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HTA Remit and Competitiveness teleconference - Public minutes May 2021

Published

28 May 2021

Version

1.0 - May 2021

Contents

Friday 28 May 2021 10:00am - 1:00pm

Present Members

Professor Andrew Farmer (HTA Programme Director) (Chair)
Professor Lucy Chappell (Chair of CET Funding Committee)
Professor Julia Brown (Chair of General Funding Committee Chair)
Professor Marian Knight (Chair of Commissioning Funding Committee)
Professor Anthony De-Soyza (Chair of Prioritisation Committee B)

NETSCC Secretariat

Mrs Vicky Taylor (Assistant Director)
Mrs Karen Williams (Senior Research Manager)
Dr Jason Horsley (NETSCC Consultant Advisor)
Dr Brogan Ashley (Research Manager)
Ms Nikita Belavate (Administrator)

Observers: Professor Rupert Pearse (Deputy Chair General Funding Committee)
Ms Gail Thornton (POC PPI member)
Dr Cheryl Battersby (Deputy Chair of Prioritisation Committee B)
Professor Catherine Hewitt (Deputy Chair Commissioning)
Dr Lisa Douet (Senior Research Manager)
Dr Nicola McArdle (Assistant Research Manager)

Apologies: Associate Professor Kamal Mahtani (Chair of Prioritisation Committee A)
Dr Claire Kidgell (Assistant Director)

21/02 HTA Researcher-led call Evidence Synthesis

NIHR134658 - Identifying the effective components of weight management strategies for postpartum women: a stakeholder informed systematic review and co-designed toolkit (Dr Amanda Rodrigues Amorim Adegboye)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Marian Knight
Recommendation: Proceed to Funding Committee

21/02 HTA Researcher-led call Evidence Synthesis

NIHR134910 - Cartilage repair in the ankle. (Professor Norman Waugh)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/02 HTA Researcher-led call Evidence Synthesis

NIHR134654 - Understanding what behaviour change techniques and implementation strategies underpin effective physical activity delivery, up-take and engagement for improving mental wellbeing and depression in adolescents. (Professor Margaret Maxwell)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

21/01 HTA Researcher-led call Primary Research

NIHR134901 - DRESING trial (Dressing to Reduce EVD Sepsis in NeurosurGery) (Mr Hiren Patel)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134258 - Effectiveness and cost-effectiveness of device-delivered abdominal massage for constipation in care home residents - Constipation in care Homes: An RCT of abdominal MassagE delivered by Device (CHARMED) (Professor Suzanne Hagen)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

21/01 HTA Researcher-led call Primary Research

NIHR134676 - Improving Sleep for Care Home Residents through Sleep Scheduling: IMPRESS Trial (Professor Robert Howard)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134879 - Social Prescribing for children and young people with Anxiety and Depression (SPADE) (Professor Barry Wright)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Catherine Hewitt
Declared a conflict and left the call: None declared
Recommendation: Out of Remit and Uncompetitive

21/01 HTA Researcher-led call Primary Research

NIHR134863 - MultiModal intervention (Exercise, Anti-inflammatory & Dietary counselling) for renal cachexia (MMEAD): Cluster Randomised Controlled Trial with Internal Pilot, Process Evaluation and Economic Appraisal. (Professor Joanne Reid)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134586 - Children’s Pill School: Pharmaceutical aspects and economic evaluation (Dr Asia Rashed)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Lucy Chappell
Recommendation: Uncompetitive

21/01 HTA Researcher-led call Primary Research

NIHR134769 - Effectiveness of mailed naloxone nasal spray compared to advice to seek naloxone from usual healthcare sources to increase use of naloxone during the experience of opioid overdose symptoms among people who misuse opioids in the UK: A randomised controlled trial (Professor John Cunningham)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

21/01 HTA Researcher-led call Primary Research

NIHR134074 - Pregabalin for treatment resistant generalized anxiety disorder (Professor Glyn Lewis)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134723 - Effectiveness and cost-effectiveness of hearing aids in patients with tinnitus: a multi-centre randomised controlled trial (Dr Magdalena Sereda)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

