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HTA Remit and Competitiveness teleconference - Public minutes June 2019

Contents

Published: 05 June 2019

Version: 1.0

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HTA Remit and Competitiveness Teleconference for NETS3 HTA Tobacco Cessation, control and harm reduction interventions, Researcher-Led Primary Research and Evidence Synthesis Applications from the May 2019 Call Close

Date and time

Wednesday 05 June 2019, 10:00-13:00

Place 

Haygarth room, Beta House

Present

Professor Hywel Williams (Chair)

Professor Steve Goodacre

Professor Lucy Chappell

Professor Andrew Farmer

Dr Ira Madan

Dr Geoff Wong

Professor David Sebag-Montefiore

NETSCC

Dr Martin Ashton-Key (Consultant Advisor)

Mrs Karen Williams (Senior Research Manager)

Dr Cristina Lujan Barroso (Research Manager)

Miss Louisa Saunders (Assistant Research Manager)

Observers

None

Apologies

Associate Professor Kamal Mahtani, Professor Andrew Bradbury, Dr Simon Fraser, Miss Louise Maclachlan, Ms Maria Oosterwijk

 

 

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129166 - E-cigarettes for Quitting Smoking in Young People: A Randomised Controlled Trial (EQuiYP)

Dr Lynne Dawkins

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129438 - Smoking cessation in the Emergency Department: a randomised controlled trial

Dr Ian Pope

Chair: Hywel Williams

Declared a conflict and left the call: Steve Goodacre

Recommendation: Proceed to Funding Committee

 

 

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129593 - Investigating the effectiveness of electronic cigarettes as an aid to smoking cessation in comparison with varenicline and the effect of vaping on lung health in patients with chronic obstructive pulmonary disease (E-CaL study)

Dr Amanda Farley

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Proceed to Funding Committee

 

 

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129607 - E-cigarettes plus behavioural and psychological support for smoking cessation for users of community secondary mental health care: A cluster-randomised and controlled trial feasibility study

Dr Gemma Taylor

Chair: Hywel Williams

Declared a conflict and left the call: Andrew Farmer, Geoff Wong

Recommendation: Out of Remit

 

 

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129627 - Do e-cigarettes help smokers quit when not accompanied by intensive behavioural support?

Dr Katie Myers Smith

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Proceed to Funding Committee

 

 

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129636 - Examining feasibility, efficacy, clinical-effectiveness and cost-effectiveness of a novel digital platform for the delivery of assessment, triage and intervention for population-wide smoking cessation support: ‘My Quit Route’

Mrs Stephanie Dugdale

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

 

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129735 - Health effects of short-term and long-term use of e-cigarettes

Professor Peter Hajek 

Chair: Hywel Williams

Declared a conflict and left the call: Andrew Farmer, Geoff Wong

Recommendation: Proceed to Funding Committee

 

 

18/166 HTA Tobacco Cessation, control and harm reduction intervention

NIHR129210 - Open-label, randomised controlled trial of nicotine replacement therapy preloading and lapse recovery for cessation and where quitting fails, for smoking reduction in pregnancy

Professor Tim Coleman

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams, Andrew Farmer, Geoff Wong

Recommendation: Proceed to Funding Committee

 

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129025 - WrIst Physiotherapy Interventions in Trauma (WIPIT Study)

Associate-Professor Ben Ollivere

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

Recommendation: Proceed to Funding Committee

 

 

19/11 HTA Researcher-led call Primary Research

NIHR128977 - EDAM: Evaluating Dislocated Acromioclavicular joint Management

Associate-Professor Rebecca Kearney 

Chair: Hywel Williams

Declared a conflict and left the call: None 

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129001 - Post-stroke Intervention Trial in fatigue (POSITIF): a randomised controlled trial of a guided self help intervention for treating post-stroke fatigue

Professor Gillian Mead 

Chair: Hywel Williams

Declared a conflict and left the call: Geoff Wong

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129114 - SISTAR: Outcomes of simultaneous versus staged resections for synchronous colorectal liver metastases – a randomised controlled trial

Mr Giuseppe Fusai

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Proceed to Funding Committee

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129172 - A radical Steroid AVoidance trial in ANti-Neutrophil cytoplasm Antibody (ANCA) associated vasculitis (SAVANNA)

