HTA Researcher-Led Primary Research and Evidence Synthesis Applications from the January 2020 Call Close
Friday 31 January 2020 10-1pm
Present Members
Professor Hywel Williams (Chair) (HTA Programme Director)
Professor Steve Goodacre (HTA Deputy Programme Director)
Professor Lucy Chappell (Chair of CET Funding Committee)
Professor Andrew Farmer (Chair of HTA General Funding Committee)
Associate Professor Kamal Mahtani (Prioritisation Committee A, Chair)
Professor Andrew Bradbury (Chair of Prioritisation Committee B)
Dr Ira Madan (Chair of Prioritisation Committee C)
NETSCC Secretariat
Dr Jason Horsley (Consultant Advisor)
Mrs Karen Williams (Senior Research Manager)
Dr Cristina Lujan Barroso (Research Manager)
Ms Maria Oosterwijk (Administrator)
Observers: Dr Olivia Wu, Dr Catherine Hewitt
Apologies: None declared
19/101 HTA Researcher-led call Evidence Synthesis
NIHR131183 - Outcomes of Office-based (Outpatient) Biopsy for Laryngopharyngeal Tumours: A Systematic Review and Meta-Analysis (Mr Jaiganesh Manickavasagam)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Uncompetitive
19/102 HTA Researcher-led call Primary Research
NIHR130762 - The clinical and cost effectiveness of group mindfulness-based therapy for distressing persecutory delusions: A definitive randomised controlled trial. (Dr Lyn Ellett)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR130984 - Evaluating dietary nitrate supplementation as a strategy to enhance exercise capacity in people with chronic obstructive pulmonary disease: the EDEN-COPD trial (Dr Nicholas Hopkinson)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit
19/102 HTA Researcher-led call Primary Research
NIHR131082 - APPROACH: Analysis of Proton vs. Photon Radiotherapy in Oligodendroglioma and Assessment of Cognitive Health (Dr Louise Murray)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit
19/102 HTA Researcher-led call Primary Research
NIHR130700 - RadiO fRequency ablatION for haemorrhoids (ORION)(Professor Steven Brown)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Steve Goodacre (Department)
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR130848 - CiproPAL (Ciprofloxacin Prophylaxis in Acute Leukaemia): A randomised trial to assess the use of ciprofloxacin prophylaxis to prevent bacterial infection in children treated on the induction phase of the ALLTogether-1 treatment protocol (Dr Robert Phillips)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Steve Goodacre (Department)
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR130905 - UK FROST-2 (United Kingdom Frozen Shoulder Trial-2) comparing hydrodilatation with manipulation under anaesthesia in the treatment of adult patients with a frozen shoulder in secondary care: a randomised controlled trial, mixed-treatment comparison and decision-analytic model (Professor Amar Rangan)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Catherine Hewitt (co-applicant)
Recommendation: Out of Remit
19/102 HTA Researcher-led call Primary Research
NIHR131208 - MOMENTUM: Evaluation of Whole Body Imaging (Computer Tomography, CT and Magnetic Resonance, MR) for Optimal Management Decision Making in Multiple Myeloma (Dr Christina Messiou)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Uncompetitive
19/102 HTA Researcher-led call Primary Research
NIHR131280 - A Randomised Phase III Clinical Trial to Investigate the Addition of Mycophenolate Mofetil Up-front to Standard of Care Steroids in the Treatment of Immune Checkpoint Inhibitor Induced Liver Injury (MUST CHECK) (Dr Sarah Welsh)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of remit
19/102 HTA Researcher-led call Primary Research
NIHR130875 - The impact of REstrictive versUs Liberal Transfusion strategy on cardiac Injury in patients undergoing surgery for Hip Fracture (RESULT-HF). (Dr Michael Gillies)
Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: Kamal Mahtani (Department)
Declared a conflict and left the call: Hywel Williams, Steve Goodacre (personal)
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131187 - The clinical and cost-effectiveness of aspirin compared with other anticoagulants for preventing venous thromboembolism following total hip replacement. A multicenter non-inferiority randomised controlled trial (Professor Ashley Blom)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: Kamal Mahtani (Department), Andrew Farmer (Department)
Declared a conflict and left the call: Steve Goodacre (Personal)
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131263 - Clinical and cost-effectiveness of progressive exercise versus best practice advice for people aged 50 years and over with ankle fractures: the AFTER trial (Dr David Keene)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: Kamal Mahtani (Department), Andrew Farmer (Department)
Declared a conflict and left the call: None declared
Recommendation: Out of Remit
19/102 HTA Researcher-led call Primary Research
NIHR131302 - A randomised controlled trial assessing if a prophylactic management strategy offers clinical benefit and cost effectiveness over a reactive management strategy for hip displacement in young people with cerebral palsy. (Mr Tim Theologis)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: Kamal Mahtani (Department), Andrew Farmer (Department)
Declared a conflict and left the call: None declared
