Date
Tuesday 25th June 2019 (Day 1)
Venue
Millennium Gloucester Hotel, Kensington, London
Present members
Professor Danny McAuley (Programme Director and Interim Chair)
Professor Eric Alton (Deputy Chair)
Dr Matthew Ahearne
Dr Louise Brown
Ms Anne-Laure Donskoy
Professor Janet Dunn
Professor Carrol Gamble
Professor Jonathan Grigg
Professor Ajit Lalvani
Professor Gregory Lip
Professor Michael Nicholson
Mr Richard Parnell
Dr Richard Peck
Professor John Petrie (from 2.00pm)
Professor Ruth Plummer
Professor Steve Thornton (from 1.00pm)
Professor Mark Thursz
Professor Chris Weir
Co-Opted Committee
Members: Professor Robert Storey (By telephone at 11.50am)
Secretariat
Dr Andrew Cook
Dr Elena Harden
Miss Helen Munday
Dr Dani Preedy
Ms Susan Solomons
Apologies
Professor Bill Deakin
Professor Iain McInnes
Professor Rustam Salman
Absent DCM comments were presented at the meeting
Observers / In attendance
Alex Wilkinson, Yorkshire and The Humber, RDS
Karolina Rusiak, RDCS Wales
Vicky Taylor, Assistant Director, Application & Funding NETSCC
Dr Penny Morton, MRC
Professor John Norrie, University of Edinburgh
Stage 2 Proposals
18/125: Researcher Led
NIHR128104: Hereditary Sensory Neuropathy Serine trial (SENSE trial)
Professor Mary Reilly
Chair: Professor Danny McAuley
Declared a conflict and left the room: Louise Brown
Arrived/left meeting: Carrol Gamble arrived at the end of the discussion and did not vote
Decision: Declined
18/86: Precision Medicine
NIHR128529: Novel blood test to personalise Early Stage Colorectal Cancer treatment
Professor David Cunningham
Chair: Professor Danny McAuley
Declared a conflict and left the room: Richard Peck
Decision: Recommended to Programme Director to consider fund with changes
18/58: Researcher Led
NIHR127461: SuSPeCT study (Stratification of Patients Suspected of Colorectal Cancer)
Professor Ramesh Arasaradnam
Chair: Professor Danny McAuley
Declared a conflict and left the room: Janet Dunn, Jonathan Grigg, Matthew Ahearne
Conflicted but not in attendance: Steve Thornton
Decision: Declined
18/125: Researcher Led
NIHR128240: Remote Ischaemic Conditioning After Stroke 3 (RECAST-3): A multicentre randomised controlled trial
Associate Professor Timothy England
Chair: Professor Danny McAuley
Declared a conflict and left the room: Chris Weir
Conflicted but not in attendance: John Petrie, Iain McInnes
Decision: Recommended to Programme Director to consider fund with changes
18/131: Urothelial Cancers
NIHR128103: Genotype of Urothelial cancer: Stratified Treatment and Oncological outcomes (GUSTO): Phase II study
Professor James Catto
Chair: Professor Danny McAuley
Declared a conflict and left the room: Andrew Cook, Richard Peck
Decision: Recommended to Programme Director to consider fund with changes
18/56: Neurodegenerative Disorders
NIHR127921: Evaluation of Triumeq as a treatment for amyotrophic lateral sclerosis: The Lighthouse 2 UK Study
Professor Ammar Al-Chalabi
Chair: Professor Danny McAuley
Declared a conflict and left the room: Jonathan Grigg
Conflicted but not in attendance: Steve Thornton
Decision: Recommended to Programme Director to consider fund with changes
18/125: Researcher Led
NIHR128445: Efficacy and mechanisms evaluation of a blood free (acellular) perfusion fluid for use in normothermic machine perfusion and transplantation of extended criteria donor livers
Professor Darius Mirza
Chair: Professor Danny McAuley
Declared a conflict and left the room: None
Arrived/left meeting: Steve Thornton and John Petrie arrived at the end of the discussion and did not vote
Decision: Declined
18/127: Transplantation
NIHR128475: Early detection of post-transplant lung allograft dysfunction by monitoring of lung clearance index
Dr Alex Horsley
Chair: Professor Danny McAuley
Declared a conflict and left the room: None
Conflicted but not in attendance: Bill Deakin
Decision: Declined
18/169: Mechanisms of Action of Health Interventions
NIHR129029: Mechanistic Evaluation of Treatments for Acute Antibody-Mediated Rejection of the Kidney Transplant
Dr Candice Roufosse
Chair: Professor Danny McAuley
Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Mark Thursz, Chris Weir
Decision: Recommended to Programme Director to consider fund with changes
18/169: Mechanisms of Action of Health Interventions
NIHR129392: “OSMOTIC Study” - Investigating the mechanisms of action of hyperosmolar therapy on neurological outcomes following acute severe traumatic brain injury
Dr Matthew Rowland
Chair: Dr Andrew Cook
Iain McInnes was not present and his comments were presented on his behalf.
