This site is optimised for modern browsers. For the best experience, please use Google Chrome, Mozilla Firefox, or Microsoft Edge.

HTA Funding Committee Public Minutes 16 - 17 March 2021

Contents

Meeting

HTA Funding Committee (General)

Day 1 - Tuesday 16th March 2021

Venue  

Virtual Meeting via Microsoft Teams

 

Present members

Professor Rupert Pearse (Deputy Chair)

Professor Andrew Farmer (Programme Director/Acting Chair)

Dr Ashley Agus

Professor Hashim Ahmed

Professor Julie Brittenden

Professor Matthew Costa

Dr Fay Crawford

Professor Jo Dumville

Professor Nick Francis

Professor Caroline Free

Professor Simon Gates

Professor Kerenza Hood

Professor Nick James

Professor Asma Khalil

Professor Steff Lewis

Dr Stephanie MacNeill

Mr Matthew Moore (PPI representative)

Professor Mark Peters

Professor Craig Ramsay

Mrs Amanda Roberts (PPI representative)

Professor Christine Roffe

Dr Whitney Scott

Dr Marc Serfaty

Dr Martin Thomas

Associate Professor Jo Thompson-Coon

Dr Sara Twaddle

Professor Tammi Walker

 

NETSCC, HTA Secretariat

Dr Simon Fraser (Consultant Advisor).

Steph Garfield-Birkbeck (Head of the HTA Programme)

Karen Williams (Senior Research Manager)

Cristina Lujan Barroso (Research manager)

Louisa Saunders (Assistant Research Manager)

Julie Herring (Administrator)

 

Apologies       

Dr Marta Soares

Professor Julia Brown

 

Observers      

Laura Bradley - new HTA Research manager (NETSCC).

Agnieszka Terry - Research Manager (ID&P NETSCC)

Nikita Belavate - new Administrator (NETSCC)

 

Quoracy Information  

Voting members: 27 Quorum = 18

Voting members present on Day 1: 26 (93%)

  

Stage 2 Commissioned (ES) proposals shortlisted at November 2020 Committee

20/79: Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy

Chair: Professor Andrew Farmer

Conflicts: Professor Craig Ramsay, Professor Jo Dumville, Professor Tammi Walker

 

NIHR132948: Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy: a systematic review and economic analysis

(Dr Mark Simmonds, University of York)

Decision: Programme Oversight Committee to consider fund with changes

 

NIHR133058: Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy

(Dr Fiona Pearson, University of Newcastle upon Tyne)

Decision: Decline

20/78: Pharmacological treatment and prevention of chronic migraine

Chair: Professor Rupert Pearse

Conflicts: Professor Andrew Farmer, Professor Simon Gates

NIHR132803: What is the comparative clinical and cost- effectiveness of pharmacological treatments for adults with chronic migraine?

(Dr Hema Mistry, University of Warwick)

Decision: Programme Oversight Committee to consider fund with changes

 

20/29: Interventions for fibromyalgia-related sleep problems

Chair: Professor Rupert Pearse

Conflicts: Professor Andrew Farmer, Professor Craig Ramsay, Professor Joanna Thompson-Coon, Professor Kerenza Hood, Professor Simon Gates

 

NIHR132490: Synthesising the evidence for interventions for fibromyalgia-related sleep problems.

(Dr Beth Fordham, University of Oxford)

Decision: Decline

 

NIHR132999: What is the evidence for interventions used to manage sleep disturbances in people with fibromyalgia? A comprehensive evidence synthesis to inform clinical practice and future research.

