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HTA Funding Committee Public Minutes 21-22 May 2019

 

Contents

 

NIHR HTA Funding Committee (Commissioning)

 

Venue

Danubius Hotel, Regent’s Park, London

Present members

Professor Joy Adamson
Professor Steven Brown
Mr Paul Charlton (Public Member)
Professor  Gary Collins
Professor  Saul Faust
Professor  Simon Gilbody (Deputy Chair)
Professor  Steve  Goodacre (Chair)
Professor  Richard  Grieve
Professor  Angela Hassiotis
Dr Gail Hayward
Mr Rakesh  Heer
Professor  Catherine Hewitt
Professor  Pip Logan
Professor  Nick  Maskell
Professor  Jane Nixon
Mr Daniel  Perry
Dr  Greta  Rait
Professor  Chris Rogers
Professor  Jonathan   Ross
Professor  Tracey       Sach
Professor  Andrew Shennan (Attending afternoon only)
Mr David  Symes (Public Member)
Professor  Catrin Tudur-Smith
Dr  Katrina Turner
Professor  Hywel  Williams (Programme Director)
Professor  Nefyn Williams

 

NETSCC, HTA Secretariat 

Dr Nick Hicks (Consultant Advisor)
Karen Williams (Senior Research Manager)
Kathy Tier (Research Manager)
Cristina Lujan-Barroso (Research Manager)
Alessandra Wilkinson-Smith (Assistant Research Manager)

Apologies

Professor  Rebecca Reynolds
Professor  Sobha  Sivaprasad

Observers

Mrs Vicky Taylor (Assistant Director, Applications and Funding, NETSCC)
Associate Professor Kamal Mahtani (Chair of Prioritisation Panel A)

Quoracy Information

Voting members: 26 Quorum = 18

Voting members present on Day 1: 24 (92%)

  

7.

Commissioning Stage 2 Proposals shortlisted at January 2019 Committee

7.1

18/80: HTA Precision Medicine

 

Chair: Steve Goodacre

Declared a conflict and left the room: Paul Charlton, Richard Grieve, Steven Brown

7.1.1

NIHR128490: PERsonalised Medicine for Intensification of Treatment (PERMIT): the case of type 2 Diabetes Mellitus

(Professor Richard Grieve, London School of Hygiene and Tropical Medicine)

 

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

7.2

18/109: Management of partial-thickness rotator cuff tears

 

Chair: Steve Goodacre

Declared a conflict and left the room: Gail Hayward, Katrina Turner, Daniel Perry, Catherine Hewitt, Chris Rogers

 Hywel Williams joined the meeting

7.2.1

NIHR128043: Partial Rotator Cuff Tear Repair Trial (PRO CURE Trial)

(Professor Jonathan Rees, University of Oxford)

 

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

 7.2.2

NIHR128604: Partial ROTator Cuff Tears Management (PROTeCT-M): A Randomised Controlled Trial

(Associate Professor David Ellard, University of Warwick)

 

Funding Committee recommendation: Decline

7.3

18/107: Intervention or expectant management for early onset fetal growth restriction in twin pregnancy

 

Chair: Simon Gilbody

Declared a conflict and left the room: Daniel Perry, Andrew Shennan, Catrin Tudur Smith, Jonathan Ross, Nefyn Williams, Saul Faust, Steve Goodacre

7.3.1

NIHR128263: SLIGHT: SeLectIve fetal GrowtH restriction in monochorionic Twins: is a randomised controlled trial of active intervention versus expectant management feasible?

(Professor Mark Kilby, University of Birmingham)

 

Funding Committee recommendation: Decline

7.3.2

NIHR128596: FERN: Intervention or Expectant Management for Early Onset Selective Fetal Growth Restriction in Monochorionic Twin Pregnancy

(Professor Asma Khalil, St George's, University of London)

 

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

7.4

18/110: Management of undisplaced intracapsular hip fracture

 

Chair: Simon Gilbody

Declared a conflict and left the room: Gail Hayward, Katrina Turner, Daniel Perry, Catherine Hewitt, Catrin Tudur Smith, Chris Rogers, Saul Faust, Tracey Sach, Nick Maskell

