Tuesday 9th March 2021 (Day 1)
Place
Virtual Meeting held via Microsoft Teams
Present members
Professor Lucy Chappell (Chair)
Professor Olivia Wu (Deputy Chair)
Professor Andrew Farmer (HTA Programme Director)
Dr Jennifer Bostock (PPI representative)
Dr Elizabeth Camacho
Mr Paul Charlton (PPI representative)
Professor Alun Davies
Professor Richard Emsley
Dr Katie Gillies
Ms Jo Haviland
Professor Daniel Hind
Professor William Hollingworth
Professor Sally Hopewell
Associate Professor Rebecca Kearney
Professor Daniel Lasserson
Professor Alan Montgomery
Professor Gavin Perkins
Professor Thomas Pinkney
Dr Elena Pizzo
Professor Jonathan Rees
Professor Kapil Sayal
Dr Elizabeth Warburton
Professor James Wason
Professor David Weller
Ms Beth Woods
Professor Olivia Wu (Deputy Chair)
Professor Andrew Farmer (HTA Programme Director)
Dr Jennifer Bostock (PPI representative)
Dr Elizabeth Camacho
Mr Paul Charlton (PPI representative)
Professor Alun Davies
Professor Richard Emsley
Dr Katie Gillies
Ms Jo Haviland
Professor Daniel Hind
Professor William Hollingworth
Professor Sally Hopewell
Associate Professor Rebecca Kearney
Professor Daniel Lasserson
Professor Alan Montgomery
Professor Gavin Perkins
Professor Thomas Pinkney
Dr Elena Pizzo
Professor Jonathan Rees
Professor Kapil Sayal
Dr Elizabeth Warburton
Professor James Wason
Professor David Weller
Ms Beth Woods
NETSCC, HTA Secretariat
Dr Nicholas Hicks (Consultant Advisor, NETSCC)
Ms Steph Garfield-Birkbeck (Head of the HTA Programme)
Mrs Karen Williams (Senior Research Manager)
Dr Brogan Ashley (Research Manager)
Ms Alessandra Wilkinson-Smith (Assistant Research Manager)
Mrs Debbie Carter (Administrator)
Ms Steph Garfield-Birkbeck (Head of the HTA Programme)
Mrs Karen Williams (Senior Research Manager)
Dr Brogan Ashley (Research Manager)
Ms Alessandra Wilkinson-Smith (Assistant Research Manager)
Mrs Debbie Carter (Administrator)
Observers
Ms Hebe Sims – New member of the HTA secretariat
Apologies
Dr Kate Brown
Professor Charlotte Coles
Dr Chloe Grimmett
Professor David Ekers
Mrs Deborah Keatley (PPI representative)
Professor Daniel Prieto-Alhambra
Dr Kathryn Radford
Professor Charlotte Coles
Dr Chloe Grimmett
Professor David Ekers
Mrs Deborah Keatley (PPI representative)
Professor Daniel Prieto-Alhambra
Dr Kathryn Radford
Quoracy Information
Voting members: 28 Quorum = 19
Voting members present on Day 1: 24 (85%)
Commissioning Stage 2 Proposals, shortlisted at November 2020 Committee meeting
19/70 Cervical spine immobilisation following blunt trauma
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Professor Alun Davies, Professor Daniel Hind, Professor Daniel Lasserson, Professor Gavin Perkins, Professor Jonathan Rees, Professor Rebecca Kearney, Professor Thomas Pinkney
Spinal Immobilisation Study (SIS)
(Professor Mark Wilson, Imperial College Healthcare NHS Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
Researcher Led Stage 2 Proposals, shortlisted at November Funding Committee meeting
20/141 Follow up for PROSPECT Study
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Dr Katie Gillies, Professor Olivia Wu
Left the meeting: Professor Alun Davies
Declared a conflict and left the meeting: Dr Katie Gillies, Professor Olivia Wu
Left the meeting: Professor Alun Davies
NIHR133665: Follow up for PROSPECT Study
(Dr Fiona Reid, Central Manchester University Hospitals NHS Foundation Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/160 HTA Researcher-led call Primary Research
Chair: Professor Olivia Wu
Declared a conflict and left the meeting: Professor Thomas Pinkney
Arrived at the meeting: Professor Alun Davies
Declared a conflict and left the meeting: Professor Thomas Pinkney
Arrived at the meeting: Professor Alun Davies
NIHR131784: The EXTEND trial: EXTENDed antibiotics to improve outcomes in patients with complicated intra-abdominal infection
(Associate Professor Andrew Kirby, University of Leeds)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/160 HTA Researcher-led call Primary Research
