EME Funding Committee Minutes November 2022

Meeting

EME Funding Committee November 2022

Date

Tuesday 1st and Wednesday 2nd November 2022

Place

Virtual Meeting

Present - Day 1

Professor Danny McAuley (Programme Director - does not vote)
Professor John Norrie (Programme Chair - does not vote)
Professor John Petrie (Deputy Chair) - afternoon only
Professor Victoria Allgar - from 10.15am
Dr Alun Bedding
Professor Maya Buch
Dr Tessa Cacciottolo - afternoon only
Professor Janet Dunn
Professor Daniel Freeman
Professor Jonathan Grigg
Mrs Hayley Hall (PPI)
Professor Alastair Hay
Professor Andrew Horne
Professor David Jones
Professor Patricia Limousin
Professor Gregory Lip
Dr Puja Mehta
Professor Michael Nicholson
Professor Manu Shankar-Hari
Professor John Simpson
Professor Deborah Stocken
Professor Stuart Taylor
Professor David Clifton - Co-optee

Secretariat

Dr Andrew Cook
Dr Juliana Callaghan
Dr Elena Harden
Ms Helen Munday
Dr Esther Sweeney
Ms Caitlin Van Abeelen
Mrs Sue White

Apologies

Professor Victoria Coyle, Committee member
Dr Ronan McMullan, Committee member
Ms Nóirín O'Neill, PPI Committee member
Ms Penny Morton, MRC observer

Observers/In attendance

Professor James Burton, new Committee member
Professor George Hanna, new Committee member
Dr Philip Pallmann, new Committee member
Professor Don Sharkey, new Committee member
Dr Ruth Pritchett, Research Design Service (RDS) - morning only
Charlie Dukes, NETSCC - morning only
Irene Moreno-Milan, NETSCC - afternoon only

Stage 2 Proposals

21/545 Efficacy and Mechanism Evaluation Programme Researcher-led

NIHR151755 -  Muir
NanO2 in Large VessEL Occlusion Stroke (NOVEL): a multicentre single-blind, randomised, placebo-controlled blinded end-point clinical trial evaluating the safety, tolerability and preliminary efficacy of perfluorocarbon in acute ischaemic stroke due to large vessel occlusion 
Chair: John Norrie
Declared a conflict and left the room: John Petrie (not present), James Burton (observer)
Decision: Recommended to Programme Director to consider Fund with Changes

21/603 NIHR James Lind Alliance Priority Setting Partnerships rolling call (EME Programme: Dec 21 - Apr 22)

NIHR152705 - Davies
Does stabilisation following posterior decompression in Degenerative Cervical Myelopathy, reduce mechanical stress and spinal cord damage? [DISTRESSED Study] 
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Straight Fund

21/515 EME Mechanisms of Action of Interventions for COVID-19

NIHR150393 - Wilkinson
Exploring and grouping COVID-19 pharmaceutical interventions to determine mechanisms of action and endotypes of response 
Chair: John Norrie
Declared a conflict and left the room: Victoria Coyle (not present), Andrew Cook
Decision: Recommended to Programme Director to consider Fund with Changes

22/18 Applications with industry collaboration - The development and evaluation of predictive algorithms using Artificial Intelligence (AI) (EME Programme)

NIHR153098 - Barrett
Multi-centre diagnostic accuracy study of artificial intelligence for magnetic resonance imaging (MRI) in prostate cancer diagnosis
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Decline – Invited to resubmit a Stage 2 application

NIHR153266 - Mills
Artificial Intelligence guided Diagnosis of acute Heart Failure (AID-HF): a randomised controlled trial 
Chair: Andrew Cook
Declared a conflict and left the room: John Simpson, Ronan McMullan (not present), Danny McAuley, Manu Shankar-Hari, John Norrie, John Petrie, Maya Buch, Alun Bedding
Decision: Decline

21/609 Efficacy and Mechanism Evaluation Programme researcher-led

NIHR152268 - Markar
Double-blind randomised controlled trial for treatment of Gastro-Oesophageal reflux disease; Linx management system vs. Fundoplication (GOLF)
Chair: John Norrie
Declared a conflict and left the room: Andrew Cook, George Hanna (observer)
Decision: Recommended to Programme Director to consider Fund with Changes