Professor Alan Salama

Chair: Hywel Williams

Declared a conflict and left the call: Lucy Chappell

Recommendation: Uncompetitive

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129189 - Quetiapine augmentation of antidepressants for treatment resistant depression

Professor Glyn Lewis 

Chair: Hywel Williams

Declared a conflict and left the call: Lucy Chappell

Recommendation: Uncompetitive

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129197 - Children’s Ear Drops for eAR pain2 (CEDAR2): pragmatic randomised controlled trial

Professor Alastair Hay

Chair: Hywel Williams

Declared a conflict and left the call: Lucy Chappell

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129693 - BUDSURF - Randomised controlled trial of Budesonide-Surfactant for the prevention of Chronic Lung Disease in extreme preterm infants

Dr Mallinath Chakraborty

Chair: Hywel Williams

Declared a conflict and left the call: Lucy Chappell

Recommendation: Uncompetitive

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129731 - Maternal POsition in the second stage of labour in nulliparous Women Without EpiduRal analgeSia: a randomised controlled trial (POWWERS)

Dr Caroline Fox 

Chair: Andrew Bradbury

Declared a conflict and left the call: Lucy Chappell

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129237 - A randomised controlled trial of low intensity psychological treatment for depression for autistic adults

Dr Ailsa Russell 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Uncompetitive

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129385 - RAPTOR: Randomised Controlled Trial of PENTOCLO in Mandibular Osteoradionecrosis

Professor Richard Shaw 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Proceed to Funding Committee

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129518 - A randomised controlled trial to determine the effect and cost-effectiveness of liberal and conservative perioperative oxygen therapy on clinical outcomes following major surgery.

Dr Daniel Martin 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Proceed to Funding Committee

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129531 - Long-term outcomes following breast conservation versus mastectomy in women aged 40 years or under with breast cancer stratified by BRCA status: POSH study follow-up extension

Dr Ellen Copson 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Uncompetitive

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129550 - MIDAS Trial: Modifying pain using Drugs Around Surgery. A randomised, double-blind, placebo-controlled trial of ibuprofen to safely reduce pain after major gastrointestinal surgery.

Dr Michael Gillies 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Proceed to Funding Committee

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129551 - CanACT2: Acceptance and Commitment Therapy versus treatment as usual for psychosocial dysfunction in people with advanced cancer; a randomised controlled trial.

Dr Marc Serfaty 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129557 - Evaluating the role of fast MRI and image-fusion biopsy for the detection of prostate cancer

Professor Hashim Ahmed 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129564 - Use of high-flow humidified oxygen TheRapy versus stAndard Care following major HEad & neck surgery: A multi-site randomIsed controlled tRial (TRACHE-AIR)

Mr Paul Twose 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129580 - WHiTE 12-WHISH: Wound Healing in Surgery for Hip fractures

Professor Matthew Costa 

Chair: Hywel Williams

Declared a conflict and left the call: Andrew Farmer

Recommendation: Uncompetitive

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129589 - ORBITA-2: A placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina

Professor Darrel Francis 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Proceed to Funding Committee

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129576 - ENCOMPASS (MYELOMA). EvaluatioN of COMorbidity and suPportive therApy StrategieS in MYELOMA

Professor Gordon Cook 

Chair: Hywel Williams

Declared a conflict and left the call: Steve Goodacre, David Sebag-Montefiore

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129002 - Exploring the effectiveness and cost-effectiveness of a community-based, exercise intervention with an embedded qualitative process evaluation for people with systemic sclerosis (EXCEL - SSc)

Dr Markos Klonizakis 

Chair: Hywel Williams

Declared a conflict and left the call: Steve Goodacre

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129711 - The NOTES Study: Neonatal Outcomes with Treatments for Epileptic Seizures. A randomised controlled trial of phenobarbital and levetiracetam for seizures associated with neonatal hypoxic ischaemic encephalopathy and their association with neuro-development outcome at 2 years

Dr Anthony Hart 

Chair: Hywel Williams

Declared a conflict and left the call: Steve Goodacre

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129592 - Cervical Orthoses in the Management of FragilitY Fractures of the Odontoid Process (COMFY)

Mr James Tomlinson 

Chair: Andrew Farmer

Declared a conflict and left the call: Hywel Williams, Steve Goodacre

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129617 - Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury (MOSAICC – Multicentre evaluation Of Sodium bicarbonate in Acute kidney Injury in Critical Care)

