximately 300-400,000 people suffer from ARDS in western countries each year and despite modern day care the mortality rate remains high, around 35-45%. Major causes include direct lung injury such as lung infection (pneumonia), aspiration pneumonia or indirect injuries such as severe sepsis, major multiple trauma or pancreatitis.

At present there is no effective drug treatment for the syndrome, so patients tend to be treated with mechanical ventilation and optimisation and support of vital functions.

The results of the trial led by UCLH medical director and Biomedical Research Centre faculty member Dr Geoff Bellingan have now been published in The Lancet Respiratory Medicine.
News Link: Read the full news item
News Date: 10/02/2014
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NIHR Biomedical Research Centre researcher recruits final patient for facial pain trialUse SHIFT+ENTER to open the menu (new window).
A NIHR Biomedical Research Centre researcher has recruited the final patient into a ground-breaking international clinical trial of a possible new treatment for facial pain.

Professor Joanna Zakrzewska is an international expert on trigeminal neuralgia, a particular form of facial pain which results in unpredictable and excruciating shock-like attacks on one side of the face.
News Link: Read more
News Date: 10/02/2014
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Major new study, led by NIHR Biomedical Research Centre Director, begins recruitment to better identify hypertension in menUse SHIFT+ENTER to open the menu (new window).
Recruitment has begun to a major new study to see if there is a better way to identify younger people with early hypertension by looking at whether the way in which their blood pressure is measured can be refined. 

Led by Biomedical Research Centre Director Professor Bryan Williams, the study was awarded £735,000 from the NIHR/MRC Efficacy and Mechanism Evaluation Programme which funds clinical studies to test interventions where proof of concept has already been demonstrated, allowing their progress through early clinical trials and on to larger, later clinical trials.
News Link: Read more
News Date: 10/02/2014
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NIHR and MCRN - GenerationR - Young People Improving Research eventUse SHIFT+ENTER to open the menu (new window).
On the 11th September 2013, the National Institute for Health Research (NIHR) Medicines for Children Research Network (MCRN) held a national event promoting the involvement of young people and families in research.

GenerationR delivered a simple message to researchers, charities and the life-sciences industry: young people improve research. It demonstrated the range of ways the MCRN’s Young Person’s Advisory Group has impacted on the delivery of clinical research in the UK and sought to stimulate collaboration between YPAG and the wider clinical research community.

The GenertionR report has just been published and provides an insight into the event itself, which was supported by high profile members of the research community including: Chief Medical Officer for England, Professor Dame Sally Davies; Coordinator of the James Lind Initiative, Sir Iain Chalmers and CEO of the NIHR Clinical Research Network, Dr Jonathan Sheffield.

The report provides access to films, interviews, plus key recommendations to improve the delivery of clinical research for young people.
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News Date: 07/02/2014
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NIHR Biomedical Research Centre part funded research discovers that pain sensitivity may be influenced by lifestyle and environmentUse SHIFT+ENTER to open the menu (new window).
Researchers at King’s College London have discovered that sensitivity to pain could be altered by a person’s lifestyle and environment throughout their lifetime. The study is the first to find that pain sensitivity, previously thought to be relatively inflexible, can change as a result of genes being switched on or off by lifestyle and environmental factors – a process called epigenetics, which chemically alters the expression of genes.

Published today in Nature Communications, the study has important implications for understanding pain sensitivity and could lead to new treatments aimed at ‘switching off’ certain genes epigenetically.

This research was funded by the NIHR Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London.
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News Date: 06/02/2014
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New call for collaborative first-in-disease clinical trials in arthritisUse SHIFT+ENTER to open the menu (new window).
Arthritis Research UK has launched a competitive call for industry and academia to develop collaborative first-in-disease clinical trials of investigational drugs for arthritis and other rheumatic diseases. Eligible studies are expected to take advantage of the UK's outstanding arthritis research infrastructure provided by Arthritis Research UK and the National Institute for Health Research.
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News Date: 06/02/2014
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Funding and Partnership Opportunities for Stratified Medicine in Non-Cancerous ConditionsUse SHIFT+ENTER to open the menu (new window).
The NIHR Efficacy and Mechanism Evaluation (EME) Programme and the NIHR Office for Clinical Research Infrastructure (NOCRI) are hosting an event to explore funding and partnership opportunities for stratified medicine in non-cancerous conditions.
 
Proposals are sought for studies evaluating the efficacy of the stratification and treatment of patients with non-cancerous conditions.
This call includes both diagnostic tests to aid in patient stratification as well as treatments whose effects are targeted at specific disease pathways.
The event's agenda will provide the opportunity to hear industry experience of working with NHS and researchers, and researcher perspectives on partnering to take advantage of EME research funding awards.
There will be opportunities for one-to-one meetings with potential partners to establish collaborations and take your funding application forward, as well as meet with members of the EME Programme.
 
For further information about the event and to register your place, please visit the NOCRI website: www.nocri.nihr.ac.uk
News Link: Visit the NOCRI website
News Date: 06/02/2014
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NIHR Themed Call: Long-term Conditions in Children and Young PeopleUse SHIFT+ENTER to open the menu (new window).
The National Institute for Health Research has issued a call for evaluative research for long-term conditions in children and young people.

