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NIHR Clinical Trials Unit Standing Advisory Committee - Public Minutes June 2019

 

Contents

Meeting

NIHR Clinical Trials Unit Standing Advisory Committee

Date and time 

Thursday 27 June 2019, 10:30 – 16:30

Members present

Professor Steve Goodacre (SG), University of Sheffield (Chair) 
Professor Cindy Cooper (CC), University of Sheffield
Professor Jane Daniels (JD), University of Nottingham
Professor Monica Busse (MB), University of Cardiff Professor
Professor Ann Marie Swart (AMS), University of East Anglia
Professor Jonathan Mant (JM), University of Cambridge
Professor John Norrie (JN), University of Edinburgh

NETSCC

Ms Helen Buxton, Research Manager (minutes) 
Ms Kate Fenton, Senior Research Manager
Ms Sally Hickman, Assistant Research Manager

Apologies

Professor Sandra Eldridge, Barts & The London School of Medicine & Dentistry
Professor Sue Pavitt, University of Leeds
Mr Mike Batley, Department of Health and Social Care 
Ms Lynn Kerridge, NETSCC

Item 5

Funding opportunity to support efficient / innovative delivery of NIHR research – Variable Funding 2019

Application 1            

Birmingham CTU: Development of Guidance for Statistical Analysis Plans for Early Phase Clinical Trials
SG chaired the discussion.

Recommendation: Fund                                 

Application  2

Cambridge CTU: Patient Involvement through a Novel Patient Led Research Initiative
JM left the room. SG chaired the discussion. 

Recommendation: Declined

Application 3     

Keele CTU: Supporting Effective and Efficient Initiation and Delivery of Individual Participant Data Meta-analyses (SEED: IPD Meta-analysis)
SG chaired the discussion. 

Recommendation: Fund

Application 4

Leicester CTU: In silico trials of surgical interventions: Methods for using routinely collected data to model trial feasibility and design efficient in vivo RCTs
SG chaired the discussion. 

Recommendation: Declined

Application 5

Liverpool CTC (1): Implementing CDSIC standards into CTUs to increase efficiency and allow for improvements for data sharing
SG chaired the discussion. 

Recommendation: Fund

Application 6

Liverpool CTC (2): Trial Activity Attributions and costs in Clinical Trials Units
SG chaired the discussion. 

Recommendation: fund

Application 7

LSHTM CTU: Enabling greater efficiencies for clinical trials by appropriately designed, conducted, analysed and reported factorial trials: development of CONSORT guidance for factorial trials
SG chaired the discussion. 

Recommendation: The project is not suitable for funding - decline.

Application 8

Manchester CTU: REDCap Cloud adoption and implementation toolkit
SG chaired the discussion. 

Recommendation: The project is suitable for funding - fund.

Application 9

Newcastle CTU: Costing Adaptive Trials (CAT): developing best practice costing guidance for CTUs supporting adaptive trials
JN chaired the discussion. 

Recommendation: The project is suitable for funding - fund.

Application 10

Nottingham CTU: Improving the design, conduct and management of test evaluation trials.
JD left the room. SG chaired the discussion. 

Recommendation: The project is not suitable for funding - decline.

Application 11

OCTRU: Reducing missing data in trials (ReMIT)
SG chaired the discussion. 

Recommendation: The project is not suitable for funding - decline.

Application 12

Sheffield CTRU: Value-based Adaptive Clinical Trial Designs for Efficient Delivery of NIHR Research
SG and CC left the room. JN chaired the discussion. 

Recommendation: The project is suitable for funding - fund.

Application 13

Southampton CTU: Presenting the evidence about digital tools for improving RCT recruitment and retention in online training packages to increase their uptake and the evidence base
SG chaired the discussion.  

Recommendation: The project is suitable for funding - fund.

Application 14

Warwick CTU (1): Developing efficient and risk adapted approaches to clinical trial closedown processes
SG chaired the discussion. 

Recommendation: The project is not suitable for funding - decline.

Application 15

Warwick CTU (2): On-line training to prepare Patients and the Public for Working with Research Teams in Clinical Trials
SG chaired the discussion. 

Recommendation: The project is not suitable for funding - decline.

Application 16

Warwick CTU (3): Case Report Form (CRF) standardisation project
SG chaired the discussion. 

Recommendation: The project is not suitable for funding - decline.