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HTA Funding Committee Public Minutes 19-20 March 2019

 

Contents

Day 1 - 19 March 2019 

Place

Danubius, London

Present members 

Professor Andrew Farmer (Chair), Professor John Norrie (Deputy Chair), Professor Hywel Williams (Programme Director), Mr Alan Chant (PPI representative), Mrs Amanda Roberts (PPI representative), Miss Kirstin Carswell, Professor Matt Costa, Professor Fay Crawford, Professor Mike Crawford, Dr Jo Dumville, Professor Caroline Free, Professor Simon Gates, Professor Colin Green, Professor Asma Khalil, Professor Julia Lawton, Professor Steff Lewis, Dr Rumana Omar, Professor Rupert Pearse, Professor Mark Peters, Professor Craig Ramsay, Dr Matthew Ridd, Dr Howard Ring, Professor Christine Roffe, Dr Marc Serfaty, Dr Sarah Stock, Professor Joanna Thompson-Coon, Professor Olivia Wu 

NETSCC, HTA Secretariat

Dr Simon Fraser (Clinical Advisor, NETSCC), Dr Duncan Fortescue-Webb (Speciality Registrar in Public Health, NIHR), Mrs Karen Williams (Senior Research Manager), Miss Louise Maclachlan (Research Manager), Miss Louisa Saunders (Assistant Research Manager), Miss Linda Welch (Assistant Research Manager)

Apologies 

Professor Julie Brittenden, Professor Mike Clarke, Dr Peter Coventry, Professor Kerenza Hood, Professor Nick James, Dr Sara Twaddle

Observers 

Quoracy Information 

Voting members: 30 Quorum = 20
Voting members present on Day 1: 24 (80%

HTA Commissioned Stage 2 Proposals

18/47 Outpatient cervical ripening for induction of labour

Chair: Andrew Farmer
Declared a conflict and left the room: Sarah Stock, Asma Khalil, Craig Ramsay, Hywel Williams, Olivia Wu, Steff Lewis, John Norrie, Julia Lawton

NIHR127990: The clinical and cost-effectiveness of outpatient induction of labour: a multi-centre observational study utilising routine data sources with economic and acceptability evaluations (OPTION study) (Walker, The University of Nottingham)
Funding Committee recommendation: Decline

NIHR127569: Cervical Ripening at Home or In-Hospital – prospective cohort study and process evaluation (CHOICE Study) (Stock, The University of Edinburgh)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/46 Pharmacological management of post-traumatic seizures

Chair: Andrew Farmer
Declared a conflict and left the room: Howard Ring

NIHR128226: Pharmacological management of post-traumatic seizures (Hutchinson, University of Cambridge)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/51 Extended duration haemodialysis

Chair: Andrew Farmer
Declared a conflict and left the room: Jo Dumville, Olivia Wu

NIHR127440: A randomised controlled trial assessing the effectiveness and cost effectiveness of thrice weekly, extended, in-centre nocturnal haemodialysis versus standard care using a mixed methods approach (Burton, University of Leicester)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes.

17/136 Sepsis

Chair: Andrew Farmer
Declared a conflict and left the room: Sarah Stock, Craig Ramsay, John Norrie, Julia Lawton, Olivia Wu, Steff Lewis

17/136/08: 5% Albumin compared with Balanced Crystalloid, Plasma-Lyte, intravenous fluid resuscitation in adult Sepsis patients presenting as an emergency to hospital: the ABC Sepsis trial (Gray, Lothian Health Board)
Funding Committee recommendation: Decline

18/49 Radiofrequency denervation for low back pain

Chair: John Norrie
Declared a conflict and left the room: Jo Dumville, Simon Fraser, Andrew Farmer, Olivia Wu, Colin Green

NIHR127689: Lumbar Zygophyseal Joint Radiofrequency denervation for chronic low back pain: A Multi-centre, Randomised, Double-blind, Sham-controlled trial (LaZeR) (Pang, Guy's and St Thomas' NHS Foundation Trust)
Funding Committee recommendation: Decline

