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NIHR HTA Funding Committee Public Minutes 17-18 March 2020

 

Contents

Date

Tuesday 17th March 2020 (Day 1)

Place

Virtual Meeting via Microsoft Teams

Present members

Professor Andrew Farmer (Chair), Southampton
Professor Olivia Wu (Deputy Chair)
Professor Hywel Williams (Programme Director), Southampton
Professor Julie Brittenden
Professor Fay Crawford
Professor Jo Dumville
Professor Nick Francis
Professor Simon Gates
Professor Colin Green
Professor Kerenza Hood
Professor Nick James
Professor Asma Khalil
Professor Steff Lewis
Dr Rumana Omar
Professor Rupert Pearse
Professor Mark Peters
Professor Craig Ramsay
Mrs Amanda Roberts (PPI)
Professor Christine Roffe
Associate Professor Jo Thompson-Coon
Dr Sarah Stock
Dr Sara Twaddle
Dr Whitney Scott
Paul Charlton (PPI)

NETSCC, HTA Secretariat

Dr Simon Fraser (Consultant Advisor)
Helen Payne (Senior Research Manager) Day 1 PM only
Mrs Karen Williams (Senior Research Manager) Day 1 AM only
Ms Kathy Tier (Research Manager)
Miss Louisa Saunders (Assistant Research Manager)
Vicky Taylor (Application & Funding Assistant Director)

Apologies

Dr Marc Serfaty
Professor Caroline Free

Observers

None

Quoracy Information

Voting members: 23 Quorum = 19
Voting members present on Day 1: 24 (%)

Broad Brief - 19/30: Strategies in older people’s care settings to prevent infection

NIHR130396: ‘StOP UTI’ - STrategies for Older People living in care homes to prevent Urinary Tract Infection: a realist synthesis of the evidence

(Associate Professor Jacqui Prieto, University of Southampton)

Chair: Andrew Farmer
Declared a conflict and left the room: None
Arrived/left meeting: Sarah Stock, Craig Ramsey left the meeting
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

HTA Commissioned Stage 2 Applications

18/112: A psychological programme for adults with intellectual disability and harmful sexual behaviours

NIHR128550: RCT of group CBT for men with intellectual and/or developmental disabilities and harmful sexual behaviour: the HaSB-IDD trial

(Professor Glynis Murphy, University of Kent)

Chair: Andrew Farmer
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/74: Neurostimulation for phantom limb pain

NIHR130711: Study of Phantom limb paIn and dorsal Root ganglIon sTimulation: the UK SPIRIT Trial

(Professor Julie Bruce, University of Warwick)

Chair: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Jo Dumville, Colin Green, Simon Gates
Declared a conflict and left the call: Whitney Scott, Olivia Wu
Funding Committee recommendation: Decline

NIHR130456: The Efficacy of Combined Dorsal Root Ganglion and Spinal Cord Stimulation in the Management of Severe Phantom Limb Pain: A Multicentre, Randomised Double-Blind Placebo-Controlled Study (PHANTOM)

(Dr Adnan Al-Kaisy, Guy's and St Thomas' NHS Foundation Trust)

Chair: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Jo Dumville, Colin Green, Simon Gates
Declared a conflict and left the call: Whitney Scott, Olivia Wu
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

19/73: The use of mucoactive agents for patients with acute respiratory failure in critical care

 

NIHR130454: Mucoactive drugs for acute respiratory failure: A 2x2 factorial, randomised, controlled, allocation concealed, open-label, Phase 3, pragmatic, clinical and cost effectiveness trial with internal pilot

(Dr Bronwen Connolly, The Queen's University of Belfast)

Chair: Olivia Wu
Declared a conflict and left the room: Andrew Farmer, Hywel Williams
Declared a conflict and left the call: Mark Peters
Declared a conflict and did not partake in the discussion or vote: Simon Gates
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

HTA Data Enabled Trials call Stage 2 Applications

19/109: HTA Call for ambitious data-enabled trials, health services and public health research studies

