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HTA Funding Committee Public Minutes 09-10 July 2019

 

Contents

 

Date

09 July 2019 (Day 1)

Place

Danubius Hotel, London

Present members

 

Professor Lucy Chappell (Chair)

Professor Julia Brown (Deputy Chair)

Professor Hywel Williams (HTA Programme Director)

Ms Gail Thornton (Public Member)

Mrs Deborah Keatley (Public Member)

Professor Tim Coleman

Professor Paul Ewings

Professor Edwin Van Teijlingen

Professor William Hollingworth

Professor Daniel Lasserson

Dr Susan Jowett

Dr Kate Brown

Professor Richard Emsley

Professor Scott Weich

Professor Peter Langhorne

Dr Kathryn Radford

Professor Alan Montgomery

Professor Steph Taylor

Dr Jennifer Logue

Mr Thomas Pinkney

Dr Charlotte Coles

Dr David Ekers

Dr Sharon Simpson

Professor Rebecca Kearney

Professor Sally Hopewell

NETSCC, HTA Secretariat

Dr Martin Ashton-Key (Consultant Advisor, NETSCC)

Mrs Karen Williams (Senior Research Manager)

Dr Cristina Lujan Barroso (Research Manager)

Miss Alessandra Wilkinson-Smith (Assistant Research Manager)

Apologies

Professor Daniel Prieto-Alhambra, Dr Athanasios Saratzis

Observers

None

Quoracy Information  

Voting members: 25 Quorum = 17

Voting members present on Day 1: 23 (92%)

 

 

Commissioning Stage 2 Proposals

18/135: Nebulised saline in patients with COPD

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Professor Stephanie Taylor

(18/135) NIHR128443: What is the clinical effectiveness and cost-effectiveness of nebulised saline in patients with chronic obstructive pulmonary disease (MucAct COPD Trial)?

(Professor Adam Hill, NHS Education for Scotland)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/96: Hormone therapy for premature ovarian insufficiency

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Jennifer Logue, Dr Kathryn Radford, Mrs Debbie Keatley, Professor Alan Montgomery, Professor Hywel Williams, Professor Lucy Chappell

(18/96) NIHR128757: Hormone therapy for premature ovarian insufficiency: randomised trial and long-term evaluation

(Dr Melanie Davies, University College London Hospitals NHS Foundation Trust)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/97: Hysteroscopic removal of uterine cavity abnormalities to improve fertility

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Susan Jowett, Professor Daniel Lasserson, Professor Hywel Williams, Professor Lucy Chappell, Professor Thomas Pinkney, Professor Scott Weich

(18/97) NIHR128979: LEave or remove uterine cavity Abnormalities to improve Fertility (the LEAF trial).

(Honorary Professor T Justin Clark, Birmingham Women's NHS Foundation Trust)

Funding Committee recommendation: Decline

(18/97) NIHR128969: HELP Infertility? (Hysteroscopic Excision of Leiomyoma and Polyp in Infertility): two randomised controlled trials

(Mr Mostafa Metwally, Sheffield Teaching Hospitals NHS Foundation Trust)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

Researcher Led Stage 2 Proposals

18/133: HTA Researcher-led call Primary Research

(18/133) NIHR128653: Improving the wellbeing of mothers through early recognition and treatment of bleeding after childbirth: Obstetric Bleeding Study 3 (OBS3) a cluster randomised trial (Professor Peter Collins, Cardiff University)

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Jennifer Logue, Professor Sharon Simpson

Funding Committee recommendation: Decline

(18/133) NIHR128351: Effect of high-flow nasal therapy on patient-centred outcomes in patients at high risk of postoperative pulmonary complications after cardiac surgery: a multicentre randomised controlled trial

(Professor Andrew Klein, Papworth Hospital NHS Foundation Trust)

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Jennifer Logue, Professor Daniel Lasserson, Professor Lucy Chappell

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

(18/133) NIHR128699: Hemithyroidectomy or Total-Thyroidectomy in ‘low-risk’ thyroid cancers (HoT trial)

(Professor Dae Kim, St George's University Hospitals NHS Foundation Trust)

Chair: Professor Julia Brown

Declared a conflict and left the room: Professor Lucy Chappell

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

(18/133) NIHR128311: ATNEC - Axillary management in T1-3N1M0 breast cancer patients with needle biopsy proven nodal metastases at presentation after neoadjuvant chemotherapy

(Associate Professor Amit Goyal, University Hospitals of Derby and Burton NHS Foundation Trust)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Associate Professor Rebecca Kearney, Dr Charlotte Coles, Dr Jennifer Logue, Mrs Debbie Keatley, Professor Alan Montgomery

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

(18/133) NIHR128768: Robotic Arthroplasty: a Clinical and cost Effectiveness Randomised controlled trial. (RACER)

(Associate Professor Andrew Metcalfe, University of Warwick)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Associate Professor Rebecca Kearney, Associate Professor Sally Hopewell, Dr Jennifer Logue, Professor Scott Weich, Professor Stephanie Taylor