NIHR127457: Radiofrequency denervation for chronic and moderate to severe low back pain: The RADICAL trial (Wylde, University of Bristol)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/50 Frail older people in primary care

Chair: John Norrie
Declared a conflict and left the room: Joanna Thompson-Coon, Fay Crawford, Jo Dumville, Sarah Stock, Simon Fraser, Andrew Farmer, Hywel Williams, Matthew Costa, Simon Gates

NIHR127905: Development and evaluation of the electronic frailty index+ (eFI+) tool: integrated prognostic-decision modelling to target interventions for older people with moderate or severe frailty (Clegg, University of Leeds)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR127980: Frail older people in primary care  (Lamb, University of Oxford)
Funding Committee recommendation: Decline

17/147 HTA Researcher-led call Primary Research Stage 2 Proposals

17/147/32: Randomised trial of clinical and cost effectiveness of Administration of Prehospital fascia Iliaca compartment block for emergency hip fracture care Delivery (RAPID) 2 (Snooks, Swansea University)

Chair: Andrew Farmer
Declared a conflict and left the room: none
Funding Committee recommendation: Decline

NIHR127914: Randomised controlled trial of contrast enhanced colonoscopy in the reduction of right sided bowel cancer. (The CONSCOP 2 study) (Dolwani, Cardiff University)

Chair: Andrew Farmer
Declared a conflict and left the room: Amanda Roberts
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR127739: Suture fixation versus tension band wiring for simple olecranon fracture fixation: a multi-centre randomised controlled trial (Simple Olecranon Fracture Fixation Trial (SOFFT)) (Watts, Wrightington, Wigan & Leigh NHS Foundation Trust)

Chair: Andrew Farmer
Declared a conflict and left the room: Jo Dumville
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

18/68 HTA Mental Health Themed Call (Primary Research) Stage 2 Proposals

NIHR127408: Comparison of Effectiveness and Cost-Effectiveness of Intensive Community Care Services versus Usual Inpatient Care for Young People with Psychiatric Emergencies (IVY): An Internal Pilot followed by a Randomised Controlled Trial Comprising All Intensive Community Service Care Teams in Great Britain. (Ougrin, King's College London)

Chair: John Norrie
Declared a conflict and left the room: Andrew Farmer
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR127683: Improving Social Recovery in Psychosis (ISRIP): A definitive randomised controlled trial of Social Recovery Therapy compared to treatment as usual for people with psychosis and severe social disability (Fowler, University of Sussex)

Chair: Andrew Farmer
Declared a conflict and left the room: none
Funding Committee recommendation: Decline

NIHR127700: Antidepressant for the prevention of DEPression following first episode Psychosis trial (ADEPP) (Upthegrove, University of Birmingham)

Chair: Andrew Farmer
Declared a conflict and left the room: Simon Gates
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR127951: Early intervention for depression and anxiety in 16-18 year olds : a multi-centre trial of self-referral psychological Stress workshop programmes in schools (BESST study - Brief Educational workshops in Secondary Schools Trial) (Brown, King's College London)

Chair: Andrew Farmer
Declared a conflict and left the room: Hywel Williams
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR127599: A tailored occupational therapy intervention for people with a psychotic disorder post-discharge from hospital to increase participation in daily life: A multi-centre randomised controlled trial (Simpson, Institute of Psychiatry, Psychology & Neuroscience, King's College London)

Chair: Andrew Farmer
Declared a conflict and left the room: Marc Serfaty, Rumana Omar
Left meeting: Mark Peters
Funding Committee recommendation: Decline

18/182 HTA Digital Technologies to Improve Health and Care Stage 1 Proposals

NIHR128271: A pragmatic randomised controlled trial to evaluate the effectiveness of a digital health intervention combining behavioural activation with physical activity to reduce severity of symptom in adults living with depression in the community: The eMotion study (Greaves, University of Birmingham)

Chair: Andrew Farmer
Declared a conflict and left the room: Joanna Thompson-Coon, Colin Green
Funding Committee recommendation: Decline

