Date
Tuesday 07 July (Day 1)
Place
Virtual Meeting held via Microsoft Teams
Present Members
Professor Lucy Chappell
Professor Julia Brown
Professor Hywel Williams
Professor Andrew Farmer
Ms Gail Thornton
Mrs Deborah Keatley
Professor William Hollingworth
Professor Daniel Lasserson
Associate Professor Rebecca Kearney
Dr Susan Jowett
Dr David Ekers
Dr Kate Brown
Professor Richard Emsley
Professor Daniel Prieto-Alhambra
Dr Kathryn Radford
Professor Alan Montgomery
Professor Thomas Pinkney
Professor Charlotte Coles
Professor Sally Hopewell
Professor Kapil Sayal
Dr Daniel Hind
Professor Alun Davies
Professor Jonathan Rees
Professor David Weller
Professor James Wason
Dr Jennifer Logue
Professor Sharon Simpson
Dr Elena Pizzo
Ms Jo Haviland
NETSCC, HTA Secretariat
Dr Jason Horsley (Consultant Advisor, NETSCC)
Steph Garfield-Birkbeck (Head of the HTA Programme Secretariat) PM only
Mrs Karen Williams (Senior Research Manager)
Dr Brogan Ashley (Research Manager)
Miss Constance Temple-Brown (Assistant Research Manager)
Mrs Debbie Carter (Administrator)
Observers
Dr Julie McCaroll – NI Devolved Administration Rep
Apologies
Dr Natalie Blencowe
Day 1
Researcher-led Stage 2 Proposals
19/102 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Associate Professor Sally Hopewell, Professor Andrew Farmer, Professor Daniel Prieto-Alhambra, Professor Jonathan Rees
Declared a conflict and left the call: None
NIHR130886: Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma (MelMarT-II) ClinicalTrials.gov Identifier: NCT03860883 (Professor Marc Moncrieff, Norfolk and Norwich University Hospitals NHS Foundation Trust)
Funding Committee recommendation: Resubmission at Stage 2
19/102 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Dr Kathryn Radford, Professor Alan Montgomery, Professor Daniel Lasserson, Professor Kapil Sayal, Professor Thomas Pinkney
Declared a conflict and left the call: Professor Hywel Williams, Dr Susan Jowett
NIHR130689: The Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial: a single-blind, randomized controlled trial of metoclopramide for the prevention of pneumonia in patients with dysphagia after an acute stroke (Professor Christine Roffe, University Hospitals of North Midlands NHS Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/102 HTA Researcher-led call Primary Research
Chair: Professor Julia Brown
Declared a conflict and did not partake in the discussion or vote: Professor Andrew Farmer, Professor Daniel Hind
Declared a conflict and left the call: None
Arrived/left meeting: Rebecca Kearney and Jo Haviland left at 10.49. Jo Haviland back at 10.51, Rebecca Kearney back at 10.57
NIHR130848: CiproPAL (Ciprofloxacin Prophylaxis in Acute Leukaemia): A randomised trial to assess the use of ciprofloxacin prophylaxis to prevent bacterial infection in children treated on the induction phase of the ALLTogether-1 treatment protocol (Dr Robert Phillips, The University of York)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/11 HTA Researcher-led call Primary Research
Chair: Professor Julia Brown
Declared a conflict and did not partake in the discussion or vote: Dr Katherine Brown, Professor Lucy Chappell
Declared a conflict and left the call: Professor Hywel Williams
NIHR129617: Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury(MOSAICC – Multicentre evaluation Of Sodium bicarbonate in Acute kidney Injury in Critical Care) (Professor Lui Forni, University of Surrey)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/102 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Professor Daniel Hind, Professor Thomas Pinkney
Declared a conflict and left the call: Professor Hywel Williams
NIHR131346: CONservative TReatment of Appendicitis in Children – a randomised controlled Trial – CONTRACT 2 (Associate Professor Nigel Hall, University of Southampton)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/102 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Professor Alan Montgomery, Professor Alun Davies, Professor Daniel Hind, Professor James Wason