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

(18/133) NIHR128761: A parallel multi-centre randomised controlled trial to determine the clinical and cost-effectiveness of DREAMS START(Dementia RElAted Manual for Sleep; STrAtegies for RelaTives)

(Dr Penny Rapaport, University College London)

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Jennifer Logue, Dr Kathryn Radford, Professor Alan Montgomery, Professor Lucy Chappell, Professor Sharon Simpson

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

(18/133) NIHR128815: A multicentre, randomised controlled trial of Laparoscopic versus Open Colorectal Surgery in the Acute Setting

(Ms Deena Harji, The Newcastle Upon Tyne Hospitals NHS Foundation Trust)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Professor Julia Brown

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

Commissioning Stage 1 Proposals

19/07: Anti-tuberculosis drug hepatotoxicity and treatment reintroduction

(19/07) NIHR129515: Reintroduction of anti-tuberculosis therapy following drug-induced liver injury: a randomised clinical trial

(Honorary Professor Wei Shen Lim, Nottingham University Hospitals NHS Trust)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Kathryn Radford, Professor Alan Montgomery, Professor Hywel Williams, Professor Thomas Pinkney, Professor William Hollingworth

Funding Committee recommendation: Shortlist

Researcher-Led Stage 1 Proposals

19/11: HTA Researcher-led call Primary Research

(19/11) NIHR127873: Pragmatic randomised trial of High Or Standard PHosphAte Targets in End-stage kidney disease - The PHOSPHATE trial

(Dr Thomas Hiemstra, University of Cambridge)

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Jennifer Logue, Dr Susan Jowett

Left meeting: Gail Thornton

Funding Committee recommendation: Shortlist

(19/11) NIHR129114: SISTAR: Outcomes of simultaneous versus staged resections for synchronous colorectal liver metastases – a randomised controlled trial

(Mr Giuseppe Fusai, Royal Free London NHS Foundation Trust)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Martin Ashton-Key

Arrived meeting: Gail Thornton

Funding Committee recommendation: Decline

 

 

 

Date

10 July 2019 (Day 2)

Place

Danubius Hotel, London

Present members

 

Professor Lucy Chappell (Chair)

Professor Julia Brown (Deputy Chair)

Professor Hywel Williams (HTA Programme Director)

Ms Gail Thornton (Public Member)

Mrs Deborah Keatley (Public Member)

Professor Tim Coleman

Professor Paul Ewings

Professor Edwin Van Teijlingen

Professor William Hollingworth

Professor Daniel Lasserson

Dr Susan Jowett

Dr Kate Brown

Professor Richard Emsley

Professor Scott Weich

Professor Peter Langhorne

Dr Kathryn Radford

Professor Alan Montgomery

Professor Steph Taylor

Dr Jennifer Logue

Mr Thomas Pinkney

Dr Charlotte Coles

Dr David Ekers

Dr Sharon Simpson

Professor Rebecca Kearney

Professor Sally Hopewell

NETSCC, HTA Secretariat 

Dr Nick Hicks (Consultant Advisor, NETSCC)

Mrs Karen Williams (Senior Research Manager)

Dr Cristina Lujan Barroso (Research Manager)

Miss Alessandra Wilkinson-Smith (Assistant Research Manager)

Apologies

Dr Martin Ashton-Key, Professor Daniel Prieto-Alhambra, Dr Athanasios Saratzis

Observers

Stephanie Garfield-Birkbeck

Quoracy Information  

Voting members: 25 Quorum = 17

Voting members present on Day 2: 23 (92%)

 

 

Tobacco Call Stage 1 Proposals

18/166: HTA Tobacco Cessation, control and harm reduction interventions

(18/166) NIHR129438: Smoking cessation in the Emergency Department: a randomised controlled trial

(Dr Ian Pope, Norfolk and Norwich University Hospitals NHS Foundation Trust)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: No conflicts

Committee recommendation: Stage 1 Resubmission

Researcher-Led Stage 1 Proposals

19/11: HTA Researcher-led call Primary Research

(19/11) NIHR128208: Safe Antimicrobial ProPHylaxIs suRgEry feasibility trial (SAPPHIRE)

(Professor Rupert Pearse, Queen Mary University of London)

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Jennifer Logue, Professor Stephanie Taylor

Committee recommendation: Decline

(19/11) NIHR129385: RAPTOR: Randomised Controlled Trial of PENTOCLO in Mandibular Osteoradionecrosis

(Professor Richard Shaw, University of Liverpool)

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Susan Jowett, Professor Lucy Chappell

Committee recommendation: Decline  

Tobacco Call Stage 1 Proposals

18/166: HTA Tobacco Cessation, control and harm reduction interventions

(18/166) NIHR129627: Do e-cigarettes help smokers quit when not accompanied by intensive behavioural support?

(Dr Katie Myers Smith, Barts & The London School of Medicine & Dentistry)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Professor Tim Coleman

Committee recommendation: Shortlist

Researcher-Led Stage 1 Proposals

19/11: HTA Researcher-led call Primary Research

(19/11) NIHR129518: A randomised controlled trial to determine the effect and cost-effectiveness of liberal and conservative perioperative oxygen therapy on clinical outcomes following major surgery.