Professor Lui Forni 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

Recommendation: Proceed to Funding Committee

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129677 - MUlticentre randomised trial of Surveillance in Inflammatory Bowel Disease (IBD): a comparison of dye spray chromoendoscopy (DCE) versus dyeless virtual electronic chromoendoscopy (VCE) (MUSIc) for precise detection and outcome of colonic neoplasia in IBD patients

Associate-Professor Marietta Iacucci 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129683 - Full Title: A cluster randomised controlled trial of using the enhanced liver fibrosis test in primary care to identify people at risk of liver fibrosis due to alcohol use disorders. Short title: DELIVER DEtecting LIVer damage using ELF In patients at RISK

Professor William Rosenberg 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129628 - LIVACOR Trial: Minimally invasive LIVer And simultaneous COlorectal Resection

Professor Mohammed Abu Hilal 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Uncompetitive

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129640 - Whole-body MRI for more efficient staging of breast cancer: internal pilot to inform a prospective multicentre comparison with standard imaging pathways.

Professor Steve Halligan 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129664 - The Effectiveness of Peroneal Nerve Functional Electrical STimulation (FES) for the Reduction of Bradykinesia in Parkinson’s DiSease: A Pragmatic Assessor Blinded Randomised Controlled Trial (STEPS II).

Professor Paul Taylor 

Chair: Hywel Williams

Declared a conflict and left the call: None 

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129668 - The use of 3D-printed insoles to prevent primary diabetic foot ulcers: a feasibility study.

Dr Panagiotis Chatzistergos 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129679 - A pragmatic multi-centre randomised controlled trial of alcohol assertive outreach treatment for patients admitted to hospital with alcohol-related liver disease (A-LIVE)

Professor Colin Drummond 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129690 - Diabetes Remission Clinical Trial for South Asians: The DISHA study

Professor Kamlesh Khunti 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Uncompetitive

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129701 - Evidence-based pain management pathway for people with chronic pancreatitis

Professor Kurinchi Gurusamy 

Chair: Hywel Williams

Declared a conflict and left the call: Geoff Wong

Recommendation: Proceed to Funding Committee - Commissioning

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129707 - UrodynAmicS as Routine Evaluation in Women with StrEss UrinaRy InconTinence (The ASSERT Study); a superiority randomised clinical trial to evaluate the clinical and cost effectiveness of routine urodynamic investigations in management of women with stress

Professor Mohamed Abdel-Fattah 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129710 - A randomised control trial to determine the influence of metformin on the growth of large abdominal aortic aneurysms in patients without diabetes who are unsuitable for surgical intervention (MEASURE – Metformin Effect on Aneurysm Size in patients Unfit for Repair)

Professor Robert Hinchliffe 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129727 - Improving outcomes for men undergoing Open AAA Repair using Prehabilitation

Mr Tristan Lane 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129728 - Impact of green tea extract on cognition and function in older adults at risk of cognitive decline and dementia: A randomised controlled trial

Dr Anne Corbett 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129748 - Surgeons Trial Of Prophylaxis for Epilepsy in seizure naïve patients with Meningioma: a randomised controlled trial (STOP’EM)

Mr Michael Jenkinson 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Proceed to Funding Committee

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129753 - Social Prescribing for Children and Young People

Professor Barry Wright 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129756 – TENSION (Trial EmbolisatioN IN oSteOarthritis)

Dr Nolan Walker 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129718 - Music Interventions for Dementia and Depression in ELderly care (MIDDEL): International cluster-randomised trial - UK arm (MIDDEL-UK)

Professor Justine Schneider 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

Recommendation: Proceed to Funding Committee

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129079 - The AVERT (Acute VErtebral fragility fractuRe augmenTation) study in hospitalised patients.

Professor Opinder Sahota 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

Recommendation: Out of Remit

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129179 - PREDNOS 3: what is the optimal steroid treatment dose to induce remission in relapses of childhood nephrotic syndrome?

Dr Martin Christian 

Chair: Steve Goodacre

Declared a conflict and left the call: Hywel Williams

Recommendation: Proceed to Funding Committee

 


19/10 HTA Researcher-led call Evidence Synthesis

NIHR129305 - Clinical and cost-effectiveness of early interventions initiated in the acute care period for managing the psychological effects of trauma and to reduce the incidence and duration of common mental disorders.

