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HTA Remit and Competitiveness teleconference - Public minutes December 2019

Contents

NETS3 Cross programme Topics received at the November 2019 Call close

HTA Liver Disease, HTA Perinatal Mental Health, and HTA Solid Organ Replacement, Transplant And Donation

Friday 13 December 2019 09:30-12pm

Present Members

Professor Hywel Williams (Chair) (HTA Programme Director)
Professor Steve Goodacre (Chair) (HTA Deputy Programme Director)
Professor Lucy Chappell (Chair of CET Funding Committee)
Professor Andrew Farmer (Chair of HTA General Funding Committee)
Professor Andrew Bradbury (Chair of Prioritisation Committee B)
Associate Professor Kamal Mahtani (Chair of Prioritisation Committee A)
Dr Lyvonne Tume (Deputy Chair of Prioritisation Committee C)

NETSCC Secretariat

Dr Nick Hicks (Consultant Advisor)
Dr Cristina Lujan Barroso (Research Manager)
Ms Maria Oosterwijk (Administrator)
Observers Dr Jason Horsley, Dr Claire Kidgell, Miss Kathy Tier, Miss Aless Wilkinson-Smith
Apologies Ira Madan

19/143 HTA Liver Disease

NIHR130888 - Integrated care in the management of alcohol use disorder in patients with alcohol-related liver disease: targeting and identification of effective interventions (Acronym: INTEGRAL – INTEGrated caRe for Alcohol-related Liver disease) (Professor Colin Drummond)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

19/143 HTA Liver Disease

NIHR131127 - Baclofen to Prevent Relapse in people with alcOhol Use disorders and advanced liver Disease (Acronym: B-PROUD) (Professor Alastair O'Brien)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

19/143 HTA Liver Disease

NIHR131189 - Supporting engagement with care for socially complex groups initiating hepatitis C treatment. (Professor Andrew Hayward)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

19/147 HTA Perinatal Mental Health

NIHR130589 - The clinical and cost-effectiveness of emotional skills groups for women with borderline personality disorder during the perinatal period (Professor Paul Moran)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

19/143 HTA Liver Disease

NIHR130832 - SANIC: A cluster randomized trial of case-finding of advanced fibrosis in primary care in patients at risk of non-alcoholic fatty liver disease (NAFLD) (Dr Emmanuel Tsochatzis)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

19/143 HTA Liver Disease

NIHR131110 - DELIVER DEtecting LIVer damage using ELF in patients at Risk of Liver Disease from Alcohol Use Disorders (Professor William Rosenberg)

Chair: Steve Goodacre
Declared a conflict, remained in the teleconference: Kamal Mahtani
Declared a conflict and left the call: Hywel Williams
Recommendation: Proceed to Funding Committee

19/143 HTA Liver Disease

NIHR131129 - An adaptive-design randomised trial of baclofen in the treatment of alcohol use disorder in patients with liver cirrhosis (BASIS) (Dr Paul Richardson)

Chair: Steve Goodacre
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Hywel Williams
Recommendation: Proceed to Funding Committee

19/147 HTA Perinatal Mental Health

NIHR130669 - A Randomised Controlled Trial Of A Patient Decision Aid For Antidepressant Use In Pregnancy (Pause-P) (Dr Fiona Challacombe)

Chair: Steve Goodacre
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Hywel Williams
Recommendation: Out of Remit

19/147 HTA Perinatal Mental Health

NIHR130771 - The MINI (Mother Infant Interaction) study: Trial and process evaluation of the effectiveness of Video Interaction Guidance in mothers with perinatal mental health problems (Dr Anja Wittkowski)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

19/147 HTA Perinatal Mental Health

NIHR131099 - CHIRPY - On-line Cognitive beHavioural therapy InteRvention in PregnancY ‘Enjoy Your Bump’: an antenatal intervention for perinatal anxiety (Professor Rebecca Reynolds)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit of the HTA Programme and reallocated to HS&DR

