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HTA Funding Committee Public Minutes 15-16 September 2020

 

Contents

Tuesday 15 September 2020 (Day 1)

Place    

Virtual Meeting via Microsoft Teams

Present members

Professor Joy Adamson
Dr Ben Ainsworth
Roshan Bootun
Mr Paul Charlton (Public member)
Professor Gary Collins
Dr Emilio Fernandez-Egea
Professor Steve Goodacre (Chair)
Professor Richard Grieve
Dr Pollyanna Hardy
Dr Rebecca Harmston (Public member)
Professor Angela Hassiotis
Professor Rakesh Heer
Professor Catherine Hewitt (Deputy Chair)
Ms Debby Lennard (Public member)
Professor Pip Logan
Professor Nick Maskell
Associate Professor Antonieta Medina-Lara
Professor Jane Nixon
Mr Daniel Perry
Dr Greta Rait
Professor Rebecca Reynolds
Professor Chris Rogers
Professor Jonathan Ross
Professor Sobha Sivaprasad
Professor Andrew Shennan
Dr Beth Stuart
Dr Chris Sutton
Professor Catrin Tudur-Smith
Dr Katrina Turner
Professor Hywel Williams (Programme Director)
Professor Nefyn Williams

NETSCC, HTA Secretariat

Dr Nick Hicks (Consultant Advisor)
Steph Garfield-Birkbeck (Head of the HTA Programme)
Karen Williams (Senior Research Manager)  
Kathy Tier (Research Manager)
Connie Temple-Brown (Assistant Research Manager)
Jane Mooney (Administrator)

Apologies

Professor Saul Faust

Observers    

Olivia Wu (Deputy Chair for HTA Funding Committee General)
Becky Clarke-Harris (NETSCC ID&P)
Andrew Farmer (Programme Director Designate)

Quoracy Information    

Voting members: 30 Quorum = 20
Voting members present on Day 1: 29 (97%)

Commissioned Stage 2 applications 

19/125: Cardiac rehabilitation for stable angina

Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Professor Catherine Hewitt, Professor Catrin Tudur-Smith, Professor Daniel Perry, Professor Philippa Logan, Professor Jonathan Ross
Declared a conflict and left the call: Professor Nefyn Williams

NIHR131014: Cardiac Rehabilitation for Stable Angina (CReST) trial
(Dr Gordon McGregor, University Hospitals Coventry & Warwickshire NHS Trust)

Funding Committee recommendation: Decline

NIHR131015: Cardiac rehabilitation for people with chronic stable angina: a randomised controlled trial

Acronym: Angina Controlled Trial Investigating the Value of the 'Activate your heart' Therapeutic E-intervention (ACTIVATE)
(Professor Nefyn Williams, University of Liverpool)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/81: Neoadjuvant endocrine therapy for postmenopausal women with breast cancer

Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Katrina Turner, , Professor Chris Rogers, Professor Nick Maskell
Declared a conflict and left the call: Professor Andrew Farmer

NIHR131046: Randomised controlled trial evaluating effectiveness of neoadjuvant endocrine treatment in post-menopausal women (EndoNET).
(Professor Michael Douek, University of Oxford, Nuffield Department of Surgical Sciences)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/76: Antipsychotics for anorexia nervosa

Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Professor Andrew Shennan

NIHR130780: Olanzapine for young PEople with aNorexia nervosa: An open-label feasibility study to test recruitment, treatment acceptance, adherence, safety, outcome measures and patients' experience to prepare for a randomised placebo-controlled trial (OPEN)
(Dr Hubertus Himmerich, King's College London)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

Commissioned Stage 1 Applications

20/18: Minimally invasive operative interventions for bladder outlet obstruction due to benign prostatic hyperplasia

Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Professor Jane Nixon, Dr Katrina Turner, Professor Rakesh Heer, Professor Chris Rogers, Professor Nick Maskell
Left meeting: Professor Angela Hassiotis, Professor Sobha Sivaprasad

