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2020 NIHR ACF PES UEA Platform Science and Bioinformatics

 

Contents

2020 NIHR Academic Clinical Fellowship in Priority Research Themes

HEE Local Office: East of England
Medical School: University of East Anglia
Research Theme: Platform Science and Bioinformatics
Specialty Options: Gastroenterology or Medical Microbiology or Urology

Plain English Summary

An ACF post is available in Platform Science in the areas of Gastroenterology, Medical Microbiology and Urology.

Gastroenterology - Risk stratification of Crohns Disease
Aims and Background: A major goal of current research in Inflammatory Bowel Disease is to classify patients in terms of the cause of their disease, the clinical course and outcome of the disease and its response to treatment. This will enable the correct treatment to be given to the correct patient. This is sometimes called personalised medicine. We aim to combine the effects of patient genes and gut bacteria to give an overall picture of how the patients disease will behave.
Design and Methods. We have already developed state-of-the-art bioinformatic and mathematical techniques for combining genetic, cellular and bacterial data of the analysis of Ulcerative Colitis in individual patients. In this project the ACF will apply these newly established techniques for the analysis of Crohns disease.
Patient and public involvement: A patient group will be established to discuss and explain this project.
Dissemination: The results of the project will be published in major journals and presented at international meetings.

Medical Microbiology – Rapid Diagnosis of Meningitis
Aims and Background: Meningitis is an infection of the protective membranes that surround the brain and spinal cord (meninges). Rapid diagnosis of meningitis is crucial to differentiate bacterial and viral meningitis. Rapid genetic tests are becoming more widely available but are not sufficiently comprehensive to detect all potential pathogens and antibiotic resistances. The aim of the project is to develop and evaluate a rapid new genetic test to identify meningitis bugs directly from cerebrospinal fluid (CSF) samples.
Design and Methods. The ACF will use a new technique called Nanopore metagenomics sequencing technology for pathogen and antimicrobial resistance profiling in CSF samples.
A clinical evaluation of the method using CSF samples from children from Norwich and Great Ormond Street Hospital.
Patient and public involvement: A patient and parent group will be established to discuss and explain this project.
Dissemination: The results of the project will be published in major journals and presented at international meetings. The new diagnostic test technology will be disseminated through NHS microbiology depts.

Urology – Genetic predictors of the behaviour of Prostate Cancer
Aims and Background: Prostate cancer is a highly varied disease with some behaving posing little threat to health to others which are highly aggressive. The reasons for this variable behavior is not fully understood. The aim of the project is to explore the genetic basis in individual cancers in order to improve treatment.
Design and Methods: We have developed a test called PUR (Prostate Urine Risk), based on a new way of measuring RNA in urine extracellular vesicles. The ACF will validate this new test using patient samples and refine the test for routine use in the NHS.
Patient and public involvement: A patient group will be established to discuss and explain this project.
Dissemination: The results of the project will be published in major journals and presented at international meetings.