Minutes of the January 2020 Meeting
Date Tuesday 21st January 2020 (Day 1)
Place Danubius Hotel, Regent’s Park, London
Present members
Professor Joy Adamson
Dr Ben Ainsworth
Mr Paul Charlton
Professor Saul Faust
Dr Emilio Fernandez-Egea
Professor Simon Gilbody
Professor Steve Goodacre
Professor Richard Grieve
Dr Rebecca Harmston
Professor Angela Hassiotis
Mr Rakesh Heer
Professor Catherine Hewitt
Professor Pip Logan
Professor Nick Maskell
Professor Jane Nixon
Mr Daniel Perry
Dr Greta Rait
Professor Rebecca Reynolds
Professor Chris Rogers
Professor Jonathan Ross
Professor Andrew Shennan
Professor Sobha Sivaprasad
Dr Chris Sutton
Professor Catrin Tudur-Smith
Dr Katrina Turner
Professor Hywel Williams
Professor Nefyn Williams
NETSCC, HTA Secretariat
Dr Nick Hicks (Consultant Advisor)
Ms Kathy Tier (Research Manager)
Mrs Karen Williams (Senior Research Manager)
Miss Alessandra Wilkinson-Smith (Assistant Research Manager)
Observers
Julie McCarroll, HSC R&D Division (Day 2 only)
Apologies
Professor Gary Collins
Professor Tracey Sach
Mr Rakesh Heer (Day 2 only)
Professor Catrin Tudur-Smith (Day 2 only)
Day 1
Commissioning Stage 2 Proposals, shortlisted at September 2019 Committee
18/43: Rotation of the fetal head at full cervical dilatation
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Associate Professor Daniel Perry, Dr Christopher Sutton, Mr Rakesh Heer, Professor Andrew Shennan, Professor Hywel Williams, Professor Rebecca Reynolds
NIHR127818: ROTATE Rotation of the fetal head at full cervical dilatation (Associate Professor Dimitrios Siassakos, UCL Institute for Women’s Health)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
NIHR127266: ManuAl verSuS InStrumental roTation: ASSIST trial (Professor Fiona Denison, The University of Edinburgh)
Funding Committee recommendation: Decline
18/186: Active management vs conservative management for symptomatic brain cavernoma
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Dr Emilio Fernandez-Egea, Dr Katrina Turner, Mr Rakesh Heer, Professor Catrin Tudur Smith, Professor Chris Rogers, Professor Rebecca Reynolds, Professor Steve Goodacre
NIHR128694: Cavernomas A Randomised Effectiveness (CARE) pilot trial, to address the effectiveness of active treatment (with neurosurgery or stereotactic radiosurgery) versus conservative management in people with symptomatic brain cavernoma (Professor Rustam Salman, The University of Edinburgh)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/31: Gastrointestinal side effects in cancer immune checkpoint therapy
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Ben Ainsworth, Professor Hywel Williams, Professor Saul Faust
NIHR129948: ARTISTIX: A randomised trial of intravenous steroid therapy +/- infliximab for gastrointestinal side effects in cancer immune checkpoint therapy (Dr Matthew Wheater, University Hospital Southampton NHS Foundation Trust)
Funding Committee recommendation: Decline Return to POC
19/32: Behavioural intervention to treat anxiety in adults with autism and moderate to severe learning disabilities
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Angela Hassiotis, Professor Chris Rogers
NIHR129804: Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities (BEAMS – ID) (Professor Peter Langdon, University of Warwick)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/33: Treating specific phobias in children with moderate to severe learning disabilities
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Angela Hassiotis, Professor Hywel Williams, Professor Simon Gilbody
NIHR130308: Treating specific phobias in children with moderate to severe learning disabilities (Professor Barry Wright, University of York)
Funding Committee recommendation: Decline
NIHR130177: Specific phobias in children with learning disabilities (SPIRIT): An adaptation and feasibility study (Professor Kylie Gray, University of Warwick)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/34: Medication for ADHD in adults with a history of psychosis or bipolar disorder
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Professor Jonathan Ross
Professor Joy Adamson joined the meeting
