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HTA Funding Committee Public Minutes 10 - 11 November 2020

 

Contents

Tuesday 10th November 2020 (Day 1)

Place    

Virtual Meeting via Microsoft Teams

Present members

Professor Julia Brown (Chair)

Professor Olivia Wu (Deputy Chair)

Professor Andrew Farmer (Programme Director)

Dr Ashley Agus

Professor Hashim Ahmed

Professor Julie Brittenden

Professor Matthew Costa

Dr Fay Crawford

Professor Jo Dumville

Professor Nick Francis

Professor Caroline Free

Professor Simon Gates

Mr Dave Green (PPI representative)

Professor Kerenza Hood

Professor Nick James

Professor Asma Khalil

Professor Steff Lewis

Ms Stephanie MacNeill

Dr Rumana Omar

Professor Rupert Pearse

Professor Mark Peters

Professor Craig Ramsay

Mrs Amanda Roberts (PPI representative)

Professor Christine Roffe

Dr Whitney Scott

Dr Marc Serfaty

Dr Marta Soares

Dr Sarah Stock

Dr Martin Thomas

Associate Professor Jo Thompson-Coon

Dr Sara Twaddle

Professor Tammi Walker

NETSCC, HTA Secretariat

Dr Simon Fraser (Consultant Advisor).

Steph Garfield-Birkbeck (Head of the HTA Programme

Karen Williams (Senior Research Manager)

Cristina Lujan Barroso (Research manager)

Louisa Saunders (Assistant Research Manager)

Julie Herring (Administrator)

Apologies           

None

Observers          

Matthew Moore, new PPI member committee member

Quoracy Information     

Voting members: 30 Quorum = 20

Voting members present on Day 1: 30 (100%)

 

Stage 2 Cross-Programme Commissioning – Liver Disease

19/143: HTA Liver Disease

Chair: Professor Julia Brown

Declared a conflict and left the call: Dr Martin Thomas, Professor Hashim Ahmed

NIHR131129: An adaptive-design randomised placebo-controlled trial of baclofen in the treatment of alcohol use disorder in patients with liver cirrhosis (BASIS)

(Dr Paul Richardson, The Royal Liverpool and Broadgreen University Hospitals NHS Trust)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/143: HTA Liver Disease

Chair: Professor Julia Brown

Declared a conflict and left the call: Dr Martin Thomas, Dr Sarah Stock, Professor Christine Roffe, Professor Simon Gates

NIHR130883: Randomised controlled trial of EArly transjugular intrahepatiC porTosystemic stent-shunt in Acute Variceal Bleeding (REACT-AVB)

(Dr Dhiraj Tripathi, University Hospitals Birmingham NHS Foundation Trust)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/143: HTA Liver Disease

Chair: Professor Julia Brown

Declared a conflict and left the call: Dr Marc Serfaty, Professor Christine Roffe, Professor Jo Dumville, Professor Rumana Omar, Ms Stephanie MacNeill

NIHR131189: Supporting engagement with care for socially complex groups initiating hepatitis C treatment.

(Professor Andrew Hayward, University College London)

Funding Committee recommendation: Decline

Stage 2 HTA Researcher-led call (Evidence Synthesis)

19/101: HTA Researcher-led call Evidence Synthesis

Chair: Professor Olivia Wu

Declared a conflict and left the call: Dr Sarah Stock, Professor Julie Brittenden, Professor Steff Lewis, Ms Stephanie MacNeill

NIHR130664: Systematic review and integrated report on the quantitative and qualitative evidence base for behaviour change interventions to promote physical activity in people with intermittent claudication

(Dr Ukachukwu Abaraogu, Glasgow Caledonian University)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

Stage 2 Cross-Programme Commissioning - Oral and Dental Health

19/155: HTA Oral and Dental Health

Chair: Professor Olivia Wu

Declared a conflict and left the call: Professor Julia Brown, Dr Marta Soares, Professor Craig Ramsay, Professor Jo Dumville

NIHR131805: The CALM trial: the clinical and cost-effectiveness of a guided self-help cognitive behavioural therapy intervention to reduce dental anxiety in children

(Professor Zoe Marshman, The University of Sheffield)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/155: HTA Oral and Dental Health

Chair: Professor Olivia Wu

Declared a conflict and left the call: Professor Craig Ramsay

Left the Meeting: Nick James

NIHR131817: CHOICE TRIAL: Changing Habits tO Prevent ChIld CariEs: A Randomized Controlled Trial of a Family-Focused Therapeutic Conversation Delivered by Dental Nurses in Primary Care