19/147 HTA Perinatal Mental Health

NIHR131122 - CALM: A multi-site randomised controlled trial to test the impact of a group treatment for antenatal anxiety to improve maternal mental health and child adjustment (Professor Pasco Fearon)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

19/147 HTA Perinatal Mental Health

NIHR131158 - What is the effectiveness and cost effectiveness of a parenting programme to reduce depression and improve mother and infant outcomes in British South Asian families? (Professor Nusrat Husain)


Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

19/147 HTA Perinatal Mental Health

NIHR131169 - Prevention and treatment of workplace traumatisation and primary and secondary post-traumatic stress disorder in maternity service staff: a mixed methods evidence synthesis of clinical and cost effectiveness (Professor Debra Bick)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

19/151 HTA Solid Organ Replacement, Transplant And Donation

NIHR130563 - Blood Purification during Liver Transplantation to improve Kidney Outcomes - A factorial randomised controlled trial. The OPULENCE Trial (Dr Jaimin Mukesh Patel)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: Andrew Bradbury
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

19/151 HTA Solid Organ Replacement, Transplant And Donation

NIHR131058 - A prospective randomized controlled trial of robotic assisted versus laparoscopic assisted living donor nephrectomy. (Mr Ioannis Loukopoulos)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

19/143 HTA Liver Disease

NIHR131008 - Development, mental health and physical wellbeing in children and young people with liver disease (Dr Marianne Samyn)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit of the HTA Programme and reallocated to HS&DR

19/143 HTA Liver Disease

NIHR131085 - A randomised controlled trial to determine the effectiveness of increased coffee consumption as a treatment for adults with non-alcoholic fatty liver disease (NAFLD). (Professor Jonathan Fallowfield)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: Claire Kidgell
Declared a conflict and left the call: None declared
Recommendation: Out of Remit of the HTA Programme and reallocated to EME

19/143 HTA Liver Disease

NIHR131106 - HCC Surveillance: Development of a model to identify patients who will benefit from HCC surveillance and to improve identification of patients at the highest risk (Dr Tim Cross)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

19/143 HTA Liver Disease

NIHR131112 - A prospective cohort study to elucidate the natural history and pathogenesis of Sickle Cell Hepatopathy in Adults and Children. (Dr Abid Suddle)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Uncompetitive

19/147 HTA Perinatal Mental Health

NIHR130691 - Feasibility, acceptability and experiences of an adapted Behavioural Family Therapy in Community Perinatal Mental Health Services (FAAB) (Dr Jelena Jankovic)

Chair: Steve Goodacre
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Hywel Williams
Recommendation: Out of Remit

19/147 HTA Perinatal Mental Health

NIHR130836 - SAFER: Study of the Assessment, Feasibility and Economics of identifying birth trauma and pReventing PTSD (Professor Susan Ayers)

Chair: Steve Goodacre
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Hywel Williams
Recommendation: Out of Remit

19/147 HTA Perinatal Mental Health

NIHR130717 - A multicentre randomised placebo controlled trial of bright light therapy for postnatal depression to augment antidepressant medication and investigation of the mechanisms of action (Dr Jonathan Evans)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

19/147 HTA Perinatal Mental Health

NIHR130768 - Feasibility and Acceptability of Mental health assessment and online psychosocial Intervention for partners during postnataL and pregnancY (FAMILY) with embedded validation of depression and anxiety assessment measures (Dr Zoe Darwin)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit and uncompetitive

19/147 HTA Perinatal Mental Health

NIHR130810 - Making routine clinical meetings in perinatal mental health services therapeutically effective – adaptation and implementation of DIALOG+ for patients with perinatal psychosis (Perinatal D+) (Dr Nikolina Jovanovic)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit of the HTA Programme and reallocated to HS&DR

19/147 HTA Perinatal Mental Health

NIHR130837 - The BDRN prospective pregnancy study: individualising the risk assessment for women at high risk of postpartum psychosis.
(Professor Ian Jones)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

19/147 HTA Perinatal Mental Health

NIHR130930 - EMMPATHY: Enhancing Migrant Mothers' Perinatal mentAl healTH through communitY-based cultural peer supporters: Optimisation and feasibility assessment (Professor Hora Soltani)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

