UKOSS: Pandemic Influenza in Pregnancy
Maternal and Perinatal Outcomes of Pandemic Influenza in Pregnancy
Sponsor: University of Oxford
CI: Prof Marian Knight
Approval Date: 20 March 2020
The previous aim of this study was to learn more about the effects of a future worldwide influenza (flu) epidemic and its treatment on pregnant women and their babies using the UK Obstetric Surveillance System (UKOSS). The study has now been extended to include information on all pregnant women hospitalised with COVID-19. It will use UKOSS to identify approximately 500 women hospitalised with an influenza pandemic (when the disease has spread across many countries) or COVID-19 in pregnancy over a 6 month period. Information will be collected through doctors and midwives in hospitals throughout the UK. By studying all the pregnant women admitted to hospital, the study hopes to identify whether certain groups of pregnant women are more at risk of the more severe problems caused by an epidemic of flu or COVID-19, and whether any particular additional treatment in pregnancy helps lessen these risks. Pregnancy and delivery information will be compared with that from previous UKOSS studies of approximately 700 women giving birth in the UK identified from the same hospitals who did not have flu or COVID-19. The information collected will be anonymous which means an individual patient cannot be identified. The research will be conducted at the University of Oxford and is funded by the NIHR Health Technology Assessment programme. [COVID-19 amendment 09/03/2020]
This NIHR supported study is a national study of women hospitalised with confirmed COVID-19 in pregnancy. The study, funded by the NIHR, will use the UK Obstetric Surveillance System (UKOSS) to collect information about all pregnant women admitted to hospital who are confirmed to have the virus infection. The information will be analysed on a continuous basis to inform ongoing guidance for women and maternity staff as we respond to the pandemic. Specifically, the study will describe incidence, management and outcomes of COVID-19 in pregnancy and identify factors associated with better outcomes for women and their babies. Anonymous information will be collected through the existing UK Obstetric Surveillance System (UKOSS) reporters, who are based in all maternity units in the UK. Reporters have been sent a live link to allow them to notify cases and complete an anonymous data collection form.
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