Minutes for the Research for Patient Benefit (RfPB) programme East Midlands Regional Advisory Committee meeting to discuss Stage 2 applications to competition 43 and Stage 1 applications to competition 44.
Date and Location
Tuesday 18 May 2021 Virtual Meeting
In attendance
Committee members
Professor Roshan das Nair (Chair)
Professor Jon Arcelus
Mrs Ajanta Biswas
Professor Matthew Bown
Mrs Cassandra Brookes
Dr Apostolos Fakis
Dr Clare Gillies
Dr Louise Jackson
Mr Trevor Jones
Professor Graham Law
Dr Paul Leighton
Professor Dileep Lobo
Dr Nicola Mackintosh
Dr Joseph Manning
Dr Jatinder Minhas
Professor Richard Morriss
Ms Pamela Rees
Miss Amanda Rudczenko
Professor Catherine Sackley
Professor Niro Siriwardena
Dr Don Sharkey
Secretariat
Mr Francesco Sciammarella (NIHR CCF)
Dr Jennie Hejdenberg (NIHR CCF)
Ms Katie Prangle (NIHR CCF)
Mr Curtis Dixon (NIHR CCF)
Ms Nishita Nair (NIHR CCF)
Mr Stuart Haylock (NIHR CCF)
Professor Sue Ziebland (Programme Director)
Observers
Ms Toqir Mukhtar RDS - LDN
Miss Lucy Musson RDS - YH
1. Competition 43 stage 2 applications considered
1.1 NIHR202726: The role of ethnicity in opioid prescribing and health service use in the last three months of life: a population-based comparative cohort study of cancer patients
Conflicts: None
Final outcome: Conditional support
1.2 NIHR202764: Is the naturally occurring prebiotic Lactoferrin an acceptable alternative to antibiotic tablets for women with bacterial vaginosis or thrush? The LISA (Lactoferrin InStead of Antibiotics) randomised feasibility trial
Conflicts: Professor Catherine Sackley
Final outcome: Conditional support
1.3 NIHR202781: The association between medicines/vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study
Conflicts: Professor Roshan das Nair, Dr Paul Leighton and Professor Dileep N Lobo. Professor Matthew Bown assumed the Chair.
Final outcome: Conditional support
1.4 NIHR202774: Optimised Inhalers to Reduce COPD Exacerbation Re-Admissions and Mortality - a Feasibility Study
Conflicts: Dr Nicola Mackintosh
Final outcome: Conditional support
2. Stage 1 applications considered
2.1 NIHR203058: Preventing Acute Kidney Injury (AKI) in patients with Peripheral Arterial Disease (PAD) and Chronic Kidney Disease (CKD): the PAD Endovascular AKi (PEAK) care checklist
Conflicts: Mrs Cassandra Brookes, Dr Paul Leighton, Professor Matthew Bown and Dr Jatinder Minhas
Outcome: Invite to Stage 2
2.2 NIHR203102: Investigating community referrals into liver disease screening pathways
Conflicts: Mrs Cassandra Brookes and Dr Paul Leighton. Professor Roshan das Nair, Dr Joseph Manning and Mr Trevor Jones. Professor Matthew Bown assumed the Chair
Outcome: Reject
2.3 NIHR203121: COVID-19 vaccination in inflammatory conditions treated with immune suppressing drugs: a study of clinical effectiveness and vaccine safety using data from Clinical Practice Research Datalink
Conflicts: Dr Paul Leighton, Professor Roshan das Nair and Dr Joseph Manning Mrs Cassandra Brookes assumed the Chair
Outcome: Invite to Stage 2
2.4 NIHR203104: Support for induction of labour: an evidence-based, inclusive and co-produced digital resource (SOLID)
Conflicts: Dr Joseph Manning Dr Nicola Mackintosh
Outcome: Invite to Stage 2
2.5 NIHR203191: Digital Assessment of Wellbeing in New Parents (DAWN-P)
Conflicts: None
Outcome: Invite to Stage 2
2.6 NIHR203206: ParkinSong-Care: Group Singing as an adjunct to standard speech and language therapy for patients with Parkinson’s - A mixed methods feasibility RCT
Conflicts: Dr Apostolos Fakis
Outcome: Reject
2.7 NIHR203052: Improving access to psychological therapy services for older people with severe mental illness (SMI)
Conflicts: None
Outcome: Reject
2.8 NIHR203080: MAnnitol for Cerebral oEdema after IntraCerebral Haemorrhage (MACE-ICH): a feasibility trial
Conflicts: Professor A. Niroshan Siriwardena and Dr Jatinder Minhas
Outcome: Invite to Stage 2
2.9 NIHR203165: A Multicentre Open-label, Feasibility Study of the Use of a Short-term Low Energy Diet in Obese Adolescents with Type 2 Diabetes Mellitus
Conflicts: Dr Joseph Manning and Dr Paul Leighton
Outcome: Invite to Stage 2
2.10 NIHR203050: Core Outcome Set Taskforce for Cystic Fibrosis (COST-CF): a patient-initiated core outcome set for CF
Conflicts: Dr Paul Leighton and Dr Joseph Manning, Professor Roshan das Nair and Dr Don Sharkey Professor Matthew Bown assumed the Chair
Outcome: Invite to Stage 2
2.11 NIHR203083: A feasibility study on using an online mindfulness intervention to improve well-being in individuals with the expanded Huntingtin gene
Conflicts: None
Outcome: Reject
2.12 NIHR203133: Long term respiratory effects of COVID-19 in children and young people
Conflicts: Dr Joseph Manning and Dr Don Sharkey
Outcome: Reject
Outcomes Table
The tables below display the mean score for each application that was assessed in the regional assessment committee meeting, and excludes applications which were rejected during the scrutiny and triage processes. The number of applications receiving each mean score are listed. The RfPB fundable range is 6-10, although a score of 6-10 does not guarantee funding or an invitation to Stage 2. In exceptional circumstances and with approval from the Programme Director, applications may be invited/funded which fall below the fundable range.
In exceptional circumstances, applications which fall below the fundable range may be invited to Stage 2 or recommended for funding by the Committee. The Programme Director reviews in detail any applications recommended for funding with a score below 7.
Stage 1
| Score | Range | Number of Applications |
|---|---|---|
| 9-10 | Invited | 0 |
| 8 | Invited | 1 |
| 7 | Invited | 3 |
| 6 | Invited | 3 |
| 5 | Rejected | 1 |
| 4 | Rejected | 3 |
| 3 | Rejected | 1 |
| 2 | Rejected | 0 |
| 1 | Rejected | 0 |
Stage 2
| Score | Range | Number of Applications |
|---|---|---|
| 9-10 | Fundable | 0 |
| 8 | Fundable | 0 |
| 7 | Fundable | 2 |
| 6 | Fundable | 2 |
| 5 | Rejected | 0 |
| 4 | Rejected | 0 |
| 3 | Rejected | 0 |
| 2 | Rejected | 0 |
| 1 | Rejected | 0 |