Meeting
EME Programme - Funding Committee Meeting
Date
Tuesday 1st and Wednesday 2nd March 2022
Place
Virtual Meeting
Present - Day 1
Professor Danny McAuley (Programme Director - does not vote)
Professor John Norrie (Programme Chair - does not vote)
Professor John Petrie (Deputy Chair)
Professor Maya Buch
Dr Tessa Cacciottolo
Professor Janet Dunn
Professor Daniel Freeman
Professor Jonathan Grigg
Mrs Hayley Hall (public contributor)
Professor Alastair Hay
Professor Dave Jones
Professor Gregory Lip
Dr Ronan McMullan
Dr Puja Mehta - available from 11am
Professor Michael Nicholson
Ms Nóirín O'Neill (public contributor)
Dr Richard Peck
Professor Ruth Plummer
Professor Rustam Salman
Professor John Simpson
Professor Deborah Stocken
Professor Chris Weir
Secretariat
Dr Dani Preedy
Dr Andrew Cook
Dr Juliana Callaghan
Ms Helen Munday
Dr Elena Harden
Dr Esther Sweeney
Ms Caitlin van Abeelen
Mrs Sue White
Apologies
Professor Manu Shankar-Hari
Professor Stuart Taylor
Professor Victoria Allgar
Observers/in attendance
Penny Morton, MRC
Professor Patricia Limousin (new committee member)
Dr Elaine Kingwell, RDS
Professor Mike Lewis, NIHR i4i Programme
Lesley Dodd, NETSCC
Stage 2 Proposals
21/506 EME Researcher Led
NIHR150098 Turner
STABILISE: a multicentre, open-label, randomised, parallel group, superiority trial to investigate the use of BCG vaccine in altering immune response and exacerbation in airways disease
Chair: John Norrie
Declared a conflict and left the meeting: Mike Lewis
Decision: Declined – invited to resubmit
NIHR150193 Morgan
MORE-KARE: A multi-centre investigation of increasing alcohol abstinence with ketamine-assisted psychological therapy in severe alcohol use disorder
Chair: John Norrie
Declared a conflict and left the meeting: Daniel Freeman, Victoria Allgar (not present)
Decision: Recommended to Programme Director to consider Fund with Changes
NIHR150375 Wilson
Weight Reduction in Asthma Programme with Semaglutide (WRAP-S): clinical efficacy and mechanisms of action.
Chair: Danny McAuley
Declared a conflict and left the meeting: Chris Weir, John Norrie, John Simpson, Michael Nicholson, Manu Shankar-Hari (not present), Stuart Taylor (not present)
Decision: Recommended to Programme Director to consider Fund with Changes
19/138 EME Researcher Led
NIHR131791 Taylor
The Efficacy of Peroneal Nerve Functional Electrical STimulation (FES) for the Reduction of Bradykinesia in Parkinson’s DiSease: An Assessor Blinded Randomised Controlled Trial (STEPS II).
Chair: John Norrie
Declared a conflict and left the meeting: Victoria Allgar (not present), Patricia Limousin (observer)
Decision: Recommended to Programme Director to consider Fund with Changes
20/143 EME Researcher Led
NIHR134096 Price
Genicular Artery Embolisation for the symptomatic treatment of knee osteoarthritis refractory to conservative management (GEKO)
Chair: John Norrie
Declared a conflict and left the meeting: Deborah Stocken, Janet Dunn, Chris Weir, Stuart Taylor (not present)
Decision: Recommended to Programme Director to consider Fund with Changes
NIHR134367 Lois
Predicting Responses to anti-VEGFs in peoplE with Diabetic macular Oedema Using Induced pluripotent stem Cell (iPSc) Technology (PREDICT)
Chair: Andrew Cook
Declared a conflict and left the meeting: Ronan McMullan, John Norrie, Danny McAuley
Decision: Declined
21/506 EME Researcher Led
NIHR150537 Kassam
HIPSTER – HIP Surgical Techniques to Enhance Rehabilitation
Chair: John Norrie
Declared a conflict and left the meeting: Victoria Allgar (not present)
Decision: Recommended to Programme Director to consider Fund with Changes
21/613 EME Fast Track March 2022
NIHR151892 Parry
A multi-centre randomised controlled trial examining the effects of temporarily pausing Bruton Tyrosine Kinase inhibitor therapy to coincide with SARS-CoV-2 vaccination and its impact on immune responses in patients with Chronic Lymphocytic Leukaemia (including a nested mechanistic sub-study).
