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2020 NIHR ACF PES Imperial Platform Science and Bioinformatics



2020 NIHR Academic Clinical Fellowship in Priority Research Themes

HEE Local Office: North West London
Medical School: Imperial College London
Research Theme: Platform Science and Bioinformatics
Specialty Options: Paediatrics

Plain English Summary

Paediatrics Research projects in Platform Science

We have an enormous array of research utilising platform sciences from which an ACF can select a project. Specific research areas aligned to the platform science theme include:

i. Discovery/development of diagnostic gene expression, protein and metabolomic signatures for infectious and inflammatory diseases, using data/samples from major datasets collected over many years from children with various infectious diseases. There is a particular focus on classification of infections in individuals with other illnesses such as sickle cell disease or cancer.

ii. Discovery and development of biomarkers from children with fevers to predict life-threatening infection (as opposed to more simple infections). We have longitudinal data from children with life-threatening disease and aim to predict future outcomes and treatment responses.

iii. Investigate interactions between children and the infective organisms using genetic sequencing to explore the biology of severe infections.

iv. Identifying specific gene signatures of babies with perinatal brain injury and sepsis in newborn infants, and integration with brain imaging, to develop rapid tests to guide personalised therapies such as brain cooling.

v. Exploration of the genetic basis of infectious disease susceptibility and severity, working with the newly established NIHR BRC Severe Infection Genetics clinic.

vi. Detailed work on treatment stratification in asthma and allergic diseases such as peanut allergy.

vii. Determination of early life genetic and other markers driving the transition from apparent normality at birth to children with recurrent wheeze or those with allergic asthma

viii. Investigating the use of routinely collected Northwest London data to target public health interventions and address unmet healthcare needs more effectively in children with multi-morbidity.