NIHR130548: Assessing SYmptom-driven versus Maintenance Preventer Therapy for the Outpatient Management of AsThma In Children (ASYMPTOMATIC)

(Dr Ian Sinha, Alder Hey Children's NHS Foundation Trust)

Chair: Olivia Wu
Declared a conflict and did not partake in the discussion or vote: Sarah Stock, Craig Ramsay, Kerenza Hood, Steff Lewis
Declared a conflict and left the room: Andrew Farmer
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR130280: Preventing stroke, premature death and cognitive decline in a broader community of patients with atrial fibrillation using healthcare data for pragmatic research (DaRe2THINK)

(Dr Dipak Kotecha, University of Birmingham)

Chair: Olivia Wu
Declared a conflict and left the room: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Simon Gates
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR130508: Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care (UK-ROX).

(Professor Daniel Martin, University College London)

Chair: Andrew Farmer
Declared a conflict and left the call: Mark Peters
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR130573: Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery – a pragmatic randomised controlled triaL (VITAL)

(Associate Professor Joyce Yeung, University of Warwick)

Chair: Andrew Farmer
Declared a conflict and left the call: Rupert Pearse
Declared a conflict and did not partake in the discussion or vote: Simon Gates
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

HTA Researcher-led Stage 2 Applications

NIHR129972: Randomised trial of clinical and cost effectiveness of Administration of Prehospital fascia Iliaca compartment block for emergency Pre-Hospital hip fracture care Delivery (RAPID 2)

(Professor Helen Snooks, Swansea University)

Chair: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote:  Joanna Thompson-Coon, Kerenza Hood, Nick Francis, Steff Lewis
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR130593: Controlled trial of High-risk percutaneous coronary Intervention with Percutaneous left ventricular unloading (CHIP)

(Professor Divaka Perera, King's College London)

Chair: Andrew Farmer
Declared a conflict and left the room: Rumana Omar
Declared a conflict and left the call: Mark Peters
Left meeting: Nick James and Caroline Free
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR130632: ERASER TRIAL: Early Rib Analgesia with Serratus. A Pragmatic Randomised Control Trial evaluating the clinical and cost-effectiveness of Serratus Anterior Plane Block with catheter insertion compared to Usual Care in patients with multiple rib fractures.

(Dr Tonny Veenith, University Hospitals Birmingham NHS Foundation Trust)

Chair: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Simon Gates
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

HTA Commissioned (Evidence Synthesis) Stage 2 Applications

19/29: Frequency of blood tests for inflammatory conditions

NIHR129778: Strategies for blood test monitoring in patients taking common immunosuppressive drugs in primary care

(Dr Sarah Lay-Flurrie, University of Oxford)

Chair: Olivia Wu
Declared a conflict and left the room: Andrew Farmer, Hywel Williams, Simon Fraser
Declared a conflict and left the call: Amanda Roberts
Declared a conflict and did not partake in the discussion or vote: Joanna Thompson-Coon, Nick Francis
Funding Committee recommendation: Decline

NIHR130580: The development of risk-stratified, cost-effective, and acceptable blood-test monitoring strategies for inflammatory conditions treated with commonly used immune suppressing drugs: a multi-method study using evidence synthesis, modelling and qualitative research.

(Dr A Abhishek, University of Nottingham)
Chair: Olivia Wu
Declared a conflict and left the room: Andrew Farmer, Hywel Williams, Simon Fraser
Declared a conflict and left the call: Amanda Roberts
Declared a conflict and did not partake in the discussion or vote: Joanna Thompson-Coon, Nick Francis
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes

NIHR130714: Optimisation of the Frequency of Blood testing for routine DMARD surveillance in Inflammatory Bowel Disease and Rheumatoid Arthritis by a risk-stratification algorithm

(Dr Fraser Cummings, University Hospital Southampton NHS Foundation Trust)

Chair: Olivia Wu
Declared a conflict and left the room: Andrew Farmer, Hywel Williams, Simon Fraser
Declared a conflict and left the call: Amanda Roberts
Declared a conflict and did not partake in the discussion or vote: Joanna Thompson-Coon, Nick Francis
Funding Committee recommendation: Decline