NIHR127773: Tele-opHthalmology-enablEd and ARtificial Intelligence-ready referral pathway for coMmunity optomEtry referralS of retinal disease: the HERMES study (Balaskas, Moorfields Eye Hospital NHS Foundation Trust)

Chair: Andrew Farmer
Declared a conflict and left the room: Craig Ramsay, Joanna Thompson-Coon
Funding Committee recommendation: Shortlist

 

Day 2 - 20 March 2019 

Venue

Danubius, London

Present members

Professor Andrew Farmer (Chair), Professor John Norrie (Deputy Chair), Professor Hywel Williams (Programme Director), Mr Alan Chant (PPI representative), Mrs Amanda Roberts (PPI representative), Miss Kirstin Carswell, Professor Matt Costa, Professor Fay Crawford, Professor Mike Crawford, Dr Jo Dumville, Professor Caroline Free, Professor Simon Gates, Professor Colin Green, Professor Asma Khalil, Professor Julia Lawton, Professor Steff Lewis, Professor Rupert Pearse, Professor Mark Peters, Professor Craig Ramsay, Dr Matthew Ridd, Dr Howard Ring, Professor Christine Roffe, Dr Marc Serfaty, Dr Sarah Stock, Professor Joanna Thompson-Coon, Professor Olivia Wu 

NETSCC, HTA Secretariat

Dr Simon Fraser (Clinical Advisor, NETSCC), Dr Duncan Fortescue-Webb (Speciality Registrar in Public Health, NIHR), Dr Sarah Puddicombe (Assistant Director), Miss Louise Maclachlan (Research Manager),  Miss Linda Welch (Assistant Research Manager)

Apologies

Professor Julie Brittenden, Professor Mike Clarke, Dr Peter Coventry, Professor Kerenza Hood, Professor Nick James, Dr Rumana Omar, Dr Sara Twaddle

Observers

None

Quoracy Information 

Voting members: 30 Quorum = 20
Voting members present on Day 2: 23 (77%)

18/132 HTA Researcher-led call Evidence Synthesis Stage 1 Proposals

NIHR128352: Antifibrinolytic Trialists Collaboration: an individual patient data meta-analysis of the effects of antifibrinolytic treatment for severe bleeding (Ker, London School of Hygiene & Tropical Medicine)

Chair: Andrew Farmer
Declared a conflict and left the room: Asma Khalil, Caroline Free
Funding Committee recommendation: Decline

NIHR128595: The clinical and cost effectiveness of interventions that seek to reduce physical, chemical and environmental restraint in long-term healthcare settings for older people: an evidence synthesis (Duxbury, Manchester Metropolitan University)

Chair: Andrew Farmer
Declared a conflict and left the room: none
Funding Committee recommendation: Decline

NIHR128513: A comprehensive model and economic evaluation of HCV elimination amongst people who inject drugs in England to guide case-finding intervention policy and implementation (Vickerman, University of Bristol)

Chair: Andrew Farmer
Declared a conflict and left the room: Matthew Ridd
Funding Committee recommendation: Shortlist

NIHR128721: Pregnancy AntihyperteNsive Drugs: which Agent is best? (giant PANDA study) (Chappell, King's College London)

Chair: John Norrie
Declared a conflict and left the room: Andrew Farmer, Asma Khalil
Funding Committee recommendation: Shortlist

18/145 HTA Pain Themed Call (Evidence Synthesis) Stage 1 Proposals

NIHR128782: A systematic review with mixed treatment comparisons meta analysis of anti-depressant treatment for adults with chronic pain (Pincus, Royal Holloway, University of London)

Chair: John Norrie
Declared a conflict and left the room: Andrew Farmer
Funding Committee recommendation: Shortlist

NIHR128842: Safe and effective gradual reduction (tapering) of opioids in people with chronic non-cancer pain: systematic review of effects, barriers and facilitators and inequalities to inform service design in the NHS (Hill, University of Liverpool)