Dr Philippa Olive

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Uncompetitive

 

 

19/10 HTA Researcher-led call Evidence Synthesis

NIHR129523 - BEhavioural Weight Management: COMponents of Effectiveness (BE:COME)

Dr Jennifer Logue

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Proceed to Funding Committee

 

 

19/10 HTA Researcher-led call Evidence Synthesis

NIHR129646 - Evaluating diagnostic performance of imaging technologies for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment: a systematic review and meta-analysis

Dr Huiqin Yang

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Uncompetitive

 

 

19/10 HTA Researcher-led call Evidence Synthesis

NIHR129708 - Safety and effectiveness of tranexamic acid in trauma and surgery in the NHS: An individual patient data meta-analysis

Dr Katharine Ker 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Proceed to Funding Committee

 

 

19/10 HTA Researcher-led call Evidence Synthesis

NIHR129713 - Effectiveness and cost-effectiveness of gynaecological surveillance for women with Lynch syndrome: systematic reviews and economic evaluation

Dr Tristan Snowsill 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Proceed to Funding Committee

 

 

19/10 HTA Researcher-led call Evidence Synthesis

NIHR129715 - Diet and physical activity in pregnancy to prevent gestational diabetes: Individual Participant Data (IPD) meta-analysis on the differential effects of interventions with economic evaluation

Professor Shakila Thangaratinam 

Chair: Hywel Williams

Declared a conflict and left the call: Lucy Chappell

Recommendation: Proceed to Funding Committee

 

 

19/10 HTA Researcher-led call Evidence Synthesis

NIHR129742 - Systematic Review and meta-analysis of clinical and cost effectiveness and feasibility of a UK extracorporeal cardiopulmonary resuscitation programme for out-of-hospital cardiac arrests

Associate-Professor Joyce Yeung 

Chair: Hywel Williams

Declared a conflict and left the call: Steve Goodacre

Recommendation: Proceed to Funding Committee

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129750 - Prostate cancer Risk Evaluation by Freehand transperineal sectoral (FHTP-24 core) versus Evaluation by Reduced (FHTP–12 core) biopsy: Randomisation for Effective Diagnosis. A randomised non-inferiority trial. Short Title: PREFERRED

Mr Rick Popert 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Uncompetitive

 

 

19/11 HTA Researcher-led call Primary Research

NIHR129649 - A multicentre randomised placebo-controlled trial of the effectiveness and cost-effectiveness of conventional vs high-frequency spinal cord stimulation in patients with neuropathic pain. CHESTNUT STUDY

Professor Sam Eldabe 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Proceed to Funding Committee

 

 

19/11 HTA Researcher-led call Primary Research

NIHR127873 - Pragmatic randomised trial of High Or Standard PHosphAte Targets in End-stage kidney disease - The PHOSPHATE trial

Dr Thomas Hiemstra 

Chair: Hywel Williams

Declared a conflict and left the call: None

Recommendation: Proceed to Funding Committee

 

18/166 - HTA Tobacco Cessation, control and harm reduction interventions (NETS3 call) – Primary Research

1.1

NIHR129166

E-cigarettes for Quitting Smoking in Young People: A Randomised Controlled Trial (EQuiYP)

(Dr Lynne Dawkins)

Decision: Out of remit

1.2

NIHR129438

Smoking cessation in the Emergency Department: a randomised controlled trial

(Dr Ian Pope)

Decision: Proceed to Funding Committee

1.3

NIHR129593

Investigating the effectiveness of electronic cigarettes as an aid to smoking cessation in comparison with varenicline and the effect of vaping on lung health in patients with chronic obstructive pulmonary disease (E-CaL study)

(Dr Amanda Farley)

Decision: Proceed to Funding Committee

1.4

NIHR129607

E-cigarettes plus behavioural and psychological support for smoking cessation for users of community secondary mental health care: A cluster-randomised and controlled trial feasibility study

(Dr Gemma Taylor)

Decision: Out of remit

1.5

NIHR129627

Do e-cigarettes help smokers quit when not accompanied by intensive behavioural support?