(Dr Daniel Martin, University College London)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Susan Jowett, Professor Daniel Lasserson, Professor Thomas Pinkney

Committee recommendation: Decline

(19/11) NIHR129589: ORBITA-2: A placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina

(Professor Darrel Francis, Imperial College Healthcare NHS Trust)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: No conflicts

Committee recommendation: Shortlist

Tobacco Call Stage 1 Proposals

18/166: HTA Tobacco Cessation, control and harm reduction interventions

(18/166) NIHR129593: Investigating the effectiveness of electronic cigarettes as an aid to smoking cessation in comparison with varenicline and the effect of vaping on lung health in patients with chronic obstructive pulmonary disease (E-CaL study)

(Dr Amanda Farley, University of Birmingham)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Susan Jowett, Professor Daniel Lasserson, Professor Thomas Pinkney

Left meeting: Tim Coleman reported a last minute conflict and left the discussion after presenting his comments.

Committee recommendation: Shortlist

Researcher-Led Stage 1 Proposals

19/11: HTA Researcher-led call Primary Research

(19/11) NIHR129617: Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury (MOSAICC – Multicentre evaluation Of Sodium bicarbonate in Acute kidney Injury in Critical Care)

(Professor Lui Forni, University of Surrey)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Professor Hywel Williams

Committee recommendation: Deferred Shortlist to March 2020

(19/11) NIHR129707: UrodynAmicS as Routine Evaluation in Women with StrEss UrinaRy InconTinence (The ASSERT Study); a superiority randomised clinical trial to evaluate the clinical and cost effectiveness of routine urodynamic investigations in management of women with stress urinary incontinence.

(Professor Mohamed Abdel-Fattah, University of Aberdeen)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Jennifer Logue, Kathryn Radford

Committee recommendation: Shortlist

Tobacco Call Stage 1 Proposal

18/166: HTA Tobacco Cessation, control and harm reduction interventions

(18/166) NIHR129735: Health effects of short-term and long-term use of e-cigarettes

(Professor Peter Hajek, Queen Mary University of London)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Jennifer Logue, Professor Tim Coleman

Funding Committee recommendation: Resubmission Stage 1

Researcher-Led Stage 1 Proposals

19/11: HTA Researcher-led call Primary Research

(19/11) NIHR129748: Surgeons Trial Of Prophylaxis for Epilepsy in seizure naïve patients with Meningioma: a randomised controlled trial (STOP’EM)

(Mr Michael Jenkinson, University of Liverpool)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: None

Funding Committee recommendation: Shortlist

(19/11) NIHR129649: A multicentre randomised placebo-controlled trial of the effectiveness and cost-effectiveness of conventional vs high-frequency spinal cord stimulation in patients with neuropathic pain. CHESTNUT STUDY

(Professor Sam Eldabe, South Tees Hospitals NHS Foundation Trust)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Associate Professor Rebecca Kearney, Dr Susan Jowett, Professor Stephanie Taylor

Funding Committee recommendation: Shortlist

Tobacco Call Stage 1 Proposal

18/166: HTA Tobacco Cessation, control and harm reduction interventions

(18/166) NIHR129210: Open-label, randomised controlled trial of nicotine replacement therapy preloading and lapse recovery for cessation and where quitting fails, for smoking reduction in pregnancy

(Professor Tim Coleman, The University of Nottingham)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Jennifer Logue, Dr Kathryn Radford, Professor Alan Montgomery, Professor Hywel Williams, Professor Tim Coleman, Professor William Hollingworth

Left meeting: Daniel Lasserson

Funding Committee recommendation: Shortlist

Researcher-Led Stage 1 Proposals

19/11: HTA Researcher-led call Primary Research

(19/11) NIHR129718: Music Interventions for Dementia and Depression in ELderly care (MIDDEL): International cluster-randomised trial - UK arm (MIDDEL-UK)

(Professor Justine Schneider, The University of Nottingham)

Chair: Professor Julia Brown

Declared a conflict and left the room: Dr Kathryn Radford, Professor Alan Montgomery, Professor Hywel Williams, Professor Lucy Chappell, Professor Tim Coleman

Funding Committee recommendation: Decline

(19/11) NIHR129179: PREDNOS 3: what is the optimal steroid treatment dose to induce remission in relapses of childhood nephrotic syndrome?

(Dr Martin Christian, Nottingham University Hospitals NHS Trust)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Susan Jowett, Professor Hywel Williams, Professor Thomas Pinkney

Funding Committee recommendation: Shortlist

(19/11) NIHR129550: MIDAS Trial: Modifying pain using Drugs Around Surgery. A randomised, double-blind, placebo controlled trial of ibuprofen to safely reduce pain after major gastrointestinal surgery.

(Dr Michael Gillies, Edinburgh Royal Infirmary)

Chair: Professor Lucy Chappell

Declared a conflict and left the room: Dr Susan Jowett, Professor William Hollingworth, Professor Thomas Pinkney, Rebecca Kearney

Left meeting: Scott Weich

Funding Committee recommendation: Decline