This site is optimised for modern browsers. For the best experience, please use Google Chrome, Mozilla Firefox, or Microsoft Edge.

Beta

This is a new site which is still under development. We welcome your feedback, which will help improve it.

Feedback form

HTA Funding Committee Public Minutes 17-18 September 2019

 

Contents

Date

Tuesday 17th September 2019 (Day 1)

Place

Danubius Hotel, London

Present members

Professor Joy Adamson

Professor Steven Brown

Mr Paul Charlton

Dr Emilio Fernandez-Egea

Professor Saul Faust

Professor Simon Gilbody (Deputy Chair)

Professor Steve Goodacre (Chair)

Professor Richard Grieve

Dr Rebecca Harmston

Professor Angela Hassiotis

Mr Rakesh Heer

Professor Catherine Hewitt

Professor Pip Logan

Professor Nick Maskell

Mr Daniel Perry

Professor Rebecca Reynolds

Professor Chris Rogers

Professor Jonathan Ross

Professor Tracey Sach

Professor Andrew Shennan (afternoon only)

Professor Sobha Sivaprasad

Professor Catrin Tudur-Smith

Dr Katrina Turner

Professor Hywel Williams (Programme Director)

Professor Nefyn Williams

NETSCC, HTA Secretariat

Dr Nick Hicks (Consultant Advisor)

Ms Helen Payne (Senior Research Manager)

Miss Connie Temple-Brown (Assistant Research Manager)

Ms Kathy Tier (Research Manager)

Mrs Karen Williams (Senior Research Manager)

Miss Alessandra Wilkinson-Smith (Assistant Research Manager)

Apologies

Professor Andrew Shennan (absent morning only), Professor Gary Collins, Professor Jane Nixon, Professor Greta Rait, Mr David Symes

Observers

No observers

Quoracy Information

Voting members: 26 Quorum = 18

Voting members present on Day 1: 23 (88%)

  

Commissioning Stage 2 Proposals, shortlisted at May 2019 Committee

18/176: HTA Precision Medicine

Chair: Professor Steve Goodacre

Declared a conflict and left the room: Professor Simon Gilbody

NIHR128636: Optimal diagnostic strategies for patients presenting in primary care with lower gastrointestinal symptoms: evidence synthesis and cost-effectiveness analysis

(Associate Professor Bethany Shinkins, University of Leeds)

Funding Committee recommendation: Decline Return to POC

18/186: Active management vs conservative management for symptomatic brain cavernoma

Chair: Professor Simon Gilbody

Declared a conflict and left the room: Professor Steven Brown, Professor Steve Goodacre, Professor Rebecca Reynolds, Professor Chris Rogers, Professor Catrin Tudur Smith, Dr Katrina Turner

NIHR128694: Cavernomas A Randomised Effectiveness (CARE) pilot trial, to address the effectiveness of active treatment (with neurosurgery or stereotactic radiosurgery) versus conservative management in people with symptomatic brain cavernoma

(Professor Rustam Salman, The University of Edinburgh)

Funding Committee recommendation: Invite stage 2 Resubmission (next funding committee meeting)

18/187: Relapsing polymyalgia rheumatica

Chair: Professor Steve Goodacre

Declared a conflict and left the room: Dr Rebecca Harmston

NIHR129150: Methotrexate versus placebo for preventing relapse in polymyalgia rheumatica (MERLIN-PMR): a multi-centre, phase III, parallel-group randomised controlled trial.

(Dr Sarah Mackie, University of Leeds)

Funding Committee recommendation: Decline Return to POC

18/189: Combination treatment for dementia with Lewy Bodies and Parkinson's disease dementia

Chair: Professor Steve Goodacre

Declared a conflict and left the room: Dr Emilio Fernandez-Egea, Dr Rebecca Harmston, Professor Angela Hassiotis, Professor Rebecca Reynolds, Professor Tracey Sach

NIHR129175: COmBining memantine And cholinesterase inhibitors in Lewy body dementia treatment Trial (COBALT)

(Professor John-Paul Taylor, Newcastle University)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/190: Blood pressure management in critically ill children

Chair: Professor Steve Goodacre

Declared a conflict and left the room: Professor Richard Grieve, Professor Hywel Williams

NIHR128895: Evaluating the clinical and cost effectiveness of using a more permissive blood pressure target to guide careful titration of vasoactive agents in critically ill children with hypotension: PRotocolised Evaluation of permiSSive blood pressure targets versus Usual caRE (PRESSURE)

(Dr David Inwald, Imperial College Healthcare NHS Trust)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/192: Pulpotomy for the management of irreversible pulpitis in mature teeth

Chair: Professor Simon Gilbody

Declared a conflict and left the room: Professor Steve Goodacre, Professor Catherine Hewitt, Professor Nefyn Williams