(Dr Pauline Adair, The Queen's University of Belfast)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/160: HTA Researcher-led Call Primary Research, shortlisted at July Funding Committee

NIHR131861: RadiO fRequency ablatION for haemorrhoids (ORION)

(Professor Steven Brown, Sheffield Teaching Hospitals NHS Foundation Trust)

Chair: Professor Olivia Wu

Declared a conflict and left the call: Professor Julia Brown

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

 

NIHR131808: Glaucoma Risk Prediction in ocular hypertension (GRIP): a cohort study using electronic medical records to validate a risk predictor and determine the cost-effectiveness of different monitoring schemes according to risk of conversion to glaucoma

(Professor Augusto Azuara-Blanco, Queen's University Belfast)

Chair: Professor Julia Brown

Declared a conflict and left the call: Professor Craig Ramsay, Professor Hashim Ahmed, Professor Kerenza Hood

Arrived meeting: Nick James    

 

NIHR131808: Glaucoma Risk Prediction in ocular hypertension (GRIP): a cohort study using electronic medical records to validate a risk predictor and determine the cost-effectiveness of different monitoring schemes according to risk of conversion to glaucoma

(Professor Augusto Azuara-Blanco, Queen's University Belfast)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

 

NIHR131865: RandomisEd Trial of EarLy craniopLasty (RETELL study)

(Professor Peter Hutchinson, University of Cambridge)

Chair: Professor Julia Brown

Declared a conflict and left the call: Professor Christine Roffe, Professor Rumana Omar, Stephanie Garfield-Birkbeck

Funding Committee recommendation: Decline

 

NIHR131647: Randomised controlled trial of the Community Navigator programme to reduce loneliness and depression for adults with treatment resistant depression in secondary mental health services

(Dr Brynmor Lloyd Evans, University College London)

Chair: Professor Olivia Wu

Declared a conflict and left the call: Dr Marc Serfaty, Professor Rumana Omar, Ms Stephanie Macneill

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

 

NIHR129820: What is the clinical-effectiveness and cost-effectiveness of surgery with medial opening wedge high tibial osteotomy (HTO) compared with non-surgical treatment in the management of osteoarthritis (OA) of the knee in patients younger than 60 years? (MOTION Trial)

(Mr Anish Amin, NHS Lothian)

Chair: Professor Olivia Wu

Declared a conflict and left the call: Dr Martin Thomas, Dr Sarah Stock, Professor Simon Gates, Professor Steff Lewis

Left meeting: Hashim Ahmed

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

Stage 1 Commissioned (Evidence Synthesis)

20/29: Interventions for fibromyalgia-related sleep problems

Chair: Professor Olivia Wu

Declared a conflict and left the call: Professor Julia Brown, Dr Sarah Stock, Dr Whitney Scott, Professor Andrew Farmer, Professor Craig Ramsay, Professor Joanna Thompson-Coon, Professor Kerenza Hood, Professor Simon Gates, Ms Stephanie MacNeill

Arrived meeting: Hashim Ahmed

Left Meeting: Asma Khalil

 

NIHR132001: Interventions for fibromyalgia-related sleep problems

(Dr Stephen Halpin, University of Leeds)

Funding Committee recommendation: Decline

 

NIHR132490: Synthesising the evidence for interventions for fibromyalgia-related sleep problems.

(Dr Beth Fordham, University of Oxford)

Funding Committee recommendation: Shortlist

 

NIHR132856: Interventions for the management of sleep problems in people living with fibromyalgia: a synthesis of evidence from studies in the fibromyalgia population and general population with sleep problems

(Mr Andrew Beswick, University of Bristol)

Funding Committee recommendation: Decline

 

NIHR132940: Interventions for managing sleep problems in people living with fibromyalgia (MySLEEP). A mixed methods umbrella review and evidence gap map

Funding Committee recommendation: Decline

 

NIHR132971: Interventions for fibromyalgia-related sleep problems – an evidence map and rapid synthesis providing focus for future research

(Ms Fiona Beyer, Newcastle University)

Funding Committee recommendation: Decline

 

NIHR132999: What is the evidence for interventions used to manage sleep disturbances in people with fibromyalgia? A comprehensive evidence synthesis to inform clinical practice and future research.