Declared a conflict and left the call: None
NIHR130993: The clinical and cost-effectiveness of biparametric MRI compared to multi-parametric MRI in detecting clinically significant prostate cancer (Professor Hashim Ahmed, Imperial College London)
Funding Committee recommendation: Decline
19/102 HTA Researcher-led call Primary Research
Chair: Professor Julia Brown
Declared a conflict and did not partake in the discussion or vote: Dr Elena Pizzo, Professor Alun Davies, Professor Lucy Chappell
Declared a conflict and left the call: None
NIHR131107: CONVOLUTE: A randomised open-label phase III trial of reduced pembrolizumab immunotherapy dose intensity for first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) utilising a novel multi-arm frequency-response optimisation design. (Professor Michael Seckl, Imperial College London)
Funding Committee recommendation: Decline
19/102 HTA Researcher-led call Primary Research
Chair: Professor Julia Brown
Declared a conflict and did not partake in the discussion or vote: Associate Professor Rebecca Kearney, Dr Jennifer Logue, Professor Lucy Chappell, Professor Sharon Simpson, Professor William Hollingworth
Declared a conflict and left the call: None
NIHR131352: A Randomised Placebo-Controlled Trial of Antenatal Corticosteroids for Planned Birth in Twins: STOPPIT-3 (Dr Sarah Stock, The University of Edinburgh)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/102 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Dr Elena Pizzo, Professor James Wason
Declared a conflict and left the call: None
Arrived/left meeting: Daniel Lasserson left at 14.23
NIHR131339: The COSI study: a multi-site RCT to explore the clinical and cost effectiveness of the Circle of Security Intervention for mothers in perinatal mental health services (Professor Peter Fonagy, Anna Freud Centre)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/102 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Dr Elena Pizzo, Dr Katherine Brown
Declared a conflict and left the call: None
NIHR131341: Cluster Randomised Controlled Trial of a Service to Support the Mental Health and Coping of Parents with Excessively Crying Infants (Professor Jayne Brown, De Montfort University)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/102 HTA Researcher-led call Primary Research
Chair: Professor Julia Brown
Declared a conflict and did not partake in the discussion or vote: Associate Professor Sally Hopewell, Professor Andrew Farmer, Professor Daniel Prieto-Alhambra, Professor Jonathan Rees
Declared a conflict and left the call: None
Arrived/left meeting: Julie McCaroll left at 3pm
NIHR131233: A randomised controlled trial of TRANSrectal biopsy versus Local Anaesthetic Transperineal biopsy Evaluation (TRANSLATE) of potential clinically significant prostate cancer. (Associate Professor Richard Bryant, University of Oxford)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/102 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Dr Kathryn Radford, Professor Daniel Lasserson, Professor Jonathan Rees, Professor Thomas Pinkney, Professor William Hollingworth, Professor Kapil Sayal
Declared a conflict and left the call: Professor Hywel Williams
NIHR130906: MULTI-CENTRE TRIAL OF HOME ENTERAL NUTRITION VERSUS USUAL CARE AFTER OESOPHAGECTOMY FOR CANCER (MONACO) (Professor David Bowrey, University Hospitals of Leicester NHS Trust)
Funding Committee recommendation: Decline
Commissioning Stage 2 Applications
19/71 OCT-angiography for the detection of neovascular age-related macular degeneration
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Dr Jennifer Logue, Dr Susan Jowett, Professor Daniel Lasserson, Professor James Wason, Professor Thomas Pinkney
Declared a conflict and left the call: None