(Dr Miriam Brazzelli, University of Aberdeen)

Decision: Programme Oversight Committee to consider fund with changes

 

20/81: Perioperative Oxygen Therapy: An overview of systematic reviews and meta-analyses

Chair: Professor Andrew Farmer

Conflicts: Professor Mark Peters, Professor Rupert Pearse, Professor Simon Gates

Left meeting: Professor Hashim Ahmed

 

NIHR132890: Perioperative oxygen therapy: an overview of systematic reviews and meta-analyses

(Professor Andrew Smith, University Hospitals of Morecambe Bay NHS Foundation Trust)

Decision: Decline

 

NIHR132987: Perioperative Oxygen Therapy: An overview of systematic reviews and meta-analyses

(Dr Joyce Yeung, University of Warwick)

Decision: Programme Oversight Committee to consider fund with changes

 

20/80: Endoscopic treatments for obesity

Chair: Professor Andrew Farmer

Conflicts: Professor Simon Gates

 

NIHR133099: Endoscopic treatments for obesity: Clinical and Cost Effectiveness

(Dr Abd Tahrani, University of Birmingham)

Decision: Programme Oversight Committee to consider fund with changes

 

NIHR133103: Endoscopic treatments for obesity - an evidence synthesis and cost-effectiveness analysis

(Miss Kirstin Carswell, Surrey and Sussex Healthcare NHS Trust)

Decision: Decline

 

HTA Injuries, accidents and urgent and emergency care themed call Stage 1

19/162: HTA Injuries, accidents and urgent and emergency care themed call (Primary Research)

Chair: Professor Rupert Pearse

Conflicts: Dr Sara Twaddle, Professor Craig Ramsay, Professor Steff Lewis

Arrived meeting: Professor Hashim Ahmed

NIHR132594: Early Vasopressors in Sepsis (EVIS)

(Dr Alasdair Corfield, NHS Greater Glasgow & Clyde)

Decision: Programme Oversight Committee to consider fund with changes

 

Chair: Professor Rupert Pearse

Conflicts: Dr Stephanie MacNeill, Professor Hashim Ahmed

NIHR132889: Conservative Management in Traumatic Pneumothoraces in the Emergency Department (CoMiT-ED): A Randomised Controlled Trial

(Associate Professor Edward Carlton, North Bristol NHS Trust)

Decision: Programme Oversight Committee to consider fund with changes

 

Chair: Professor Andrew Farmer

Conflicts: Dr Simon Fraser, Dr Stephanie MacNeill, Professor Jo Dumville

Left meeting: Professor Kerry Hood

NIHR132968: Aspirin after hospitalisation with Pneumonia to prevent cardiovascular Events randomised Controlled Trial (ASPECT)

(Professor Nick Maskell, University of Bristol)

Decision: Programme Oversight Committee to consider fund with changes

 

HTA Researcher-Led (Primary Research) Stage 2

20/38: HTA Researcher-led call Primary Research

NIHR132317: Dietary Approaches to the Management Of type 2 Diabetes (DIAMOND) cluster randomised trial

(Professor Paul Aveyard, University of Oxford)

Chair: Professor Rupert Pearse

Conflicts: Professor Andrew Farmer

Decision: Programme Oversight Committee to consider fund with changes

 

19/160: HTA Researcher-led call Primary Research

NIHR131850: The clinical and cost-effectiveness of elective primary total knee replacement with PAtellar Resurfacing compared to selective patellar resurfacing. A pragmatic multicentre randomised controlled Trial with blinding (PART)

(Professor Ashley Blom, University of Bristol)

Chair: Professor Andrew Farmer

Conflicts: Dr Stephanie MacNeill, Professor Simon Gates

Decision: Programme Oversight Committee to consider fund with changes

 

Day 2 - Wednesday 17th March 2021 

 

Venue  

Virtual Meeting via Microsoft Teams

 

Present members

Professor Rupert Pearse (Deputy Chair)

Professor Andrew Farmer (Programme Director/Acting Chair)

Dr Ashley Agus

Professor Hashim Ahmed

Professor Julie Brittenden

Professor Matthew Costa

Dr Fay Crawford

Professor Nick Francis

Professor Caroline Free

Professor Simon Gates

Professor Kerenza Hood

Professor Nick James

Professor Asma Khalil

Professor Steff Lewis

Dr Stephanie MacNeill

Mr Matthew Moore (PPI representative)

Professor Mark Peters

Professor Craig Ramsay

Mrs Amanda Roberts (PPI representative)

Professor Christine Roffe

Dr Whitney Scott

Dr Marc Serfaty

Dr Marta Soares

Dr Martin Thomas

Associate Professor Jo Thompson-Coon

Dr Sara Twaddle

Professor Tammi Walker

 

NETSCC, HTA Secretariat

Dr Simon Fraser (Consultant Advisor).