(Dr Katie Myers Smith)

Decision: Proceed to Funding Committee

1.6

NIHR129636

Examining feasibility, efficacy, clinical-effectiveness and cost-effectiveness of a novel digital platform for the delivery of assessment, triage and intervention for population-wide smoking cessation support: ‘My Quit Route’

(Mrs Stephanie Dugdale)

Decision: Out of remit

1.7

NIHR129735

Health effects of short-term and long-term use of e-cigarettes

(Professor Peter Hajek)

Decision: Proceed to Funding Committee

1.8

NIHR129210

Open-label, randomised controlled trial of nicotine replacement therapy preloading and lapse recovery for cessation and where quitting fails, for smoking reduction in pregnancy

(Professor Tim Coleman)

Decision: Proceed to Funding Committee

 

 

19/11 HTA Researcher-led call - Primary Research

1.9

NIHR129025

WrIst Physiotherapy Interventions in Trauma (WIPIT Study)

(Associate-Professor Ben Ollivere)

Decision: Proceed to Funding Committee

1.10

NIHR128977

EDAM: Evaluating Dislocated Acromioclavicular joint Management

(Associate-Professor Rebecca Kearney)

Decision: Out of remit

1.11

NIHR129001

Post-stroke Intervention Trial in fatigue (POSITIF): a randomised controlled trial of a guided self help intervention for treating post-stroke fatigue

(Professor Gillian Mead)

Decision: Out of remit

1.12

NIHR129114

SISTAR: Outcomes of simultaneous versus staged resections for synchronous colorectal liver metastases – a randomised controlled trial

(Mr Giuseppe Fusai)

Decision: Proceed to Funding Committee

1.13

NIHR129172

A radical Steroid AVoidance trial in ANti-Neutrophil cytoplasm Antibody (ANCA) associated vasculitis (SAVANNA)

(Professor Alan Salama)

Decision: Uncompetitive

1.14

NIHR129189

Quetiapine augmentation of antidepressants for treatment resistant depression

(Professor Glyn Lewis)

Decision: Uncompetitive

1.15

NIHR129197

Children’s Ear Drops for eAR pain2 (CEDAR2): pragmatic randomised controlled trial

(Professor Alastair Hay)

Decision: Out of remit

1.16

NIHR129693

BUDSURF - Randomised controlled trial of Budesonide-Surfactant for the prevention of Chronic Lung Disease in extreme preterm infants

(Dr Mallinath Chakraborty)

Decision: Uncompetitive

1.17

NIHR129731

Maternal POsition in the second stage of labour in nulliparous Women Without EpiduRal analgeSia: a randomised controlled trial (POWWERS)

(Dr Caroline Fox)

Decision: Out of remit

1.18

NIHR129237

A randomised controlled trial of low intensity psychological treatment for depression for autistic adults

(Dr Ailsa Russell)

Decision: Uncompetitive

1.19

NIHR129385

RAPTOR: Randomised Controlled Trial of PENTOCLO in Mandibular Osteoradionecrosis

(Professor Richard Shaw)

Decision: Proceed to Funding Committee

1.20

NIHR129518

A randomised controlled trial to determine the effect and cost-effectiveness of liberal and conservative perioperative oxygen therapy on clinical outcomes following major surgery.

(Dr Daniel Martin)

Decision: Proceed to Funding Committee

1.21

NIHR129531

Long-term outcomes following breast conservation versus mastectomy in women aged 40 years or under with breast cancer stratified by BRCA status: POSH study follow-up extension

(Dr Ellen Copson)

Decision: Uncompetitive

1.22

NIHR129550

MIDAS Trial: Modifying pain using Drugs Around Surgery. A randomised, double-blind, placebo-controlled trial of ibuprofen to safely reduce pain after major gastrointestinal surgery.

(Dr Michael Gillies)

Decision: Proceed to Funding Committee

1.23

NIHR129551

CanACT2: Acceptance and Commitment Therapy versus treatment as usual for psychosocial dysfunction in people with advanced cancer; a randomised controlled trial.