Recommendation: Out of Remit
19/102 HTA Researcher-led call Primary Research
NIHR131344 - The clinical and cost effectiveness of a holistic online self-management platform for people with diabetes compared to routine care: A mixed-methods stepped-wedge cluster randomised controlled trial. (Dr Iskandar Idris)
Chair: Steve Goodacre
Declared a conflict, remained in the teleconference: Kamal Mahtani (Department)
Declared a conflict and left the call: Hywel Williams
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131338 - Metabolic Assessment in Stone Treatment: comparing the clinical and cost effectiveness of full metabolic assessment and personalised therapy with standard dietary advice alone in people with recurrent kidney stone disease. (Dr Ben Turney)
Chair: Steve Goodacre
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Hywel Williams
Recommendation: Out of Remit
19/102 HTA Researcher-led call Primary Research
NIHR131354 - Inpatient graduated compression stocking use as an adjunct to extended duration pharmacoprophylaxis for venous thromboembolism prevention – a multi-centre randomised controlled trial (Professor Alun Davies)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Bradbury (Co-applicant), Steve Goodacre (Personal)
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131368 - Early Vitrectomy vs Laser Treatment for Proliferative Diabetic Retinopathy (Acronym: EVERLAST-PDR): A Multi-Centre Prospective Clinical Trial (Miss Louisa Wickham)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit
19/101 HTA Researcher-led call Evidence Synthesis
NIHR131333 - Results of the use of the Manchester Short Assessment of Quality of Life (MANSA): A systematic review (Professor Peter Huxley)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Uncompetitive and Out of Remit
19/102 HTA Researcher-led call Primary Research
NIHR130846 - Orthopedic Implant Identification using Artificial Intelligence (Dr Vineet Batta)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit
19/102 HTA Researcher-led call Primary Research
NIHR131246 - WHiTE-RIIiO: World Hip Trauma Evaluation- Reducing Implant Infection in Orthopaedics. A randomised trial comparing forced air versus resistive fabric warming technologies on post-operative infection rates following following hip fracture surgery (Professor Matthew Costa)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: Kamal Mahtani (Department), Andrew Farmer (Department)
Declared a conflict and left the call: None declared
Recommendation: Out of Remit
19/102 HTA Researcher-led call Primary Research
NIHR131281 - The application of pre and post-surgery automatic-continuous positive airway pressure (APAP) in newly diagnosed moderate to severe Obstructive Sleep Apnoea (OSA) to reduce the complications of surgery and improve outcomes; a Randomised controlled trial (Dr Martina Mason)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit
19/102 HTA Researcher-led call Primary Research
NIHR131326 - A randomised controlled trial to measure the clinical and cost-effectiveness of Therapeutic Rituximab in patients with active, IVIg-dependent, Chronic Inflammatory Demyelinating Polyradiculoneuropathy: The TRIC Study (Professor Michael Lunn)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Transfer to EME Programme
19/102 HTA Researcher-led call Primary Research
NIHR131349 - A sham-controlled randomised superiority trial of the clinical and cost-effectiveness of intermittent theta-burst stimulation plus treatment as usual (TAU) in patients with severe enduring anorexia nervosa: The ARTEMIS (Anorexia Theta Magnetic Stimulation) trial. (Professor Ulrike Schmidt)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit
19/102 HTA Researcher-led call Primary Research
NIHR131364 - Identification of novel biomarkers of inflammation and clonal haemopoiesis that predict for development of the age-related ischaemic heart disease, cerebrovascular disease, dementia and depression (Professor Ghulam Mufti)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit
19/102 HTA Researcher-led call Primary Research
NIHR131105 - Pre-hospitAl Randomised triAl of MEDICation route in out-of-hospital cardiac arrest (PARAMEDIC3) (Professor Gavin Perkins)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: Andrew Bradbury
Declared a conflict and left the call: Steve Goodacre (Personal)
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131233 - A randomised controlled trial of TRANSrectal biopsy versus Local Anaesthetic Transperineal biopsy Evaluation (TRANSLATE) of potential clinically significant prostate cancer. (Associate-Professor Richard Bryant)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer (Personal)
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131306 - Multi-modality local consolidative treatment versus conventional care of advanced lung cancer after first line systemic anti-cancer treatment: a multi-centre randomised controlled trial with an internal pilot. RAdical Management Of Advanced Non-small cell lung cancer (RAMON) (Professor Eric Lim)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131350 - Clinical and cost effectiveness of triple chronotherapy (wake therapy) v sleep therapy for the rapid treatment of depression: a parallel randomised controlled trial (Professor David Veale)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR130863 - STudy of Antibiotic Treatment In Children with Protracted Bacterial Bronchitis (STATIC PBB) (Dr Francis Gilchrist)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR130886 - Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma (MelMarT-II)
