Urgent Public Health COVID-19 Studies

If you are a journalist and are interested in one of the nationally prioritised studies listed below, please contact the Press Office of the funding organisation.

NameTypeFunderSponsorStatusApprovalDate
OCTAVEnot availableNIHR / UKRIUniversity of BirminghamOpen01 March 2021
HORIZON 2not availableJanssen Vaccines & Prevention B.V.Janssen Vaccines & Prevention B.V.Withdrawnnot available
BASIL+BothNIHR Central Commissioning Facility (CCF)Tees, Esk and Wear Valleys NHS Foundation TrustOpen28 May 2020
PRONTOBothNIHRUniversity of LiverpoolOpen08 December 2020
A phase II study of a candidate COVID-19 vaccine in children (COV006)BothNIHR Central Commissioning Facility (CCF)not availableClosed17 February 2021
REMAP-CAPInterventionalEuropean CommissionUniversity Medical Centre Utrecht (Netherlands)Open 27 March 2020
Repair of ARDS by Stromal Cell Administration (REALIST)InterventionalPublic Health Agency for Northern Ireland; Wellcome TrustBelfast Health & Social Care TrustSuspended02 April 2020
A phase I/II trial of a candidate COVID-19 vaccine (COV001)InterventionalNIHR/UKRIUniversity of OxfordClosed11 March 2020
SARS-CoV-2 infectionInterventionalSYNAIRGEN RESEARCH LIMITEDSYNAIRGEN RESEARCH LIMITEDClosed30 March 2020
RECOVERY trialInterventionalNIHR/UKRIUniversity of OxfordOpen11 March 2020
PRINCIPLEInterventionalNIHR/UKRIUniversity of OxfordOpen11 March 2020
5774 Safety & Antiviral Activity of Remdesivir for moderate COVID-19InterventionalGilead Sciences IncGilead Sciences IncClosed25 March 2020
5773 Safety and Antiviral Activity of Remdesivir for severe COVID-19InterventionalGilead Sciences IncGilead Sciences IncClosed25 March 2020
A study to evaluate TCZ in patients with severe COVID-19 PneumoniaInterventionalF. Hoffmann-La Roche LtdF. Hoffmann-La Roche LtdClosed26 March 2020
Adaptive COVID-19 Treatment Trial (ACTT)InterventionalNational Institutes of Health (NIH), United StatesUniversity of Minnesota (USA)Closed27 March 2020
COPCOV trialInterventionalWellcome TrustUniversity of OxfordClosed30 March 2020
CANCOVIDInterventionalNovartisNovartisClosed06 April 2020
RUXCOVIDInterventionalNovartisNovartisClosed06 April 2020
ILIAD 7InterventionalRevImmuneRevImmuneOpen06 April 2020
RECOVERY - Respiratory SupportInterventionalDepartment of Health and Social CareUniversity of WarwickClosed13 April 2020
DeVENTInterventionalEuropean CommissionImperial College of Science, Technology and MedicineClosed13 April 2020
STOP-COVID19InterventionalInsmed IncUniversity of DundeeClosed21 April 2020
ACCORDInterventionalBERGENBIO ASUNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUSTSuspended21 April 2020
Investigating a Vaccine Against COVID-19 (COV002)InterventionalNIHR/UKRIUniversity of OxfordClosed30 April 2020
OSCARInterventionalGlaxoSmithKlineGlaxoSmithKlineClosed07 May 2020
CATALYSTInterventionalnot availableUniversity of BirminghamClosed11 May 2020
TACTIC-R InterventionalEly Lilly and Company; Alexion PharmaceuticalsCambridge University Hospitals NHS Foundation TrustClosed11 May 2020
DEFINEInterventionalnot availablenot availableSuspended11 May 2020
COG-UK HOCIInterventionalUK Research and Innovation (UKRI)University College LondonClosed11 May 2020
COVAC 1InterventionalNIHR/UKRIImperial College LondonClosed20 May 2020
BASIL-C19InterventionalNIHRTees, Esk and Wear Valleys NHS Foundation TrustClosed28 May 2020
REPROVIDEInterventionalNIHRUniversity of BristolOpen28 May 2020
Humoral Immune Correlates for COVID19InterventionalNIHR/UKRIRoyal Papworth Hospital NHS Foundation TrustOpen01 July 2020
