Study Detail

What's the STORY

What's the STORY (Serum Testing of Representative Youngsters) Sero-epidemiological survey of England

Status: Open

Type: Observational


Sponsor: University of Oxford

CI: Prof Matthew Snape

IRAS-Number: 263097

CPMS-ID: 42523

Approval Date: 06 April 2020


With Public Health England, they will use an existing study of infectious disease immunity in children and teenagers 0 to 19 years old to study the presence of antibodies against COVID-19 (a marker of having had the disease and now having immunity) in approximately 400 children and teenagers per month for the duration of the COVID-19 outbreak, and they will collect information on recent respiratory illnesses and relevant medical history.


What's the STORY (Serological testing of Representative Youngsters) is a sero-epidemiology study led by the Oxford Vaccine Group, University of Oxford, in collaboration with Public Health England and a network of NIHR Clinical Research Network sites throughout England. Initially designed to assess serological protection against vaccine preventable diseases such as diphtheria and group C meningococcus in 0 to 24 year olds, following the COVID-19 outbreak the study has been adapted to evaluate the prevalence of antibodies against novel coronavirus SARS-CoV-2 in health children and adolescents. Blood samples will be collected from 3500 healthy 0 to 24 year olds accompanied by questionnaires on health and demographic data. Participants will be recruited throughout 2020 by a combination of direct mail out to designated postcodes (selected to be representative of regional demography) and through direct publicity. The study has received funding from NIHR and been designated an NIHR CRN Public Health Emergency Priority study.

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