21/01 HTA Researcher-led call Primary Research

NIHR134628 - DOes early gdM diagnosis Improve pregNancy Outcomes (DOMINO)? (Professor Rebecca Reynolds)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: Marian Knight
Recommendation: Proceed to Funding Committee

21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR134453 - Promoting equitable access to remote prehabilitation amongst a high risk cancer population (Miss Stephanie Fraser)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

21/01 HTA Researcher-led call Primary Research

NIHR134878 - Osteoarthritis Preoperative Package of care of Orthotics, Rehabilitation, Topical and oral agent Usage and Nutrition to Improve outcomes aT a Year (2) (OPPORTUNITY2) (Professor Hamish Simpson)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Julia Brown
Recommendation: Uncompetitive

21/01 HTA Researcher-led call Primary Research

NIHR134052 - RandomiseD ContRol Trial to test the Null Hypothesis that discontinuation of bEta blockade 12 months after Acute Myocardial infarction with preserved Left Ventricular function will cause no harm. DREAM LV (Professor Christopher Gale)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Julia Brown
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134290 - Tackling hospital acquired malnutrition in critically ill patients: A randomised trial of intermittent versus continuous feeding (Dr Zudin Puthucheary)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: Rupert Pearse
Recommendation: Proceed to Funding Committee

20/109 Shorter vs longer fixed-course antibiotic treatments

NIHR134582 - A multi-arm cluster and individually randomised trial to identify shorter antibiotic durations for common infections in primary care and to guide general practitioners and patients towards implementing best practice (SHORT) (Dr Victoria Palin)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR134238 - Enhancing Psychological Prehabilitation Outcomes in breast Cancer (EPPOC): a randomised single-blind phase III trial of home-based metacognitive therapy (Professor Adrian Wells)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20 21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR134417 - PRO PANC :A phase 2 study encompassing Prehabilitation, Rehabilitation and Optimisation for patients undergoing treatment for PANCreatic cancer (Mr Declan Dunne)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20/109 Shorter vs longer fixed-course antibiotic treatments

NIHR134061 - STudy of Antibiotic Treatment In Children with Protracted Bacterial Bronchitis (STATIC PBB) (Dr Francis Gilchrist)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer
Recommendation: Uncompetitive

21/01 HTA Researcher-led call Primary Research

NIHR134774 - Safety and effectiveness of Acute heart Failure carE as Out-patient: a multi-centre randomised controlled trial (SAFE) (Dr Kenneth Wong)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR134215 - A multicentre, randomised controlled trial comparing digital cognitive behavioural therapy for insomnia to sleep hygiene in newly diagnosed breast cancer patients (Dr Leanne Fleming)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Out of Remit

21/01 HTA Researcher-led call Primary Research

NIHR133874 - Clinical and cost-effectiveness of early patient-directed rehabilitation versus standard rehabilitation after surgical repair of the rotator cuff of the shoulder: a multi-centre, randomised controlled trial with integrated Quintet Recruitment Intervention (RaCeR 2) (Professor Chris Littlewood)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

20/109 Shorter vs longer fixed-course antibiotic treatments

NIHR133560 - TOPical Glycopeptides vs Usual antibiotics in Neck of femur: TOPGUN (Professor Ben Ollivere)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Andrew Farmer, Rupert Pearse
Recommendation: Proceed to Funding Committee

21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR134257 - Evaluation of PeRsOnalised PrEhabilitation in acute myeloid Leukaemia (PROPEL). (Professor Janet Dunn)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer, Julia Brown, Marian Knight
Recommendation: Proceed to Funding Committee

21/02 HTA Researcher-led call Evidence Synthesis

NIHR134771 - Does negative pressure wound therapy lead to patient benefit? A comprehensive evidence synthesis of clinical effectiveness, cost-effectiveness and the value of further research. (Dr Marta Soares)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Andrew Farmer, Catherine Hewitt
Recommendation: Uncompetitive

21/01 HTA Researcher-led call Primary Research

NIHR134641 - Study of Tendo Achilles Rupture Rehabilitation: UKSTAR2 (Professor Rebecca Kearney)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Out of Remit