COVID-19 Germ Defence ImplementationInterventionalNIHR/UKRIUniversity of BristolClosed10 August 2020
A Phase 3 COVID-19 Vaccine StudyInterventionalJanssen-Cilag LtdJanssen-Cilag LtdClosed28 August 2020
A trial to evaluate SARS-CoV-2 Recombinant Nanoparticle vaccineInterventionalNOVAVAX, INC.NOVAVAX, INC.Closed28 August 2020
PROVENTInterventionalAstraZenecaAstraZenecaClosed09 October 2020
STORM CHASERInterventionalAstraZenecaAstraZenecaClosed19 October 2020
ADAPT-Sepsis TrialInterventionalNIHRUniversity of ManchesterOpen19 October 2020
SARS-COV-2 Virus Vaccine (VLA2001) against COVID-19InterventionalValnevaValnevaClosed29 October 2020
Phase III trial of inhaled anti-viral (SNG001) for SARS-CoV-2InterventionalSynairgen Research LimitedSynairgen Research LimitedOpen14 October 2020
CORONAVITInterventionalPHARMA NORD (UK) LIMITEDQueen Mary University of LondonClosednot available
SG016 Home StudyInterventionalnot availableSynairgen Research LimitedClosed13 January 2021
A Randomized, Double-blind, Placebo-controlled Phase 2a Study to Evaluate a Range of Dose Levels and Vaccination Intervals of Ad26.COV2.S in Healthy Adults Aged 18 to 55 Years Inclusive and Adults Aged 65 Years and Older and to Evaluate 2 Dose Levels of AInterventionalnot availableJanssenClosed13 January 2021
Non-inferiority study comparing immunogenicity against COVID-19 of VLA2001 with [ACTIVE COMPARATOR]Interventionalnot availableValnevaClosed13 January 2021
Com-COV: Comparing COVID-19 Vaccine Schedule CombinationsInterventionalDepartment for Business, Energy and Industrial StrategyUniversity of OxfordClosed13 January 2021
SPIKE-1InterventionalLIFEARCCancer Research UKOpen01 February 2021
CoVLPInterventionalMedicagoMedicagoClosed21 December 2020
Study of the safety of & response to a COVID-19 vaccine in pregnancyInterventionalJanssen-Cilag LtdJanssen-Cilag LtdWithdrawn17 February 2021
COVID-19 Vacc Maternal ImmunisationInterventionalPfizer Inc.Pfizer Inc.Open13 January 2021
PROTECT VInterventionalLIFEARCCAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUSTOpen17 March 2021
HEAL-COVID trialInterventionalNational Institute for Health Research (NIHR)CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUSTOpen17 March 2021
Comparing COVID-19 Vaccine Schedule Combinations - Stage 2 (Com-COV2)InterventionalDEPARTMENT FOR BUSINESS, ENERGY AND INDUSTRIAL STRATEGYUniversity of OxfordClosed25 March 2021
ComFluCovInterventionalNIHR Central Commissioning Facility (CCF)UNIVERSITY HOSPITALS BRISTOL AND WESTON NHS FOUNDATION TRUSTClosed26 March 2021
PROTECT-CHInterventionalNIHRUniversity of NottinghamIn Setup01 March 2021
AGILE: CST-2InterventionalMerck Sharp & Dohme LimitedUniversity of LiverpoolOpen17 March 2021
AGILE: CST-3AInterventionalUnitaidUniversity of LiverpoolOpen17 March 2021
AGILE: CST-5InterventionalGLAXOSMITHKLINE RESEARCH & DEVELOPMENT LIMITED; VIR BIOTECHNOLOGY, INC.University of LiverpoolOpen17 March 2021
The PRIEST StudyObservationalNIHRSHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUSTClosed20 March 2020
FLU-CATs : Evaluation and refinement of pandemic influenza community assessment toolsObservationalNIHRUniversity of LiverpoolOpen20 March 2020
Clinical Characterisation Protocol (CCP) for Severe Emerging InfectionObservationalWellcome TrustUniversity of OxfordOpen24 January 2020
UKOSS: Pandemic Influenza in PregnancyObservationalNIHRUniversity of OxfordOpen20 March 2020
GenOMICCObservationalWellcome TrustNHS LothianOpen02 April 2020