Date

Wednesday 18th March 2020 (Day 2)

Place

Virtual Meeting via Microsoft Teams

Present members

Professor Andrew Farmer (Chair),
Professor Olivia Wu (Deputy Chair),
Professor Hywel Williams (Programme Director),
Professor Matt Costa,
Professor Fay Crawford,
Professor Jo Dumville,
Professor Nick Francis,
Professor Simon Gates,
Professor Colin Green,
Professor Kerenza Hood,
Professor Nick James,
Professor Steff Lewis,
Professor Rupert Pearse,
Professor Mark Peters,
Professor Craig Ramsay,
Mrs Amanda Roberts (PPI),
Associate Professor Jo Thompson-Coon,
Dr Sarah Stock,
Dr Sara Twaddle,
Dr Whitney Scott,
Paul Charlton (PPI)

NETSCC, HTA Secretariat

Dr Simon Fraser (Consultant Advisor)
Mrs Karen Williams (Senior Research Manager)
Ms Kathy Tier (Research Manager)
Miss Louisa Saunders (Assistant Research Manager)
Vicky Taylor (Application & Funding Assistant Director)

Apologies

Dr Marc Serfaty
Dr Rumana Omar
Professor Julie Brittenden
Professor Christine Roffe
Professor Caroline Free

Observers

None

Quoracy Information

Voting members: 20 Quorum = 19
Voting members present on Day 2: 21 (84%)

HTA Research-Led Stage 1 Applications

19/102 HTA Researcher-led call Primary Research

NIHR130875: The impact of REstrictive versUs Liberal Transfusion strategy on cardiac Injury in patients undergoing surgery for Hip Fracture (RESULT-HF).

(Dr Michael Gillies, Edinburgh Royal Infirmary)

Chair: Olivia Wu
Declared a conflict and left the room: Andrew Farmer, Hywel Williams,
Declared a conflict and left the call: Sarah Stock
Declared a conflict and did not partake in the discussion or vote: Jo Dumville, Matthew Costa, Rupert Pearse, Simon Gates, Steff Lewis
Funding Committee recommendation: Shortlist

NIHR131354: Inpatient graduated compression stocking use as an adjunct to extended duration pharmacoprophylaxis for venous thromboembolism prevention – a multi-centre randomised controlled trial

(Professor Alun Davies, Imperial College London)

Chair: Andrew Farmer
Declared a conflict and left the room: Jo Dumville, Craig Ramsay, Steff Lewis
Declared a conflict and left the call: Sarah Stock
Left meeting: Rupert Pearce
Funding Committee recommendation: Decline

NIHR130762: The clinical and cost effectiveness of group mindfulness-based therapy for distressing persecutory delusions: A definitive randomised controlled trial.

(Dr Lyn Ellett, Royal Holloway, University of London)

Chair: Andrew Farmer
Funding Committee recommendation: Decline

NIHR131334: The Self-harm, Assessment, Formulation, Engagement Trial of Psychodynamic Interpersonal Therapy (SAFE-PIT)

(Professor Elspeth Guthrie, University of Leeds)

Chair: Andrew Farmer
Arrived/left meeting: Paul Charlton
Funding Committee recommendation: Shortlist

NIHR130700: RadiO fRequency ablatION for haemorrhoids (ORION)

(Professor Steven Brown, Sheffield Teaching Hospitals NHS Foundation Trust)

Chair: Andrew Farmer
Funding Committee recommendation: Decline invite to resubmit stage 1

NIHR131353: Hip arthroscopy versus periacetabular osteotomy for borderline hip dysplasia in young adults: a randomised controlled trial and economic evaluation

(Mr Ajay Malviya, Northumbria Healthcare NHS Foundation Trust)

Chair: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Jo Dumville
Arrived in the meeting: Rupert Pearce
Funding Committee recommendation: Decline

NIHR131362: Tailoring treatment for HER2 positive early breast cancer – the HER2-RADiCAL study (Response ADaptive CAre pLan)

(Professor Andrew Wardley, The Christie NHS Foundation Trust)
Chair: Andrew Farmer
Declared a conflict and left the room: Olivia Wu, Nick James
Declared a conflict and did not partake in the discussion or vote: Steff Lewis
Funding Committee recommendation: Shortlist

19/72: Pain relief strategies for dressing change in chronic wounds (Evidence Synthesis)

NIHR130617: Self management of chronic wound dressing change pain in community settings: systematic review, exploration of current practice and recommendations for manualised interventions.

