Efficacy and Mechanism Evaluation (EME)

The Efficacy and Mechanism Evaluation Programme calls on the expertise, knowledge and opinion of a large number of people to ensure that the identification of research areas and funding decisions are chosen in a clear and fair way.

The EME Strategy Group advises the EME Programme Director on identification, development and prioritisation of research areas for advertisement through the commissioned workstream. In addition, it prioritises outline proposals received to the commissioned workstream for shortlisting by the EME Board.

The EME Board assesses outline and full proposals and makes funding decisions for the researcher-led workstream, and makes funding recommendations to the Department of Health for the commissioned workstream.

Members of EME advisory groups are required to declare any interests which conflict, or may be considered to conflict, with EME business, or may be perceived as influencing decisions made in the course of their work within the EME programme in line with the Conflicts of Interest Policy. All members are asked to complete the Register of Interest form (annually), which is intended to capture long term predictable interests that could be perceived to lead to conflicts of interest. These and other interests are judged on a case by case basis at individual meetings. View the Register of Interests for each EME programme advisory group.

Our Programme Director

Tom WalleyProfessor Tom Walley CBE, has been Programme Director of the EME Programme since its inception in 2008. He is also Director of NIHR Evaluation, Trials and Studies and Chair of the EME Strategy Group.

He is Professor of Clinical Pharmacology at Liverpool University and also works as a Consultant Physician at the Royal Liverpool University Hospital.

He formerly headed a research group at Liverpool University, focusing on drug prescribing, pharmaceutical policy, and clinical effectiveness and cost-effectiveness.

In June 2008, he was awarded a CBE by the Queen for his services to medicine.

The EME Board 

Professor David Crossman Dean and Head of School of Medicine, University of St Andrews

David Crossman

Professor David Crossman, is Bute Professor of Medicine and the Dean and Head of Faculty of Medicine at University of St. Andrews, Honorary Consultant Cardiologist for NHS Fife Health Board and Chief Scientist for Health, Scotland (from November 2017).

His previous appointments include Head of the School of Medicine at the Norwich Medical School, UEA, Director of the NIHR Cardiovascular Biomedical Research Centre and Professor of Clinical Cardiology at the University of Sheffield.  

He has served on the EME Board (2010-2015) as well as the Wellcome Trust Expert Review Group – Physiology in Health and Disease (2010-2014), British Heart Foundation Chairs and Programme Grants Committee (2004-2009), MRC Physiological Systems and Clinical Sciences Board (2004-2008), as Vice President of Education and Research and Chair of Programme Committee for the British Cardiovascular Society (2006-2008). He was on the cardiovascular panel of RAE 2008 and Unit of assessment panel 1 in REF 2014.

His research interests centre on the inflammatory basis of atherosclerosis and the pathogenesis of myocardial infarction.

Deputy ChairOrganisation
Professor Carl Clarke Professor of Clinical Neurology, Department of Neurology, Sandwell and West Birmingham Hospitals
Member (non-voting)Organisation
Professor Tom Walley CBE Director, EME Programme Department of Pharmacology & Therapeutics University of Liverpool
Professor Eric Alton Professor of Gene Therapy and Respiratory Medicine Imperial College London
Dr Simon Bond Senior Statistician from Cambridge Clinical Trials Unit, Addenbrooke’s Hospital Cambridge University Hospitals NHS Foundation Trust
Dr Louise Brown Senior Statistician, MRC Clinical Trials Unit, University College London
Professor Bill Deakin Professor of Psychiatry and Director NPU, Manchester University
Professor Anthony Dorling Professor of Transplant Inflammation and Repair, MRC Centre for Transplantation, King’s College London
Dr Simon Drysdale Clinical Lecturer and honorary specialty registrar in paediatric infectious diseases, University of Oxford and the Children’s Hospital, Oxford.
Professor Janet Dunn Professor of Clinical Trials & Head of Cancer Trials, University of Warwick
Mr Stephen Edgar Public board member
Professor Carrol Gamble Reader Medical Statistics, University of Liverpool
Professor Paula Ghaneh Professor of Surgery, University of Liverpool, Honorary Consultant Surgeon in Hepatobiliary Surgery, Royal Liverpool University Hospital
Professor Fiona Gilbert Consultant Radiologist, Head of Department of Radiology at the University of Cambridge, Cambridge University Hospitals NHS Foundation Trust
Professor Andrew Hughes Professor of Experimental Cancer Medicine, The Christie NHS Foundation Trust, University of Manchester
Professor Mark Hull Professor of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James's University Hospital
Professor Ajit Lalvani Director of Tuberculosis Research Centre, National Heart and Lung Institute, Imperial College London
Professor Iain McInnes Professor of Experimental Medicine / Director of Research Institute, University of Glasgow
Mr Richard Parnell Public board member
Professor Susan Pavitt Professor in Translational & Applied Health Research, Director of DenTCRU [Dental Translational and Clinical Research Unit], School of Dentistry, University of Leeds
Professor John Petrie Professor of Diabetic Medicine, University of Glasgow
Dr Duncan Richards Vice President, Clinical Head GSK Academic DPU, GlaxoSmithKline
Professor Robert Storey Professor and Honorary Consultant in Cardiology, Medical School, University of Sheffield
Professor Frank Sullivan Professor of Family and Community Medicine, University of St Andrews
Professor Steve Thornton Vice Principal (Health) and Executive Dean, Queen Mary University of London


Our community of reviewers play a vital part in maintaining and improving the quality of the EME Programme projects and outputs. They are sought from a variety of fields, including from those who work in and use NHS services. To demonstrate our gratitude to our reviewers and acknowledge the important work they do for the programme the names of the past year’s reviewers are listed below.

View a list of EME 2017 reviewers.