Coronavirus infection in immunosuppressed childrenObservationalBritish Paediatric Allergy, Immunity and Infection GroupUNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUSTClosed02 April 2020
DIAMONDS SEARCH ObservationalEuropean CommissionImperial College of Science, Technology and MedicineOpen02 April 2020
What's the STORY ObservationalNIHR/UKRIUniversity of OxfordClosed06 April 2020
Virus WatchObservationalNIHR/UKRIUniversity College LondonOpen18 April 2020
Pregnancy and Neonatal Outcomes in COVID-19ObservationalNIHR/UKRIImperial College of Science, Technology and MedicineClosed18 April 2020
Neonatal complications of coronavirus disease (COVID-19)ObservationalNIHRUniversity of OxfordOpen21 April 2020
MERMAIDS - ARIObservationalEuropean CommissionUniversity of OxfordOpen07 May 2020
SIREN - SARS-COV2 immunity and reinfection evaluationObservationalPublic Health EnglandPublic Health EnglandClosed18 May 2020
FALCON C-19ObservationalNIHR/UKRI Manchester University NHS Foundation TrustOpen04 May 2020
RAPTOR C-19ObservationalNIHR/UKRIUniversity of OxfordOpen04 May 2020
VIVALDIObservationalDepartment of Health and Social CareUniversity College LondonOpen02 June 2020
COVID-HEARTObservationalnot availableLeeds Teaching Hospitals NHS TrustClosed04 June 2020
UK Coronavirus Immunology Consortium (CIC)ObservationalNIHR/UKRIUniversity of BirminghamOpen01 July 2020
PHOSP-COVIDObservational NIHR/UKRIUniversity of LeicesterOpen01 July 2020
C-MORE Capturing MultiORgan Effects of COVID-19ObservationalNIHR/UKRIUniversity of OxfordOpen04 June 2020
TraCK: Transmission of COVID-19 in KidsObservationalAction Medical ResearchImperial College of Science, Technology and MedicineOpen16 July 2020
NHS CHECKObservationalNIHR/UKRIKing's College LondonClosed05 August 2020
COVID-19 Infection SurveyObservationalOffice for National StatisticsUniversity of OxfordOpen20 August 2020
CLARITYObservationalF. Hoffmann-La Roche Ltd; Hull University Teadhing Hospitals NHS TrustRoyal Devon and Exeter NHS Foundation TrustClosednot available
AERATORObservationalNIHR/UKRINorth Bristol NHS TrustOpennot available
UK-REACHObservationalNIHR/UKRIUniversity of Leicester Open20 July 2020
Characterisation of COVID-19 long-term immune responseObservationalMedical Research CouncilUniversity of BristolClosed01 October 2020
RECAPObservationalOxford team: UKRI. Imperial team: Community Jameel (philanthropic) fundImperial College LondonOpen14 October 2020
FALCON C-19 (Workstream B)ObservationalNIHR / UKRIManchester University NHS Foundation TrustOpen04 May 2020
CCP-Cancer UKObservationalCLATTERBRIDGE CANCER CHARITY; NIHR / UKRITHE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUSTOpen06 November 2020
COVID-CNSObservationalMRC / UKRIUniversity of LiverpoolOpen21 December 2020
CO@h patient experience study (V1.0)ObservationalNIHRUniversity College LondonClosed29 January 2021
Children & young people with Long Covid (CLoCk) studyObservationalNIHR / UKRIGREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUSTOpen10 March 2021
CoMMinSObservational/InterventionalNIHR/UKRIUniversity of BristolOpen05 August 2020
Rapid development of manufacturing processes for future production of adenovirus-vectored COVID19 vaccine at million-dose scalePre-clinicalNIHR/UKRIUniversity of Oxfordnot available11 March 2020
nCoV: Developing CoV-bnMABs for therapy of highly pathogenic coronaviruses including SARS-CoV-2Pre-clinicalNIHR/UKRInot availablePossible pre-clinical study11 March 2020
Repurposing FDA-Approved Drugs for Treatment of 2019-nCoV-induced DiseasePre-clinicalNIHR/UKRIQueens University Belfastnot available11 March 2020