Rakesh Heer joined the meeting

7.4.1

NIHR128399: World Hip Trauma Evaluation - FRUITI: Fix or Replace Undisplaced Intracapsular fractures Trial of Interventions

(Associate Professor Xavier Griffin, University of Oxford)

 

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

7.4.2

NIHR128553: Fixation Or REplacement Surgery In General Hip Trauma (FORESIGHT) Trial

(Mr Gorav Datta, University Hospital Southampton NHS Foundation Trust)

 

Funding Committee recommendation: Decline

7.5

18/112: A psychological programme for adults with intellectual disability and harmful sexual behaviours

 

Chair: Steve Goodacre

Declared a conflict and left the room: Tracey Sach

7.5.1

NIHR128550: RCT of group CBT for men with intellectual and/or developmental disabilities and harmful sexual behaviour: the HaSB-IDD trial

(Professor Glynis Murphy, University of Kent)

 

Funding Committee recommendation: Decline return to POC

7.6

18/113: Trauma-focused cognitive behavioural therapy for post-traumatic stress disorder in schizophrenia

 

Chair: Steve Goodacre

Declared a conflict and left the room: Catrin Tudur Smith

7.6.1

NIHR128623: Multisite Randomised Controlled Trial of Trauma-Focused Cognitive Behaviour Therapy for psychosis (TF-CBTp) to reduce post-traumatic stress disorder (PTSD) symptoms in patients with co-morbid PTSD and psychosis, compared to usual treatment: the TRUST (TRa

(Dr Emmanuelle Peters, King's College London)

 

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

7.7

18/116: Medication for ADHD in children and young people with a co-existing tic disorder

 

Chair: Simon Gilbody

Declared a conflict and left the room: Greta Rait, Hywel Williams, Jonathan Ross, Philippa Logan, Saul Faust, Tracey Sach

7.7.1

NIHR128472: Stimulant Medication for ADHD and Tics - Understanding Response versus Non-stimulants (SATURN study): a randomised trial of the clinical and cost-effectiveness of methylphenidate versus guanfacine for ADHD in children and young people with a co-existing tic disorder

(Professor Chris Hollis, The University of Nottingham)

 

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

7.8

18/117: Adjustable hook-and-loop-fastened compression systems for the treatment of venous leg ulcers

 

Chair: Steve Goodacre

Declared a conflict and left the room: Catherine Hewitt, Hywel Williams, Jane Nixon, Joy Adamson

7.8.1

NIHR128462: Adjustable hook and loop wRAp DevIces versus standard Compression bandaging for venous Leg ulcEration: the RADICLE trial.

(Mr Prakash Saha, King's College London)

 

Funding Committee recommendation: Decline

7.8.2

NIHR128625: A randomised controlled trial of compression therapies for the treatment of venous leg ulcers.

(Dr Jo Dumville, The University of Manchester)

 

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

7.9

18/118: Timing of stoma closure in neonates

 

Chair: Simon Gilbody

Declared a conflict and left the room: Daniel Perry, Catrin Tudur Smith, Nefyn Williams, Saul Faust, Steve Goodacre

7.9.1

NIHR128617: Timing of Stoma Closure in Neonates (ToSCiN) Study

(Mr Nick Lansdale, Royal Manchester Children's Hospital)

 

Funding Committee recommendation: Programme Oversight Committee to consider straight fund with comments

7.10

18/120: Identification of older patients likely to require enhanced care on discharge from hospital

 

Chair: Simon Gilbody

Declared a conflict and left the room: Philippa Logan, Tracey Sach

7.10.1

NIHR128109: Identification of older patients likely to require enhanced care on discharge from hospital

(Professor Simon Conroy, University of Leicester)

 

Funding Committee recommendation: Decline

7.11

18/121: Improving engagement and health and care outcomes for people with co-existing mental health and substance misuse conditions

 

Chair: Steve Goodacre

Declared a conflict and left the room: Catherine Hewitt

7.11.1

NIHR128128: The RECO study: Realist Evaluation of service models and systems for CO- existing serious mental health and alcohol/drug conditions.