The research should aim to provide the evidence base to improve the health outcomes for children and young people that result from long-term conditions. The call is in support of the annual report of the Chief Medical Officer 2012 entitled “Our Children Deserve Better: Prevention Pays”.

A writing workshop for researchers considering applying to this call for research has been developed by the Royal College of Paediatrics and Child Health (RCPCH) and the NIHR Research Design Service (RDS).

For further information on the writing workshop, participating programmes, and to apply, please visit the NIHR website: www.themedcalls.nihr.ac.uk/children
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News Date: 06/02/2014
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A video produced from a NIHR Research for Patient Benefit funded study shows that improving balance through dance could help those with Parkinson’sUse SHIFT+ENTER to open the menu (new window).
It is estimated that 6.3 million people worldwide have Parkinson's disease (PD). Currently there is no cure -- treatments are focused on reducing the symptoms of the disease.
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News Date: 06/02/2014
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NIHR supported TwinsUK cohort study suggests ingredients found in tea and berries could guard against diabetesUse SHIFT+ENTER to open the menu (new window).
Eating high levels of flavonoids including anthocyanins and other compounds (found in berries, tea, and chocolate) could offer protection from type 2 diabetes - according to research from King’s College London and the University of East Anglia.

Findings published today in the Journal of Nutrition reveal that high intakes of these dietary compounds are associated with lower insulin resistance and better blood glucose regulation. 

A study of almost 2,000 people (volunteers from TwinsUK) also found that these food groups lower inflammation which, when chronic, is associated with diabetes, obesity, cardiovascular disease, and cancer. 
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News Date: 06/02/2014
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NIHR Research for Patient Benefit funded researchers have shown that Cognitive therapy is “safe and acceptable” to treat schizophrenia Use SHIFT+ENTER to open the menu (new window).
Researchers from The University of Manchester have shown cognitive therapy can be used as a safe and acceptable alternative treatment to for people with schizophrenia spectrum disorders who have chosen not to take antipsychotic drugs.

Research published in The Lancet shows cognitive therapy significantly reduced psychiatric symptoms in patients not taking antipsychotic drugs.

The study, funded by the NIHR Research for Patient Benefit Programme, aimed to establish whether cognitive therapy was effective in reducing psychiatric symptoms in people with schizophrenia spectrum disorders who had chosen not to take antipsychotic drugs.
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News Date: 06/02/2014
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NIHR Programme Grants for Applied Research funded project is recruiting service users and carers for a series of studies that will allow them to make more decisions about the care they receiveUse SHIFT+ENTER to open the menu (new window).
The study will allow service users to use their lived experiences for the benefit of future patients. The research is being completed as part of the EQUIP (Enhancing the Quality of User Involvement in Care Planning in Mental Health Services) Programme Grant.

The EQUIP project is funded by the NIHR Programme Grants for Applied Research (PGfAR) Programme and is sponsored by Manchester Mental Health and Social Care Trust.
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News Date: 06/02/2014
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NIHR Clinical Research Network - News from the Network - January 2014 editionUse SHIFT+ENTER to open the menu (new window).
The January 2014 edition of "News from the Network " from the NIHR Clinical Research Network is available.
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News Date: 04/02/2014
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NIHR Health Technology Assessment Programme January 2014 Bulletin availableUse SHIFT+ENTER to open the menu (new window).
The January 2014 Bulletin from the NIHR Health Technology Assessment (HTA) Programme is available to read.
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News Date: 04/02/2014
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The third edition of the NIHR Biomedical Research Centre at Great Ormond Street Hospital and University College London newsletter is out nowUse SHIFT+ENTER to open the menu (new window).
Sharing with you the new initiatives that the NIHR Biomedical Research Centre has supported, as well as news and successes from their faculty members, often in collaboration with other organisations.
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News Date: 04/02/2014
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New NIHR/HEE training opportunities Use SHIFT+ENTER to open the menu (new window).
NIHR TCC have now opened Round 5 for applications

• NIHR/HEE Clinical Doctoral Research Fellowship
• NIHR/HEE Clinical Lectureship and
• NIHR/HEE Senior Clinical Lectureship

The competition will close on Wednesday 30th April 2014 for Nurses, Midwives and Allied Health Professionals.

Applications are also welcomed from pharmacists for the NIHR / HEE Clinical Doctoral Research Fellowships.
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News Date: 31/01/2014
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£12 million further investment following results from successful NIHR Oxford Biomedical Research Centre supported trial of gene therapy for form of blindnessUse SHIFT+ENTER to open the menu (new window).
Nightstar, a new spin-out company from the University of Oxford and its research commercialisation company Isis Innovation, is to receive a £12 million investment from Syncona, an independent subsidiary of the Wellcome Trust.

The company has been formed to develop and commercialise therapies for retinal dystrophies – degenerative conditions that affect vision.

The announcement follows promising results earlier this month from the first clinical trial of a gene therapy for an inherited form of progressive blindness called choroideremia.

The gene therapy for choroideremia is currently being studied in a 12 patient Phase I clinical trial, supported by the Health Innovation Challenge Fund, a partnership between the Wellcome Trust and the Department of Health.

The research has received additional support from the NIHR Oxford Biomedical Research Centre and the charity Fight for Sight. Plans for an independent, grant-funded Phase II study are already underway.
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News Date: 31/01/2014
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