NIHR129817: The clinical and cost-effectiveness of Stimulant compared with Non-stimulant medication for adults with Attention-deficit / hyperactivity disorder and a history of Psychosis or biPolar disordER: SNAPPER (Professor Steven Marwaha, University of Birmingham)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/37: Deep infiltrating endometriosis
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Christopher Sutton, Dr Katrina Turner, Mr Rakesh Heer, Professor Chris Rogers, Professor Hywel Williams, Professor Philippa Logan, Professor Rebecca Reynolds
NIHR130310: Deep infiltrating endometriosis: management by medical treatment versus early surgery: DIAMOND (Professor Kevin Cooper, NHS Grampian)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/38: Scanning confocal ophthalmoscopy for diabetic eye screening
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Professor Catrin Tudur Smith, Professor Sobha Sivaprasad
NIHR129647: Scanning confocal ophthalmoscopy for diabetic eye screening (Professor Peter Scanlon, Gloucestershire Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline Return to POC
19/39: Minimally invasive operative interventions for bladder outlet obstruction due to benign prostatic hyperplasia
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Dr Christopher Sutton, Dr Katrina Turner, Mr Rakesh Heer, Professor Chris Rogers, Professor Steve Goodacre
Saul Faust left the meeting
NIHR129747: A randomised trial of minimally invasive treatments for bladder outlet obstruction due to enlarged prostate in the National Health Service using a network of treating centres.
Acronym: OPTIONS Trial. Options for Prostate Treatment Innovation Or Normal Surgery (Dr Tobias Page, The Newcastle Upon Tyne Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline Return to POC
19/40: Needle and syringe exchange schemes and opiate substitution therapy in the UK
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Katrina Turner, Professor Chris Rogers, Professor Greta Rait
NIHR129798: Title: Understanding the contextual factors that impact on the effective provision of opiate substitution therapy (OST) and needle and syringe programmes (NSP) in the UK: a multi-method study and realist evaluation of what works, for whom and under what c (Dr Alison Munro, University of Dundee)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
NIHR130004: ENGAGE - A realist informed evaluation of the combined effectiveness of needle and syringe provision and opioid substitution therapy programmes for people who inject drugs (Professor Vivian Hope, Liverpool John Moores University)
Funding Committee recommendation: Decline
Stage 1 applications from call close December 2019
19/151: HTA Solid Organ Replacement, Transplant And Donation
Chair: Professor Steve Goodacre
No conflicts
NIHR131124: Statins in Organ Donor Management. An evaluation of the benefits of giving a single dose of Simvastatin to brain-stem dead organ donors on outcomes in recipients of organs from the donor
SIGNET Statins for Improving orGan outcomE in Transplantation (Professor John Dark, University of Newcastle upon Tyne)
Funding Committee recommendation: Shortlist
19/151: HTA Solid Organ Replacement, Transplant And Donation
Chair: Professor Steve Goodacre
No conflicts
NIHR130656: A randomized controlled trial assessing the safety and efficacy of robotic assisted versus open living donor kidney transplantation (Professor Nizam Mamode, Guy's and St Thomas' NHS Foundation Trust)
Funding Committee recommendation: Decline
NIHR131058: A prospective randomized controlled trial of robotic assisted versus laparoscopic assisted living donor nephrectomy. (Mr Ioannis Loukopoulos, Guy's and St Thomas' NHS Foundation Trust)
Funding Committee recommendation: Decline
19/151: HTA Solid Organ Replacement, Transplant And Donation
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Rakesh Heer, Jane Nixon
NIHR130679: A randomised controlled trial of Intra-operative Mannitol for the Prevention of delayed grAft function in deceased donor Renal Transplant (IMPART) (Mr Adam Barlow, Leeds Teaching Hospitals NHS Trust)
Funding Committee recommendation: Decline
19/41: Clozapine for children and young people with treatment resistant schizophrenia
Chair: Professor Steve Goodacre
DCMs: 1. Professor Joy Adamson, 2. Professor Philippa Logan, 3. Professor Gary Collins(w)