(Professor Elizabeth Hughes, University of Leeds)

 

Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

 

 

Venue

Danubius Hotel, Regent’s Park, London

Present members

Professor Joy Adamson
Mr Paul Charlton (Public Member)
Professor  Gary Collins
Professor  Saul Faust
Professor  Simon Gilbody (Deputy Chair)
Professor  Steve  Goodacre (Chair)
Professor  Richard  Grieve
Professor  Angela Hassiotis
Dr Gail Hayward
Mr Rakesh  Heer
Professor  Catherine Hewitt
Professor  Nick  Maskell
Professor  Jane Nixon
Mr Daniel  Perry
Dr  Greta  Rait
Professor  Chris Rogers
Professor  Jonathan   Ross
Professor  Tracey       Sach
Professor  Andrew Shennan
Mr David  Symes (Public Member)
Professor  Catrin Tudur-Smith
Dr  Katrina Turner
Professor  Hywel  Williams (Programme Director)
Professor  Nefyn Williams

NETSCC, HTA Secretariat

Dr Nick Hicks (Consultant Advisor)
Steph Garfield-Birkbeck (Head of the HTA Programme)
Karen Williams (Senior Research Manager)
Kathy Tier (Research Manager)
Alessandra Wilkinson-Smith (Assistant Research Manager)

Apologies

Professor Steven Brown
Professor Pip Logan
Professor  Rebecca Reynolds
Professor  Sobha  Sivaprasad

Observers

Mr Mike Batley, Department of Health and Social Care

Quoracy Information

Voting members: 26 Quorum = 18

Voting members present on Day 2: 22 (85%)

 

 

 

 

8

Commissioning Stage 1 proposals – received from April 2019 call close

8.1

18/185: Antipsychotics for anorexia nervosa

 

Chair: Simon Gilbody

Declared a conflict and left the room:  Andrew Shennan

8.1.1

NIHR129103: Randomised placebo-controlled trial on short- and long-term effectiveness, Safety and Adherence during treatment with OLanzapine vs. placebo for young people with Anorexia nervosa (SAOLA)

(Dr Hubertus Himmerich, King's College London)

 

Funding Committee recommendation:  Return to POC

8.2

18/186: Active management vs conservative management for symptomatic brain cavernoma

 

Chair: Simon Gilbody

Declared a conflict and left the room: Catrin Tudur Smith, Rebecca Reynolds, Steve Goodacre, Steven Brown

8.2.1

NIHR128694: Cavernomas A Randomised Effectiveness (CARE) pilot trial, to address the effectiveness of treatment (with neurosurgery or stereotactic radiosurgery) versus conservative management in people with symptomatic brain cavernoma

(Professor Rustam Salman, The University of Edinburgh)

 

Funding Committee recommendation: Shortlist

8.3

18/188: Pain relief strategies for dressing change in chronic wounds

 

Chair: Steve Goodacre

Declared a conflict and left the room: Catherine Hewitt, Jane Nixon

8.3.1

NIHR129517: Pain relieving strategies at dressing changes: a mixed methods systematic review and UK survey of current practice

(Professor Michelle Briggs, The University of Manchester)

 

Funding Committee Recommendation: Decline Return to POC

8.4

18/189: Combination treatment for dementia with Lewy Bodies and Parkinson's disease dementia

 

Chair: Simon Gilbody

Declared a conflict and left the room: Rakesh Heer, Greta Rait, Philippa Logan, Rebecca Reynolds, Saul Faust, Tracey Sach

8.4.1

NIHR129175: COmBining memantine And cholinesterase inhibitors in Lewy body dementia treatment Trial (COBALT)

(Dr John-Paul Taylor, Newcastle University)

 

Funding Committee recommendation: Shortlist

8.5

18/190: Blood pressure management in critically ill children

 

Chair: Steve Goodacre

Declared a conflict and left the room: Hywel Williams, Richard Grieve

8.5.1

NIHR128895: Evaluating the clinical and cost effectiveness of using a more permissive blood pressure target to guide careful titration of vasoactive agents in critically ill children with hypotension: PRotocolised Evaluation of permiSSive blood pressure targets versu

(Dr David Inwald, Imperial College Healthcare NHS Trust)

 

Funding Committee recommendation: Shortlist

8.6

18/195: Extended treatment in early intervention in psychosis services

 

Chair: Simon Gilbody

Declared a conflict and left the room: Catrin Tudur Smith, Jonathan Ross, Steve Goodacre

8.6.1

NIHR129032: EXTRA: EXtended TReAtment in Early Intervention in Psychosis Services

(Dr Rachel Upthegrove, University of Birmingham)

 

Funding Committee recommendation: Decline

8.6.2

NIHR129501: Extended treatment in early intervention in psychosis services.

