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2020 NIHR ACF PES Hull York Platform Science and Bioinformatics



2020 NIHR Academic Clinical Fellowship in Priority Research Themes

HEE Local Office: Yorkshire and Humber
Medical School: Hull York Medical School
Research Theme: Platform Science and Bioinformatics
Specialty Options: Clinical Oncology or Medical Oncology

Plain English Summary

The post: This post - in Clinical Oncology or Medical Oncology – will focus on Cancer Genomics and Bio(medical)informatics. It will be based at the Biomedical Sciences Department (in the new £28 million Allam Research Building, at Hull York Medical School, University of Hull), and the Fellow will also be embedded with our NHS partner – Hull University Teaching Hospitals NHS Trust (Castle Hill Hospital site, based in the Queen’s Centre).

The research opportunities: Pancreatic cancer is one of the main research areas of expertise of Professor Maraveyas and his team. In 2017-2018, a team from the Faculty of Health Sciences pioneered and established a bioinformatics ‘pipeline’ in the field of medical genomics in Hull. A cluster of eight academics, led by Leonid Nikitenko (and called the Health*GDP Cluster), successfully developed this ‘pipeline’ and have already generated valuable findings. The Fellow will join this group and study the molecular pathways within pancreatic cancers, supervised and supported by Professor Anthony Maraveyas and Leonid Nikitenko (on behalf of the Health*GDP Cluster). The Fellow will work on molecular pathways in pancreatic tissue that lead to cancer and/or enable invasion of the cancer, using up-to-date techniques; next generation and whole genome sequencing, and bio(medical) informatics analysis. This will readily provide a project that could lead to a PhD for the Fellow. The University of Hull biobank have recently given approvals to store pancreatic cancer tissues from resections undertaken by the Queen’s Centre surgeons, and the Fellow will be well-supported in all aspects of research (including training in use of relevant materials, and in laboratory and bioinformatics techniques), working with a collaborative inter-disciplinary team in this area of research. People with pancreatic cancer have helped to inform priorities in this research, and will continue to input to shape the relevance of the project.

The training opportunities: We view our Academic Clinical Fellows as the academic leaders of tomorrow and our programme is designed to equip them accordingly. We ensure individual Fellows are well supported and can make best use of the extensive research training available to them. Together with exposure to an on-going NIHR portfolio of multi-centre clinical research in pancreatic cancer, the Fellow will receive comprehensive training and support in becoming a clinical investigator in this field, including techniques, and training on the informatics project. Many trainees have commented on the excellent support available. If appropriate, the Fellow will register for the MSc in Medical Sciences by Thesis, which delivers comprehensive research methods training and delivers the skills to progress to a PhD or MD. Those with an MSc already have an individually-tailored training programme to further develop their research skills and help them prepare a PhD Fellowship application. The team also organises two bespoke training days each year, with an annual presentation day and a Yorkshire-wide presentation day for all trainees from Hull York, Leeds and Sheffield. This supports networking and provides a wider context for the trainee to gain insights into their progression and achievements.