Declared a conflict and left the room: Danny McAuley, Janet Dunn
Decision: Declined - invited to resubmit
18/169: Mechanisms of Action of Health Interventions
NIHR128930: HABSelect2: Hyaluronan-based sperm selection, protection against male-mediated miscarriage
Dr Jackson Kirkman-Brown
Chair: Professor Danny McAuley
Iain McInnes was not present and his comments were presented on his behalf.
Declared a conflict and left the room: None
Decision: Declined
18/126: Functional Imaging
NIHR128494: Application of functional MRI to improve assessment of chronic kidney disease (AFiRM study)
Associate Professor Nicholas Selby
Chair: Professor Danny McAuley
Declared a conflict and left the room: None
Decision: Recommended to Programme Director to consider fund with changes
18/86: Precision Medicine
NIHR128465: Positioning Imatinib for Pulmonary Arterial Hypertension
Professor Martin Wilkins
Chair: Professor Danny McAuley
Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Mark Thursz, Michael Nicholson, Chris Weir
Decision: Recommended to Programme Director to consider fund with changes
11/30: Researcher Led Contract Extension
11/30/07: Multi-centre Randomized Controlled Trial of angiotensin converting enzyme inhibitor (ACEi) /angiotensin receptor blocker (ARB) - withdrawal in chronic kidney disease – STOP-ACEi-STUDY (SAS)
Professor Sunil Bhandari
Chair: Professor Danny McAuley
Iain McInnes was not present and his comments were presented on his behalf.
Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Mark Thursz, Matthew Ahearne
Decision: Approved
Stage 1 Proposals
18/125: Researcher Led - Resubmission
NIHR128602: Randomised Evaluation of the Effect of Atrial Fibrillation Targeted Treatment Strategies on Exercise Capacity in Heart Failure with Preserved Ejection Fraction (EASE-HFpEF) Trial
Dr Tom Wong
Chair: Professor Danny McAuley
Declared a conflict and left the room: Andrew Cook, Eric Alton, Ajit Lalvani, Mark Thursz, John Petrie
Conflicted but not in attendance: Iain McInnes
Decision: Declined
18/127: Transplantation - Resubmission
NIHR128600: PROpHET - Perfusion and Recovery Of HEarts for Transplantation
Mr Pedro Catarino
Chair: Professor Danny McAuley
Iain McInnes was not present and his comments were presented on his behalf.
Declared a conflict and left the room: Andrew Cook, Chris Weir
Conflicted but not in attendance: Bill Deakin
Decision: Declined
18/140: Frailty Themed Call
NIHR128926: Using METformin to PREVENT progression to frailty for older people (MET-PREVENT) – a randomised controlled trial
Professor Miles Witham
Chair: Professor Danny McAuley
Declared a conflict and left the room: Ruth Plummer, Chris Weir
Decision: Declined
Date
Wednesday 26th June 2019 (Day 2)
Venue
Millennium Gloucester Hotel, Kensington, London
Present Members
Professor Danny McAuley (Programme Director and Interim Chair)
Professor Eric Alton (Deputy Chair)
Dr Matthew Ahearne
Dr Louise Brown
Professor Bill Deakin
Ms Anne-Laure Donskoy
Professor Janet Dunn
Professor Carrol Gamble
Professor Jonathan Grigg
Professor Ajit Lalvani
Professor Gregory Lip
Professor Iain McInnes
Professor Michael Nicholson (left at 3.00pm)
Mr Richard Parnell
Dr Richard Peck
Professor John Petrie
Professor Ruth Plummer
Professor Steve Thornton
Professor Mark Thursz
Professor Chris Weir
Secretariat
Dr Andrew Cook
Dr Elena Harden
Miss Helen Munday
Dr Dani Preedy
Ms Susan Solomons
Apologies
Professor Rustam Salman
Observers/In attendance
Dr Penny Morton, MRC
Helen Risebro, RDS
Phillip Pallmann, RDCS, Wales
Stage 1 Proposals
18/141: Chronic Pain Themed Call
NIHR128682: NAvigation guided transcranial MAgnetic STimulation for chronic cEntral post stroke pain (NAMASTE). A randomised double blind sham controlled clinical trial.