(Dr Miriam Brazzelli, University of Aberdeen)

Funding Committee recommendation: Shortlist

20/79 Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy

Chair: Professor Julia Brown

Declared a conflict and left the call: Dr Marta Soares, Professor Craig Ramsay, Professor Hashim Ahmed, Professor Jo Dumville

Arrived Meeting: Asma Khalil

NIHR132722: PanREtinal Photocoagulation compared to Anti-vegf drugs in diabetic REtinopathy (PREPARE)

(Professor Noemi Lois, The Queen's University of Belfast)

Funding Committee recommendation: Decline

 

NIHR132948: Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy: a systematic review and economic analysis

(Dr Mark Simmonds, University of York)

Funding Committee recommendation: Shortlist

 

NIHR133058: Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy

(Dr Fiona Pearson, University of Newcastle upon Tyne)

Funding Committee recommendation: Shortlist

 

20/78 Pharmacological treatment and prevention of chronic migraine

Chair: Professor Julia Brown

Declared a conflict and left the call: Professor Rumana Omar, Professor Simon Gates

NIHR132803: What is the comparative clinical and cost- effectiveness of pharmacological treatments for adults with chronic migraine?

(Dr Hema Mistry, University of Warwick)

Funding Committee recommendation: Shortlist

 

Wednesday 11th November 2020 (Day 2)

Place    

Virtual Meeting via Microsoft Teams

Present members

Professor Julia Brown (Chair)

Professor Olivia Wu (Deputy Chair)

Professor Andrew Farmer (Programme Director)

Dr Ashley Agus

Professor Hashim Ahmed

Professor Julie Brittenden

Professor Matthew Costa

Dr Fay Crawford

Professor Jo Dumville

Professor Nick Francis

Professor Caroline Free

Professor Simon Gates

Mr Dave Green (PPI representative)

Professor Kerenza Hood

Professor Nick James

Professor Asma Khalil

Professor Steff Lewis

Ms Stephanie MacNeill

Dr Rumana Omar

Professor Rupert Pearse

Professor Mark Peters

Professor Craig Ramsay

Mrs Amanda Roberts (PPI representative)

Professor Christine Roffe

Dr Marc Serfaty

Dr Marta Soares

Dr Martin Thomas

Associate Professor Jo Thompson-Coon

Dr Sara Twaddle

Professor Tammi Walker

 

NETSCC, HTA Secretariat

Dr Simon Fraser (Consultant Advisor).

Steph Garfield-Birkbeck (Head of the HTA Programme

Karen Williams (Senior Research Manager)

Cristina Lujan Barroso (Research manager)

Louisa Saunders (Assistant Research Manager)

Julie Herring (Administrator)

Apologies           

Dr Whitney Scott

Dr Sarah Stock

Observers          

Matthew Moore, new PPI member committee member

Doreen Sekibo, NETSCC

Quoracy Information     

Voting members: 30 Quorum = 20

Voting members present on Day 2: 28 (94%)

 

 

 

Stage 1 HTA Broad Brief

20/33: Reducing Overtreatment

Chair: Professor Julia Brown

Declared a conflict and left the call: Dr Martin Thomas

NIHR133077: Reducing overtreatment In very old people with hypertension and frailty (REVERIFY)

(Dr Eduard Shantsila, University of Liverpool)

Funding Committee recommendation: Decline

20/33: Reducing Overtreatment

Chair: Professor Julia Brown

Declared a conflict and left the call: Dr Marc Serfaty, Professor Hashim Ahmed, Professor Rumana Omar

NIHR132729: Reducing overtreatment of renal masses by NEphron Sparing management with Tumour Biopsy (NEST-B).

(Associate Professor Maxine Tran, University College London)

Funding Committee recommendation: Decline

20/33: Reducing Overtreatment

Chair: Professor Olivia Wu

Declared a conflict and left the call: Dr Marc Serfaty, Professor Andrew Farmer, Professor Joanna Thompson-Coon, Professor Rumana Omar

NIHR132854: Reducing overtreatment for children and young people with mental health disorders in the context of long-term physical conditions

(Professor Roz Shafran, University College London)

Funding Committee recommendation: Decline

20/33: Reducing Overtreatment

Chair: Professor Julia Brown

Declared a conflict and left the call: Dr Marc Serfaty, Professor Hashim Ahmed, Professor Rumana Omar

Left Meeting: Andrew Farmer

NIHR133011: CONVOLUTE: A randomised open-label phase III trial of reduced pembrolizumab immunotherapy dose intensity for first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) utilising a novel multi-arm frequency-response optimisation design.

(Professor Michael Seckl, Imperial College London)

Funding Committee recommendation: Shortlist

20/33: Reducing Overtreatment

Chair: Professor Julia Brown

Declared a conflict and left the call: Dr Marc Serfaty, Dr Martin Thomas, Professor Christine Roffe, Professor Julie Brittenden, Professor Mark Peters, Professor Olivia Wu, Professor Rumana Omar, Professor Simon Gates

Arrived meeting: Andrew Farmer, Hashim Ahmed

NIHR131829: Overtreatment in patients with anca associated vasculitis - can longterm immunosuppression be safely de-escalated? A randomised controlled trial of immunosuppression de-escalation versus continuous immunosuppression.