NIHR129089: Pulpotomy vs Root canal trEatment for cariouS teEth with IRreVersiblE pulpitis (PRESERVE)

(Dr Ikhlas El karim, The Queen's University of Belfast)

Funding Committee recommendation: Decline

NIHR129230: Pulpotomy for the management of irreversible pulpitis in mature teeth (Pulpotomy for Irreversible Pulpitis - PIP Trial)

(Professor Janet Clarkson, University of Dundee)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/193: Laparoscopic hysterectomy

Chair: Professor Steve Goodacre

Declared a conflict and left the room: Dr Rebecca Harmston, Professor Nick Maskell, Professor Jonathan Ross

Professor Andrew Shennan joined the meeting

NIHR128991: LAparoscopic Versus Abdominal hysterectomy (LAVA) trial

(Professor T Justin Clark, Birmingham Women's NHS Foundation Trust)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/195: Extended treatment in early intervention in psychosis services

Chair: Professor Simon Gilbody

Declared a conflict and left the room: Professor Steven Brown, Dr Emilio Fernandez-Egea, Professor Steve Goodacre, Professor Angela Hassiotis, Professor Jonathan Ross

NIHR129501: Extended treatment in early intervention in psychosis services.

(Dr Paul French, Pennine Care NHS Foundation Trust)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/197: Hysteroscopic removal of retained placenta

Chair: Professor Steve Goodacre

Declared a conflict and left the room: Dr Rebecca Harmston, Professor Nick Maskell, Mr Daniel Perry, Professor Rebecca Reynolds, Professor Chris Rogers, Dr Katrina Turner

NIHR129561: The Hysteroscopic removAl of Retained Placenta (HARP) study

(Dr Islam Gamaleldin, University of Bristol)

Funding Committee recommendation: Decline Return to POC

18/198: Exercise therapy for the treatment of tendinopathies

Chair: Professor Steve Goodacre

Declared a conflict and left the room: Professor Nick Maskell, Professor Chris Rogers, Dr Katrina Turner

NIHR128950: Exercise therapy for the treatment of tendinopathies: a synthesis of the evidence

(Mr Andrew Beswick, University of Bristol)

Funding Committee recommendation: Decline

NIHR129388: Exercise therapy for the treatment of tendinopathies: A mixed methods evidence synthesis

(Professor Kay Cooper, Robert Gordon University)

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

  

Date

Wednesday 18th September 2019 (Day 2)

Place

Danubius Hotel, London

Present members

 

Professor Steven Brown

Mr Paul Charlton

Dr Emilio Fernandez-Egea

Professor Saul Faust

Professor Simon Gilbody (Deputy Chair)

Professor Steve Goodacre (Chair)

Professor Richard Grieve

Professor Angela Hassiotis

Professor Catherine Hewitt

Professor Nick Maskell

Mr Daniel Perry

Professor Rebecca Reynolds

Professor Chris Rogers

Professor Jonathan Ross

Professor Tracey Sach

Professor Andrew Shennan (morning only)

Professor Sobha Sivaprasad

Professor Catrin Tudur-Smith

Professor Hywel Williams (Programme Director)

Professor Nefyn Williams

 

NETSCC, HTA Secretariat

Dr Nick Hicks (Consultant Advisor)

Ms Kathy Tier (Research Manager)

Miss Alessandra Wilkinson-Smith (Assistant Research Manager)

Mrs Karen Williams (Senior Research Manager)

Apologies

Professor Joy Adamson, Professor Gary Collins, Dr Rebecca Harmston, Professor Rakesh Heer, Professor Pip Logan, Professor Jane Nixon, Professor Greta Rait, Professor Andrew Shennan (afternoon only), Mr David Symes, Dr Katrina Turner

Observers

No observers

 

Quoracy Information

Voting members: 18 Quorum = 18

Voting members present on Day 2: 18 (67%)

   

Commissioning Stage 1 proposals – received from July call close

19/31: Gastrointestinal side effects in cancer immune checkpoint therapy

Chair: Professor Steve Goodacre

Declared a conflict and left the room: Professor Saul Faust, Professor Tracey Sach, Professor Hywel Williams

NIHR129948: ARTISTIX: A randomised trial of intravenous steroid therapy +/- infliximab for gastrointestinal side effects in cancer immune checkpoint therapy

(Dr Matthew Wheater, University Hospital Southampton NHS Foundation Trust)

Funding Committee recommendation: Shortlist

19/32: Behavioural intervention to treat anxiety in adults with autism and moderate to severe learning disabilities

Chair: Professor Steve Goodacre

Declared a conflict and left the room: Professor Angela Hassiotis, Professor Chris Rogers

NIHR129839: Addressing anxiety in autistic adults with moderate to severe intellectual disability: an intervention development study.