(Dr Marc Serfaty)

Decision: Out of remit

1.24

NIHR129557

Evaluating the role of fast MRI and image-fusion biopsy for the detection of prostate cancer

(Professor Hashim Ahmed)

Decision: Out of remit

1.25

NIHR129564

Use of high-flow humidified oxygen TheRapy versus stAndard Care following major HEad & neck surgery: A multi-site randomIsed controlled tRial (TRACHE-AIR)

(Mr Paul Twose)

Decision: Out of remit

1.26

NIHR129580

WHiTE 12-WHISH: Wound Healing in Surgery for Hip fractures

(Professor Matthew Costa)

Decision: Uncompetitive

1.27

NIHR129589

ORBITA-2: A placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina

(Professor Darrel Francis)

Decision: Proceed to Funding Committee

1.28

NIHR129576

ENCOMPASS (MYELOMA)

EvaluatioN of COMorbidity and suPportive therApy StrategieS in MYELOMA

(Professor Gordon Cook)

Decision: Out of remit

1.29

NIHR129002

Exploring the effectiveness and cost-effectiveness of a community-based, exercise intervention with an embedded qualitative process evaluation for people with systemic sclerosis (EXCEL - SSc)

(Dr Markos Klonizakis)

Decision: Out of remit

1.30

NIHR129711

The NOTES Study: Neonatal Outcomes with Treatments for Epileptic Seizures

A randomised controlled trial of phenobarbital and levetiracetam for seizures associated with neonatal hypoxic ischaemic encephalopathy and their association with neuro-developme

(Dr Anthony Hart)

Decision: Out of remit

1.31

NIHR129592

Cervical Orthoses in the Management of FragilitY Fractures of the Odontoid Process (COMFY)

(Mr James Tomlinson)

Decision: Out of remit

1.32

NIHR129617

Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury (MOSAICC – Multicentre evaluation Of Sodium bicarbonate in Acute kidney Injury in Critical Care)

(Professor Lui Forni)

Decision: Proceed to Funding Committee

1.33

NIHR129677

MUlticentre randomised trial of Surveillance in Inflammatory Bowel Disease (IBD): a comparison of dye spray chromoendoscopy (DCE) versus dyeless virtual electronic chromoendoscopy (VCE) (MUSIc) for precise detection and outcome of colonic neoplasia in I

(Associate-Professor Marietta Iacucci)

Decision: Out of remit

1.34

NIHR129683

Full Title: A cluster randomised controlled trial of using the enhanced liver fibrosis test in primary care to identify people at risk of liver fibrosis due to alcohol use disorders. Short title: DELIVER DEtecting LIVer damage using ELF In patients at

(Professor William Rosenberg)

Decision: Out of remit

1.35

NIHR129628

LIVACOR Trial: Minimally invasive LIVer And simultaneous COlorectal Resection

(Professor Mohammed Abu Hilal)

Decision: Uncompetitive

1.36

NIHR129640

Whole-body MRI for more efficient staging of breast cancer: internal pilot to inform a prospective multicentre comparison with standard imaging pathways.

(Professor Steve Halligan)

Decision: Out of remit

1.37

NIHR129664

The Effectiveness of Peroneal Nerve Functional Electrical STimulation (FES) for the Reduction of Bradykinesia in Parkinson’s DiSease: A Pragmatic Assessor Blinded Randomised Controlled Trial (STEPS II).

(Professor Paul Taylor)

Decision: Out of remit

1.38

NIHR129668

The use of 3D-printed insoles to prevent primary diabetic foot ulcers: a feasibility study.

(Dr Panagiotis Chatzistergos)

Decision: Out of remit

1.39

NIHR129679

A pragmatic multi-centre randomised controlled trial of alcohol assertive outreach treatment for patients admitted to hospital with alcohol-related liver disease (A-LIVE)

(Professor Colin Drummond)

Decision: Out of remit

1.40

NIHR129690

Diabetes Remission Clinical Trial for South Asians: The DISHA study

(Professor Kamlesh Khunti)

Decision: Uncompetitive

1.41

NIHR129701

Evidence-based pain management pathway for people with chronic pancreatitis

(Professor Kurinchi Gurusamy)

Decision: Proceed to Funding Committee

1.42

NIHR129707

UrodynAmicS as Routine Evaluation in Women with StrEss UrinaRy InconTinence (The ASSERT Study); a superiority randomised clinical trial to evaluate the clinical and cost effectiveness of routine urodynamic investigations in management of women with stress

(Professor Mohamed Abdel-Fattah)

Decision: Proceed to Funding Committee

1.43

NIHR129710

A randomised control trial to determine the influence of metformin on the growth of large abdominal aortic aneurysms in patients without diabetes who are unsuitable for surgical intervention (MEASURE – Metformin Effect on Aneurysm Size in patients Unfi

