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HTA Remit and Competitiveness teleconference - Public minutes September 2019

 

Contents

NIHR HTA Remit and Competitiveness Teleconference

 

Minutes of the September 2019 Meeting

 

Minutes

Meeting:

HTA Remit and Competitiveness Teleconference for NETS3 HTA Tobacco Cessation, control and harm reduction interventions Call, HTA Researcher-Led Primary Research and Evidence Synthesis Applications from the September 2019 Call Close

Date and time:

Monday 30 September 2019 2-5 pm

Place:

Haygarth room, Beta House

 

 

Present Members

 

 

 

Professor Steve Goodacre (Chair) (HTA Deputy Programme Director)

Professor Hywel Williams (HTA Programme Director)

Professor Lucy Chappell (Chair of CET Funding Committee)

Professor John Norrie (Deputy Chair of HTA General Funding Committee)

Professor Andrew Bradbury (Chair of Prioritisation Committee B)

Dr Victoria Tzortziou Brown (Prioritisation Committee A, Joint Deputy Chair)

Dr Ira Madan (Chair of Prioritisation Committee C)

 

 

NETSCC Secretariat

 

 

 

 

Dr Martin Ashton-Key (Consultant Advisor)

Mrs Karen Williams (Senior Research Manager)

Dr Cristina Lujan Barroso (Research Manager)

Miss Louise Maclachlan (Research Manager)

Ms Maria Oosterwijk (Administrator)

 

Observers

None

Apologies

Professor Andrew Farmer, Associate Professor Kamal Mahtani, Professor David Sebag-Montefiore, Dr Simon Fraser

 

 

 

 


 

 

19/59 HTA Researcher-led call Primary Research

1

19/59 HTA Researcher-led call Primary Research

NIHR130057 - Creating an efficient and supportive IVF environment by using digital technology with MEDIcation Timeline and EMOtional Support (MediEmo)

Professor Ying Cheong

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: Martin Ashton-Key

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

2

19/59 HTA Researcher-led call Primary Research

NIHR130561 - Maintaining Independence in People with Dementia who have had a fall: a cluster randomised controlled trial (the Maintain study)

Professor Louise Allan

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: Hywel Williams

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

3

19/59 HTA Researcher-led call Primary Research

NIHR130423 - Cognitive Behaviour therapy for the prevention of suicide attempts among young people (GRADY): A feasibility study.

Dr Maria Michail

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: Andrew Bradbury

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

4

19/59 HTA Researcher-led call Primary Research

NIHR129809 - Digital CONtraCEption Provision and supporT integrated with usual care compared with usual care alone: a randomised controlled trial of the effects on unplanned pregnancy among sexually active women aged 16-44 in the UK (D-CONCEPT: 24 trial)

Professor Caroline Free

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

5

19/59 HTA Researcher-led call Primary Research

NIHR130183 - SYNAPSE: SYNbiotic to Avert Preterm SEpsis

Professor Paul Heath

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

6

19/59 HTA Researcher-led call Primary Research

NIHR130468 - A pilot randomised controlled trial of an intervention to address unhealthy alcohol consumption among people with poorly controlled hypertension in primary care (Alc-HyP)

Dr Duncan Stewart

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Uncompetitive

7

19/59 HTA Researcher-led call Primary Research

NIHR130489 - Tranexamic acid for women with antepartum bleeding: a UK feasibility study

Professor Ian Roberts

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

8

19/58 HTA Researcher-led call Evidence Synthesis

NIHR130437 - Mixed method systematic review to identify the most effective and helpful components of early intervention programmes aimed at promoting parent-child interaction from conception to 5 years

Professor Jane Barlow

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

9

19/60 HTA Tobacco Cessation, Control and Harm Reduction Interventions

NIHR130528 - The effectiveness of e-cigarettes for tobacco smoking cessation and harm reduction in (treated) opiate use disorder: a randomized controlled trial

Professor Tim Millar

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Uncompetitive

10

19/59 HTA Researcher-led call Primary Research

NIHR130067 - Early Lung Cancer Identification and Diagnosis study 2 (ELCID2): Clinical and cost-effectiveness of Low Dose Computed Tomography for the assessment of primary care patients with symptoms of possible lung cancer

Professor Richard Neal

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Uncompetitive

11

19/59 HTA Researcher-led call Primary Research

NIHR130347 - Treatment of cardiovascular disease with low dose Rivaroxaban in Advanced Chronic Kidney Disease (TRACK)

Professor Patrick Mark

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

12

19/59 HTA Researcher-led call Primary Research

NIHR130487 - A randomised controlled trial of a facilitated home-based rehabilitation intervention in patients with heart failure with preserved ejection fraction and their caregivers: the REACH-HFpEF Study

Professor Rod Taylor

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

13

19/59 HTA Researcher-led call Primary Research

NIHR130509 - EVIDENCE EValuatIng DiurEtics in Normal CarE: - a cluster randomised study of prescribing policy for thiazide-type drugs used for primary hypertension