Chair: Professor Olivia Wu
Declared a conflict and left the meeting: Professor Alan Montgomery
Left meeting: Professor Daniel Lasserson
Declared a conflict and left the meeting: Professor Alan Montgomery
Left meeting: Professor Daniel Lasserson
NIHR131687: A cluster randomised trial of clinically-assisted hydration in cancer patients in the last days of life (CHELsea II study)
(Professor Andrew Davies, Trinity College Dublin)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
20/38 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Professor Daniel Hind, Professor Daniel Lasserson, Professor Gavin Perkins, Professor Jonathan Rees, Professor Katherine Brown, Professor Rebecca Kearney, Professor William Hollingworth
Declared a conflict and left the meeting: Professor Daniel Hind, Professor Daniel Lasserson, Professor Gavin Perkins, Professor Jonathan Rees, Professor Katherine Brown, Professor Rebecca Kearney, Professor William Hollingworth
NIHR131533: Randomised trial of the clinical and cost effectiveness of a supraglottic airway device versus tracheal intubation during in-hospital cardiac arrest (AIRWAYS-3).
(Professor Jonathan Benger, University of the West of England)
(Professor Jonathan Benger, University of the West of England)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
20/38 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Professor Jonathan Rees, Professor William Hollingworth
Arrived at the meeting: Professor Daniel Lasserson
Declared a conflict and left the meeting: Professor Jonathan Rees, Professor William Hollingworth
Arrived at the meeting: Professor Daniel Lasserson
NIHR132009: A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus laparoscopic cholecystectomy in patients after ERCP and clearance of gallstones from their common bile duct - The Sunflower-ERCP Trial
(Professor Giles Toogood, Leeds Teaching Hospitals NHS Trust)
Funding Committee recommendation: Decline
20/38 HTA Researcher-led call Primary Research
Chair: Professor Andrew Farmer
Declared a conflict and left the meeting: Professor Alan Montgomery, Professor Daniel Lasserson, Professor Kapil Sayal, Professor Lucy Chappell, Professor Olivia Wu
NIHR132016: Pharyngeal Electrical stimulation for Acute Stroke dysphagia Trial (PhEAST)
(Professor Philip Bath, The University of Nottingham)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
20/38 HTA Researcher-led call Primary Research
Chair: Professor Olivia Wu
Declared a conflict and left the meeting: Professor James Wason, Professor Lucy Chappell, Professor Richard Emsley
NIHR132896: Long term effectiveness and cost-effectiveness of early mental health intervention: Follow up to the Healthy Start, Happy Start study
(Professor Paul Ramchandani, University of Cambridge)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
20/38 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Professor Daniel Hind, Professor Daniel Lasserson, Professor Gavin Perkins, Professor Jonathan Rees, Professor Rebecca Kearney
Left the meeting: Dr Katie Gillies
Declared a conflict and left the meeting: Professor Daniel Hind, Professor Daniel Lasserson, Professor Gavin Perkins, Professor Jonathan Rees, Professor Rebecca Kearney
Left the meeting: Dr Katie Gillies
NIHR132871: Remote multicomponent rehabilitation intervention in survivors of critical illness post hospital discharge: a randomised controlled assessor blind clinical and cost effectiveness trial with internal pilot
(Dr Brenda O'Neill, University of Ulster)
(Dr Brenda O'Neill, University of Ulster)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
20/38 HTA Researcher-led call Primary Research
Chair: Professor Tom Pinkney
Declared a conflict and left the meeting: Dr Elizabeth Camacho, Professor Andrew Farmer, Professor Lucy Chappell, Professor Olivia Wu, Professor Richard Emsley, Professor Daniel Hind
Arrived at the meeting: Dr Katie Gillies