Chair: John Norrie
Declared a conflict and left the meeting: Manu Shankar-Hari (not present)
Decision: Recommended to Programme Director to consider Fund with Changes
21/508 NIHR NICE Rolling Call (EME Programme: Apr 21 - Aug 21)
NIHR150009 Veldtman
EFFECTS OF SGLT2 INHIBITION ON QUALITY OF LIFE AND EXERCISE CAPACITY IN ADULTS WITH CONGENITAL HEART DISEASE AND A FAILING SYSTEMIC RIGHT VENTRICLE: A RANDOMISED CROSS-OVER TRIAL WITH 12 -WEEK TREATMENT PERIODS.
Chair: John Norrie
Declared a conflict and left the meeting: Gregory Lip, John Petrie, Dave Jones
Decision: Declined
20/143 EME Researcher Led
NIHR134276 Rankin
SarcoSIGHT- A randomised controlled trial of fluorescence guided sarcoma surgery versus standard of care
Chair: John Norrie
Declared a conflict and left the meeting: Dave Jones, Chris Weir, John Simpson, Ruth Plummer
Decision: Recommended to Programme Director to consider Fund with Changes
21/516 EME Mechanisms of Action of Health Interventions (pilot of expanded remit)
NIHR150308 Egerton
Mechanisms of action of clozapine in schizophrenia
Chair: John Petrie
Declared a conflict and left the meeting: Chris Weir, Daniel Freeman, John Norrie, Manu Shankar-Hari (not present)
Decision: Recommended to Programme Director to consider Fund with Changes
22/13 EME Contract Variation - March 2022
NIHR152202 Bhattacharrya
16/126/53 - CANnabidiol as a Treatment fOr Psychosis clinical high-risk state- a Randomised Clinical Trial (CANTOP-RCT) - CONTRACT VARIATION
Chair: John Norrie
Declared a conflict and left the meeting: Daniel Freeman, Manu Shankar-Hari (not present)
Decision: Declined
Stage 1 Proposals
21/545 Efficacy and Mechanism Evaluation Programme Researcher-led
NIHR151564 Khan
A prospective randomised open blinded-endpoint (PROBE) trial to determine whether the administration of inclisiran to reduce lipoprotein a levels leads to a reduction in inflammation and subsequently halts and/or delays the progression of valve calcification in people with moderate aortic stenosis.
