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2020 NIHR ACF PES Liverpool Acute Care



2020 NIHR Academic Clinical Fellowship in Priority Research Themes

HEE Local Office: North West Medical
School: University of Liverpool
Research Theme: Acute Care
Specialty Options: Obstetrics and Gynaecology

Plain English Summary

Peri-conceptional Research that spans both Obstetrics & Gynaecology is the overarching theme offered with this ACF post. The suitable candidate have the option of either following either a gynaecology orientated (early pregnancy biomarker programme; supervised by Prof Hapangama) or an obstetrically orientated (late pregnancy biomarker programme; supervised by Dr Sharp) research project, dependent on their desire. Both obstetrics & Gynaecology research streams are multidisciplinary: (a) with laboratory scientists, clinical scientists, clinical trialists, consumers, (b) social scientists, clinical trialists, public health doctors. Our research programme is based on the previous and the current ongoing ground-breaking work at our department; including 3D culture models of the human endometrium, and biomarker studies in pre-term labour and in pre-eclampsia. The ACF will get an opportunity to also work collaboratively with a group of internationally renowned researchers worldwide (UK-Newcastle, London, Birmingham, Oxford and Edinburgh and international- Karolinska- Sweden, Michigan-USA, LA-USA, China, Norway and Australia). We have an established large tissue bank providing patient derived samples for the ACF and our biomarker programme, utilising cutting edge research methodologies and metabolomics, proteomic and genomic approaches. The candidate will have opportunities to gain experience in advanced laboratory techniques including advanced in vitro 3D tissue culturing, animal models (e.g. Chick chorio-alantoic membrane (CAM) model), gene manipulation (siRNA/ shRNA), microarrays/RNA sequencing, laser capture microdissection, bioinformatics and all advanced molecular techniques as well as to conduct clinical trials. All these research methodology will be at the disposal of the successful ACF candidate to utilise in developing novel avenues for their future research. The last 2 ACFs attached to our department, received training in Liverpool and in other prominent centres in UK and abroad, developed successful nationally competitive Clinical Research Training Fellowship applications to obtain externally funded PhD studentships, and successful completed their PhDs, to be appointed as NIHR clinical lecturers in our department. This highlight the continuing support and opportunities available in training at our department. The successful ACF will be working with other PhD students and scientists in the department acquiring all transferable academic skills as well as developing their own research project that will provide the basis for a fellowship application.

Description of clinical training component of the programme.

The clinical training will all take place at Liverpool Women’s Hospital. The environment is excellent for the clinical training of both early career trainees (as would be the case with ACFs) as well as later career trainees (because of the well developed, regional subspecialty programmes in fetal medicine, gynaecological oncology, urogynaecology and reproductive medicine) as well as a British Society of Gynaecological Endoscopists accredited Endometriosis centre for advanced minimal access surgery. Clinical training will allow the post holder to achieve his/her core competencies, as defined by the RCOG, for whatever level of clinical training they are at. The ACF will undergo annual review of competence progression (ARCP) using the documentation produced by the Academy of Medical Sciences. Educational supervisors will be allocated at the start of the rotation. At Liverpool Women’s Hospital, there will be separate clinical supervisors for Obstetrics and for Gynaecology. The core curriculum training and log book completion will be overseen by the Specialty Tutor at Liverpool Women’s Hospital, the Regional Training Programme Director and the Academic Representative of Health Education England, the North West deanery of Obstetrics and Gynaecology.