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2020 NIHR ACF PES Hull York Therapeutics or Clinical Pharmacology

 

Contents

2020 NIHR Academic Clinical Fellowship in Priority Research Themes

HEE Local Office: Yorkshire and Humber
Medical School: Hull York Medical School
Research Theme: Therapeutics or Clinical Pharmacology
Specialty Options: Haematology

Plain English Summary

Academic Clinical Fellow in Haematology at Hull York Medical School.

The post: This post is based in the Department of Haematology in Hull, and at the Centre for Atherosclerosis and Metabolic Disease at Hull York Medical School. The Fellow will work in the well-equipped research laboratories in the Wolfson (medical school) and Hardy (NHS trust) buildings, accessing world-class biomedical research laboratories as well as NHS clinical facilities. On-site facilities include cell and tissue culture suites, biomolecular and histological facilities, and the microscopy suite. The Centre for Atherosclerosis and Metabolic Disease - led by Professor Tim Palmer, Centre Director and Chair in Cardiovascular Biology - has a highly active research environment and a strong record for supporting training. It holds weekly joint laboratory meetings, journal clubs, seminars, and also offers active mentorship of trainees by post-doctoral scientists. An established monthly external speaker seminar series allows the trainees to interact on a scientific and personal level with an established high-calibre scientists. Trainees are supported to present their research in both national and international conferences.

The research opportunities: The Academic Clinical Fellow will work on targeted re-purposing of diabetes medicines to reduce thrombosis (blood clots) in patients with haematological illnesses such as polycythaemia vera, essential thrombocythaemia, and primary myelofibrosis. Over 3,000 people in the UK are diagnosed with these conditions every year. A common cause of these illnesses is a protein mutation, which drives disease progression. The Fellow will study the link between this protein mutation and thrombosis (blood clots) which often complicate the illness to reduce both quality-of-life and life expectancy. They will also assess how diabetic medicines may be used to help. People experiencing these conditions and their complications help to inform this research, especially which outcomes are important and how these are best assessed and measured.

The training opportunities: We view our Academic Clinical Fellows as the academic leaders of tomorrow and our programme is designed to equip them accordingly. We ensure individual Fellows are well supported and can make best use of the extensive research training available to them. Many trainees have commented on the excellent support available. If appropriate, the Fellow will register for the MSc in Medical Sciences by Thesis, which delivers comprehensive research methods training and delivers the skills to progress to a PhD or MD. Those with an MSc already have an individually-tailored training programme to further develop their research skills and help them prepare a PhD Fellowship application. The team also organises two bespoke training days each year, with an annual presentation day and a Yorkshire-wide presentation day for all trainees from Hull York, Leeds and Sheffield. This supports networking and provides a wider context for the trainee to gain insights into their progression and achievements.