(Dr Penny Furness, Sheffield Hallam University)

Chair: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Jo Dumville, Joanna Thompson-Coon
Funding Committee recommendation: Decline

NIHR131023: Pain relief strategies for dressing change in chronic wounds: a mixed-methods systematic review and survey of UK practice

(Dr Marrissa Martyn-St James, The University of Sheffield)

Chair: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Jo Dumville, Joanna Thompson-Coon
Funding Committee recommendation: Shortlist

NIHR131433: Optimal Pain Relief Strategies at Dressing Change for Chronic Wounds.

(Dr Gwenllian Wynne-Jones, Keele University)

Chair: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Jo Dumville, Joanna Thompson-Coon
Funding Committee recommendation: Shortlist

NIHR131434: Pain relief strategies for dressing change in chronic wounds

(Mr Ioan Humphreys, Swansea University)

Chair: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Jo Dumville, Joanna Thompson-Coon
Funding Committee recommendation: Decline

NIHR131437: A mixed methods evidence synthesis of the current research and an overview of current UK practice for pain relief at dressing changes for people with chronic wounds care for in the community

(Professor Michelle Briggs, The University of Manchester)

Chair: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Jo Dumville, Joanna Thompson-Coon
Funding Committee recommendation: Decline

19/132: A clinical prediction rule for post-operative atrial fibrillation in patients undergoing cardiac surgery

NIHR131227: Predicting AF after Cardiac Surgery - the PARADISE Score A Clinical Prediction Rule for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

(Professor Benjamin O'Brien, Barts Health NHS Trust)

Chair: Olivia Wu
Declared a conflict and left the room: Andrew Farmer, Simon Fraser
Declared a conflict and left the call: Rupert Pearse
Declared a conflict and did not partake in the discussion or vote: Jo Dumville
Funding Committee recommendation: Shortlist

NIHR131401: Development, Validation and Impact of a Clinical Prediction Rule for Post-Operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

(Dr Tom Wong, Royal Brompton & Harefield NHS Foundation Trust)

Chair: Olivia Wu
Declared a conflict and left the room: Andrew Farmer, Simon Fraser
Declared a conflict and left the call: Rupert Pearse
Declared a conflict and did not partake in the discussion or vote: Jo Dumville
Funding Committee recommendation: Decline

NIHR131442: PostopeRativE carDIaC surgery aTrial fibrillation. PREDICT study

(Associate Professor Umberto Benedetto, University of Bristol)

Chair: Olivia Wu
Declared a conflict and left the room: Andrew Farmer, Simon Fraser
Declared a conflict and left the call: Rupert Pearse
Declared a conflict and did not partake in the discussion or vote: Jo Dumville
Funding Committee recommendation: Decline

NIHR131476: Development and evaluation of a novel real-time dynamic model for the prediction of atrial fibrillation after cardiac surgery

(Mr Stuart Grant, The University of Manchester)

Chair: Olivia Wu
Declared a conflict and left the room: Andrew Farmer, Simon Fraser
Declared a conflict and left the call: Rupert Pearse
Declared a conflict and did not partake in the discussion or vote: Jo Dumville
Funding Committee recommendation: Shortlist

HTA Cross-Programme Commissioned Stage 1 Applications

19/143: HTA Liver Disease

NIHR130832: SANIC: A cluster randomized trial of case-finding of advanced fibrosis in primary care in patients at risk of non-alcoholic fatty liver disease (NAFLD)