21/01 HTA Researcher-led call Primary Research

NIHR134096 - Genicular Artery Embolisation for the symptomatic treatment of knee osteoarthritis refractory to conservative management (GEKO) (Professor Andrew Price)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Out of Remit

21/01 HTA Researcher-led call Primary Research

NIHR134344 - Surveillance After Resection of Oesophageal aNd Gastric cancer (SARONG) trial (Associate Professor Sheraz Markar)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

21/02 HTA Researcher-led call Evidence Synthesis

NIHR134463 - Investigating the efficacy of varenicline to aid gradual smoking cessation: a randomised controlled superiority trial (the VERSA trial) (Dr Nicola Lindson)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Andrew Farmer, Catherine Hewitt
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134681 - Distal Radius Acute Fracture Trial - CASP: Cast versus Splint (Professor Matthew Costa)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134868 - BEAT-AD: Blood biomarkers for equitable, accurate and timely Alzheimer's diagnosis (Dr Charles Marshall)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Andrew Farmer, Rupert Pearse
Recommendation: Out of Remit

21/01 HTA Researcher-led call Primary Research

NIHR134412 - Optimal timing of parenteral nutrition for very preterm babies. The OPTIMAL trial (Dr Sabita Uthaya)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer, Lucy Chappell, Marian Knight, Cheryl Battersby
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134388 - PLACES: Pharmacist-Led Asthma Cost-Effectiveness Study (Professor Andrea Manfrin)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer, Marian Knight
Recommendation: Out of Remit

21/01 HTA Researcher-led call Primary Research

NIHR134532 - Implementation of Metformin theraPy to Ease Decline of kidney function in Polycystic Kidney Disease (IMPEDE-PKD) Randomised Placebo-Controlled Trial (Dr Ragada El-Damanawi)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR134476 - A randomised controlled trial of the effects of a digital, multimodal prehabilitation intervention for improving mental wellbeing in breast cancer patients (iPrep) (Professor Andrew Turner)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer
Recommendation: Out of Remit and Uncompetitive

21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR133894 - The ENHANCE study: EvaluatiNg the role of a smartpHone App to deliver large scale prehabilitation prior to luNg Cancer surgEry (Dr William Ricketts)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Rupert Pearse
Recommendation: Out of Remit

21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR134229 - Development of Nutrition Assessment, Monitoring and Outcomes (NEMO) core dataset for use in Cancer Prehabilitation Services: Multi-methods Study (Dr Sorrel Burden)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Julia Brown
Recommendation: Out of Remit

21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR134500 - High-protein supplement prehabilitation for older breast cancer patients undergoing neo-adjuvant and adjuvant chemotherapy (The PRESERVE Trial): a feasibility study (Professor Bernard Corfe)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Anthony de-Soyza
Recommendation: Out of Remit

21/02 HTA Researcher-led call Evidence Synthesis

NIHR134086 - A systematic evidence review of the effectiveness of vector control interventions for reducing human malaria risk in the East Africa Lake Victoria Basin Riparian Countries (Dr Gabriel Owuor Dida)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

21/01 HTA Researcher-led call Primary Research

NIHR134025 - A phase III multi-centre, randomised controlled, parallel group, open-label trial of adjuvant atorvastatin versus usual care for people with oesophageal adenocarcinoma undergoing curative surgery. (Professor Andrew Hart)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

21/01 HTA Researcher-led call Primary Research

NIHR134919 - External Validation of the Risk-stratification of Emergency Department suspected Sepsis (REDS) score – EVaREDS study (Dr Narani Sivayoham)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Uncompetitive

21/01 HTA Researcher-led call Primary Research

NIHR134911 - Pupillometer Light Affect Response Study (POLAR) (Dr Terence McLoughlin)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer
Recommendation: Out of Remit

21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR133872 - Pre-opFit: Complex Needs-Based Multimodal Prehabilitation Interventions in Patients Prior to Major Elective Cancer Surgery - A Randomised Controlled Trial Assessing Clinical and Cost-Effectiveness. (Professor Sandy Jack)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer, Rupert Pearse, Julia Brown
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134839 - PRESSURE 3: Pressure ulcer prevention - early heel specific adjunct devices for heel pressure ulcer prevention in people with a fractured hip (Professor Jane Nixon)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Andrew Farmer, Julia Brown
Recommendation: Proceed to Funding Committee