ClinicalTrials.gov Identifier: NCT03860883 (Professor Marc Moncrieff)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR130993 - Evaluating the clinical and cost-effectiveness of biparametric MRI compared to multi-parametric MRI in detecting and ruling-out important prostate cancer (Professor Hashim Ahmed)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131090 - A randomised controlled trial of up to 12 months antibiotic prophylaxis for patients with immune systems severely impaired by blood cancer and its therapy; assessment for risk of carriage of antibiotic resistant bacteria and benefit from reduced deaths and infections requiring antibiotics (Professor Mark Drayson)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131107 - A randomised trial of standard versus reduced frequency of pembrolizumab for first-line patients with advanced non-small cell lung Cancer (NSCLC) utilising a novel multi-arm frequency-response optimisation design - CONVOLUTE (Professor Michael Seckl)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR130906 - Multi-Centre Trial Of Home Enteral Nutrition Versus Usual Care After Oesophagectomy For Cancer (Monaco 1) (Professor David Bowrey)
Chair: Steve Goodacre
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Hywel Williams
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131334 - The Self-harm, Assessment, Formulation, Engagement Trial of Psychodynamic Interpersonal Therapy (SAFE-PIT) (Professor Elspeth Guthrie)
Chair: Steve Goodacre
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Hywel Williams
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR130689 - The Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial: a double-blind, randomised controlled trial of metoclopramide for the prevention of pneumonia in patients with dysphagia after an acute stroke (Professor Christine Roffe)
Chair: Steve Goodacre
Declared a conflict, remained in the teleconference: Andrew Bradbury (Department)
Declared a conflict and left the call: Hywel Williams
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131346 - CONservative TReatment of Appendicitis in Children – a randomised controlled Trial – CONTRACT 2 (Associate-Professor Nigel Hall)
Chair: Steve Goodacre
Declared a conflict, remained in the teleconference: Kamal Mahtani (Department)
Declared a conflict and left the call: Hywel Williams
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131200 - Prophylactic antenatal corticosteroids for the prevention of short- and long-term morbidity associated with induction of labour at 34 – 37 weeks of gestation: a multi-centre randomised controlled trial (Dr Paul Ayuk)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: Lucy Chappell (Department), Kamal Mahtani (Department), Andrew Farmer (currently collaborating with co-applicants)
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131370 - A randomised controlled trial assessing the clinical and cost effectiveness of the modified ketogenic diet for adults with treatment refractory epilepsy (KESTREL (Professor Anthony Marson)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: Andrew Farmer (currently collaborating with co-applicants)
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131231 - Evaluation of the Ampcare ESP (Effective Swallowing Protocol) for swallowing difficulties post stroke: a multi-centred, randomised, controlled trial. (Professor Susan Pownall)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131313 - Impact of a new risk tool (STUMBL Score) on the management of blunt chest wall trauma: a stepped wedge, cluster randomised controlled trial (STUMBL2 trial (Associate-Professor Ceri Battle)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: Steve Goodacre (Department)
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131339 - The COSI study: a multi-site RCT to explore the clinical and cost effectiveness of the Circle of Security Intervention for mothers in perinatal mental health services (Professor Peter Fonagy)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131341 - Cluster Randomised Controlled Trial of a Service to Support the Mental Health and Coping of Parents with Excessively Crying Infants (Professor Jayne Brown)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131352 - A Randomised Placebo-Controlled Trial of Antenatal Corticosteroids for Planned Birth in Twins: STOPPIT-3 (Dr Sarah Stock)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: Olivia Wu (Department)
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131353 - Hip arthroscopy versus periacetabular osteotomy for borderline hip dysplasia in young adults: a randomised controlled trial and economic evaluation (Mr Ajay Malviya)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Catherine Hewitt (co-applicant)
Recommendation: Proceed to Funding Committee
19/102 HTA Researcher-led call Primary Research
NIHR131362 - Tailoring treatment for HER2 positive early breast cancer – the HER2-RADiCAL study (Response ADaptive CAre pLan) (Professor Andrew Wardley)
Chair: Hywel Williams
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee
Summing up