Dr Alexander Doney

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

14

19/59 HTA Researcher-led call Primary Research

NIHR130605 - The clinical effect and cost-effectiveness of oral anticoagulants for reducing risk of thromboembolic events in patients receiving neoadjuvant chemotherapy for Muscle invasive bladder cancer

Professor Syed Hussain

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: Steve Goodacre

 

Recommendation: Out of Remit

15

19/58 HTA Researcher-led call Evidence Synthesis

NIHR130625 - Individual participant data meta-analysis of randomised controlled trials comparing elective freezing of embryos followed by thawed frozen embryo transfer versus fresh embryo transfer in in-vitro fertilisation (INFORM)

Professor Abha Maheshwari

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: John Norrie

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

16

19/60 HTA Tobacco Cessation, Control and Harm Reduction Interventions

NIHR129780 - The ENHANCE-D Study – ENHANCing smoking cEssation interventions in Dentistry

Dr Richard Holliday

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: John Norrie

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

17

19/60 HTA Tobacco Cessation, Control and Harm Reduction Interventions

NIHR130218 - RAndomised controlled trial of TobaCco Harm rEducTion for people with serious mental illness (RATCHET)

Dr Paul Aveyard

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

18

19/59 HTA Researcher-led call Primary Research

NIHR130445 - UK Asymptomatic Mitral Regurgitation Study (UK-AdMiRe)

Associate-Professor Saul Myerson

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: Steve Goodacre

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

19

19/59 HTA Researcher-led call Primary Research

NIHR130614 - The Efficacy Of Prolotherapy Injections For Chronic Sacroiliac Pain – A Randomised Controlled Trial (PROSIP)

Dr Catherine Price

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: Victoria Tzortziou Brown, Martin Ashton-Key

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

20

19/59 HTA Researcher-led call Primary Research

NIHR130500 - Clinical Performance Evaluation and Cost Effectiveness of Volumetric Absorptive Microsampling and Conventional Sampling for Tacrolimus Monitoring in Kidney Transplant Recipients.

Dr Joyce Popoola

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: Victoria Tzortziou Brown

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

21

19/60 HTA Tobacco Cessation, Control and Harm Reduction Interventions

NIHR129865 - A randomised controlled trial to study the effectiveness of sMoking cessation in the sURgical pathway befoRe mAjor lung sugerY. Project MURRAY

Dr Babu Naidu

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: Andrew Bradbury

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

22

19/60 HTA Tobacco Cessation, Control and Harm Reduction Interventions

NIHR130552 - Smoking cessation in pregnancy: A randomised controlled trial comparing carbon monoxide self-monitoring with standard care in pregnant smokers. Working title = COMPASS Trial: Carbon mOnoxide Monitoring – Personal Smokefree Surveillance

Dr Helen Baston

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: Steve Goodacre, John Norrie

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

23

19/59 HTA Researcher-led call Primary Research

NIHR130062 - Vaginal Laser treatment for Genitourinary Syndrome following Breast Cancer: double blinded, parallel group, placebo controlled randomised trial. (VALIANT: VAginal Laser In women After breast Neoplasia Treatment)

Ms Swati Jha

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: Steve Goodacre, John Norrie

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

24

19/59 HTA Researcher-led call Primary Research

NIHR129900 - Effectiveness of Modified Pilates as an adjunct to standard physiotherapy care for urinary incontinence in women: a randomised controlled trial

Professor Joanna Jackson

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

25

19/59 HTA Researcher-led call Primary Research

NIHR130373 - Pragmatic effectiveness randomised controlled trial of modular, motion-assisted memory desensitisation and reconsolidation (3MDR) versus usual care for treatment-resistant post-traumatic stress disorder.

Professor Jonathan Bisson

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

26

19/59 HTA Researcher-led call Primary Research

NIHR130463 - Lancashire Teaching Hospitals NHS Foundation Trust

Dr Elizabeth Lightbody

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

27

19/59 HTA Researcher-led call Primary Research

NIHR130511 - SUPER Trial. SUper mini vs Pcnl for the Eradication of Renal stones. Multi-centre randomised controlled trial comparing standard with super-mini percutaneous nephrolithotomy for the treatment of kidney stones

Mr Simon Choong

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

28

19/59 HTA Researcher-led call Primary Research

NIHR130512 - Real-world implementation of online self-management and peer support for youth with arthritis: evaluation of feasibility, sustainability and cost-effectiveness.

Dr Line Caes

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

29

19/59 HTA Researcher-led call Primary Research

NIHR130594 - ElastoMeric infusion Pumps for Hospital AntibioTICs (EMPHATIC)

Dr Jonathan Sandoe

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

30

19/58 HTA Researcher-led call Evidence Synthesis

NIHR130415 - The health economics of the implementation of new technology in knee surgery: an analysis of the Stryker Mako Robotic Assisted UKA system in the context of public healthcare. Project to be carried out as work towards MD.

Mr Patrick Reynolds

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

31

19/58 HTA Researcher-led call Evidence Synthesis

NIHR130615 - Promoting mental health in schools -- what works and does not work in school-based intervention

Professor Matthias Schwannauer

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: John Norrie

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit and Uncompetitive

32

19/60 HTA Tobacco Cessation, Control and Harm Reduction Interventions

NIHR130559 - Smoking cessation interventions in pregnant women and their predicted long-term health and economic impact in the UK: A systematic review with network meta-analysis and simulation modelling.