20/109 Shorter vs longer fixed-course antibiotic treatments

NIHR134854 - DURATION OF ANTIBIOTIC TREATMENT IN URINARY TRACT INFECTION (DurATIon-UTI Trial) Impact of duration of antibiotic therapy on effectiveness, safety and selection of antibiotic resistance in adult women with urinary tract infections (UTI): a randomised controlled trial (Associate Professor Gail Hayward)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer, Lucy Chappell, Marian Knight
Recommendation: Proceed to Funding Committee

20/109 Shorter vs longer fixed-course antibiotic treatments

NIHR134867 - Cellulitis Optimal Antibiotic Treatment: COAT study (Professor Nick Francis)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

20/109 Shorter vs longer fixed-course antibiotic treatments

NIHR134336 - Impact of duration of intravenous antibiotic therapy on effectiveness, safety and colonisation by resistant bacteria in culture-negative neonatal sepsis (Dr Julia Bielicki)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer, Lucy Chappell, Marian Knight
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134890 - A randomised controlled trial of remote Cognitive Behavioural Therapy with a Trauma Focus versus Usual Care for women with Post-traumatic Stress Disorder following miscarriage (Professor Thomas Bourne)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Lucy Chappell, Marian Knight
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134034 - Azithromycin at Caesarean Section to prevent Maternal Infection: a Randomised Controlled Trial (Dr Victoria Hodgetts Morton)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Lucy Chappell, Marian Knight
Recommendation: Proceed to Funding Committee

21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR134537 - Comprehensive Geriatric Assessment with or without Remote Symptom Monitoring for People Living with Frailty and Metastatic Colorectal Cancer: the CAREFOR study (Dr Paul Ross)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Lucy Chappell
Recommendation: Proceed to Funding Committee

20/109 Shorter vs longer fixed-course antibiotic treatments

NIHR134534 - Cefalexin for UTIs – Right treatment Length in Young children (the CURLY trial). A multi-centre, pragmatic, randomised trial to determine the optimal duration of cefalexin therapy for the treatment of febrile urinary tract infections in children. (Dr Stuart Hartshorn)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Lucy Chappell
Recommendation: Proceed to Funding Committee

21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR133932 - PREhabilitation - a combined Exercise and Nutrition programme for Head and Neck Cancer patients treated with (chemo)radiotherapy (PRE-ENHANCE) (Professor Joanne Patterson)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR134386 - Could it be Magic? A 2-component prehabilitation programme to optimise outcomes in older adults undergoing elective intra-abdominal cancer surgery. (Professor Susan Moug)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/46 HTA Prehabilitation: Living with and beyond cancer

NIHR134214 - Fit4Surgery 2: A randomised controlled trial to investigate an App-based, motivation-theory grounded, personalised, comprehensive, prehabilitation programme versus usual care to enhance recovery of physical function and reduce complications after lung cancer surgery (Dr Babu Naidu)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134431 - Radioactive Iodine: Long-Term Safety and Cost-Effectiveness for the Treatment of Hyperthyroidism (Dr Diarmuid Coughlan)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Anthony de-Soyza
Recommendation: Proceed to Funding Committee

20/109 Shorter vs longer fixed-course antibiotic treatments

NIHR134101 - A randomised controlled trial of SHORT duration antibiotic thERapy for critically ill patients with sepsis: SHORTER Trial (Dr Thomas Hellyer)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Anthony de-Soyza
Recommendation: Proceed to Funding Committee

20/109 Shorter vs longer fixed-course antibiotic treatments

NIHR133876 - Seven versus Fourteen Days Antibiotics for Patients with Bronchiectasis Requiring Intravenous Antibiotics- SBIVA Study (Professor Adam Hill)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Anthony de-Soyza
Recommendation: Proceed to Funding Committee

