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HTA Funding Committee Public Minutes 16-17 July 2019

 

Contents

Date

16 July 2019 (Day 1)

Place

Danubius, London

Present members

 

Professor Andrew Farmer (Chair)

Professor John Norrie (Deputy Chair)

Professor Hywel Williams (Programme Director)

Mr Alan Chant (PPI representative)

Mr Dave Green (PPI representative)

Professor Julie Brittenden

Miss Kirstin Carswell

Professor Mike Clarke

Professor Matt Costa

Professor Fay Crawford

Dr Jo Dumville

Professor Caroline Free

Professor Simon Gates

Professor Kerenza Hood

Professor Nick James

Professor Asma Khalil

Professor Steff Lewis

Dr Rumana Omar

Professor Rupert Pearse

Professor Mark Peters

Dr Matthew Ridd

Professor Christine Roffe

Dr Marc Serfaty

Dr Sarah Stock

Dr Sara Twaddle

NETSCC, HTA Secretariat

Dr Duncan Fortescue-Webb (Specialty Registrar in Public Health, NIHR)

Mr Kevin Campbell (Senior Research Manager)

Miss Louise Maclachlan (Research Manager)

Miss Louisa Saunders (Assistant Research Manager)

Apologies

Mrs Amanda Roberts

Dr Colin Green

Professor Craig Ramsay

Professor Olivia Wu

Professor Julia Lawton

Associate Professor Joanna Thompson-Coon

Observers

None

Quoracy Information

Voting members: 29 Quorum = 20

Voting members present on Day 1: 79%


 

Researcher-led Stage 2 Proposals

NIHR128513: A comprehensive model and economic evaluation of HCV elimination amongst people who inject drugs in England to guide case-finding intervention policy and implementation

(Professor Peter Vickerman, University of Bristol)

Chair: Andrew Farmer

Declared a conflict and left the room: Matthew Ridd, Caroline Free, Hywel Williams

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR128721: Pregnancy AntihyperteNsive Drugs: which Agent is best? (giant PANDA study)

(Professor Lucy Chappell, King's College London)

Chair: John Norrie

Declared a conflict and left the room: Andrew Farmer, Asma Khalil

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

Pain Themed Call Stage 2 Proposals

NIHR128782: A systematic review with mixed treatment comparisons meta analysis of anti-depressant treatment for adults with chronic pain

(Professor Tamar Pincus, Royal Holloway, University of London)

Chair: John Norrie

Declared a conflict and left the room: Andrew Farmer

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

Frailty Themed Call Stage 2 Proposals

NIHR128741: A randomised controlled trial of mobility training with or without protein supplementation to prevent or reverse frailty in community dwelling older people.

(Professor Sarah Lamb, University of Oxford)

Chair: John Norrie

Declared a conflict and left the room: Andrew Farmer, Matthew Costa, Simon Gates

Funding Committee recommendation: Decline

NIHR128334: Clinical and cost-effectiveness of a personalised health promotion intervention enabling independence in older people with mild frailty (‘HomeHealth’): A Randomised Controlled Trial

(Professor Kate Walters, University College London)

Chair: Andrew Farmer

Declared a conflict and left the room: Marc Serfaty, Hywel Williams, Rumana Omar

Left meeting: Mike Clarke

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR128862: Community-based complex interventions to sustain independence in older people, stratified by frailty: a systematic review and network meta-analysis

(Dr Andrew Clegg, University of Leeds)

Chair: Andrew Farmer

Declared a conflict and left the room: Fay Crawford, Jo Dumville, Hywel Williams, John Norrie

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

Commissioned Stage 2 Proposals

18/98: Oral nutritional interventions in malnourished frail elderly

Chair: Andrew Farmer

Declared a conflict and left the room: none

NIHR128157: Oral nutritional interventions for malnourished, frail older people

(Professor Alison Avenell, University of Aberdeen)

Funding Committee recommendation: Decline

NIHR128729: Assessing the effectiveness and cost-effectiveness of oral nutritional interventions in malnourished frail elderly people

(Dr Sheena Ramsay, University of Newcastle upon Tyne)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/100: Strategies for the management of chronic constipation in childhood

Chair: Andrew Farmer

Declared a conflict and left the room: None

NIHR128470: Strategies Used for Constipation in Children - Evidence Synthesis involving Stakeholders (SUCCESS)

(Professor Doreen McClurg, Glasgow Caledonian University)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/134: Active case finding of coeliac disease

Chair: John Norrie

Declared a conflict and left the room: Jo Dumville, Matthew Ridd, Andrew Farmer, Hywel Williams, Kerenza Hood

NIHR129020: What is the optimum strategy for identifying adults and children with coeliac disease? A systematic review and economic models.