Declared a conflict and left the meeting: Dr Elizabeth Camacho, Professor Andrew Farmer, Professor Lucy Chappell, Professor Olivia Wu, Professor Richard Emsley, Professor Daniel Hind
Arrived at the meeting: Dr Katie Gillies
NIHR132690: Remote psychosocial interventions to prevent avoidable psychiatric hospital admissions in people with serious mental health problems: a multi-arm multi-stage trial
(Professor Anthony Morrison, Greater Manchester Mental Health NHS Foundation Trust)
(Professor Anthony Morrison, Greater Manchester Mental Health NHS Foundation Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
20/38 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Dr Elizabeth Camacho, Professor Alan Montgomery, Professor Daniel Hind, Professor Kapil Sayal, Professor Katherine Brown
Declared a conflict and left the meeting: Dr Elizabeth Camacho, Professor Alan Montgomery, Professor Daniel Hind, Professor Kapil Sayal, Professor Katherine Brown
NIHR132808: BAY: Behavioural Activation for Young people with depression in specialist child and adolescent mental health services
(Dr Bernadka Dubicka, Pennine Care NHS Foundation Trust)
(Dr Bernadka Dubicka, Pennine Care NHS Foundation Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
Wednesday 10 March 2021 (Day 2)
Place
Virtual Meeting held via Microsoft Teams
Present members
Professor Lucy Chappell (Chair)
Professor Olivia Wu (Deputy Chair)
Professor Andrew Farmer (HTA Programme Director)
Dr Jennifer Bostock (PPI representative)
Dr Kate Brown
Mr Paul Charlton – (PPI representative)
Dr Elizabeth Camacho
Professor Charlotte Coles
Professor Alun Davies
Professor Richard Emsley
Dr Katie Gillies
Dr Chloe Grimmett
Ms Jo Haviland
Professor Daniel Hind
Professor William Hollingworth
Professor Sally Hopewell
Associate Professor Rebecca Kearney
Professor Gavin Perkins
Professor Jonathan Rees
Professor Kapil Sayal
Dr Elizabeth Warburton
Professor James Wason
Professor David Weller
Ms Beth Woods
Professor Andrew Farmer (HTA Programme Director)
Dr Jennifer Bostock (PPI representative)
Dr Kate Brown
Mr Paul Charlton – (PPI representative)
Dr Elizabeth Camacho
Professor Charlotte Coles
Professor Alun Davies
Professor Richard Emsley
Dr Katie Gillies
Dr Chloe Grimmett
Ms Jo Haviland
Professor Daniel Hind
Professor William Hollingworth
Professor Sally Hopewell
Associate Professor Rebecca Kearney
Professor Gavin Perkins
Professor Jonathan Rees
Professor Kapil Sayal
Dr Elizabeth Warburton
Professor James Wason
Professor David Weller
Ms Beth Woods
NETSCC, HTA Secretariat
Dr Nicholas Hicks (Consultant Advisor, NETSCC)
Steph Garfield-Birkbeck (Head of the HTA Programme)
Mrs Karen Williams (Senior Research Manager)
Dr Brogan Ashley (Research Manager)
Alessandra Wilkinson-Smith (Assistant Research Manager)
Mrs Debbie Carter (Administrator)
Observers
Ms Julie Hannay – NIHR Hub Team administrator (secretariat)
Ms Nikita Belavate – new member of the HTA secretariat
Apologies
Professor Daniel Lasserson
Professor Alan Montgomery
Professor Thomas Pinkney (from 13:00)
Dr Elena Pizzo (09:00 – 11:00)
Mrs Deborah Keatley (PPI representative)
Professor Daniel Prieto-Alhambra
Dr Kathryn Radford
Professor David Ekers
Quoracy Information
Voting members: 28 Quorum = 19
Voting members present on Day 1: 24 (85%)
Researcher Led Stage 1 Proposals from January 2021 Call Close
20/90 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Professor Daniel Hind, Professor James Wason
Declared a conflict and left the meeting: Professor Daniel Hind, Professor James Wason
NIHR133580: Adjunctive Local Drug Treatment at the Time Of Endoscopic Surgery for Primary and Recurrent Bulbar Urethral Stricture in Men (ReBUS)
(Mr Nadir Osman, Sheffield Teaching Hospitals NHS Foundation Trust)
(Mr Nadir Osman, Sheffield Teaching Hospitals NHS Foundation Trust)
Committee recommendation: Shortlist
20/90 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Professor Daniel Hind, Professor Thomas Pinkney
Declared a conflict and left the meeting: Professor Daniel Hind, Professor Thomas Pinkney