20/109 Shorter vs longer fixed-course antibiotic treatments

NIHR133875 - SHorter vs Longer CoUrse AnTibiotics – an AdaptivE BaYEsian Design Study (SHUTEYE) (Honorary Professor Tony Whitehouse)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/02 HTA Researcher-led call Evidence Synthesis

NIHR134660 - Randomised Evaluation of Sodium Dialysate Levels on Vascular Events (RESOLVE). (Professor David Wheeler)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/02 HTA Researcher-led call Evidence Synthesis

NIHR134472 - Ultrasound and magnetic resonance imaging for hepatocellular cancer surveillance in the UK (Associate Professor James Franklin)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/02 HTA Researcher-led call Evidence Synthesis

NIHR134670 - The benefits, harms and costs of surveillance for hepatocellular carcinoma in people with cirrhosis: synthesis of observational and diagnostic test accuracy data and cost–utility analysis (Mr Gabriel Rogers)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/02 HTA Researcher-led call Evidence Synthesis

NIHR134862 - Physical rehabilitation for older people in care homes: a systematic review and network meta-analysis (Dr Thomas Crocker)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Julia Brown
Recommendation: Proceed to Funding Committee

21/02 HTA Researcher-led call Evidence Synthesis

NIHR134407 - An evidence synthesis of interventions to prevent maternal suicidality in women during the perinatal period: a systematic review, meta-analysis and meta-synthesis of quantitative and qualitative studies evaluating their clinical effectiveness, the cost-effectiveness, safety and acceptability (Dr Anja Wittkowski)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/02 HTA Researcher-led call Evidence Synthesis

NIHR134786 - The effectiveness of antibiotic therapies for pelvic inflammatory disease: a systematic review, core outcome set development and network meta-analysis (Dr Ruaraidh Hill)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134379 - A randomised controlled trial assessing the clinical and cost effectiveness of compression HOSiery to Treat varicose vein Symptoms - the HOSTS study (Professor Alun Davies)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134746 - Perineural Local Anaesthetic Catheter aftEr Major lowEr limb amputatioN Trial (PLACEMENT) (Mr David Bosanquet)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR133889 - Palliative Long-term Abdominal Drains Versus Repeated Drainage in Untreatable Ascites Due to Advanced Cirrhosis: A Randomised Controlled Trial (Professor Sumita Verma)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134574 - PREDNOS3: What is the optimal steroid treatment dose to treat relapses of childhood nephrotic syndrome? (Dr Martin Christian)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134886 - Early versus Later AntiPlatelet uSE after Chronic Subdural Haematoma (ELAPSE-CSDH) (Mr Paul Brennan)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134248 - RecommenD iT: a randomised trial on timing of Recommencement of Direct oral anticoagulants in Traumatic intracranial haemorrhage. (Miss Catherine McMahon)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR134593 - Study of technologies for the diagnosis of angle closure glaucoma (ACE) (Professor Augusto Azuara-Blanco)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

21/01 HTA Researcher-led call Primary Research

NIHR133797 - A randomised trial to compare the effectiveness of Gardasil-9 HPV vaccine versus no additional therapy in PREVENTing recurrence in patients with eradicated high-grade anogenital intraepithelial neoplasia (the PREVENT trial) (Dr Sadie Jones)

Chair: Not discussed
Declared a conflict, remained in the teleconference: Not applicable
Declared a conflict and left the call: Not applicable
Return to CET Committee

21/01 HTA Researcher-led call Primary Research

NIHR133774 - Optimising Prescription of Treatment In older patients with Mild hypertension at Increased risk of Serious adverse Events (OPTIMISE2): a non-inferiority trial (Professor Richard McManus)

Chair: Not discussed
Declared a conflict, remained in the teleconference: Not applicable
Declared a conflict and left the call: Not applicable
Return to CET Committee

20/90 HTA Researcher-led call Primary Research

NIHR133611 - Inpatient graduated compression stocking use as an adjunct to extended duration pharmacoprophylaxis for venous thromboembolism prevention – a multi-centre randomised controlled trial (Professor Alun Davies)

Chair: Not discussed
Declared a conflict, remained in the teleconference: Not applicable
Declared a conflict and left the call: Not applicable
Return to General Committee


Summary