Steph Garfield-Birkbeck (Head of the HTA Programme)

Karen Willams (Senior Research Manager)

Cristina Lujan Barroso (Research manager)

Louisa Saunders (Assistant Research Manager)

Julie Herring (Administrator)

 

Apologies       

Professor Julia Brown

Professor Jo Dumville

 

Observers      

Laura Bradley - new HTA Research manager (NETSCC).

Lucy Upshall – Research Manager (PPI & Ext Review NETSCC)

 

Quoracy Information  

Voting members: 27 Quorum = 18

Voting members present on Day 2: 26 (93%)

 

 

HTA Broad Brief Stage 2 Proposals

19/130: Bipolar Disorder

Chair: Professor Rupert Pearse

Conflicts: Dr Martin Thomas, Dr Stephanie MacNeill, Mr Matthew Moore, Professor Andrew Farmer, Professor Christine Roffe, Professor Hashim Ahmed, Dr Marc Serfaty

NIHR132773: Aripiprazole/ sertraline combination: Clinical and cost-effectiveness in comparison with quetiapine for the treatment of bipolar depression. An open label randomised controlled trial. (ASCEnD)

(Dr Stuart Watson, University of Newcastle upon Tyne)

Decision: Programme Oversight Committee to consider fund with changes

 

Chair: Professor Rupert Pearse

Conflicts: Mr Matthew Moore, Professor Andrew Farmer, Professor Christine Roffe

NIHR131483: Clinical and cost effectiveness of an online integrated bipolar parenting intervention: A randomised controlled trial

(Professor Steven Jones, Lancaster University)

Decision: Programme Oversight Committee to consider fund with changes

 

HTA Broad Brief Stage 2 20/33

20/33: Reducing Overtreatment

Chair: Professor Andrew Farmer

Declared a conflict and left the meeting: Professor Hashim Ahmed, Professor Nicholas James, Dr Marc Serfaty

NIHR133011: REFINE-Lung (formerly known as CONVOLUTE): A randomised open-label phase III trial of REduced Frequency pembrolizumab ImmuNothErapy for first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) utilising a novel multi-arm frequency-response optimisation design.

(Professor Michael Seckl, Imperial College London)

Decision: Programme Oversight Committee to consider fund with changes

 

Stage 1 Proposals  

20/28: Repair and rehabilitation of hand flexor tendon injury

Chair: Professor Rupert Pearse

Conflicts: Professor Hashim Ahmed, Dr Martin Thomas, Professor Christine Roffe, Dr Marta Soares, Professor Andrew Farmer

Left meeting: Dr Whitney Scott

NIHR133763: A multicentre randomised controlled trial comparing Wide-awake Anaesthesia No Tourniquet (WALANT) versus General and Regional Anaesthesia for Flexor Tendon Repair (FLEXOR Trial)

(Professor Afshin Mosahebi, Royal Free London NHS Foundation Trust)

Decision: Decline

 

NIHR133748: Wide-Awake local anaesthesia no tourniquet Surgical technique and early functional Hand Use Rehabilitation Protocol for treatment of finger flexor tendon injuries in adults: a 2x2 factorial randomised trial

The WASHUP Study

(Mr Jason Wong, The University of Manchester)

Decision: Decline

 