(Professor Paul French, Greater Manchester Mental Health NHS Foundation Trust)

 

Funding Committee recommendation: Shortlist

8.7

18/194: Vagus nerve stimulation for highly treatment-resistent depression

 

Chair: Steve Goodacre

Declared a conflict and left the room: Hywel Williams

8.7.1

NIHR129288: Vagus Nerve Stimulation for highly treatment-resistant depression. "VNS MEND"

(Professor Allan Young, Institute of Psychiatry, Psychology and Neuroscience, King's College London)

 

Funding Committee recommendation: Decline return to POC

8.8

18/198: Exercise therapy for the treatment of tendinopathies

 

Chair: Simon Gilbody

Declared a conflict and left the room: Katrina Turner, Daniel Perry, Catherine Hewitt, Catrin Tudur Smith, Chris Rogers, Hywel Williams, Jane Nixon, Nefyn Williams, Nick Maskell, Steve Goodacre, Steven Brown

8.8.1

NIHR128904: Exercise therapy for the treatment of tendinopathies

(Dr Chris Littlewood, Keele University)

 

Funding Committee recommendation: Decline

8.8.2

NIHR128950: Exercise therapy for the treatment of tendinopathies: a synthesis of the evidence

(Mr Andrew Beswick, University of Bristol)

 

Funding Committee recommendation: Shortlist

8.8.3

NIHR129109: Exercise therapies for the treatment of tendinopathies: an evidence synthesis by systematic review

(Associate Professor Sally Hopewell, University of Oxford)

 

Funding Committee recommendation: Decline

8.8.4

NIHR129388: Exercise therapy for the treatment of tendinopathies: A mixed methods evidence synthesis

(Professor Kay Cooper, Robert Gordon University)

 

Funding Committee recommendation: Shortlist

8.8.5

NIHR129505: Exercise therapy for the treatment of tendinopathies

(Associate Professor Rebecca Kearney, University of Warwick)

 

Funding Committee recommendation: Decline

8.8.6

NIHR129525: Exercise therapy for the treatment of tendinopathies

(Professor Philip Conaghan, University of Leeds)

 

Funding Committee recommendation: Decline

8.9

18/191: Care planning intervention for people with dementia who do not have regular contact with an informal carer

 

Chair: Steve Goodacre

Declared a conflict and left the room: Catherine Hewitt, Philippa Logan, Tracey Sach

Gail Hayward left the meeting

8.9.1

NIHR128906: Informal Care and Dementia: Scoping and Exploring New Therapeutic Interventions and Alliances (INCANDESCENT)

(Dr Paul Clarkson, The University of Manchester)

 

Funding Committee recommendation: Decline return to POC

8.9.2

NIHR128949: CarE planning intervention for people with Dementia who do not have Regular contact with an Informal Carer (CEDRIC study).

(Professor Louise Allan, University of Exeter Medical School)

 

Funding Committee recommendation: Decline return to POC

8.9.3

NIHR129105: Care planning intervention for people with dementia who do not have regular contact with an informal carer

(Professor Gillian Parker, University of York)

 

Funding Committee recommendation: Decline return to POC

8.10

18/192: Pulpotomy for the management of irreversible pulpitis in mature teeth

 

Chair: Simon Gilbody

Declared a conflict and left the room: Rakesh Heer, Catherine Hewitt, Nefyn Williams, Steve Goodacre

8.10.1

NIHR129089: Pulpotomy vs Root canal trEatment for cariouS teEth with IRreVersiblE pulpitis (PRESERVE)

(Dr Ikhlas El karim, The Queen's University of Belfast)

 

Funding Committee recommendation: Shortlist

8.10.2

NIHR129230: Pulpotomy for the management of irreversible pulpitis in mature teeth (Pulpotomy for Irreversible Pulpitis - PIP Trial)