NIHR131984: Prostate Resection versus Minimally Invasive Surgery Evaluation Trial- PREMISE trial.
(Dr Tobias Page, The Newcastle Upon Tyne Hospitals NHS Foundation Trust)

Funding Committee recommendation: Shortlist

20/19: Nasal decolonisation of MRSA

Chair: Hywel Williams
Declared a conflict and did not partake in the discussion or vote: Dr Ben Ainsworth, Dr Christopher Sutton, Professor Jane Nixon, Professor Joy Adamson, Professor Steve Goodacre
Declared a conflict and left the call: Professor Catherine Hewitt

NIHR132718: A multi-centre randomised controlled non-inferiority and cost effectiveness trial comparing Mupirocin to Octenidine or Naseptin for nasal methicillin-resistant Staphylococcus aureus (MRSA) decolonisation amongst adult hospital in-patients: DEMON trial.
(Professor Mike Reed, Northumbria Healthcare NHS Foundation Trust)

Funding Committee recommendation: Shortlist

NIHR132665: The DECOL trial: Comparing alternative agents to mupirocin for the nasal DECOLonisation of MRSA.
(Associate Professor Andrew Kirby, University of Leeds)

Funding Committee recommendation: Decline

19/124: Effectiveness of meniscal allograft transplantation

Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Christopher Sutton, Professor Daniel Perry
Declared a conflict and left the call: Professor Andrew Farmer

NIHR131629: The Meniscal Transplant surgery or Optimised Rehabilitation full randomised trial (MeTeOR2)
(Associate Professor Andrew Metcalfe, University of Warwick)

Funding Committee recommendation: Shortlist

20/25: Guided self-help for depression in adults with autism spectrum disorders

Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Ben Ainsworth, Dr Katrina Turner, Professor Angela Hassiotis, Professor Chris Rogers, Professor Nick Maskell

NIHR132343: A randomised controlled trial of guided self-help for depression for autistic adults
(Dr Ailsa Russell, University of Bath)

Funding Committee recommendation: Shortlist

20/27: Management of ankle fractures in children

Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Professor Catrin Tudur Smith, Professor Daniel Perry, Professor Nefyn Williams
Declared a conflict and left the call: Professor Andrew Farmer, Professor Hywel Williams
Arrived: Sobha Sivaprasad

NIHR132675: Outcomes of Displaced Distal tibial fractures - Surgery Or Casts in Kids (ODD SOCKS). A multi-centre prospective randomized superiority trial of conservative versus surgical treatment for displaced distal tibial fractures in children.
(Mr Nicholas Peterson, Alder Hey Children's NHS Foundation Trust)

Funding Committee recommendation: Shortlist

20/21: Subcutaneous vs oral methotrexate for rheumatoid arthritis

Chair: Professor Catherine Hewitt
Declared a conflict and did not partake in the discussion or vote: Dr Ben Ainsworth, Dr Christopher Sutton, Professor Rakesh Heer, Professor Jonathan Ross, Professor Philippa Logan, Professor Steve Goodacre
Declared a conflict and left the call: Professor Hywel Williams

NIHR132711: Multi-centre randomised open-label assessor-blinded two arm parallel group trial of subcutaneous versus oral methotrexate for rheumatoid arthritis (RA), with feasibility assessment, economic evaluation and qualitative study.
Short-title: Methotrexate Oral Or SubcutanEous for RA [The MOOSE study].
(Professor Abhishek Abhishek, University of Nottingham)

Funding Committee recommendation: Shortlist

NIHR132072: COmparison of Subcutaneous Methotrexate compared with oral methotrexate treatment strategy In patients with early rheumatoid arthritis, aiming for remission:  an open label Clinical trial. The COSMIC trial.
(Dr Suzanne Verstappen, The University of Manchester)

Funding Committee recommendation: Shortlist

NIHR132209: The subCutaneous versus Oral Methotrexate for RheumAtoiD arthritis cost EffectivenesS (COMRADES) Study.
(Dr Arthur Pratt, University of Newcastle upon Tyne)