(Professor Lorraine Harper, University of Birmingham)

Funding Committee recommendation: Decline

Stage 1 HTA Commissioned (Evidence Synthesis)

20/80: Endoscopic treatments for obesity

Chair: Professor Julia Brown

Declared a conflict and left the call: Professor Andrew Farmer, Professor Hashim Ahmed

NIHR133000: Endoscopic treatments for obesity

(Mr Sheraz Markar, Imperial College Healthcare NHS Trust)

Funding Committee recommendation: Decline

 

NIHR133008: Endoscopic treatments for adults and children with obesity or overweight: systematic review and economic evaluation

(Dr Alexander Miras, Imperial College London)

Funding Committee recommendation: Decline

 

NIHR133099: Endoscopic treatments for obesity: Clinical and Cost Effectiveness

(Dr Abd Tahrani, University of Birmingham)

Funding Committee recommendation: Shortlist

 

NIHR133103: Endoscopic treatments for obesity - an evidence synthesis and cost-effectiveness analysis

(Miss Kirstin Carswell, Surrey and Sussex Healthcare NHS Trust)

Funding Committee recommendation: Shortlist

Stage 1 HTA Broad Brief (Primary Research)

19/130: Bipolar Disorder

Chair: Professor Julia Brown

Declared a conflict and left the call: Professor Andrew Farmer, Professor Christine Roffe, Mr Matthew Moore

NIHR131483: Clinical and cost effectiveness of a digital integrated bipolar parenting intervention: A randomised controlled trial

(Professor Steven Jones, Lancaster University)

Funding Committee recommendation: Shortlist

19/130: Bipolar Disorder

Chair: Professor Julia Brown

Declared a conflict and left the call: Dr Marc Serfaty, Professor Rumana Omar, Professor Simon Gates

NIHR131529: The clinical and cost-effectiveness of a specialised care package for early course bipolar disorder compared to treatment as usual: SPECIALISE-BD

(Professor Steven Marwaha, University of Birmingham)

Funding Committee recommendation: Decline

19/130: Bipolar Disorder

Chair: Professor Julia Brown

Declared a conflict and left the call: Dr Marc Serfaty, Dr Martin Thomas, Professor Andrew Farmer, Professor Rumana Omar, Ms Stephanie MacNeil

NIHR132773: Aripiprazole/ sertraline combination: Efficacy, safety and cost-effectiveness in comparison with quetiapine for the treatment of bipolar depression. An open label randomised controlled trial. (ASCEnD)

(Dr Stuart Watson, University of Newcastle upon Tyne)

Funding Committee recommendation: Shortlist

Stage 1 HTA Injuries, accidents and urgent and emergency care themed call

19/162: HTA Injuries, accidents and urgent and emergency care themed call (Primary Research)

Chair: Professor Julia Brown

Declared a conflict and left the call: Dr Sara Twaddle, Dr Sarah Stock, Professor Craig Ramsay, Professor Olivia Wu, Professor Steff Lewis

Left meeting: Hashim Ahmed

NIHR132594: Early Vasopressors in Sepsis (EVIS)

(Dr Alasdair Corfield, NHS Greater Glasgow & Clyde)

Funding Committee recommendation: Shortlist

19/162: HTA Injuries, accidents and urgent and emergency care themed call (Primary Research)

Chair: Professor Julia Brown

Declared a conflict and left the call: Dr Sarah Stock, Professor Craig Ramsay, Professor Steff Lewis, Professor Andrew Farmer

NIHR132106: ACUte Care of Rapid Atrial fibrillation: Treatment Evaluations in the Emergency Department (ACCURATE - ED). A multicentre pragmatic trial across UK emergency departments evaluating the early emergency management of patients presenting with recent onset atrial fibrillation.