Dr Bernhard Frank
Chair: Professor Danny McAuley
Declared a conflict and left the room: Iain McInnes, Carrol Gamble, Gregory Lip
Decision: Declined
18/141: Chronic Pain Themed Call
NIHR129335: The Efficacy of Dorsal Root Ganglion Burst Stimulation in the Management of Complex Regional Pain Syndrome. A Multicentre, Randomised Double-Blind Sham-Controlled Study. “Typhoon”
Dr Adnan Al-Kaisy
Chair: Professor Danny McAuley
Declared a conflict and left the room: Andrew Cook, Louise Brown, Carrol Gamble, Gregory Lip
Arrived/left meeting: Ajit Lalvani arrived at the end of the discussion and did not vote.
Decision: Shortlisted
18/168: Precision Medicine
NIHR129046: [18F]FDOPA-PET IMAGING AS A BIOMARKER FOR TREATMENT STRATIFICATION IN PSYCHOSIS
Dr Mattia Veronese
Chair: Professor Danny McAuley
Declared a conflict and left the room: Bill Deakin
Decision: Declined - invited to resubmit
18/168: Precision Medicine
NIHR128718: Withdrawal of Immunosuppression in lupus Nephritis trial: The WIN trial
Dr Michael Robson
Chair: Professor Danny McAuley
Declared a conflict and left the room: None
Decision: Declined
18/168: Precision Medicine
NIHR129203: Improved non-invasive diagnostic assessment and monitoring of non alcoholic steatohepatitis (NASH):The IMPROVISE study
Professor Chris Byrne
Chair: Professor Danny McAuley
Declared a conflict and left the room: Phillip Pallman (observer)
Decision: Declined
18/168: Precision Medicine
NIHR129219: Investigation of genetic susceptibility to retinal toxicity in patients taking Hydroxychloroquine
Associate Professor Susan Downes
Chair: Professor Danny McAuley
Declared a conflict and left the room: None
Decision: Declined
18/168: Precision Medicine
NIHR129023: Optimising Psoriatic Arthritis Therapy with Immunological Methods to Increase Standard Evaluation (OPTIMISE)
Dr Laura Coates
Chair: Professor Danny McAuley
Declared a conflict and left the room: Iain McInnes, John Petrie
Decision: Shortlisted
18/168: Precision Medicine
NIHR128878: Precision RnA Guided Management of TuberculosIs Contacts (PRAGMATIC) 1
Professor Mahdad Noursadeghi
Chair: Professor Danny McAuley
Declared a conflict and left the room: Louise Brown, Eric Alton, Ajit Lalvani, Mark Thursz
Decision: Declined – invited to resubmit
18/170: Researcher Led
NIHR128981: HYDRation and urinary Alkalinisation to prevent renal injury after endovascular aortic intervention: the HYDRA randomised controlled trial
Mr Athanasios Saratzis
Chair: Professor Danny McAuley
Declared a conflict and left the room: Matthew Ahearne, Janet Dunn
Decision: Declined
18/168: Precision Medicine
NIHR129268: A biomarker stratified randomized trial of chemotherapy plus cetuximab or panitumumab, versus chemotherapy alone, in the first-line treatment of RAS wild-type advanced colorectal cancer with a right-sided primary tumour location
Dr Jenny Seligmann
Chair: Professor Danny McAuley
Declared a conflict and left the room: Phillip Pallman (observer), Louise Brown, Iain McInnes
Decision: Shortlisted
18/168: Precision Medicine
NIHR128816: Risk stratification of patients with compensated liver cirrhosis for oesophageal varices needing treatment using MRI
Dr Michael Pavlides
Chair: Professor Danny McAuley
Declared a conflict and left the room: None
Decision: Shortlisted
18/170: Researcher Led
NIHR129389: Beta-blocker Efficacy Assessment using MRI in Guiding Therapy of Varices (BEAMinG)
Professor Guruprasad Aithal
Chair: Professor Danny McAuley
Declared a conflict and left the room: Louise Brown, Chris Weir
Arrived/left meeting: Ajit Lalvani left the room at the start of the discussion.