Declared a conflict and left the room: Dr Christopher Sutton, Dr Emilio Fernandez-Egea, Professor Angela Hassiotis, Professor Catrin Tudur Smith, Professor Greta Rait
NIHR131175: CLEAR: (CLozapine in EARly psychosis) A Multi-Centre, Randomised Controlled trial of Clozapine for Young People with Treatment Resistant Psychosis in Real World Settings (Professor James MacCabe, Kings College London)
Funding Committee recommendation: Shortlist
19/42: Selective serotonin reuptake inhibitor to prevent depression following traumatic brain injury
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Dr Christopher Sutton, Dr Emilio Fernandez-Egea, Professor Catrin Tudur Smith, Professor Jonathan Ross, Professor Rebecca Reynolds, Professor Steve Goodacre
NIHR130879: RandomIsed COnTrol Trial Anti depressants in Traumatic Brain Injury, RICOTTA-TBI (Mr Adel Helmy, University of Cambridge)
Funding Committee recommendation: Shortlist
NIHR131170: ENDBIT - ENding Depression in Brain Injury Trial. A placebo randomised controlled trial of fluoxetine to prevent depression in traumatic brain injury. (Professor Diane Playford, University of Warwick)
Funding Committee recommendation: Decline
NIHR131125: A multi-centre randomised controlled trial of the clinical and cost-effectiveness of sertraline in preventing depression in adults following a traumatic brain injury (Professor Khalida Ismail, King's College London)
Funding Committee recommendation: Shortlist
19/43: Amitriptyline for the prevention of post-herpetic neuralgia
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Ben Ainsworth, Dr Katrina Turner, Professor Chris Rogers, Professor Jane Nixon
NIHR131035: Prevention of Shingles Pain Trial (PROSPECT) (Professor Julie Bruce, University of Warwick)
Funding Committee recommendation: Shortlist
NIHR129720: ATHENA: AmiTritypline for the prevention of post-HErpetic NeuralgiA (Dr Matthew Ridd, University of Bristol)
Funding Committee recommendation: Shortlist
19/44: Nutrient enriched diet for babies with a brain injury
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Mr Rakesh Heer, Professor Andrew Shennan, Dr Christopher Sutton
NIHR129699: 19/44 Nutrient enriched diet for babies with a brain injury (Dr Suresh Victor, King's College London)
Funding Committee recommendation: Decline
NIHR130925: Investigating the clinical and cost-effectiveness of a nutrient enriched diet for babies with a brain injury: The Dolphin Randomised controlled trial (Professor Jeremy Parr, University of Newcastle upon Tyne)
Funding Committee recommendation: Shortlist
Day 2
Commissioning Stage 1 proposals – received from December 2019 call close
19/76: Antipsychotics for anorexia nervosa
Chair: Professor Simon Gilbody
No conflicts
NIHR130780: Olanzapine for young PEople with aNorexia nervosa: An open-label feasibility study to test recruitment, treatment acceptance, adherence, safety, outcome measures and patients' experience to prepare for a randomised placebo-controlled trial (OPEN) (Dr Hubertus Himmerich, King's College London)
Funding Committee recommendation: Shortlist
19/75: Stem cell transplant for adults with severe sickle cell disease
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Professor Andrew Shennan, Professor Hywel Williams, Professor Steve Goodacre, Associate Professor Daniel Perry
NIHR130674: Randomised trial of Haploidentical Transplantation compared to standard of care for Adults with Sickle Cell Disease (Dr Victoria Potter, King's College Hospital NHS Foundation Trust)
Funding Committee recommendation: Shortlist
19/88: Ablative and non-invasive therapies for hepatocellular carcinoma
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Greta Rait, Professor Jonathan Ross, Professor Rebecca Reynolds, Professor Simon Gilbody
NIHR131224: Ablative and non-invasive therapies for hepatocellular carcinoma (Professor Alison Eastwood, University of York)
Funding Committee recommendation: Shortlist
NIHR131201: Ablative and non-invasive therapies for hepatocellular carcinoma (Dr David Moore, University of Birmingham)
Funding Committee recommendation: Decline
NIHR131177: Ablative and non-ablative therapies in the management of early stage hepatocellular cancer: comprehensive meta-analysis and systematic review (Dr Rohini Sharma, Imperial College London)