Funding Committee recommendation: Decline

NIHR132302: Clinical and Health Economic Assessment of Methotrexate Oral versus Subcutaneous Therapy (CHEAMOST)
(Professor Ernest Choy, Cardiff University)

Funding Committee recommendation: Decline

Wednesday 16 September 2020 (Day 2)

Place    

Virtual Meeting via Microsoft Teams

Present members

Professor Joy Adamson
Dr BenAinsworth
Mr Roshan Bootun
Mr Paul Charlton (Public member)
Professor Gary Collins
Dr Emilio Fernandez-Egea
Professor Steve Goodacre (Chair)
Professor Richard Grieve
Dr Pollyanna Hardy
Dr Rebecca Harmston (Public member)
Professor Angela Hassiotis
Professor Catherine Hewitt (Deputy Chair)
Ms Debby Lennard (Public member)
Professor Pip Logan
Associate Professor Antonieta Medina-Lara
Professor Jane Nixon
Mr Daniel Perry
Dr Greta Rait
Professor Rebecca Reynolds
Professor Chris Rogers
Professor Jonathan Ross
Professor Sobha Sivaprasad
Professor Andrew Shennan
Dr Beth Stuart
Dr Chris Sutton
Professor Catrin Tudur-Smith
Dr Katrina Turner
Professor Hywel Williams (Programme Director)
Professor Nefyn Williams

NETSCC, HTA Secretariat

Dr Nick Hicks (Consultant Advisor)
Steph Garfield-Birkbeck (Head of the HTA Programme)
Karen Williams (Senior Research Manager)  
Kathy Tier (Research Manager)
Connie Temple-Brown (Assistant Research Manager)
Jane Mooney (Administrator)

Apologies    

Professor Rakesh Heer
Professor Nick Maskell
Professor Saul Faust

Observers    

Amy Halls (NETSCC ID&P team)
Andrew Farmer (Programme Director Designate)

Quoracy Information    

Voting members: 30 Quorum = 20
Voting members present on Day 2: 27 (90%)

20/23: Diagnostic tools to establish the presence and severity of peripheral arterial disease in people with diabetes

Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Christopher Sutton, Professor Chris Rogers, Professor Jonathan Ross, Professor Rebecca Reynolds, Professor Richard Grieve
Declared a conflict and left the call: Professor Andrew Farmer, Professor Jane Nixon
Arrived: Rebecca Harmston

NIHR131855: Diagnostic tools to establish the presence and severity of peripheral arterial disease in people with diabetes
(Mr Usman Jaffer, Imperial College Healthcare NHS Trust)

Funding Committee recommendation: Shortlist

NIHR132461: diAgnostiC aCcuracy tEsting of Peripheral arterial disease in paTiEnts with Diabetes: The ACCEPTED study
(Professor James Woodburn, Glasgow Caledonian University)

Funding Committee recommendation: Decline

NIHR132681: Accuracy of Non-Invasive Vascular Laboratory tests in patients with diabetes and Peripheral Arterial Disease (ANVIL study)
(Professor Andrew Boulton, The University of Manchester)

Funding Committee recommendation: Decline

NIHR132140: Peripheral Arterial Disease in Diabetes Mellitus: Diagnosis and Assessment of Severity. The PAD DIAGNOSE study.
(Mr Patrick Coughlin, Cambridge University Hospital Trusts)

Funding Committee recommendation: Shortlist

NIHR132654: Evaluating specific diagnostic tools to establish the presence and severity of PAD in people with diabetes in primary care and specialized foot clinic and assess cost-effectiveness
(Professor Christian Heiss, University of Surrey)

Funding Committee recommendation: Decline

20/24: Psychological intervention for complex post-traumatic stress disorder

Chair: Professor Catherine Hewitt
Declared a conflict and did not partake in the discussion or vote: Dr Ben Ainsworth, Dr Christopher Sutton, Professor Jonathan Ross
Declared a conflict and left the call: Professor Andrew Farmer, Professor Hywel Williams