NIHR133817: Randomised trial of TRans Anal vs Vaginal rEpair of rectoceLe for chronic constipation (TRAVELS)
(Mr Jon Lacy-Colson, Royal Shrewsbury Hospital)
Committee recommendation: Decline
20/90 HTA Researcher-led call Primary Research
Chair: Professor Olivia Wu
Declared a conflict and left the meeting: Ms Jennifer Bostock, Professor Daniel Hind, Professor Lucy Chappell, Professor Thomas Pinkney
Declared a conflict and left the meeting: Ms Jennifer Bostock, Professor Daniel Hind, Professor Lucy Chappell, Professor Thomas Pinkney
NIHR133739: The effectiveness and cost-effectiveness of semaglutide 2.4mg therapy, in individuals with obesity or overweight and cardiometabolic co-morbidity, on long-term weight loss maintenance following total dietary replacement (TDR), and augmentation of weight loss in sub-optimal TDR responders
(Professor Melanie Davies, University of Leicester)
Committee recommendation: Decline
20/90 HTA Researcher-led call Primary Research
Chair: Professor Olivia Wu
Declared a conflict and left the meeting: Professor Katherine Brown, Professor Lucy Chappell, Professor Rebecca Kearney, Professor Thomas Pinkney
Declared a conflict and left the meeting: Professor Katherine Brown, Professor Lucy Chappell, Professor Rebecca Kearney, Professor Thomas Pinkney
NIHR133642: PROMIS: Prostaglandin Pessary vs Oral Misoprostol for Induction of Labour at Term
(Dr Andrew Sharp, University of Liverpool)
Committee recommendation: Shortlist
20/90 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Professor Daniel Hind, Professor Gavin Perkins, Professor Rebecca Kearney
NIHR133688: Implementation of extracorporeal-cardiopulmonary resuscitation (E-CPR) in the NHS: a decision-analytic health economic modelling study
(Dr Keith Couper, Warwick Clinical Trials Unit, Health Services Research Institute, University of Warwick
Committee recommendation: Decline
20/90 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Professor Daniel Hind, Professor William Hollingworth
Declared a conflict and left the meeting: Professor Daniel Hind, Professor William Hollingworth
NIHR133796: A Phase III Randomized, Open Label, Multi-Centre Study of Apixaban Compared to Standard of Care for Thromboembolism Prevention in Patients with Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) Treated with Pegylated L-Asparaginase, the ASTA trial
The ASTA trial
(Dr Charlotte Bradbury, University of Bristol)
Committee recommendation: Decline
20/90 HTA Researcher-led call Primary Research
Chair: Professor Olivia Wu
Declared a conflict and left the meeting: Professor Lucy Chappell, Professor Thomas Pinkney
NIHR133599: The Utility Of Frequency-Modulated Electromagnetic Neural Stimulation (FREMS) As A Third Line Treatment In Patients With Painful Diabetes-Related Peripheral Neuropathy: A Randomised Controlled Trial (FREMS-PDPN)
(Dr Abd Tahrani, University of Birmingham)
Committee recommendation: Shortlist
20/90 HTA Researcher-led call Primary Research
Chair: Professor Olivia Wu
Declared a conflict and left the meeting: Dr Katie Gillies, Ms Jennifer Bostock, Professor Andrew Farmer, Professor Jonathan Rees, Professor Lucy Chappell, Professor William Hollingworth
Declared a conflict and left the meeting: Dr Katie Gillies, Ms Jennifer Bostock, Professor Andrew Farmer, Professor Jonathan Rees, Professor Lucy Chappell, Professor William Hollingworth
NIHR133774: Optimising Prescription of Treatment In older patients with Mild hypertension at Increased risk of Serious adverse Events (OPTIMISE2): a non-inferiority trial
(Professor Richard McManus, University of Oxford)
Committee recommendation: Invite Resubmission
20/90 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: None
Declared a conflict and left the meeting: None
NIHR133797: A randomised trial to compare the effectiveness of Gardasil-9 HPV vaccine versus no additional therapy in PREVENTing recurrence in patients with eradicated high-grade anogenital intraepithelial neoplasia (the PREVENT trial)