Funding Committee recommendation: Decline
NIHR131150: Systematic review and network meta-analysis of ablative and non-invasive therapies for hepatocellular carcinoma under 3 centimetres. (Dr Thomas Drake, The University of Edinburgh)
Funding Committee recommendation: Decline
NIHR130791: Ablative and non-invasive therapies for small hepatocellular carcinoma: a systematic review and network meta-analysis (Professor Kurinchi Gurusamy, University College London)
Funding Committee recommendation: Decline
19/77: Monitoring and follow-up for adults with hearing loss
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Christopher Sutton, Professor Hywel Williams, Professor Jonathan Ross, Professor Philippa Logan
NIHR131159: Follow-up and structured monitoring for adults offered a NHS hearing aid for the first time (FAMOUS): a cluster randomised controlled trial (Professor Kevin MUNRO, The University of Manchester)
Funding Committee recommendation: Shortlist
NIHR130644: Clinical efficacy and cost-effectiveness of treatment and follow-up regimens for management of mild-to-moderate hearing loss in adults. (Professor Manohar Bance, Cambridge University Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline
NIHR131166: Does e-follow-up improve outcomes for adults with hearing loss compared with existing practice? (Mr Adam Beckman, University Hospitals Plymouth NHS Trust)
Funding Committee recommendation: Decline
19/78: Ambulatory oxygen therapy in idiopathic pulmonary fibrosis
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Jonathan Ross
NIHR130294: A phase III parallel group randomized controlled multi-centre trial to evaluate effects of ambulatory oxygen on quality of life and its cost-effectiveness in patients with idiopathic pulmonary fibrosis and isolated exertional hypoxia. (Dr Elisabetta Renzoni, Royal Brompton & Harefield NHS Foundation Trust)
Funding Committee recommendation: Shortlist
NIHR131149: Ambulatory oxygen for pulmonary fibrosis (OxyPuF) (Dr Alice Turner, University of Birmingham)
Funding Committee recommendation: Shortlist
19/79: Idiopathic intracranial hypertension
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Associate Professor Daniel Perry, Mr Rakesh Heer, Professor Hywel Williams, Professor Jonathan Ross, Professor Nefyn Williams
NIHR131211: The Resolution by Intervention in IIH Trial: clinical effectiveness and cost effectiveness (RIIHT Trial) (Professor Alexandra Sinclair, University of Birmingham)
Funding Committee recommendation: Shortlist
NIHR130823: Randomised Evaluation of Venous Intervention versus Shunting in IIH with Optic Nerve disc swelling (REVISION) (Miss Catherine McMahon, The Walton Centre NHS Foundation Trust)
Funding Committee recommendation: Shortlist
19/80: Posterior decompressive surgery with fixation for degenerative cervical myelopathy
Chair: Professor Steve Goodacre
No conflicts
NIHR130825: Title: Decompression and fusion versus decompression alone in degenerative cervical myelopathy, a randomised controlled trial (DAFVED trial) (Mr Jasmeet Dhir, University Hospitals Birmingham NHS Foundation Trust)
Funding Committee recommendation: Decline
NIHR131243: FUSION4DCM? Posterior decompressive surgery with fixation for degenerative cervical myelopathy (Dr Mark Kotter, University of Cambridge)
Funding Committee recommendation: Shortlist
19/81: Neoadjuvant endocrine therapy for postmenopausal women with breast cancer
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Associate Professor Daniel Perry, Dr Katrina Turner, Professor Chris Rogers, Professor Saul Faust
NIHR131046: Randomised controlled trial evaluating effectiveness of neoadjuvant endocrine treatment in post-menopausal women (EndoNET) (Professor Michael Douek, University of Oxford, Nuffield Department of Surgical Sciences)
Funding Committee recommendation: Shortlist
NIHR130895: NEO-LEAP: Defining patient centred benefit of neoadjuvant letrozole alone versus letrozole plus palbociclib in genomically defined ER-positive, HER2-Negative Primary Breast Cancer
(Professor Carlo Palmieri, University of Liverpool)
Funding Committee recommendation: Decline
19/82: Conservative management of odontoid fracture in the elderly: to immobilise or not?
