Studies within a trial

Studies within a Trial (SWATs)

Randomised trials play a central role in improving clinical care in the UK and are a key component of many clinical practice guidelines developed by NICE and others, but such studies can be inefficient. Reasons for study inefficiencies include the complex and unpredictable nature of some trials, but more commonly, the lack of evidence to support trial process decision-making

To increase the evidence base, we are conducting a pilot to allow researchers to embed a study evaluating alternative ways of undertaking a trial process (e.g. public involvement, trial recruitment, retention, data collection etc) to provide evidence about how we can improve the way we perform that process. We welcome proposals that include embedded studies aimed at improving the successful completion of trials. The findings of SWATs are anticipated to be generalisable to other trials but may also be of specific benefit to the host trial itself, by supporting trial delivery process decision points. The pilot is open to SWATs relating to recruitment and any other aspect of trial delivery. Applicants who wish to include a SWAT in their application should read the relevant sections of the first stage guidance notes for further details.

Supporting Information

SWAT registry

Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)?

Strategies to improve recruitment to randomised trials

PRioRiTy: Prioritising Recruitment in Randomised Trials.  This is a priority setting partnership which was completed using James Lind Alliance methodology and has developed a prioritised research agenda for trial recruitment research.