Chair: Andrew Farmer
Declared a conflict and left the room: Jo Dumville, Colin Green
Funding Committee recommendation: Shortlist

NIHR128843: Assessment of perioperative interventions for the reduction of chronic pain following surgery: a systematic review of randomised controlled trials, network meta-analyses, and cost-effectiveness analysis (Bampoe, University College London Hospitals NHS Foundation Trust)

Chair: Andrew Farmer
Declared a conflict and left the room: Asma Khalil, Mark Peters
Funding Committee recommendation: Decline

18/143 HTA Frailty Themed Call (Evidence Synthesis) and 18/144 HTA Frailty Themed Call (Primary Research) Stage 1 Proposals

NIHR128862: Community-based complex interventions for older people, stratified by frailty: a systematic review and network meta-analysis (Clegg, University of Leeds)

Chair: Andrew Farmer
Declared a conflict and left the room: Sarah Stock, Simon Fraser, Amanda Roberts, Fay Crawford, Hywel Williams
Funding Committee recommendation: Shortlist

NIHR128334: Clinical and cost-effectiveness of a personalised health promotion intervention enabling independence in older people with mild frailty (‘HomeHealth’): A Randomised Controlled Trial (Walters, University College London)

Chair: Andrew Farmer
Declared a conflict and left the room: Marc Serfaty, Simon Fraser, Hywel Williams
Funding Committee recommendation: Shortlist

NIHR128832: A randomised controlled trial of cognitive behavioural therapy with behavioural activation PLUS exercise training versus cognitive behavioural therapy alone for falls, frailty and fear of falling in older people. The STRategies for Increasing inDependence (Parry, University of Newcastle upon Tyne)

Chair: John Norrie
Declared a conflict and left the room: Andrew Farmer, Craig Ramsay, Hywel Williams
Funding Committee recommendation: Decline

NIHR128741: A Randomised Controlled Trial of Mobility Rehabilitation (Mohab) to prevent and reverse frailty and related adverse outcomes in community dwelling frail older people (Lamb, University of Oxford)

Chair: John Norrie
Declared a conflict and left the room: Andrew Farmer, Matthew Costa, Simon Gates, Colin Green
Funding Committee recommendation: Shortlist

HTA Commissioned Stage 1 Proposals

18/103 Recurrent intra-articular corticosteroid injections in osteoarthritis

Chair: John Norrie
Declared a conflict and left the room: Andrew Farmer, Hywel Williams

NIHR128622: Recurrent intra-articular corticosteroid injections in osteoarthritis (Zhang, The University of Nottingham)
Funding Committee recommendation: Decline

NIHR129011: RecUrrent Intra-articular Corticosteroid injections in Osteoarthritis; the RUbICOn study (Whitehouse, University of Bristol)
Funding Committee recommendation: Shortlist

18/105 Non-invasive neurally adjusted ventilator assist for neonates requiring respiratory support

Chair: John Norrie
Declared a conflict and left the room: Andrew Farmer

NIHR128578: Randomised trial to determine the clinical effectiveness and cost-effectiveness of non-invasive NAVA versus other non-invasive methods of respiratory support (Greenough, King's College London)
Funding Committee recommendation: Decline Return to POC

18/98 Oral nutritional interventions in malnourished frail elderly

Chair: Andrew Farmer
Declared a conflict and left the room: Joanna Thompson-Coon, Jo Dumville, Sarah Stock, Craig Ramsay, Colin Green

NIHR128157: Oral nutritional interventions for malnourished, frail older people (Avenell, University of Aberdeen)
Funding Committee recommendation: Shortlist

NIHR128585: The clinical and cost effectiveness of oral nutrition supplements in frail older adults with, or at risk of, malnutrition (Abbott, University of Exeter Medical School)
Funding Committee recommendation: Decline

NIHR128703: Oral nutritional interventions in malnourished frail older people: mixed methods evidence synthesis and economic evaluation (Bunn, University of Hertfordshire)
Funding Committee recommendation: Decline