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Associate Professor Daniel Perry, Professor Catherine Hewitt, Professor Chris Rogers, Professor Hywel Williams, Professor Jonathan Ross, Professor Joy Adamson, Professor Rebecca Reynolds, Professor Steve Goodacre
NIHR131213: Cervical Orthoses in the Management of FragilitY Fractures of the Odontoid Process (COMFY) (Mr James Tomlinson, Sheffield Teaching Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline
NIHR130880: Management of C2 Odontoid Vertebral Fractures (MOVe) Trial (Mr Peter Wall, University of Warwick)
Funding Committee recommendation: Decline
NIHR131230: Conservative management of odontoid fractures in the elderly. To immobilise or not? (Professor Antonio Belli, University of Birmingham)
Funding Committee recommendation: Shortlist
NIHR131118: DENS Study: Duration of External Neck Stabilisation following odontoid fracture in older or frail adults: a randomised controlled trial of collar versus no collar (Mr Paul Brennan, The University of Edinburgh)
Funding Committee recommendation: Shortlist
19/84: Surgical treatment for severe stable slipped capital femoral epiphysis (SCFE) in children
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Associate Professor Daniel Perry, Dr Katrina Turner, Professor Nefyn Williams
NIHR131176: The British Orthopaedic SCFE Surgery Study for Severe Stable Slips (The Big BOSS Study): A multi-centre prospective randomised superiority trial of an acute deformity correction versus pinning in-situ for severe stable SCFE in children. (Associate Professor Daniel Perry, University of Liverpool)
Funding Committee recommendation: Shortlist
19/85: Anti-reflux medication to reduce stricture formation following oesophageal atresia repair
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Nefyn Williams, Professor Saul Faust
NIHR131136: Anti-reflux medication to reduce stricture formation in oesophageal atresia (Associate Professor Nigel Hall, University of Southampton)
Funding Committee recommendation: Shortlist
19/86: Thromboprophylaxis in pregnancy and after delivery
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Dr Katrina Turner, Professor Andrew Shennan, Professor Chris Rogers, Professor Hywel Williams, Professor Philippa Logan, Professor Rebecca Reynolds, Professor Steve Goodacre
NIHR131021: Thromboprophylaxis in pregnancy and after delivery (Ms Sarah Davis, The University of Sheffield)
Funding Committee recommendation: Shortlist
NIHR130849: Thromboprophylaxis in pregnancy and after delivery (Professor Siobhan Quenby, University of Warwick)
Funding Committee recommendation: Decline
NIHR131131: The expected return on investment from a study of risk assessment for, and prevention of, venous thromboembolism during and immediately after pregnancy: a systematic review, economic evaluation and value of information analysis. (Dr Edward Wilson, University of East Anglia)
Funding Committee recommendation: Shortlist
19/87: Night-time only bracing for scoliosis
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Associate Professor Daniel Perry, Dr Katrina Turner, Professor Catherine Hewitt, Professor Joy Adamson, Professor Nefyn Williams, Professor Steve Goodacre
Julie McCaroll left the meeting
NIHR131081: Night-time Only Bracing in Adolescent Idiopathic Scoliosis Trial (NOBAIST) (Mr Ashley Cole, Sheffield Children's NHS Foundation Trust)
Funding Committee recommendation: Shortlist
NIHR130574: Is night-time bracing equivalent to full-time bracing for the management of adolescent idiopathic scoliosis? (Mr Adrian Gardner, The Royal Orthopaedic Hospital NHS Foundation Trust)
Funding Committee recommendation: Decline
NIHR130884: The effects of night-time only bracing compared to day and night-time bracing for prevention of curve progression, and avoidance of surgery, in young people with adolescent idiopathic scoliosis: a non-inferiority randomised controlled trial (Associate Professor Sally Hopewell, University of Oxford)
Funding Committee recommendation: Decline