NIHR152798 - Birchenall

PravastatIn tO preveNt prEtErm biRth (PIONEER): a parallel group randomised placebo-controlled trial
Chair: John Petrie
Declared a conflict and left the room: John Norrie, Manu Shankar-Hari, Ruth Pritchett (observer), Sarah Berhane (observer - not present)
Decision: Recommended to Programme Director to consider Fund with Changes

21/545 Efficacy and Mechanism Evaluation Programme Researcher-led

NIHR151052 - Fallon
A Phase II RCT Of OrAl Cannabinoid Versus Placebo In The Treatment Of Chemotherapy Induced Peripheral NeurOpathic PaiN (ACTION) 
Chair: John Petrie
Declared a conflict and left the room:  Janet Dunn, Philip Pallmann (observer), Manu Shankar-Hari, John Norrie, Andrew Horne
Decision: Recommended to Programme Director to consider Fund with Changes

21/609 Efficacy and Mechanism Evaluation Programme researcher-led

NIHR153014 - Griffith
INtravenous iron and eryThropoietin to treat Anaemia following CriTical care-2 (INTACT-2): a multi-centre, randomised, parallel group, double-blind, placebo-controlled, phase II efficacy trial with an embedded mechanistic evaluation.
Chair: John Petrie
Declared a conflict and left the room: John Simpson, John Norrie, Danny McAuley, Philip Pallmann (observer), Manu Shankar-Hari, Janet Dunn, Ronan McMullan (not present)
Decision: Decline – invited to resubmit a Stage 2 application

Stage 1 Proposals 

22/43 Efficacy and Mechanism Evaluation Programme researcher-led

NIHR153905 - Sin
Mechanisms affecting carers of individuals with psychosis using complex digital interventions: A re-analysis of two trials to optimise future service provision (MAXImise) 
Chair: John Petrie
Declared a conflict and left the room: John Norrie, Danny McAuley, John Simpson
Decision: Decline

NIHR153209 - Antcliffe
FLuid strategies and Inflammatory Phenotypes in the SepTIC trial (FLIP-SepTIC) 
Chair: John Petrie
Declared a conflict and left the room: John Simpson, Manu Shankar-Hari, Ronan McMullan (not present), Victoria Coyle (not present), John Norrie, Stuart Taylor, Danny McAuley, George Hanna (observer)
Decision: Shortlist

NIHR154842 - Ackland
GlucoVITAL: randomised controlled mechanistic substudy of the Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery (VITAL) trial [NIHR130573]
Chair: John Norrie
Declared a conflict and left the room: Janet Dunn, Danny McAuley
Decision: Shortlist

NIHR154749 - Hartley
IMPACT (‘IMplemented by Parents And Carers’ Therapy) trial: A multicentre randomised controlled trial to evaluate the efficacy of a parent-implemented therapy on language development in deaf children with cochlear implants, and the mechanisms by which this therapy exerts its effects
Chair: John Norrie
Declared a conflict and left the room: Don Sharkey (observer)
Decision: Shortlist

NIHR154893 - MacGowan
TOcilizumab to impRove Patient outcomes in sEpsis: a ranDOmised trial (TORPEDO) 
Chair: John Norrie
Declared a conflict and left the room: Alastair Hay, Alun Bedding, Danny McAuley, Manu Shankar-Hari
Decision: Decline

22/42 NIHR James Lind Alliance Priority Setting Partnerships rolling call (EME Programme: April 22 - August 22)

NIHR154244 - Crosbie
Refining Adjuvant treatment IN endometrial cancer Based On molecular features (RAINBO) programme
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Decline - invited to resubmit a Stage 1 application

NIHR154883 - Liu
Using music-assisted programmes (MAP) to improve spoken language in autistic children with no or few words: An efficacy and mechanism evaluation (EME) study 
Chair: John Norrie
Declared a conflict and left the room: Philip Pallmann (observer)
Decision: Decline

Present - Day 2

Professor Danny McAuley (Programme Director - does not vote)
Professor John Norrie (Programme Chair - does not vote)
Professor Victoria Allgar
Dr Alun Bedding
Professor Maya Buch
Dr Tessa Cacciottolo
Professor Janet Dunn
Professor Daniel Freeman
Mrs Hayley Hall (PPI)
Professor Alastair Hay
Professor Andrew Horne
Professor Patricia Limousin
Professor Gregory Lip
Dr Puja Mehta
Professor Michael Nicholson
Professor Manu Shankar-Hari
Professor John Simpson
Professor Deborah Stocken
Professor Stuart Taylor