(Professor Alasdair Gray, Lothian Health Board)

Funding Committee recommendation: Decline

 

19/162: HTA Injuries, accidents and urgent and emergency care themed call (Primary Research)

Chair: Professor Julia Brown

Declared a conflict and left the call: Professor Hashim Ahmed, Ms Stephanie MacNeil

Left meeting: Tammi Walker

Arrived meeting but did not join as conflicted: Hashim Ahmed

NIHR132889: Conservative Management in Traumatic Pneumothoraces in the Emergency Department (CoMiT-ED): A Randomised Controlled Trial

(Dr Edward Carlton, North Bristol NHS Trust)

Funding Committee recommendation: Shortlist

19/162: HTA Injuries, accidents and urgent and emergency care themed call (Primary Research)

Chair: Professor Julia Brown

Declared a conflict and left the call: Professor Simon Gates

Left meeting: Stephanie Garfield-Birkeck

NIHR132868: Clinical and Cost effectiveness of Regional versus General Anaesthesia in Reducing Post-operative morbidity in patients with hip fractures (REGARD)

(Associate Professor Joyce Yeung, University of Warwick)

Funding Committee recommendation: Decline

20/33: Reducing Overtreatment

Chair: Professor Olivia Wu

Declared a conflict and left the call: Dr Simon Fraser, Professor Andrew Farmer, Professor Nick Francis, Professor Kerry Hood

Left Meeting: Nick James, Mark Peters

NIHR132876: Reducing antibiotic and oral corticosteroid overtreatment in the self-management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Primary Care

(Professor Michael Steiner, University of Leicester)

Funding Committee recommendation: Decline

19/162: HTA Injuries, accidents and urgent and emergency care themed call (Primary Research)

Chair: Professor Julia Brown

Declared a conflict and left the call: None

Arrived meeting: Tammi Walker

NIHR132684: Impact of a fully validated risk tool (STUMBL Score) on the management of blunt chest wall trauma: a stepped wedge, cluster randomised controlled trial (STUMBL2 Trial)

(Dr Ceri Battle, Swansea Bay University Health Board)

Funding Committee recommendation: Decline

19/162: HTA Injuries, accidents and urgent and emergency care themed call (Primary Research)

Chair: Professor Julia Brown

Declared a conflict and left the call: Dr Simon Fraser, Professor Jo Dumville, Ms Stephanie MacNeill

Arrived meeting: Hashim Ahmed

NIHR132968: Aspirin after hospitalisation with Pneumonia to prevent cardiovascular Events randomised Controlled Trial (ASPECT)

(Professor Nick Maskell, University of Bristol)

Funding Committee recommendation: Shortlist

19/162: HTA Injuries, accidents and urgent and emergency care themed call (Primary Research)

Chair: Professor Olivia Wu

Declared a conflict and left the call: Dr Ashley Agus

NIHR132874: Re-Evaluating the inhibition of stress erosions: Gastrointestinal Bleeding Prophylaxis in ICU

(Dr Marlies Ostermann, Guy's and St Thomas' NHS Foundation Trust)

Funding Committee recommendation: Decline

19/163: HTA Injuries, accidents and urgent and emergency care themed call (Evidence Synthesis)

Chair: Professor Olivia Wu

Declared a conflict and left the call: Professor Caroline Free

NIHR132672: Tranexamic acid for mild traumatic brain injury: evidence synthesis, decision modelling, and cost-effectiveness analysis

(Dr Katharine Ker, London School of Hygiene & Tropical Medicine)

Funding Committee recommendation: Decline

Stage 1 Commissioned (Evidence Synthesis)

20/81: Perioperative Oxygen Therapy: An overview of systematic reviews and meta-analyses

Chair: Professor Olivia Wu

Declared a conflict and left the call: Professor Andrew Farmer, Professor Craig Ramsay, Professor Kerenza Hood, Professor Simon Gates

Left meeting: Andrew Farmer

NIHR132759: Perioperative Oxygen Therapy: An overview of systematic reviews and meta-analyses

(Dr Helen Morgan, Cardiff University)

Funding Committee recommendation: Decline

 

NIHR132890: Perioperative oxygen therapy: an overview of systematic reviews and meta-analyses

(Professor Andrew Smith, University Hospitals of Morecambe Bay NHS Foundation Trust)

Funding Committee recommendation: Shortlist

 

NIHR132987: Perioperative Oxygen Therapy: An overview of systematic reviews and meta-analyses

(Associate Professor Joyce Yeung, University of Warwick)

Funding Committee recommendation: Shortlist

 

NIHR133059: Perioperative use of oxygen therapy: an overview of systematic reviews and meta-analyses.

(Professor Patrice Forget, University of Aberdeen)

Funding Committee recommendation: Decline

Stage 1 Researcher-Led (Primary Research)

20/38: HTA Researcher-Led Primary Research

Chair: Professor Julia Brown

Declared a conflict and left the call: Professor Nick Francis

Arrived meeting: Mark Peters

NIHR132317: Dietary Approaches to the Management Of type 2 Diabetes (DIAMOND) cluster randomised trial.

(Professor Paul Aveyard, University of Oxford)

Funding Committee recommendation: Shortlist