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Professor Pepper was appointed as a Professor of Cardiothoracic Surgery at the Brompton and Harefield hospitals in 1990. His clinical work spans across adult cardiac surgery, with a special interest in heart failure, mechanical circulatory support, aortic valve surgery and surgery of the thoracic aorta.
Prof Pepper has initiated ten randomised trials, all of which has resulted as papers in high impact journals. He is also the lead clinician for Aortic and Valve research for the Cardiovascular Biomedical Research Unit, and lead clinician for the Aortic theme in the Institute of Cardiovascular Medicine and Science (ICMS) between Brompton and Liverpool.
Since 2010, Prof Pepper has been chair of the Structural Heart Disease Care Group, at the Royal Brompton and Harefield NHS Foundation Trust. During this time the TAVI team has continued to grow and the UK TAVI trial recruiting to time and target.
Over the last eight years he has served on several trial steering committees and drug safety committees, working closely with the Imperial College Clinical Trials Unit. Prof Pepper is currently the NIHR Clinical Research Network National Specialty Lead for Cardiovascular Disease, with a special remit for heart failure and surgery.