Chair: John Petrie
Declared a conflict and left the meeting: Rustam Salman, John Norrie, Mike Lewis
Decision: Declined
NIHR151755 Muir
NanO2 in Large VessEL Occlusion Stroke (NOVEL): a multicentre single-blind, randomised, placebo-controlled blinded end-point clinical trial evaluating the safety, tolerability and preliminary efficacy of perfluorocarbon in acute ischaemic stroke due to large vessel occlusion
Chair: John Norrie
Declared a conflict and left the meeting: John Petrie
Decision: Shortlisted
NIHR151542 Cehajic-Kapetanovic
Robot-assisted endovascular surgery for retinal vein occlusion
Chair: John Norrie
Declared a conflict and left the meeting: N/A
Decision: Declined
Present - Day 2
Professor Danny McAuley (Programme Director - does not vote)
Professor John Norrie (Programme Chair - does not vote)
Professor John Petrie (Deputy Chair)
Professor Maya Buch
Dr Tessa Cacciottolo
Professor Janet Dunn
Professor Daniel Freeman
Professor Jonathan Grigg
Mrs Hayley Hall (public contributor)
Professor Alastair Hay
Professor Dave Jones
Professor Gregory Lip - available afternoon session only
Dr Ronan McMullan
Dr Puja Mehta
Professor Michael Nicholson - available until 1pm
Ms Nóirín O'Neill (public contributor)
Dr Richard Peck
Professor Ruth Plummer
Professor Rustam Salman
Professor Deborah Stocken
Professor Chris Weir
Professor David Clifton - co-optee
Secretariat
Dr Dani Preedy
Dr Andrew Cook
Dr Juliana Callaghan
Ms Helen Munday
Dr Elena Harden
Dr Esther Sweeney
Ms Caitlin van Abeelen
Mrs Sue White
Apologies
Professor Manu Shankar-Hari
Professor Stuart Taylor
Professor Victoria Allgar
Professor John Simpson
Observers/in attendance
Penny Morton, MRC
Professor Patricia Limousin (new committee member)
Dr Susanne Murphy, RDS
Stage 1 Proposals
21/562 - Early Detection of Disease
NIHR151607 Maddison
Investigating Detection of Apoptosing Retinal Cells (DARC) Technology for the Earlier detection of Glaucomatous disease in patients referred to hospital by Optometrists/primary care (DEGO trial)
Chair: John Norrie
Declared a conflict and left the meeting: N/A
Decision: Declined
NIHR150935 Alam
Artificial Intelligence for the early Detection of diabEtic Neuropathy (AIDEN) study
Chair: John Norrie
Declared a conflict and left the meeting: Gregory Lip
Decision: Declined
21/561 NIHR James Lind Alliance Priority Setting Partnerships Rolling Call (EME Programme: Sep 21 - Dec 21)
NIHR151282 Robson
Paclitaxel or sirolimus coated balloons for ArterioVEnous fistulas (PAVE-2 trial)
Chair: John Norrie
Declared a conflict and left the meeting: Manu Shankar-Hari (not present)
Decision: Shortlisted
21/546 NIHR NICE Rolling Call (EME Programme: Aug 21 - Dec 21)
NIHR151274 Torkington
The PICCOS Trial (PIPAC in Cancers of the Colon, Ovaries and Stomach): A randomised controlled phase II trial in Colorectal, Ovarian and Stomach cancers to define the efficacy of Pressurised IntraPeritoneal Aerosolised Chemotherapy (PIPAC) in the management of peritoneal metastases.
Chair: John Norrie
Declared a conflict and left the meeting: Ronan McMullan
Decision: Shortlisted
21/507 EME Dementia
NIHR150496 Mallucci
Suppressing the Unfolded Protein Response to treat Alzheimer’s Disease Using Remote Assessment and Monitoring - SUPER-DREAM
Chair: John Norrie
Declared a conflict and left the meeting: Michael Nicholson
Decision: Declined
21/545 Efficacy and Mechanism Evaluation Programme Researcher-led
NIHR151223 Longden
A novel dialogical therapy (Talking With Voices) in comparison to treatment as usual in adults with distressing and persistent auditory hallucinations: A randomised controlled trial to investigate the efficacy of a treatment strategy targeted at trauma-related mechanisms
Chair: John Petrie
Declared a conflict and left the meeting: John Norrie, Daniel Freeman, Chris Weir, Manu Shankar-Hari (not present)
Decision: Shortlisted
NIHR151052 Fallon
A Phase II RCT Of OrAl Cannabinoid Versus Placebo In The Treatment Of Chemotherapy Induced Peripheral NeurOpathic PaiN (ACTION)
Chair: John Petrie
Declared a conflict and left the meeting: Chris Weir, Janet Dunn, Manu Shankar-Hari (not present), Rustam Salman, John Norrie
Decision: Shortlisted
NIHR150986 Gbinigie
What is the efficacy of cranberry extract to reduce antibiotic consumption for symptoms of acute, uncomplicated Urinary Tract Infection (UTI)? A randomised, placebo-controlled trial
Chair: John Norrie
Declared a conflict and left the meeting: Alastair Hay
Decision: Declined – 12 month resubmission rule waived
NIHR151140 Philpott
SALVATION: A randomised controlled trial for Smell TrAining in COVID-19 related Post-Viral OlfActory DysfuncTION
Chair: John Norrie
Declared a conflict and left the meeting: N/A
Decision: Declined
NIHR151144 Silvestri
Safety and Efficacy of the Intravitreal Dexamethasone Steroid Implant (DEX-Implant) for the Treatment of Cystoid Macular Oedema in Retinitis Pigmentosa (RP- DEX Study)
Chair: John Norrie
Declared a conflict and left the meeting: Ronan McMullan, Danny McAuley
Decision: Declined
NIHR151191 Robson
Withdrawal of Immunosuppression in lupus Nephritis trial: the WIN trial
Chair: John Norrie
Declared a conflict and left the meeting: Maya Buch, Manu Shankar-Hari (not present)
Decision: Shortlisted
NIHR151678 Arshad
Treatment of Vestibular Migraine with Flunarizine: a mechanistic study and a randomised, placebo-controlled trial.