(Professor Jacqueline Rodgers, University of Newcastle upon Tyne)

Funding Committee recommendation: Decline

NIHR129804: Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities (BEAMS – ID)

(Professor Peter Langdon, University of Warwick)

Funding Committee recommendation: Shortlist

19/33: Treating specific phobias in children with moderate to severe learning disabilities

Chair: Professor Steve Goodacre

Declared a conflict and left the room: Professor Angela Hassiotis, Professor Catherine Hewitt, Professor Hywel Williams

NIHR130308: Treating specific phobias in children with moderate to severe learning disabilities

(Professor Barry Wright, University of York)

Funding Committee recommendation: Shortlist

NIHR130177: Specific phobias in children with learning disabilities (SPIRIT): An adaptation and feasibility study

(Professor Kylie Gray, University of Warwick)

Funding Committee recommendation: Shortlist

19/34: Medication for ADHD in adults with a history of psychosis or bipolar disorder

Chair: Professor Simon Gilbody

Declared a conflict and left the room: no conflicts declared

NIHR129817: The clinical and cost-effectiveness of Stimulant compared with Non-stimulant medication for adults with Attention-deficit / hyperactivity disorder and a history of Psychosis or biPolar disordER: SNAPPER

(Professor Steven Marwaha, University of Birmingham)

Funding Committee recommendation: Shortlist

19/36: Antioxidant supplements to slow AMD progression

Chair: Professor Steve Goodacre

Declared a conflict and left the room: Professor Saul Faust, Professor Angela Hassiotis, Professor Catherine Hewitt, Professor Rebecca Reynolds, Professor Chris Rogers, Professor Sobha Sivaprasad

NIHR129653: A Randomised Controlled Trial of Antioxidants to Slow Progression of Age-Related Macular Degeneration (the AEON Study)

(Dr Praveen Patel, Moorfields Eye Hospital NHS Foundation Trust)

Funding Committee recommendation: Decline Return to POC

NIHR130108: Prevention of late age-related macular degeneration using anitoxidant supplementation (PAMDAS) study.

(Dr Ruth Hogg, The Queen's University of Belfast)

Funding Committee recommendation: Decline Return to POC

19/37: Deep infiltrating endometriosis

Chair: Professor Steve Goodacre

Declared a conflict and left the room: Professor Rebecca Reynolds, Professor Chris Rogers, Professor Hywel Williams

NIHR130310: Deep infiltrating endometriosis: management by medical treatment versus early surgery: DIAMOND

(Professor Kevin Cooper, NHS Grampian)

Funding Committee recommendation: Shortlist

19/38: Scanning confocal ophthalmoscopy for diabetic eye screening

Chair: Professor Simon Gilbody

Declared a conflict and left the room: Professor Sobha Sivaprasad

NIHR129647: Scanning confocal ophthalmoscopy for diabetic eye screening

(Professor Peter Scanlon, Gloucestershire Hospitals NHS Foundation Trust)

Funding Committee recommendation: Shortlist

19/39: Minimally invasive operative interventions for bladder outlet obstruction due to benign prostatic hyperplasia

Chair: Professor Simon Gilbody

Declared a conflict and left the room: Professor Steve Goodacre, Professor Chris Rogers

NIHR129747: A randomised trial of minimally invasive treatments for bladder outlet obstruction due to enlarged prostate in the National Health Service using a network of treating centres.

Acronym: OPTIONS Trial

 Options for Prostate Treatment Innovation Or Normal Surgery

(Dr Tobias Page, The Newcastle Upon Tyne Hospitals NHS Foundation Trust)

Funding Committee recommendation: Shortlist

19/40: Needle and syringe exchange schemes and opiate substitution therapy in the UK

Chair: Professor Steve Goodacre

Declared a conflict and left the room: Professor Richard Grieve, Professor Chris Rogers

NIHR129726: Enhancing access to needle and syringe programmes and opioid substitution therapy for under-served populations of people who inject drugs: Developing a programme theory through qualitative and realist review methods.

(Dr Magdalena Harris, London School of Hygiene & Tropical Medicine)

Funding Committee recommendation: Decline

NIHR129798: Title: Understanding the contextual factors that impact on the effective provision of opiate substitution therapy (OST) and needle and syringe programmes (NSP) in the UK: a multi-method study and realist evaluation of what works, for whom and under what circumstances

(Dr Alison Munro, University of Dundee)

Funding Committee recommendation: Shortlist

NIHR130004: ENGAGE - A realist evaluation of the combined effectiveness of needle and syringe provision and opioid substitution therapy programmes for people who inject drugs

(Professor Vivian Hope, Liverpool John Moores University)

Funding Committee recommendation: Shortlist

19/11: HTA Researcher-led call Primary Research

Chair: Professor Steve Goodacre

Declared a conflict and left the room: no conflicts declared

NIHR129701: Evidence-based pain management pathway for people with chronic pancreatitis

(Professor Kurinchi Gurusamy, University College London)

Funding Committee recommendation: Decline