19/147 HTA Perinatal Mental Health

NIHR130962 - A multi-centre randomised controlled trial to evaluate the effectiveness of Rewind, a brief trauma-focussed psychological intervention, to reduce symptoms of birth-related post-traumatic stress disorder. (Dr Susan Channon)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

19/147 HTA Perinatal Mental Health

NIHR130996 - The Improving Maternal and Infant wellbeing (or IMAgINE) 2 study: A randomised controlled trial of the Baby Triple P Positive Parenting Programme for mothers with moderate to severe perinatal mental health problems (Dr Anja Wittkowski)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

19/147 HTA Perinatal Mental Health

NIHR131073 - Addressing reproductive health inequalities for women with mental illness - the importance of preconception care and pregnancy planning (Professor Kathryn Abel)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit of the HTA Programme and reallocated to HS&DR

19/147 HTA Perinatal Mental Health

NIHR131162 - The Rewind pilot study: Pilot randomised trial to assess the feasibility of a full randomised controlled trial of Rewind therapy for post-traumatic stress disorder following childbirth (PTSDFC) (Dr Helen West)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

19/151 HTA Solid Organ Replacement, Transplant And Donation

NIHR130975 - Normothermic mAchine Perfusion of the Liver to Enable transplantation in difficult recipientS 2 (NAPLES 2) (Professor Darius Mirza)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit of the HTA Programme and reallocated to EME

19/151 HTA Solid Organ Replacement, Transplant And Donation

NIHR130992 - TRANSfusion in Transplantation Study (TRANSiT) (Dr Michelle Willicombe)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

19/151 HTA Solid Organ Replacement, Transplant And Donation

NIHR131020 - The clinical utility and effect on patient activation of using a web-based application to monitor renal transplant recipients compared with standard clinic-based care.(REMOTE - TX) (Dr Robert Lewis)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit of the HTA Programme and reallocated to HS&DR

19/151 HTA Solid Organ Replacement, Transplant And Donation

NIHR131029 - Optimising kidney transplant health: defining the role of the donor derived DNA OrganScan technology in the earlier detection of kidney transplant rejection (Dr Andrew Lewington)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

19/151 HTA Solid Organ Replacement, Transplant And Donation

NIHR131124 - Statins in Organ Donor Management An evaluation of the benefits of giving a single dose of Simvastatin to brain-stem dead organ donors on outcomes in recipients of organs from the donor SIGNET Statins for Improving orGan outcomE in Transplantation (Professor John Dark)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

19/143 HTA Liver Disease

NIHR130883 - Randomised controlled trial of EArly transjugular intrahepatiC porTosystemic stent-shunt in Acute Variceal Bleeding (REACT-AVB) (Dr Dhiraj Tripathi)

Chair: Steve Goodacre
Declared a conflict, remained in the teleconference: Andrew Bradbury, Claire Kidgell
Declared a conflict and left the call: Hywel Williams
Recommendation: Proceed to Funding Committee

19/143 HTA Liver Disease

NIHR131059 - Palliative Long-term Abdominal Drains Versus Repeated Drainage in Untreatable Ascites Due To Advanced Cirrhosis: A Randomised Controlled Trial (Professor Sumita Verma)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

19/147 HTA Perinatal Mental Health

NIHR130741 - Supporting Perinatal Anxiety; a feasibility study investigating the use of an eHealth program to support mild-to-moderate levels of anxiety in a perinatal cohort. (Dr Virginia Harrison)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

19/151 HTA Solid Organ Replacement, Transplant And Donation

NIHR130656 - A randomized controlled trial assessing the safety and efficacy of robotic assisted versus open living donor kidney transplantation (Professor Nizam Mamode)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

19/151 HTA Solid Organ Replacement, Transplant And Donation

NIHR130679 - A randomised controlled trial of Intra-operative Mannitol for the Prevention of delayed grAft function in deceased donor Renal Transplant (IMPART) (Mr Adam Barlow)

Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee