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2020 NIHR ACF PES Southampton Acute Care



2020 NIHR Academic Clinical Fellowship in Priority Research Themes

HEE Local Office: Wessex
Medical School: University of Southampton
Research Theme: Acute Care
Specialty Options: Anaesthetics

Plain English Summary

The Southampton ACF Programme in Anaesthesia and Perioperative Medicine prepares ACFs for rewarding and influential careers in academic anaesthesia and perioperative medicine. The University of Southampton / University Hospital Southampton NHS Foundation Trust partnership has a global reputation as a centre of excellence in anaesthesia and perioperative medicine research. We work across boundaries: between the University and the Trust, with other University Faculties (Faculty of Engineering and Physical Sciences, Faculty of Environmental and Life Sciences), and around the UK (University College London, Kings College London, and Cambridge).

The team work with UCL (Bloomsbury Innovation Group) to offer opportunities in med-tech / device development. We work closely with commissioners to rapidly translate research findings into the regional healthcare setting (e.g. Wessex Fit-4-Surgery). Our research focuses on translational integrative human physiology for patient benefit. We have a critical mass of clinicians, clinician scientists and scientists, engaged in experimental work of relevance to patients undergoing major surgery. This spans the spectrum from bench-top laboratory work, through experimental medicine and clinical trials, to health services research.

Together we currently host the leadership of three large (>1000 patient) clinical trials (FLOELA, WESFIT, INSPIRE) and have a large number of smaller trials on-going. The NIHR Biomedical Research Centre (BRC) is the research interface between the University and the trust with Southampton being the only BRC with an identified theme in critical care (incorporating anaesthesia and perioperative medicine). The team offer a wide variety of specific projects across a spectrum of interests including: preoperative risk evaluation; surgery & cancer therapies (Fit-4-Surgery); exercise testing & training; anaemia & surgery; perioperative fluid therapy; perioperative oxygen therapy; perioperative health services research (clinical epidemiology); applied health research in perioperative medicine (e.g. pathway development, quality improvement); technology innovation; as well as integrative environmental physiology (Xtreme-Everest oxygen research).

The team aim for, and achieve, a high level of success with fellowship applications to major funders. The period of time between appointment and commencement of the initial ACF academic time is used to identify the field of study and refine specific questions that will subsequently be explored. Previous projects have spanned the spectrum from developing entirely novel areas based on ideas developed by our ACFs, expanding established programmes (e.g. Fit-4-Surgery) to encompass ACF projects and using current cohorts and clinical trials as a platform for focussed or mechanistic ACF led studies.