(Dr Penny Whiting, University of Bristol)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR128685: Cost-effectiveness of active case finding of coeliac disease in at-risk groups in primary care

(Dr Matthew Kurien, The University of Sheffield)

Funding Committee recommendation: Decline

18/102: Left ventricular assist devices as destination therapy for advanced heart failure

Chair: Andrew Farmer

Declared a conflict and left the room: Jo Dumville, Matthew Ridd, Nick James

NIHR129038: Left ventricular assist devices (LVAD) as destination therapy (DT) for advanced heart failure (HF)

(Dr Maria Pufulete, University of Bristol)

 

Funding Committee recommendation: Decline

NIHR128996: Left ventricular assist devices as destination therapy for advanced heart failure

(Dr David Moore, University of Birmingham)

Funding Committee recommendation: Prioritisation Oversight Committee to consider fund with changes

18/99: Lifestyle modification interventions in adults with learning disabilities

Chair: Andrew Farmer

Declared a conflict and left the room: Rumana Omar

NIHR128755: Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities.

(Dr Leanne Harris, University of Glasgow)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR128887: The clinical and cost-effectiveness of LifEstyle modifications in Adults with a leaRNing disability: a mixed studies review and convergent synthesis of quantitative and qualitative evidence. The LEARN Study.

(Professor Suzanne Richards, University of Leeds)

Funding Committee recommendation: Decline

18/101: Interventions for the management of perceptual disorders following stroke

Chair: Andrew Farmer

Declared a conflict and left the room: Fay Crawford, John Norrie, Steff Lewis, Sarah Stock

NIHR128829: Perceptual disorders after stroke InterventiON EvidencE Review (PIONEER): a scoping review and Cochrane Review revision and expansion

(Professor Marian Brady, Glasgow Caledonian University)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

 

 

Date

17 July 2019 (Day 2)

Place

Danubius, London

Present members

 

Professor Andrew Farmer (Chair)

Professor Hywel Williams (Programme Director)

Mr Dave Green (PPI representative)

Professor Julie Brittenden

Miss Kirstin Carswell

Professor Mike Clarke

Professor Matt Costa

Professor Fay Crawford

Dr Jo Dumville

Professor Caroline Free

Professor Kerenza Hood

Professor Asma Khalil

Professor Steff Lewis

Dr Rumana Omar

Professor Rupert Pearse

Professor Mark Peters

Dr Matthew Ridd

Professor Christine Roffe

Dr Marc Serfaty

Dr Sarah Stock

Dr Sara Twaddle

NETSCC, HTA Secretariat

 

 

Dr Duncan Fortescue-Webb (Specialty Registrar in Public Health, NIHR)

Mr Kevin Campbell (Senior Research Manager)

Miss Louise Maclachlan (Research Manager)

Miss Louisa Saunders (Assistant Research Manager)

Apologies

Mrs Amanda Roberts

Dr Colin Green

Professor Craig Ramsay

Professor Olivia Wu

Mr Alan Chant

Professor Simon Gates

Professor Nick James

Professor Julia Lawton

Associate Professor Joanna Thompson-Coon

Professor John Norrie (Deputy Chair)

Observers

Katherine Cowan, JLA Senior Advisor

 

Quoracy Information

Voting members: 29 Quorum = 19

Voting members present on Day 2: 66%

 

Day 2

Commissioned Stage 2 Proposals (continued)

18/104: Prevention and treatment of incontinence-associated dermatitis

Chair: Andrew Farmer

Declared a conflict and left the room: Matthew Ridd, Hywel Williams, Kerenza Hood, Michael Clarke, Rumana Omar

NIHR128434: Implementation of Incontinence Associated Dermatitis prevention guidance in care home and community settings: a feasibility study

(Professor Fiona Cowdell, Birmingham City University)

Committee recommendation: Decline

NIHR128865: PREVENTion and treatment of Incontinence-Associated Dermatitis (IAD) through optimising care: development and feasibility of the IAD Manual (PREVENT-IAD)

(Dr Sue Woodward, King's College London)

Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR Cross-Programme Commissioning – Stage 2 Digital call proposals

NIHR127773: Tele-opHthalmology-enablEd and ARtificial Intelligence-ready referral pathway for coMmunity optomEtry referralS of retinal disease: the HERMES study - a Cluster Randomised Superiority Trial with a linked Observational Diagnostic Accuracy Study

(Dr Konstantinos Balaskas, Moorfields Eye Hospital NHS Foundation Trust)

Chair: Andrew Farmer

Declared a conflict and left the room: none.

