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Delivering complex and innovative trials: Case study library


Case studies demonstrating delivery of complex and innovative trial design

Case studies demonstrating innovative delivery techniques

Podcast series looking at complex and innovative trial design and delivery

These short podcasts inform, educate and answer the common questions around the management and delivery of CID trials. They are presented by a range of experts inclufing experienced researchers, patients, ethic committee members and more. Both series have been created in collaboration with the Health Research Authority.

Listen to Complex and Innovative Design Trials podcast series one (2020)

Listen to Complex and Innovative Design Trials podcast series two: Perspectives from the pandemic (2021)

Transcripts are available on SoundCloud once you have accesed a specific podcast.

  • Emma Lowe explains the importance and impact of innovation in clinical research during the COVID-19 pandemic
  • Professor Matt Sydes discusses the importance of communicating trial results to the study participants
  • Professor Sir Munir Pirmohamed describes the NHS as the UK's "not so secret weapon" in delivering COVID-19 research
  • Dr Hugh Davies talks about how the pandemic and clinical experience can be a new preface to clinical research
  • Dr Emma Gray explains the development of the Muliti-Arm, Multi-Stage (MAMS) design trial ‘Octopus’ for people with progressive Multiple Sclerosis (MS)
  • Professor Tim Maughan reveals lessons from running the adaptive FOCUS 4 trial
  • Professor Thomas Jaki discusses the AGILE initiative and the advantages and challenges of platform trials
  • Professor Pam Kearns talks about the CATALYST trial: Accelerating drug development for COVID-19
  • Dr Camille Carroll explains the role of digital technology in clinical trials
  • Kirsty Wydenbach provides the regulators perspective complex deign trials, and how COVID-19 has impacted the MHRA ways of working
  • Yan Yiannakou talks about running a wholly virtual trial during the COVID-19 pandemic.

More info

Learn more about how the NIHR has been supporting the delivery of novel, complex and innovative clinical trials.