(Professor Janet Clarkson, University of Dundee)

 

Funding Committee recommendation: Shortlist

8.11

18/193: Laparoscopic hysterectomy

 

Chair: Simon Gilbody

Declared a conflict and left the room: Rakesh Heer, Hywel Williams, Jonathan Ross, Saul Faust, Steve Goodacre

8.11.1

NIHR128991: LAparoscopic Versus Abdominal hysterectomy (LAVA) trial

(Honorary Professor T Justin Clark, Birmingham Women's NHS Foundation Trust)

 

Funding Committee recommendation: Shortlist

8.11.2

NIHR129434: The TOTAL study: Trial Of Total Abdominal or Laparoscopic hysterectomy for women with benign gynaecological conditions

(Mr Saad Amer, The University of Nottingham)

 

Funding Committee recommendation: Decline

8.12

18/187: Relapsing polymyalgia rheumatica

 

Chair: Steve Goodacre

Declared a conflict and left the room: Jane Nixon, Gary Collins

8.12.1

NIHR129150: Methotrexate versus placebo for relapsing polymyalgia rheumatica (MERLIN-PMR)

(Dr Sarah Mackie, University of Leeds)

 

Funding Committee recommendation: Shortlist

8.13

18/197: Hysteroscopic removal of retained placenta

 

Chair: Steve Goodacre

Declared a conflict and left the room: Chris Rogers, Nick Maskell, Rebecca Reynolds, Katrina Turner

8.13.1

NIHR129561: The Hysteroscopic removAl of Retained Placenta (HARP) study

(Dr Islam Gamaleldin, University of Bristol)

 

Funding Committee recommendation: Shortlist

8.14

18/177: HTA End of Life Care

 

Chair: Steve Goodacre

There were no conflicts declared

8.14.1

NIHR129180: An advance care planning pathway for complex high-risk children in intensive care or high dependency areas: initial testing, refinement and pilot trial of a complex intervention

The CHiRP ACPP Study

(Dr Katherine Brown, Great Ormond Street Hospital for Children NHS Foundation Trust)

 

Funding Committee recommendation: Decline

8.15

18/177: HTA End of Life Care

 

Chair: Steve Goodacre

Declared a conflict and left the room: Hywel Williams, Saul Faust

8.15.1

NIHR129126: Palliative Long-term Abdominal Drains Versus Repeated Drainage in Untreatable Ascites due to Advanced Cirrhosis: a Randomised Controlled Trial

(Professor Sumita Verma, University of Sussex)

 

Funding Committee recommendation: Decline

8.16

18/176: HTA Precision Medicine

 

Chair: Steve Goodacre

Declared a conflict and left the room: Andrew Shennan

Joy Adamson and Greta Rait left the meeting

8.16.1

NIHR129127: EMMA (Evaluating Maternal Markers of Adverse outcome) – a precision timing of delivery trial

(Professor Laura Magee, King's College London)

 

Funding Committee recommendation: Decline

8.17

18/176: HTA Precision Medicine

 

Chair: Simon Gilbody

Declared a conflict and left the room: Jonathan Ross, Jane Nixon

8.17.1

NIHR129396: Evaluating the Clinical and Cost-effectiveness of Early and Precise Diagnosis of Treatable Developmental Disorders using Next Generation Sequencing Technology

(Dr Caroline Wright, University of Exeter Medical School)

 

Funding Committee recommendation: Decline

8.18

18/176: HTA Precision Medicine

 

Chair: Steve Goodacre

Declared a conflict and left the room: Gail Hayward, Jane Nixon

8.18.1

NIHR128636: Optimal diagnostic strategies for patients presenting in primary care with lower gastrointestinal symptoms: evidence synthesis and cost-effectiveness analysis

(Dr Bethany Shinkins, University of Leeds)

 

Funding Committee recommendation: Shortlist

8.19

18/176: HTA Precision Medicine

 

Chair: Steve Goodacre

No conflicts declared

8.19.1

NIHR129397: Precision medicine for rhythm control therapy in patients with atrial fibrillation; risk-based approach.

(Professor Dr Paulus Kirchhof, University of Birmingham)

 

Funding Committee recommendation: Decline