Study Detail


Multi-centre EuRopean study of MAjor Infectious Disease Syndromes (MERMAIDS): Acute Respiratory Infections in Adults

Status: Open

Type: Observational

Funder: European Commission

Sponsor: University of Oxford

CI: Professor Peter Horby

IRAS-Number: 168492

CPMS-ID: 19790

Approval Date: 07 May 2020


Pathogens causing acute respiratory infections (ARI) are among themost likely candidates to cause the next pandemic. We need to better understand why some people become much more ill than others when they have an ARI. It is likely that individual risk factors affect the body's response to ARI in different ways and this in turn can influence the severity of disease. Within broad risk groups it is currently not possible to predict which individuals are at increased risk of becoming severely ill. Consequently, there are no opportunities to tailor preventive and therapeutic interventions. In people who become moderately or severely ill, there is an assumption that the body's underlying response to disease is the same and hence that everyone will benefit equally from the same treatments. Increased insight into how different individuals respond to respiratory pathogens can allow us to better anticipate severity at individual patient levels. This in turn will enable us to formulate strategies for individualized treatment options to reduce disease severity, risk of complications and hospitalisations. In this study we will recruit people attending primary and secondary care in order to capture people with mild to severe ARI. We will analyse samples to observe individual gene activity and we will compare samples from people with different risk factors for more severe disease. This will provide a detailed insight into how the body responds to infection and provide opportunities to understand the specific contributions of different risk factors

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