Chair: John Norrie
Declared a conflict and left the meeting: Manu Shankar-Hari (not present)
Decision: Declined
NIHR151253 Holmes
Probenecid Plus Oral Flucloxacillin For The Treatment Of Cellulitis: A Double-blinded, Placebo, Randomised Control Trial
Chair: John Norrie
Declared a conflict and left the meeting: Chris Weir, Richard Peck
Decision: Declined – invited to resubmit
NIHR151878 Brough
Pronuts 2: A randomized controlled study of oral tolerance induction of nuts and/or sesame seed in food allergic children
Chair: John Norrie
Declared a conflict and left the meeting: Manu Shankar-Hari (not present)
Decision: Declined
21/544 EME Mechanisms of Action of Health Interventions (pilot call of expanded remit)
NIHR151108 Frost
Increase colonic propionate as a method of preventing weight gain in adults aged 20-40 years understanding inflammatory response. Iprevent-plus
Chair: John Norrie
Declared a conflict and left the meeting: Manu Shankar-Hari (not present), Dave Jones
Decision: Declined
NIHR151302 Lord
Trans-EndoNET: The influence of patient metabolism on the response to neoadjuvant endocrine therapy in post-menopausal women with oestrogen receptor positive breast cancer
Chair: John Petrie
Declared a conflict and left the meeting: Janet Dunn, Manu Shankar-Hari (not present), John Norrie
Decision: Shortlisted
NIHR151287 Dushianthan
Oxidative stress, redox status and surfactant metabolism in mechanically ventilated patients requring different supplementary oxygen strategies
Chair: John Petrie
Declared a conflict and left the meeting: Danny McAuley, John Norrie
Decision: Shortlisted
NIHR151548 Helmy
BIOmarkers Stratification of POst Traumatic Seizures Risk, BIOSPOTS-R
Chair: John Norrie
Declared a conflict and left the meeting: Chris Weir, Deborah Stocken, Michael Nicholson, Danny McAuley
Decision: Declined – invited to resubmit
NIHR151317 Lundy
Elucidating the mechaNism of action of behavioural changes on Child tOoth decay in the Randomised controlled CHOICE trial – a role for salivary lactic Acid? (ENCOURAGE)
Chair: John Norrie
Declared a conflict and left the meeting: Manu Shankar-Hari (not present), Ronan McMullan, Danny McAuley
Decision: Shortlisted
NIHR150929 Kirby
The IMMUNE-EXTEND study: A mechanistic study into extended antibiotics and immune exhaustion in patients with complicated intra-abdominal infection.
Chair: John Norrie
Declared a conflict and left the meeting: Deborah Stocken, Danny McAuley
Decision: Declined
NIHR151210 Mahil
Dissecting shared mechanisms of drug response within the BEACON eczema multi-arm clinical trial: a single-cell approach
Chair: John Norrie
Declared a conflict and left the meeting: Dave Jones, Manu Shankar-Hari (not present), Ruth Plummer, Deborah Stocken, John Simpson (not present)
Decision: Shortlisted