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ACF UCL Therapeutics or Clinical Pharmacology



2019 NIHR Academic Clinical Fellowship in Priority Research Themes

HEE Local Office: North Central and East London

Medical School: University College London

Research Theme: Therapeutics or Clinical Pharmacology

Specialty Options: Clinical Pharmacology and Therapeutics or Cardiology or Respiratory Medicine

Plain English Summary of the research training associated with the Academic Clinical Fellowship

The Clinical Pharmacology and Therapeutics (CPT) Theme for this ACF incorporates the specialties of Clinical Pharmacology, Cardiology and Respiratory at UCLH and Bart’s Heart Centre. The clinical component  will incorporate general medicine; for Cardiology ACF’s exposure to the full range of experience in Cardiology subspecialties at including imaging, structural intervention and electrophysiology to train ACFs in clinical investigation methodologies in cardiac patients for mechanistic and interventional studies and for Respiratory, training will include specialist care of all the common lung diseases including asthma, smoking related lung diseases, cancer, lung infections (including TB and infections related to immunosuppression), and lung infiltrations. Trainees will learn the role of and how to perform specialist procedures such as bronchoscopy (including specialist biopsy techniques and intra-bronchial tumour treatments) and pleural ultrasound. These attachments will ensure a broad range of experience and skill acquisition required to attain IMT competencies and MRCP.

Within each chosen speciality the types of research project will be unique although the overarching theme of CPT training encompasses all aspects of drug action in man. We offer a range of academic activities from which trainees can choose. This includes basic bench science where the trainee will acquire basic and advanced laboratory techniques investigating mechanistic effects of mediators, molecules and compounds using cellular, organ or system based approaches. Human clinical science can be carried out in the form of first in man studies in house, as part of the UCLH BRC Clinical Research Facility or as secondment to industry. Moreover for both basic and human research CPT can offer secondment or experience with industry through in-reach projects. CPT has strong links to the Institute of Health Informatics and HDR-UK offering experience in cutting edge analysis of ‘big data’ using statistical and machine learning approaches for genomic and other mulit-omic data at a population scale. Groups here are interested in how genomics and other multi-omics can be used for recreate an in-silico drug discovery pipeline i.e. target identification for a new medicine or for repurposing, deciphering on and off target effects and using this pipeline to determine efficacy for a given outcome. For this we utilise both in house and internationally collaborative cohorts, both disease specific and population based. There is also the opportunity to be involved with national cohorts as well as disease specific cohorts that are run by contributing specialities to CPT. The CPT speciality itself has more direct NHS facing role through policy commitments locally and regionally on formulary committees where evidence is reviewed  for the introduction of new medicines to the NHS. This offers training in undertaking systematic reviews, further enhanced by being co-located with the Cochrane Heart Group. Finally there is an opportunity to be trained in teaching methods and to deliver teaching to medical students and undergraduates as part a broad teaching portfolio. CPT is broad, drawn together by the theme of medicines and training focussed in the way medicines are developed, tested and introduced into clinical practice and the NHS.