Dr Laura Webber

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: Hywel Williams

 

Recommendation: Proceed to Funding Committee

33

19/59 HTA Researcher-led call Primary Research

NIHR129917 - Tranexamic acid for hyper acute spontaneous intracerebral haemorrhage TICH-3

Professor Nikola Sprigg

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: John Norrie

Declared a conflict and left the call: Hywel Williams

 

Recommendation: Proceed to Funding Committee

34

19/59 HTA Researcher-led call Primary Research

NIHR129926 - Best systemic treatments for adults with atopic eczema over the long term (BEACON): A randomised, double blind trial comparing ciclosporin, methotrexate and dupilumab

Professor Catherine Smith

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: Ira Madan, John Norrie

Declared a conflict and left the call: Hywel Williams

 

Recommendation: Proceed to Funding Committee

35

19/59 HTA Researcher-led call Primary Research

NIHR129789 - COLP Study - Cold coagulation or LLETZ Pre-term birth and miscarriage study

Dr Martyn Underwood

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: Andrew Bradbury

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

36

19/59 HTA Researcher-led call Primary Research

NIHR130632 - ERASER TRIAL: Early Rib Analgesia with Serratus. A Pragmatic Randomised Control Trial evaluating the clinical and cost-effectiveness of Serratus Anterior Plane Block with catheter insertion compared to Usual Care in patients with multiple rib fractures.

Dr Tonny Veenith

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: Andrew Bradbury

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

37

19/59 HTA Researcher-led call Primary Research

NIHR129820 - What is the clinical-effectiveness and cost-effectiveness of surgery with medial opening wedge high tibial osteotomy (HTO) compared with non-surgical treatment in the management of osteoarthritis (OA) of the knee in patients younger than 60 years? (MOTION

Mr Anish Amin

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: John Norrie

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

38

19/59 HTA Researcher-led call Primary Research

NIHR130092 - Randomised Controlled Trial on Effectiveness of Medication to Manage Sexual Preoccupation in Adult Male Prisoners Convicted of Sexual Offences (TEMMPASO)

Dr Artemis Igoumenou

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

39

19/59 HTA Researcher-led call Primary Research

NIHR130507 - Best practice in preterm nutritional care: A randomised controlled two-by-two factorial trial of timing of commencement of parenteral nutrition after birth and routine fortification of breast milk in very preterm babies. The SPRUCE trial.

Dr Sabita Uthaya

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: John Norrie

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

40

19/59 HTA Researcher-led call Primary Research

NIHR130593 - Controlled trial of High-risk percutaneous coronary Intervention with Percutaneous left ventricular unloading (CHIP)

Professor Divaka Perera

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

41

19/59 HTA Researcher-led call Primary Research

NIHR129972 - Randomised trial of clinical and cost effectiveness of Administration of Prehospital fascia Iliaca compartment block for emergency Pre-Hospital hip fracture care Delivery (RAPID 2)

Professor Helen Snooks

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: Steve Goodacre

 

Recommendation: Proceed to Funding Committee

42

19/58 HTA Researcher-led call Evidence Synthesis

NIHR130464 - Cow's milk protein allergy: evaluating the accuracy, effectiveness and cost-effectiveness of tests and strategies to aid the diagnostic process

Dr Jaime Peters

 

Chair: Steve Goodacre

Declared a conflict and remained in the teleconference: None declared

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

43

19/59 HTA Researcher-led call Primary Research

NIHR130585 - DEtecting LIVer Damage using the ELF test in patients at Risk of alcohol related liver disease (DELIVER)

Professor William Rosenberg

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: Steve Goodacre

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

44

19/59 HTA Researcher-led call Primary Research

NIHR130633 - Surgery for endometrioma: SEnd

Professor Abha Maheshwari

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: John Norrie

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

45

19/60 HTA Tobacco Cessation, Control and Harm Reduction Interventions

NIHR129438 - Smoking cessation in the Emergency Department: a randomised controlled trial

Dr Ian Pope

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: Steve Goodacre

Declared a conflict and left the call: John Norrie

 

Recommendation: Proceed to Funding Committee

46

19/60 HTA Tobacco Cessation, Control and Harm Reduction Interventions

NIHR129735 - Health effects of short-term and long-term use of e-cigarettes

Professor Peter Hajek

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: Victoria Tzortziou Brown

Declared a conflict and left the call: None declared

 

Recommendation: Proceed to Funding Committee

47

19/59 HTA Researcher-led call Primary Research

NIHR130533 - A randomised controlled trial assessing the clinical and cost effectiveness of the modified ketogenic diet for adults with treatment refractory epilepsy (KESTREL)

Professor Anthony Marson

 

Chair: Hywel Williams

Declared a conflict and remained in the teleconference: Steve Goodacre

Declared a conflict and left the call: None declared

 

Recommendation: Out of Remit

 

Summing up