Decision: Declined
18/172: Benign Gynaecological Disorders
NIHR129283: UCON2 - Ulipristal acetate versus CONventional medical treatment in women (of reproductive age) with heavy menstrual bleeding due to adenomyosis
Professor Hilary Critchley
Chair: Professor Danny McAuley
Declared a conflict and left the room: Phillip Pallmann (observer), Chris Weir
Arrived/left meeting: Ajit Lalvani returned to the room at the start of the discussion.
Decision: Declined - invited to resubmit
18/172: Benign Gynaecological Disorders
NIHR128827: PurFECT2: A multicentre randomised double-blind placebo-controlled trial to evaluate the efficacy of Omega-3 polyunsaturated fatty acids in the management of endometriosis-associated pain in women
Professor Andrew Horne
Chair: Professor Danny McAuley
Declared a conflict and left the room: Chris Weir, Richard Peck
Decision: Declined
19/17: Digital Technologies to Improve Health and Care
NIHR129493: Touch and Image Guided Robotic Surgery (TIGERS): An internal pilot study and randomised trial with economic evaluation to compare the use of prostate MRI derived 3D printed models during robotic assisted radical prostatectomy to improve outcomes
Professor Prokar Dasgupta
Chair: Professor Danny McAuley
Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Mark Thursz, Ruth Plummer
Decision: Declined
18/158: Cannabis-based products for medicinal use themed call
NIHR129384: CASCADE: CAnnabidiol for Smoking Cessation in generalised Anxiety DisordEr
Professor Celia Morgan
Chair: Professor Danny McAuley
Declared a conflict and left the room: Louise Brown, Steve Thornton
Decision: Declined
18/170: Researcher Led
NIHR129318: Home-based EXercise and motivAtional program before and after Liver Transplantation: ExaLT trial
Dr Matthew Armstrong
Chair: Professor Danny McAuley
Declared a conflict and left the room: Louise Brown
Decision: Shortlisted
18/170: Researcher Led
NIHR129340: Double blind comparison of optimised Deep Brain Stimulation for severe Tourette syndrome
Professor Patricia Limousin
Chair: Professor Danny McAuley
Declared a conflict and left the room: Louise Brown
Decision: Declined - invited to resubmit
18/170: Researcher Led
NIHR129451: PROgenitor Cell Expansion and Steroids in Severe Alcoholic Hepatitis (PROCESSAH)
Professor Stephen Ryder
Chair: Professor Danny McAuley
Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Mark Thursz, Michael Nicholson, Iain McInnes, John Petrie
Decision: Declined
18/170: Researcher Led
NIHR129325: Improving treatment of glioblastoma: validating the efficacy of a machine learning model to detect pseudoprogression
Dr Thomas Booth
Chair: Professor Danny McAuley
Declared a conflict and left the room: None
Arrived/left meeting: Steve Thornton left the room at the start of the discussion.
Decision: Declined
18/170: Researcher Led
NIHR129407: Woven EndoBridge safety Compared to Alternative Management for treatment of wide-neck bifurcation aneurysms (WEBCAM)
Dr Thomas Booth
Chair: Professor Danny McAuley
Declared a conflict and left the room: Ruth Plummer
Arrived/left meeting: Steve Thornton returned to the room for the start of this discussion.
Decision: Declined
18/170: Researcher Led
NIHR129476: Culture media UK: impact on offspring conceived through in-vitro fertilisation
Dr Abha Maheshwari
Chair: Professor Danny McAuley
Declared a conflict and left the room: Phillip Pallmann (observer), Bill Deakin
Decision: Declined
18/171: Dental Health - Disorders of the teeth and gums
NIHR129163: Can a near infrared light transillumination device be used to accurately detect caries in a general dental practice setting?
