NIHR HTA Funding Committee - 22-23 January 2019
Stage 2 Applications
The following Stage 2 applications have been supported by the HTA Prioritisation Group, subject to certain conditions.
NIHR127849 Dr Michael Whitehouse University of Bristol
A Randomised Controlled Trial of Scaffold InSertion and MIcrofracture Compared to Microfracture Alone for the Treatment of Chondral or Osteochondral Defects of the Knee: The SISMIC Study
NIHR127850 Professor Barnaby Reeves University of Bristol
Surgical interventions to treat severe pressure sores (SIPS)
NIHR127550 Professor Opinder Sahota Nottingham University Hospitals NHS Trust
The BLAST OFF (Bisphosphonate aLternAtive regimenS for the prevenTion of Osteoporotic Fragility Fractures) Study
NIHR127460 Professor Mehul Dattani UCL Institute of Child Health
The GHD reversal study
NIHR127385 Dr James Frith Newcastle University
A comparison of fludrocortisone, midodrine or usual care to treat orthostatic hypotension – a multi-arm multi-stage randomised controlled trial
NIHR127489 Associate-Professor Oliver Rivero-Arias University of Oxford
Valuing the benefits and harms of antenatal and newborn screening programmes in health economic assessments
NIHR127674 Associate-Professor Daniel Perry University of Oxford
CRAFFT – Children’s Radius Acute Fracture Fixation Trial. A multi-centre prospective randomized trial of surgical reduction versus non-surgical casting for displaced distal radius fractures in children.
NIHR127810 Professor Barry Wright The University of York Routinely used interventions for improving attachment in infants and young children: an updated systematic review and comprehensive UK survey
NIHR127755 Professor Oliver Howes Institute of Psychiatry, Psychology & Neuroscience, King's College London
ATLANTIS: AnTiconvuLsant AugmeNtation Trial In Schizophrenia
NIHR127337 Professor Dheeraj Rai Avon and Wiltshire Mental Health NHS Partnership Trust
A multicentre double-blind placebo-controlled randomised trial of SerTRaline for AnxieTy in adults with Autism (STRATA)
Further information on the above projects will be provided on the HTA website once the project has started.
Stage 1 Applications
The following Stage 1 applications have been shortlisted to submit a Stage 2 application for consideration by the NIHR HTA Funding Committee at its next meeting.
NIHR128490 Professor Richard Grieve London School of Hygiene & Tropical Medicine PERsonalised Medicine for Intensification of Treatment (PERMIT): the case of type 2 Diabetes Mellitus
NIHR128263 Professor Mark Kilby University of Birmingham SLIGHT: SeLectIve fetal GrowtH restriction in monochorionic Twins: is a randomised controlled trial of active intervention versus expectant management feasible?
NIHR128596 Professor Asma Khalil St George's, University of London FERN: Intervention or Expectant Management for Early Onset Selective Fetal Growth Restriction in Monochorionic Twin Pregnancy
NIHR128043 Professor Jonathan Rees The Chancellor Masters and Scholars of the University of Oxford Partial Rotator Cuff Tear Repair Trial (PRO CURE Trial)
NIHR128604 Dr David Ellard University of Warwick Partial ROTator Cuff Tears Management (PROTeCT-M): A Randomised Controlled Trial
NIHR128399 Associate-Professor Xavier Griffin University of Oxford World Hip Trauma Evaluation - FRUITI: Fix or Replace Undisplaced Intracapsular fractures Trial of Interventions
NIHR128553 Mr Gorav Datta University Hospital Southampton NHS Foundation Trust Fix Or REplace Surgery In General Hip Trauma (FORESIGHT) Trial
NIHR128550 Professor Glynis Murphy University of Kent RCT of group CBT for men with intellectual and/or developmental disabilities and harmful sexual behaviour: the HaSB-IDD trial
NIHR128128 Professor Elizabeth Hughes University of Leeds The RECO study: Realist Evaluation of service models and systems for CO- existing mental health and substance use conditions.
NIHR128472 Professor Chris Hollis University of Nottingham Stimulant Medication for ADHD and Tics - Understanding Response versus Non-stimulants (SATURN study): a randomised trial of the clinical and cost-effectiveness of methylphenidate versus guanfacine for ADHD in children and young people with a co-existing tic disorder
NIHR128109 Professor Simon Conroy University of Leicester Identification of older patients likely to require enhanced care on discharge from hospital
NIHR128625 Dr Jo Dumville The University of Manchester Adjustable hook-and-loop-fastened compression systems for the treatment of venous leg ulcers
NIHR128462 Dr Prakash Saha King's College London Velcro wRAp DevIces versus standard Compression bandaging for venous Leg ulcEration: the RADICLE trial.
NIHR128617 Mr Nick Lansdale Royal Manchester Children's Hospital Timing of Stoma Closure in Neonates (ToSCiN) Study
NIHR128623 Dr Emmanuelle Peters King's College London Multisite Randomised Controlled Trial of Trauma-Focused Cognitive Behaviour Therapy for psychosis (TF-CBTp) to reduce post-traumatic stress disorder (PTSD) symptoms in patients with co-morbid PTSD and psychosis, compared to usual treatment: the TRUST (TRaUma and pSychosis Therapy) trial