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COVID-19 Prophylaxis Oversight Group - terms of reference


Published: 04 January 2021

Version: 1

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In July 2020, the Department of Health and Social Care (DHSC) established the COVID-19 Prophylaxis Oversight Group (POG) to guide development of pre- and post-exposure prophylaxis for SARS-CoV2 infection.

The POG is formed of a group of independent experts with no vested interests who have the expertise to cover the key issues related to prophylaxis. The group is chaired by Professor David Lalloo.

Overall responsibilities of the Oversight Group

  • To advise on national priorities for prophylaxis
  • To assist with a coordinated national approach to prophylaxis with other relevant stakeholders
  • To oversee the design and development of platform trials for the study of prophylactic agents
  • To determine potential trial criteria including the threshold for adverse effects, effect size, patient populations and target product profiles for future prophylaxis trials
  • To determine how prophylactic trials fit into the COVID-19 trial landscape
  • To support and oversee the prioritisation of prophylaxis agents through the UK CTAP Prophylaxis panel


 Name  Organisation
 David Lalloo (Chair)  Liverpool School of Tropical Medicine
 Dipti Patel  NHS Imperial
 Helen Steel   GSK
 Hywel Williams   University of Nottingham
 Jonathan Van Tam   Department of Health and Social Care
 Liam Smeeth   London School of Hygiene & Tropical Medicine
 Michael Jacobs   University College London
 Nick Lemoine  NIHR
 Chris Whitty   Department of Health and Social Care

Oversight Group secretariat

  • The POG will be supported by a DHSC-led secretariat
  • The secretariat will organise the meetings and make all arrangements.
  • The secretariat will take minutes of POG meetings. These will be signed off by the Chair and distributed amongst the membership.