Arrived/left meeting: David Ekers left at 15.35
NIHR131432: OpticAl Coherence TomograpHy Angiography for the dEtection of Neovascular Age-related Macular Degeneration: a Comprehensive Diagnostic Accuracy Study - the ATHENA study (Dr Konstantinos Balaskas, Moorfields Eye Hospital NHS Foundation Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
Day 2
Tuesday 08 July
Present Members
Professor Lucy Chappell
Professor Julia Brown
Professor Hywel Williams
Professor Andrew Farmer
Ms Gail Thornton
Mrs Deborah Keatley
Professor William Hollingworth
Professor Daniel Lasserson
Dr Susan Jowett
Dr David Ekers
Dr Kate Brown
Professor Richard Emsley
Professor Daniel Prieto-Alhambra
Dr Kathryn Radford
Professor Alan Montgomery
Professor Thomas Pinkney
Professor Charlotte Coles
Professor Sally Hopewell
Professor Kapil Sayal
Dr Daniel Hind
Professor Alun Davies
Professor Jonathan Rees
Professor David Weller
Professor James Wason
Dr Jennifer Logue
Professor Sharon Simpson
Dr Elena Pizzo
Ms Jo Haviland
NETSCC, HTA Secretariat
Dr Jason Horsley (Consultant Advisor, NETSCC)
Steph Garfield-Birkbeck (Head of the HTA Programme Secretariat) PM only
Mrs Karen Williams (Senior Research Manager)
Dr Brogan Ashley (Research Manager)
Miss Constance Temple-Brown (Assistant Research Manager)
Mrs Debbie Carter (Administrator)
Apologies
Dr Natalie Blencowe
Associate Professor Rebecca Kearney
Day 2
Researcher-Led Stage 1 applications received from May 2020 Call Close
19/160 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Dr Kathryn Radford, Professor Alan Montgomery, Professor Daniel Hind
Declared a conflict and left the call: Professor Hywel Williams
Arrived/left meeting: David Ekers arrived at 09.18
NIHR131443: A randomised controlled trial, with an embedded process evaluation, assessing the effectiveness and cost-effectiveness of supervised exercise as an adjunct therapy to compression in adult patients with venous leg ulcers (RECEESE - VLUs). (Dr Markos Klonizakis, Sheffield Hallam University)
Funding Committee recommendation: Decline
19/160 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Dr Susan Jowett, Professor Daniel Lasserson, Professor Thomas Pinkney
Declared a conflict and left the call: None
Arrived/left meeting: Katherine Brown arrived at 09:27
NIHR131699: A randomised controlled trial to investigate the effectiveness of a nutritional intervention to enhance patient recovery after elective major lung surgery- ThIRSTY-2 (Mr Babu Naidu, University of Birmingham)
Funding Committee recommendation: Decline
19/160 HTA Researcher-led call Primary Research
Chair: Professor Julia Brown
Declared a conflict and did not partake in the discussion or vote: Dr Kathryn Radford, Dr Susan Jowett, Professor Alan Montgomery, Professor Andrew Farmer, Professor Kapil Sayal, Professor Lucy Chappell
Declared a conflict and left the call: Professor Hywel Williams
NIHR131837: The clinical and cost-effectiveness of a neonatal sepsis calculator (neoGBS) (Professor Jane Daniels, The University of Nottingham)
Funding Committee recommendation: Shortlist
19/160 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: None
Declared a conflict and left the call: None
NIHR131870: A multicentre randomised pragmatic trial to evaluate the effectiveness of MT in improving the quality of life of palliative care patients, and the impact on those close to them. (Professor Sam Porter, Bournemouth University)
Funding Committee recommendation: Shortlist
19/160 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Associate Professor Sally Hopewell, Dr Jennifer Logue, Professor Jonathan Rees, Professor Daniel Prieto-Alhambra
Declared a conflict and left the call: None
NIHR131407: Robotic Arthroplasty: a Clinical and cost Effectiveness Randomised controlled trial for Hips (RACER-HIP) (Mr Peter Wall, University of Warwick)
Funding Committee recommendation: Shortlist
19/160 HTA Researcher-led call Primary Research