(Professor Robert Hinchliffe)

Decision: Out of remit

1.44

NIHR129727

Improving outcomes for men undergoing Open AAA Repair using Prehabilitation

(Mr Tristan Lane)

Decision: Out of remit

1.45

NIHR129728

Impact of green tea extract on cognition and function in older adults at risk of cognitive decline and dementia: A randomised controlled trial

(Dr Anne Corbett)

Decision: Out of remit

1.46

NIHR129748

Surgeons Trial Of Prophylaxis for Epilepsy in seizure naïve patients with Meningioma: a randomised controlled trial (STOP’EM)

(Mr Michael Jenkinson)

Decision: Proceed to Funding Committee

1.47

NIHR129753

Social Prescribing for Children and Young People (Professor Barry Wright)

Decision: Out of remit

1.48

NIHR129756

TENSION (Trial EmbolisatioN IN oSteOarthritis)

(Dr Nolan Walker)

Decision: Out of remit

1.49

NIHR129718

Music Interventions for Dementia and Depression in ELderly care (MIDDEL): International cluster-randomised trial - UK arm (MIDDEL-UK)

(Professor Justine Schneider)

Decision: Proceed to Funding Committee

1.50

NIHR129079

The AVERT (Acute VErtebral fragility fractuRe augmenTation) study in hospitalised patients.

(Professor Opinder Sahota)

Decision: Out of remit

1.51

NIHR129179

PREDNOS 3: what is the optimal steroid treatment dose to induce remission in relapses of childhood nephrotic syndrome?

(Dr Martin Christian)

Decision: Proceed to Funding Committee

1.59

NIHR129750

Prostate cancer Risk Evaluation by Freehand transperineal sectoral (FHTP-24 core) versus Evaluation by Reduced (FHTP–12 core) biopsy: Randomisation for Effective Diagnosis. A randomised non-inferiority trial. Short Title: PREFERRED

(Mr Rick Popert)

Decision: Uncompetitive

 

19/10 HTA Researcher-led call - Evidence Synthesis

1.52

NIHR129305

Clinical and cost-effectiveness of early interventions initiated in the acute care period for managing the psychological effects of trauma and to reduce the incidence and duration of common mental disorders.

(Dr Philippa Olive)

Decision: Uncompetitive

1.53

NIHR129523

BEhavioural Weight Management: COMponents of Effectiveness (BE:COME)

(Dr Jennifer Logue)

Decision: Proceed to Funding Committee

1.54

NIHR129646

Evaluating diagnostic performance of imaging technologies for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment: a systematic review and meta-analysis

(Dr Huiqin Yang)

Decision: Uncompetitive

1.55

NIHR129708

Safety and effectiveness of tranexamic acid in trauma and surgery in the NHS: An individual patient data meta-analysis

(Dr Katharine Ker)

Decision: Proceed to Funding Committee

1.56

NIHR129713

Effectiveness and cost-effectiveness of gynaecological surveillance for women with Lynch syndrome: systematic reviews and economic evaluation

(Dr Tristan Snowsill)

Decision: Proceed to Funding Committee

1.57

NIHR129715

Diet and physical activity in pregnancy to prevent gestational diabetes: Individual Participant Data (IPD) meta-analysis on the differential effects of interventions with economic evaluation

(Professor Shakila Thangaratinam)

Decision: Proceed to Funding Committee

1.58

NIHR129742

Systematic Review and meta-analysis of clinical and cost effectiveness and feasibility of a UK extracorporeal cardiopulmonary resuscitation programme for out-of-hospital cardiac arrests

(Associate-Professor Joyce Yeung)

Decision: Proceed to Funding Committee

 

19/11 HTA Researcher-led call – Primary Research

1.60

NIHR129649

A multicentre randomised placebo-controlled trial of the effectiveness and cost-effectiveness of conventional vs high-frequency spinal cord stimulation in patients with neuropathic pain. CHESTNUT STUDY

(Professor Sam Eldabe)

Decision: Proceed to Funding Committee

1.61

NIHR127873

Pragmatic randomised trial of High Or Standard PHosphAte Targets in End-stage kidney disease - The PHOSPHATE trial

(Dr Thomas Hiemstra)

Decision: Proceed to Funding Committee