(Dr Emmanuel Tsochatzis, University College London)

Chair: Andrew Farmer
Declared a conflict and left the room: Hywel Williams, Simon Fraser
Declared a conflict and did not partake in the discussion or vote: Colin Green, Joanna Thompson-Coon, Simon Gates
Funding Committee recommendation: Decline

NIHR131110: DELIVER DEtecting LIVer damage using ELF in patients at Risk of Liver Disease from Alcohol Use Disorders

(Professor William Rosenberg, University College London)

Chair: Andrew Farmer
Declared a conflict and left the room: Hywel Williams, Simon Fraser
Declared a conflict and did not partake in the discussion or vote: Colin Green, Joanna Thompson-Coon, Simon Gates
Funding Committee recommendation: Decline

NIHR131189: Supporting engagement with care for socially complex groups initiating hepatitis C treatment.

(Professor Andrew Hayward, University College London)

Chair: Andrew Farmer
Declared a conflict and left the room: None
Funding Committee recommendation: Shortlist

NIHR131129: An adaptive-design randomised trial of baclofen in the treatment of alcohol use disorder in patients with liver cirrhosis (BASIS)

(Dr Paul Richardson, Royal Liverpool Hospital)

Chair: Andrew Farmer
Declared a conflict and left the room: Hywel Williams
Funding Committee recommendation: Shortlist

NIHR130883: Randomised controlled trial of EArly transjugular intrahepatiC porTosystemic stent-shunt in Acute Variceal Bleeding (REACT-AVB)

(Dr Dhiraj Tripathi, University Hospitals Birmingham NHS Foundation Trust)

Chair: Andrew Farmer
Declared a conflict and left the room: Hywel Williams, Simon Gates
Declared a conflict and left the call: Nick James
Declared a conflict and did not partake in the discussion or vote: Simon Gates
Funding Committee recommendation: Shortlist

NIHR131059: Palliative Long-term Abdominal Drains Versus Repeated Drainage in Untreatable Ascites Due To Advanced Cirrhosis: A Randomised Controlled Trial

(Professor Sumita Verma, University of Sussex)

Chair: Andrew Farmer
Left meeting: Hywel Williams, Nick James
Funding Committee recommendation: Shortlist

NIHR130888: Integrated care in the management of alcohol use disorder in patients with alcohol-related liver disease: targeting and identification of effective interventions (Acronym: INTEGRAL –INTEGrated caRe for Alcohol-related Liver disease)

(Professor Colin Drummond, King's College London)

Chair: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Whitney Scott
Arrived at meeting: Nick James
Funding Committee recommendation: Decline

19/147: HTA Perinatal Mental Health

NIHR131122: CALM: A multi-site randomised controlled trial to test the impact of a group treatment for antenatal anxiety to improve maternal mental health and child adjustment

(Professor Pasco Fearon, University College London)

Chair: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Colin Green, Joanna Thompson-Coon
Arrived at meeting: Hywel Williams
Funding Committee recommendation: Decline

19/147 HTA Perinatal Mental Health

NIHR131158: What is the effectiveness and cost effectiveness of a parenting programme to reduce depression and improve mother and infant outcomes in British South Asian families?

(Professor Nusrat Husain, The University of Manchester)

Chair: Andrew Farmer
Funding Committee recommendation: Decline

NIHR131169: Prevention and treatment of workplace traumatisation and primary and secondary post-traumatic stress disorder in maternity service staff: a mixed methods evidence synthesis of clinical and  cost effectiveness

(Professor Debra Bick, University of Warwick)

Chair: Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Simon Gates
Funding Committee recommendation: Decline

NIHR130741: Supporting Perinatal Anxiety; a feasibility study investigating the use of an eHealth program to support mild-to-moderate levels of anxiety in a perinatal cohort.

(Dr Virginia Harrison, The Open University)

Chair: Olivia Wu
Declared a conflict and left the room: Andrew Farmer
Left the meeting: Rupert Pearce
Funding Committee recommendation: Decline