Chair: Professor Rupert Pearse

Conflicts: Dr Marta Soares, Professor Andrew Farmer, Professor Hashim Ahmed

NIHR133784: A 2 x 2 factorial randomised trial to determine the clinical and cost effectiveness of not repairing flexor digitorum superficialis and a new rehabilitation regime versus usual care for treatment of complete zone II flexor tendon injuries: the FLexor repAir and REhabilitation (FLARE) Trial

(Mr Matthew Gardiner, Frimley Health NHS Foundation Trust)

Decision: Shortlist

 

Chair: Professor Rupert Pearse

Conflicts: Dr Marta Soares, Professor Andrew Farmer, Professor Hashim Ahmed

Arrived meeting: Steph Garfield-Birkbeck

NIHR133582: Prospective randomised controlled trial comparing three splints for finger flexor tendon repairs (FIRST study).

(Mrs Emma Bamford, Derby Hospitals NHS Foundation Trust)

Decision: Shortlist

 

NSAG ES call 20/140: Faecal immunochemical test (FIT) based tools to triage patients in primary care

Chair: Professor Rupert Pearse

Conflicts: Professor Andrew Farmer, Professor Joanna Thompson-Coon

 

NIHR133852: COLOFIT - Optimal use of Faecal Immunochemical Testing for patients with symptoms of possible colorectal cancer.

(Professor Colin Rees, University of Newcastle upon Tyne)

Decision: Shortlist

 

NIHR133953: Faecal immunochemical test (FIT) based tools to triage patients in primary care

(Ms Megan Dale, Cardiff and Vale University Health Board)

Decision: Decline

 

HTA Researcher-Led Stage 1

20/89: HTA Researcher-led call Evidence Synthesis

NIHR133834: Palliative treatment of jaundice in people with malignant distal biliary obstruction: a systematic review of randomised controlled trials, network meta-analysis, and cost-effectiveness analysis

(Professor Kurinchi Gurusamy, University College London)

Chair: Professor Andrew Farmer

Conflicts: Dr Marc Serfaty

Decision: Decline

 

20/90: Researcher-led call Primary Research

NIHR133611: Inpatient graduated compression stocking use as an adjunct to extended duration pharmacoprophylaxis for venous thromboembolism prevention – a multi-centre randomised controlled trial

(Professor Alun Davies, Imperial College London)

Chair: Professor Andrew Farmer

Conflicts: Professor Craig Ramsay, Professor Hashim Ahmed, Professor Steff Lewis

Decision: Stage 1 Resubmission

 

NIHR133581: Furosemide against Bumetanide for the treatment of recently decompensated heart failure

(Dr David Wilson, Worcestershire Acute Hospitals NHS Trust)

Chair: Professor Andrew Farmer

Conflicts: Professor Caroline Free, Professor Rupert Pearse, Professor Simon Gates

Left meeting: Professor Julie Brittenden

Decision: Shortlist

 

NIHR133719: Staphylococcus aureus Network Adaptive Platform (SNAP) Trial

(Dr Anna Goodman, Guy's and St Thomas' NHS Foundation Trust)

Chair: Professor Rupert Pearse

Conflicts: Professor Andrew Farmer, Professor Nick Francis, Professor Kerenza Hood

Decision: Shortlist

 

NIHR133467: The clinical and cost-effectiveness and safety of haematopoietic interventions administered to recovering patients with anaemia following major non-elective surgery: a phase IV, adaptive randomised controlled multicentre study.

(Professor Iain Moppett, The University of Nottingham)

Chair: Dr Simon Fraser

Conflicts: Professor Andrew Farmer, Professor Matthew Costa, Professor Rupert Pearse

Left meeting: Professor Tammi Walker

Decision: Shortlist

 

NIHR133776: Examining the benefit of graduated compression stockings in the Prevention of vEnous Thromboembolism in low-risk Surgical patients: a multicentre cluster randomised controlled trial (PETS Trial)

(Professor Alun Davies, Imperial College London)

Chair: Professor Andrew Farmer

Conflicts: Professor Craig Ramsay, Professor Hashim Ahmed, Professor Steff Lewis

Decision: Shortlist