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

Commissioned Stage 2 Proposals (continued)

18/103: Recurrent intra-articular corticosteroid injections in osteoarthritis

Chair: Hywel Williams

Declared a conflict and left the room: Matthew Ridd, Andrew Farmer, Rumana Omar

NIHR129011: RecUrrent Intra-articular Corticosteroid injections in Osteoarthritis; the RUbICOn study

(Mr Michael Whitehouse, University of Bristol)

 Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

Researcher-led Evidence Synthesis Stage 1 Proposals

NIHR129708: Safety and effectiveness of tranexamic acid in trauma and surgery in the NHS: An individual patient data meta-analysis

(Dr Katharine Ker, London School of Hygiene & Tropical Medicine)

Chair: Andrew Farmer

Declared a conflict and left the room: Caroline Free, Michael Clarke, Asma Khalil

Funding Committee recommendation: Shortlist

NIHR129742: Systematic Review and meta-analysis of clinical and cost effectiveness and feasibility of a UK extracorporeal cardiopulmonary resuscitation programme for out-of-hospital cardiac arrests

(Associate Professor Joyce Yeung, University Hospitals Birmingham NHS Foundation Trust)

Chair: Andrew Farmer

Declared a conflict and left the room: Rupert Pearse

Funding Committee recommendation: Decline

NIHR129715: Diet and physical activity in pregnancy to prevent gestational diabetes: Individual Participant Data (IPD) meta-analysis on the differential effects of interventions with economic evaluation

(Professor Shakila Thangaratinam, Queen Mary University of London)

Chair: Hywel Williams

Declared a conflict and left the room: Andrew Farmer, Fay Crawford, Jo Dumville, Sarah Stock, Asma Khalil

Funding Committee recommendation: Shortlist

NIHR129713: Effectiveness and cost-effectiveness of gynaecological surveillance for women with Lynch syndrome: systematic reviews and economic evaluation

(Dr Tristan Snowsill, University of Exeter)

Chair: Andrew Farmer

Declared a conflict and left the room: Jo Dumville

Funding Committee recommendation: Shortlist

NIHR129523: BEhavioural Weight Management: COMponents of Effectiveness (BE:COME)

(Dr Jennifer Logue, University of Glasgow)

Chair: Andrew Farmer

Declared a conflict and left the room: Julie Brittenden

Left meeting: Matt Costa

Funding Committee recommendation: Shortlist

Researcher-Led Primary Research Stage 1 proposals

NIHR129025: WrIst Physiotherapy Interventions in Trauma (WIPIT Study)

(Associate Professor Ben Ollivere, The University of Nottingham)

Chair: Rupert Pearse

Declared a conflict and left the room: Jo Dumville, Andrew Farmer, Hywel Williams, Michael Clarke

Funding Committee recommendation: Decline

Commissioned Stage 1 proposals

19/28: Endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused by unresectable cancer

Chair: Andrew Farmer

Declared a conflict and left the room: none

NIHR129784: Endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused by unresectable cancer - evidence synthesis.

(Dr John Leeds, The Newcastle Upon Tyne Hospitals NHS Foundation Trust)

Funding Committee recommendation: Shortlist

NIHR Cross-Programme Commissioning – Stage 1 Digital call proposals

NIHR128803: A Prospective Mixed Methods Study of the Effects of Measuring Adherence to Chest Physiotherapy in Cystic Fibrosis (SEARCH-CF)

(Dr Edward Nash, University Hospitals Birmingham NHS Foundation Trust)

Chair: Andrew Farmer

Declared a conflict and left the room: Hywel Williams

Funding Committee recommendation: Decline

NIHR129153: Telemedicine Screening for Retinopathy of Prematurity: A Clinical Study of Efficacy and Safety of Video grading to Still Image Grading with Health Economic Impact Assessment.

(Dr Susmito Biswas, Manchester University NHS Foundation Trust)

Chair: Andrew Farmer

Declared a conflict and left the room: none

Funding Committee recommendation: Decline

NIHR129255: DISSH: Evaluating Digital health Intervention Supporting young people who Self-Harm

(Dr Martina Di Simplicio, Imperial College London)

Chair: Andrew Farmer

Left the meeting: Hywel Williams

Funding Committee recommendation: Decline

NIHR129334: The effectiveness and cost-effectiveness of home-based active video gaming therapy vs. treatment as usual on motor function of children with cerebral palsy: a pragmatic multi-centre randomised controlled trial with embedded economic evaluation and parallel process evaluation

(Dr William Farr, Sussex Community NHS Trust)

Chair: Andrew Farmer

Declared a conflict and left the room: None

Funding Committee recommendation: Invite Resubmission

NIHR129248: Digital technologies for home monitoring glaucoma: a feasibility study.

(Dr Katie Gillies, University of Aberdeen)

Chair: Andrew Farmer

Declared a conflict and left the room: Julie Brittenden, Kerenza Hood, Michael Clarke

Funding Committee recommendation: Shortlist

Close of day 2