Chair: Professor Julia Brown
Declared a conflict and did not partake in the discussion or vote: Dr Kathryn Radford, Dr Susan Jowett, Professor Alan Montgomery, Professor Andrew Farmer, Professor Daniel Lasserson, Professor Lucy Chappell, Professor Thomas Pinkney
Declared a conflict and left the call: Professor Hywel Williams
Arrived/left meeting: Professor Hywel Williams left the meeting at 10:46,
NIHR131876: Chemoprevention of skin cancers using nicotinamide (vitamin B3) in organ transplant recipients (COUNT Trial) (Dr Rubeta Matin, Oxford University Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline
19/160 HTA Researcher-led call Primary Research
Chair: Professor Julia Brown
Declared a conflict and did not partake in the discussion or vote: Dr Susan Jowett, Professor Daniel Lasserson, Professor Lucy Chappell, Professor Thomas Pinkney
Declared a conflict and left the call: Professor Hywel Williams
NIHR131513: Tube versus Trabeculectomy in Uveitic Glaucoma (TTUG) study (Mr Velota Sung, Sandwell and West Birmingham Hospitals NHS Trust)
Funding Committee recommendation: Decline
19/160 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Dr Kathryn Radford, Dr Susan Jowett, Professor Andrew Farmer, Professor Daniel Lasserson, Professor Kapil Sayal
Declared a conflict and left the call: Professor Alan Montgomery, Professor Hywel Williams
NIHR131440: Randomised controlled trial of a new relief inhaler in mild asthma. (Professor Timothy Harrison, The University of Nottingham)
Funding Committee recommendation: Shortlist
19/160 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Dr Katherine Brown, Professor Daniel Hind
Declared a conflict and left the call: Professor David Ekers
Arrived/left meeting: Mrs Debbie Keatley left at 11:48, Professor Alan Montgomery joined at 11:49, Professor Hywel Williams joined at 11:49
NIHR131584: The NOTES Study: Neonatal Outcomes with Treatments for Epileptic Seizures. A randomised controlled trial of phenobarbital and levetiracetam for seizures caused by neonatal hypoxic ischaemic encephalopathy and their association with neuro-developmental outcome at 2 years. (Dr Anthony Hart, Sheffield Children's NHS Foundation Trust)
Funding Committee recommendation: Decline
19/160 HTA Researcher-led call Primary Research
Chair: Professor Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Professor Daniel Lasserson, Professor Julia Brown, Professor Lucy Chappell, Professor Sharon Simpson
Declared a conflict and left the call: Professor Hywel Williams, Professor William Hollingworth
Arrived/left meeting: Professor David Ekers joined at 11:58 and Mrs Debbie Keatley joined at 12:09
NIHR131558: CLopidogrel and Aspirin after Revascularisation wIth angioplasTY for CLTI (CLARITY) trial (Mr Christopher Twine, North Bristol NHS Trust)
Funding Committee recommendation: Decline
19/160 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Professor Alan Montgomery, Professor Julia Brown
Declared a conflict and left the call: Professor Hywel Williams
NIHR131760: To assess whether fixed duration therapy in chronic lymphocytic leukaemia (CLL) is more clinically and cost effective than continuous treatment until disease progression: A Randomised Investigation of Venetoclax-Rituximab and Ibrutinib in Relapsed CLL (RIVER) (Dr David Allsup, Hull York Medical School)
Funding Committee recommendation: Decline
19/160 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Dr Susan Jowett, Professor Daniel Lasserson, Professor Julia Brown, Professor Thomas Pinkney
Declared a conflict and left the call: None
NIHR131784: The EXTEND trial: EXTENDed antibiotics to improve outcomes in patients with complicated intra-abdominal infection. (Associate Professor Andrew Kirby, University of Leeds)
Funding Committee recommendation: Shortlist
19/160 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Ms Gail Thornton, Professor Daniel Hind, Professor Daniel Lasserson, Professor William Hollingworth