NIHR128729: Assessing the effectiveness and cost-effectiveness of oral nutritional interventions in malnourished frail elderly people (Ramsay, Newcastle University)
Funding Committee recommendation: Shortlist

NIHR128315: A review of the evidence base on the use of oral nutritional supplements in malnourished frail older people (Burden, University of Manchester)
Funding Committee recommendation: Decline

NIHR129044: What is the clinical and cost-effectiveness of oral nutritional interventions in frail elderly who are malnourished or at risk of malnutrition? (Savovic, University of Bristol)
Funding Committee recommendation: Decline

18/104 Prevention and treatment of incontinence-associated dermatitis

Chair: Andrew Farmer
Declared a conflict and left the room: Matthew Ridd, Amanda Roberts, Hywel Williams

NIHR128434: PISCES: Prevention of Incontinence aSsoCiated dErmatitiS in care home and community settings: a feasibility study (Cowdell, Birmingham City University)
Funding Committee recommendation: Shortlist

NIHR128865: PREVENTion and treatment of Incontinence-Associated Dermatitis through optimising care: development and feasibility of the IAD Manual (PREVENT-IAD) (Woodward, King's College London)
Funding Committee recommendation: Shortlist

18/100 Strategies for the management of chronic constipation in childhood

Chair: Andrew Farmer
Declared a conflict and left the room: Simon Fraser, Craig Ramsay, John Norrie

NIHR127927: A programme of Cochrane reviews on constipation in childhood with strategic translation to practice (Gordon, University of Central Lancashire)
Funding Committee recommendation: Decline

NIHR128470: Strategies Used for Constipation in Children - Evidence Synthesis involving stakeholders (SUCCESS) (McClurg, Glasgow Caledonian University)
Funding Committee recommendation: Shortlist

18/134 Active case finding of coeliac disease

Chair: John Norrie
Declared a conflict and left the room: Simon Fraser, Andrew Farmer, Craig Ramsay, Matthew Ridd, Hywel Williams
Left meeting: Julia Lawton

NIHR129020: What is the optimum strategy for identifying adults and children with coeliac disease? A systematic review and economic models (Whiting, University of Bristol)
Funding Committee recommendation: Shortlist

NIHR128685: Cost-effectiveness of active case finding of coeliac disease in at-risk groups in primary care (Kurien, The University of Sheffield)
Funding Committee recommendation: Shortlist

18/102 Left ventricular assist devices as destination therapy for advanced heart failure

Chair: Andrew Farmer
Declared a conflict and left the room: Jo Dumville, Matthew Ridd

NIHR129038: Left ventricular assist devices (LVAD) as destination therapy (DT) for advanced heart failure (HF) (Pufulete, University of Bristol)
Funding Committee recommendation: Shortlist

NIHR128996: Left ventricular assist devices as destination therapy for advanced heart failure (Moore, University of Birmingham)
Funding Committee recommendation: Shortlist

18/99 Lifestyle modification interventions in adults with learning disabilities

Chair: Andrew Farmer
Declared a conflict and left the room: Olivia Wu, Joanna Thompson-Coon

NIHR128732: Lifestyle modification interventions in adults with learning disabilities (Marriott, NDTi)
Funding Committee recommendation: Decline

NIHR128755: Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities (Dr Harris, University of Glasgow)
Funding Committee recommendation: Shortlist

NIHR128887: The clinical and cost-effectiveness of LifEstyle modifications in Adults with leaRNing disabilities: a mixed studies review and convergent synthesis of quantitative and qualitative evidence. The LEARN Study (Richards, University of Leeds)
Funding Committee recommendation: Shortlist

18/101 Interventions for the management of perceptual disorders following stroke

Chair: Andrew Farmer
Declared a conflict and left the room: Sarah Stock, John Norrie, Steff Lewis

NIHR128829: Interventions for the management of perceptual disorders following stroke: a scoping review and Cochrane review update (Brady, Glasgow Caledonian University)
Funding Committee recommendation: Shortlist

Close of day 2