(Dr Sadie Jones, Cardiff University)
Committee recommendation: Invite Resubmission
20/90 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Dr Chloe Grimmett, Dr Elizabeth Camacho, Mrs Joanne Haviland
Declared a conflict and left the meeting: Dr Chloe Grimmett, Dr Elizabeth Camacho, Mrs Joanne Haviland
NIHR133518: ThOracic Umbrella RadIotherapy STudy in stage IV NSCLC – TOURIST
(Dr David Woolf, The Christie NHS Foundation Trust)
Committee recommendation: Shortlist
20/90 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Dr Elena Pizzo, Professor Andrew Farmer, Professor Kapil Sayal
Declared a conflict and left the meeting: Dr Elena Pizzo, Professor Andrew Farmer, Professor Kapil Sayal
NIHR133708: Stepped Care for comorbid mental and physical health disorders in children and young people (StepChange)
(Professor Roz Shafran, University College London)
Committee recommendation: Shortlist
20/90 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Dr Katie Gillies, Professor Andrew Farmer
Declared a conflict and left the meeting: Dr Katie Gillies, Professor Andrew Farmer
NIHR133666: Maximising Extent of Resection using intra-operative Imaging Technology in Brain Tumours (MERIT BT)
(Honorary Professor Conor Mallucci, Alder Hey Children's NHS Foundation Trust)
Committee recommendation: Decline
20/90 HTA Researcher-led call Primary Research
Chair: Professor Olivia Wu
Declared a conflict and left the discussion: Professor Lucy Chappell, Professor Andrew Farmer, Professor William Hollingworth
Declared a conflict and left the discussion: Professor Lucy Chappell, Professor Andrew Farmer, Professor William Hollingworth
NIHR133027: The clinical effectiveness and cost effectiveness of Structured Psychological Support for people with a diagnosis of personality disorder: Randomised controlled trial
(Professor Mike Crawford, Imperial College London)
Committee recommendation: Shortlist
20/90 HTA Researcher-led call Primary Research
Chair: Professor Olivia Wu
Declared a conflict and left the meeting: Associate Professor Sally Hopewell, Professor Andrew Farmer, Professor Lucy Chappell
Declared a conflict and left the meeting: Associate Professor Sally Hopewell, Professor Andrew Farmer, Professor Lucy Chappell
NIHR133787: Randomised trial of Suction for Primary Pneumothorax Early Resolution
(Dr Rob Hallifax, University of Oxford)
Committee recommendation: Shortlist
20/90 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Dr Elizabeth Camacho, Professor William Hollingworth
Declared a conflict and left the meeting: Dr Elizabeth Camacho, Professor William Hollingworth
NIHR133464: Test-guided dietary advice in children with eczema: randomised controlled trial with internal pilot and nested economic and process evaluation
(Dr Matthew Ridd, University of Bristol)
Committee recommendation: Shortlist
20/90 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: Professor Gavin Perkins, Professor Jonathan Rees, Associate Professor Rebecca Kearney
Left the meeting: Dr Kate Brown, Dr Chloe Grimmett, Dr Katie Gillies
Declared a conflict and left the meeting: Professor Gavin Perkins, Professor Jonathan Rees, Associate Professor Rebecca Kearney
Left the meeting: Dr Kate Brown, Dr Chloe Grimmett, Dr Katie Gillies
NIHR133056: Sugammadex for preventIoN oF pOst-operative pulmoNary complIcAtions (SINFONIA)
(Dr Jon Silversides, Belfast Health and Social Care Trust)
Committee recommendation: Shortlist
20/90 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and left the meeting: None
Left the meeting: Professor Alun Davies
Declared a conflict and left the meeting: None
Left the meeting: Professor Alun Davies
NIHR133371: Impact of early reoperation and extent of resection in molecularly-subtyped low-grade gliomas – a phase III, prospective, randomized, controlled trial
(The EREBIO Trial)
(Mr George Samandouras, University College London Hospitals NHS Foundation Trust)
Committee recommendation: Decline