Declared a conflict and left the call: None
NIHR131533: Randomised trial of the clinical and cost effectiveness of a supraglottic airway device versus tracheal intubation during in-hospital cardiac arrest (AIRWAYS-3). (Professor Jonathan Benger, UWE Bristol)
Funding Committee recommendation: Resubmission at stage 1. Waive 12-month rule
19/160 HTA Researcher-led call Primary Research
Chair: Professor Julia Brown
Declared a conflict and did not partake in the discussion or vote: Dr Elena Pizzo, Professor Andrew Farmer, Professor Lucy Chappell
Declared a conflict and left the call: None
Arrived/left meeting: Professor Hywel Williams arrived at 14:12
NIHR131822: T4P (Threshold for Platelets) (Associate Professor Peter Watkinson, University of Oxford)
Funding Committee recommendation: Shortlist
19/160 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Dr Susan Jowett, Professor Daniel Hind, Professor Daniel Lasserson, Professor Daniel Prieto-Alhambra, Professor James Wason, Professor Jonathan Rees, Professor Julia Brown, Professor Sharon Simpson
Declared a conflict and left the call: None
NIHR131638: Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: a randomised multi-arm multi-stage (MAMS) adaptive trial (TReatments of Exercise AnD Orthotics for plaNtar heel pain (TREADON)) (Dr Edward Roddy, Keele University)
Funding Committee recommendation: Shortlist
19/160 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: None
Declared a conflict and left the call: None
Arrived/left meeting: Steph Garfield-Birkbeck left the meeting at 15:03
NIHR131687: A cluster randomised trial of clinically-assisted hydration in cancer patients in the last days of life (CHELsea II study) (Dr Andrew Davies, Royal Surrey County Hospital NHS Foundation Trust)
Funding Committee recommendation: Deferred stage 2
19/160 HTA Researcher-led call Primary Research
Chair: Professor Julia Brown
Declared a conflict and did not partake in the discussion or vote: Dr Susan Jowett, Professor Daniel Lasserson, Professor Lucy Chappell, Professor Sharon Simpson, Professor Thomas Pinkney
Declared a conflict and left the call:
Arrived/left meeting: Dr Katherine Brown left at 15:25
NIHR131863: Maternal POsition in the second stage of labour in nulliparous Women Without EpiduRal analgeSia: a randomised controlled trial (POWWERS) (Dr Caroline Fox, Birmingham Women's and Children's NHS Foundation Trust)
Funding Committee recommendation: Decline
19/160 HTA Researcher-led call Primary Research
Chair: Professor Julia Brown
Declared a conflict and did not partake in the discussion or vote: Professor Daniel Hind, Professor David Ekers, Professor Lucy Chappell
Declared a conflict and left the call: None
NIHR131806: A randomised controlled trial of first line incobutulinumtoxinA versus usual care for sialorrhoea in motor neuron disease (Professor Christopher McDermott, The University of Sheffield)
Funding Committee recommendation: Decline
19/160 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Dr Susan Jowett, Professor Sharon Simpson
Declared a conflict and left the call: None
NIHR131856: A prospective, multicentre randomised controlled trial to examine the clinical effectiveness and cost-effectiveness of intrathecal drug delivery in chronic, refractory, non-cancer pain (PROVIDE) (Professor Sam Eldabe, South Tees Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline
19/160 HTA Researcher-led call Primary Research
Chair: Professor Lucy Chappell
Declared a conflict and did not partake in the discussion or vote: Dr Jennifer Logue, Professor Daniel Hind
Declared a conflict and left the call: None
NIHR131692: The clinical and cost-effectiveness of the DESMOND-ID education programme for adults with intellectual disability and Type 2 Diabetes (Dr Laurence Taggart, University of Ulster)
Funding Committee recommendation: Shortlist