Secretariat

Dr Andrew Cook
Dr Juliana Callaghan
Dr Elena Harden
Dr Esther Sweeney
Ms Caitlin Van Abeelen

Apologies

Professor Victoria Coyle, Committee member
Professor Jonathan Grigg, Committee member
Professor David Jones, Committee member
Dr Ronan McMullan, Committee member
Ms Nóirín O'Neill, PPI Committee member
Professor John Petrie, Deputy Chair
Penny Morton, MRC observer
Professor George Hanna, new Committee member observer

Observers/in attendance

Professor James Burton, new Committee member
Dr Philip Pallmann, new Committee member
Professor Don Sharkey, new Committee member
Dr Sarah Berhane, Research Design Service (RDS)

22/60 Mechanisms of action of health interventions in patients with multiple long-term conditions (MLTC)

NIHR154867 - Basu
Determining cytokine-based exercise mimetics for the alleviation of co-morbid chronic fatigue 
Chair: Andrew Cook
Declared a conflict and left the room: John Petrie (not present), John Norrie
Decision: Decline

NIHR155021 - Wells
Mechanisms of Change in Group Metacognitive Therapy for Depression and Anxiety in Cardiac Rehabilitation Patients 
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Decline

22/43 Efficacy and Mechanism Evaluation Programme researcher-led

NIHR155053 - Evans
Evaluating the efficacy of the ApplTree app to support prospective memory in people with memory impairment after brain injury 
Chair: John Norrie
Declared a conflict and left the room: Philip Pallmann (observer), James Burton (observer), John Petrie (not present)
Decision: Decline

NIHR153865 - Sturt
Efficacy and mechanisms evaluation of novel therapy called Reconsolidation of Traumatic Memories (RTM) vs Waiting List control for Post-Traumatic Stress Disorder (PTSD) in UK military veterans 
Chair: John Norrie
Declared a conflict and left the room: Danny McAuley
Decision: Shortlist

NIHR154042 - Gbinigie
What is the efficacy of cranberry extract to reduce antibiotic consumption for symptoms of acute, uncomplicated Urinary Tract Infection (UTI)? A randomised, placebo-controlled trial
Chair: John Norrie
Declared a conflict and left the room: Alastair Hay, Philip Pallmann (observer), Andrew Cook
Decision: Decline

NIHR154410 - Lowe
Host immunE Response to SARS-CoronavirUs-2 oraL antiviral medicinES (HERCULES) 
Chair: John Norrie
Declared a conflict and left the room: Alastair Hay, Sarah Berhane (observer)
Decision: Decline

NIHR154978 - Abhishek
Multiple multi-centre randomised controlled trials examining effect of temporarily suspending immunosuppression around the time of COVID-19 booster vaccination on humoral and cell mediated immunity in adults with inflammatory conditions. Short title: Vaccine Response On/Off Medications
Chair: John Norrie
Declared a conflict and left the room: Dave Jones (not present), Jonathan Grigg (not present), Don Sharkey (observer), John Simpson
Decision: Decline

NIHR154807 - Ayling
Bio-psychological Mechanisms of Action in Improving Diabetic Foot Ulcer Outcomes
Chair: John Norrie
Declared a conflict and left the room: Alastair Hay, Deborah Stocken, John Petrie (not present), Don Sharkey (observer)
Decision: Shortlist

NIHR154017 - Basu
Transforming the Severity of Fatigue in Inflammatory Rheumatic Disease 
Chair: John Norrie
Declared a conflict and left the room: Dave Jones (not present), John Petrie (not present), John Simpson, Philip Pallmann (observer), James Burton (observer)
Decision: Decline

NIHR154840 - Fisher
REmission induction of Arthritis caused by Cancer ImmunoTherapy (REACT): a randomised multicentre trial to guide initial therapy for checkpoint inhibitor (CPI) induced arthritis
Chair: John Norrie
Declared a conflict and left the room: Dave Jones (not present), John Simpson, Maya Buch
Decision: Shortlist