Professor Tanya Walsh
Chair: Professor Danny McAuley
Declared a conflict and left the room: Bill Deakin
Decision: Shortlisted
18/171: Dental Health - Disorders of the teeth and gums
NIHR129218: The efficacy of different treatment strategies in the regeneration of furcation defects in periodontitis. A single-blind randomised controlled non-inferiority trial with mechanistic sub-study
Professor Nikolaos Donos
Chair: Professor Danny McAuley
Declared a conflict and left the room: Jonathan Grigg, Steve Thornton, Louise Brown, Chris Weir
Decision: Declined
18/167: End of Life Care
NIHR129411: Investigation of changes in volatile organic compounds towards the end of life in patients with breast, colorectal or prostate cancer
Dr Seamus Coyle
Chair: Professor Danny McAuley
Declared a conflict and left the room: Carrol Gamble, Gregory Lip
Decision: Declined
18/170: Researcher Led
NIHR129244: STOP-POUCHITIS - A randomised controlled trial of faecal microbiota transplantation for pouchitis
Mr Andrew Beggs
Chair: Professor Danny McAuley
Declared a conflict and left the room: Iain McInnes, John Petrie, Mark Thursz
Arrived/left meeting: Bill Deakin left the room at the start of the discussion.
Decision: Declined
18/170: Researcher Led
NIHR128778: Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis; a randomised placebo controlled trial (BLIPA; Bacterial Lysate in Preventing Asthma)
Professor Jonathan Grigg
Chair: Dr Andrew Cook
Declared a conflict and left the room: Danny McAuley, Jonathan Grigg, Steve Thornton, Chris Weir, Carrol Gamble, Gregory Lip
Decision: Declined – invited to resubmit
18/170: Researcher Led
NIHR128948: The Efficacy and Mechanism Evaluation of Simvastatin as adjuvant therapy for Community Acquired Pneumonia on Outcomes in Older Patients with Pneumonia (EME-SNOOPI)
Dr Jaimin Patel
Chair: Professor Eric Alton
Declared a conflict and left the room: Danny McAuley, Chris Weir
Decision: Declined
18/170: Researcher Led
NIHR128918: Pioneering imaging techniques for optimising dose delivery in post-operative prostate radiotherapy (The PINPOINT study)
Dr Emma Harris
Chair: Professor Danny McAuley
Declared a conflict and left the room: None
Decision: Declined
18/170: Researcher Led
NIHR128995: Open label efficacy and mechanism Phase II basket trial of multiple sequential randomised single agents permissive for rare cancers of unmet need (RareCan1)
Professor Andrew Hassan
Chair: Professor Danny McAuley
Declared a conflict and left the room: Chris Weir, Louise Brown
Conflicted but not in attendance: Bill Deakin
Arrived/left the meeting: Michael Nicholson left the meeting at the beginning of the discussion
Decision: Declined
18/170: Researcher Led
NIHR129265: Dietary antioxidant defence (DAD) study: a double blind randomised trial of Impryl® for male infertility to improve natural conception and live birth rate
Dr Sarah Martins da Silva
Chair: Professor Danny McAuley
Declared a conflict and left the room: Phillip Pallman (observer), Chris Weir, Iain McInnes, John Petrie
Decision: Declined – invited to resubmit
18/170: Researcher Led
NIHR129382: Neoadjuvant chemotherapy (Gemcitabine & Cisplatin vs. Cabazitaxel & Cisplatin) with or without immunotherapy (Cemiplimab) for muscle invasive bladder cancer (MIBC): a factorial randomised controlled trial (RCT) with internal pilot
Professor Amit Bahl
Chair: Professor Danny McAuley
Declared a conflict and left the room: Iain McInnes
Conflicted but not in attendance: John Petrie, Bill Deakin
Arrived/left the room: Ajit Lalvani and John Petrie left the meeting at the start of the discussion
Decision: Shortlisted
18/170: Researcher Led
NIHR128980: Using kisspeptin to trigger oocyte maturation to improve the safety of IVF treatment
Professor Waljit Dhillo
Chair: Professor Danny McAuley
Declared a conflict and left the room: Eric Alton, Mark Thursz
Conflicted but not in attendance: Ajit Lalvani
Decision: Shortlisted
18/170: Researcher Led
NIHR128426: An evaluation of the effect of Therapeutic Targeted Temperature in brain dead organ donors on donor kidney function at 12 months post-transplantation: the 3T study
Professor Christopher Watson
Chair: Professor Danny McAuley
Declared a conflict and left the room: None
Conflicted but not in attendance: Michael Nicholson
Decision: Declined