NIHR132022: Community treatment for COmplex Posttraumatic stress disorder (ComCoP)
(Dr Mark Freestone, Queen Mary University of London)

Funding Committee recommendation: Decline

NIHR132705: Does a Phased Approach Enhance Outcomes for Trauma-Focused Cognitive Therapy for Complex Posttraumatic Stress Disorder?
(Professor Anke Ehlers, University of Oxford)

Funding Committee recommendation: Shortlist

NIHR131832: Stabilising complex post-traumatic stress disorder in male offenders: a randomized control trial
(Dr Adam Mahoney, The University Court of Edinburgh Napier University)

Funding Committee recommendation: Decline

NIHR132403: Psychological intervention for complex post-traumatic stress disorder
(Associate Professor Anke Karl, University of Exeter)

Funding Committee recommendation: Decline

NIHR131977: Randomised controlled trial of enhanced skills training in affective and interpersonal regulation coupled with exposure work (ESTAIR) versus trauma focused cognitive behavioural therapy (TFCBT) for complex post-traumatic stress disorder (CPTSD).
(Professor Jonathan Bisson, Cardiff University)

Funding Committee recommendation: Shortlist

20/26: Antifungal Stewardship in Haemato-oncology

Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Christopher Sutton, Professor Catherine Hewitt, Professor Joy Adamson

NIHR132329: Improving Antifungal Stewardship in Haemato-oncology using a Biomarker-guided algorithm Versus Empirical treatment (I-SAVE)
(Dr Samir Agrawal, Barts & The London  School of Medicine & Dentistry)

Funding Committee recommendation: Shortlist

NIHR132674: Biomarker Driven Antifungal Stewardship in AML: The BioDriveAFS Trial
(Dr Gavin Barlow, Hull York Medical School)

Funding Committee recommendation: Shortlist

19/128: Administration routes of steroids in the first-line treatment of idiopathic sensorineural hearing loss

Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Christopher Sutton, Dr Katrina Turner, Professor Chris Rogers, Professor Greta Rait, Professor Jonathan Ross

NIHR131528: Administration routes of steroids in the first-line treatment of idiopathic sudden sensorineural hearing loss
(Mr James Tysome, Cambridge University Hospitals NHS Foundation Trust)

Funding Committee recommendation: Shortlist

NIHR131660: Steroids as a first-line treatment for idiopathic Sudden Sensorineural Hearing Loss: the SeaSHeL Trial
(Professor Anne Schilder, UCL Ear Institute)

Funding Committee recommendation: Shortlist

NIHR131614: The Steroids for ACute Hearing Loss (SACHEL) Trial
(Mr James O'Hara, Newcastle upon Tyne Hospitals NHS Foundation Trust)

Funding Committee recommendation: Decline

20/20: Imaging in paediatric osteomyelitis

Chair: Professor Catherine Hewitt
Declared a conflict and did not partake in the discussion or vote: Professor Catrin Tudur Smith, Professor Nefyn Williams, Professor Steve Goodacre
Declared a conflict and left the call: Professor Andrew Farmer, Professor Daniel Perry

NIHR132430: Paediatric Osteomyelitis Imaging (the PROMISING study): a multi-centre cohort study to understand the role of MRI and ultrasound in the diagnosis of acute haematogenous osteoarticular infection in children
(Mr Tim Theologis, Oxford University Hospitals NHS Trust)

Funding Committee recommendation: Decline Return to POC

19/120: Relapsing polymyalgia rheumatica

Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: N/A
Declared a conflict and left the call: Professor Andrew Farmer, Professor Jane Nixon

NIHR131475: Steroid-Reducing Options for ReLapsING PMR (STERLING-PMR): a pragmatic, randomised trial to compare the clinical and cost-effectiveness of adding immunosuppression to steroid-tapering treatment for patients with relapsing PMR, versus steroid-tapering alone.
(Dr Sarah Mackie, University of Leeds)

Funding Committee recommendation: Shortlist