HTA Funding Committee Public Minutes 14 March 2023

  • Published: 22 May 2023
  • Version: V1
  • 5 min read

Day 1 - Tuesday 14 March 2023

Venue

Microsoft Teams

Present members

  • Julia Brown (Chair)
  • Mark Peters (Deputy Chair)
  • Andrew Farmer (Programme Director)
  • David Green (Public Committee Member)
  • Ashley Agus
  • Hashim Ahmed
  • Jo Dumville
  • Nick Francis
  • Caroline Free
  • Simon Gates
  • David Keene
  • Stephanie MacNeill
  • Marta Soares
  • Joanna Thompson-Coon
  • Laura Coates (Committee Member Development Scheme Participant)
  • Khalida Ismail
  • Hema Mistry
  • Dawn-Marie Walker
  • Athanasios Saratzis
  • Matthew Moore (Public Committee Member)
  • Stuart McIntosh
  • Ben Carter
  • Abdullah Pandor
  • Thomas Hellyer (Committee Member Development Scheme Participant)
  • Garry Barton
  • Victoria Goodwin
  • Joyce Yeung
  • Sarah Markham (Public Committee Member)

Secretariat

  • Vicky Taylor (Assistant Director)
  • Jason Horsley (Consultant Advisor)
  • Cristina Lujan Barroso (Research Manager)
  • Kathy Tier (Research Manager)
  • Daniel Housego (Research Manager)
  • Karen Williams (Senior Research Manager)
  • Louisa Saunders (Assistant Research Manager)

Apologies

  • Jugdeep Dhesi
  • David Harrison

Observers

  • Martin Dixon
  • Anto John
  • Benaya Kaunda

Quoracy information

  • Voting members: 29 (Emergency Quoracy = 19 = 66%)
  • Voting members present on Day 1: 27 (93%)

Stage 2 Applications

22/37 Non-pharmacological interventions for fatigue management in adults with long-term health conditions

NIHR154660 - Effectiveness of Interventions For Fatigue in Long term conditions (EIFFEL) (Christopher Burton) 
Chair: Julia Brown
Conflicts: Joanna Thompson-Coon, David Keene, Abdullah Pandor, Thomas Hellyer
Decision: Programme Oversight Committee to consider fund with changes

22/4 NIHR James Lind Alliance Priority Setting Partnerships Rolling Call (HTA Programme: Jan 22 - May 22)

NIHR153258 - DEBI: clinical and cost-effectiveness of desogestrel versus the combined oral contraceptive pill for problem bleeding on the etonogestrel implant (Kate Walker) 
Chair: Julia Brown
Conflicts: Caroline Free, Hema Mistry
Decision: Stage 2 resubmission

22/12 The development and evaluation of predictive algorithms using Artificial Intelligence (AI) - HTA

NIHR153364 - StratCare Trial 2: Evaluating the clinical and cost-effectiveness of AI-driven stratified care for depression (Jaime Delgadillo) 
Chair: Julia Brown
Conflicts: Andrew Farmer, Jo Dumville, Abdullah Pandor
Arrived at the meeting: Matthew Moore
Left the meeting: Sarah Markham
Decision: Programme Oversight Committee to consider fund with changes

22/61 HTA Researcher-led call Primary Research

NIHR155294 - Inpatient GRAduated Compression stocking use as an adjunct to Extended duration pharmacoprophylaxis for venous thromboembolism prevention – the GRACE multi-centre randomised controlled trial (Alun Davies)
Chair: Julia Brown
Conflicts: Jo Dumville, Athanasios Saratzis, Abdullah Pandor, Hashim Ahmed, David Keene, Laura Coates, Andrew Farmer, Simon Gates, Joyce Yeung
Arrived at the meeting: Janet Diffin (observer)
Decision: Programme Oversight Committee to consider fund with changes

22/64 NIHR James Lind Alliance Priority Setting Partnerships Rolling Call (HTA Programme: May 22 - Aug 22)

NIHR154252 - Randomised trial examining clinical and cost effectiveness of three antithrombotic regimens following endovascular lower limb revascularisation for chronic limb threatening ischaemia: CLARITY (CLopidogrel, Aspirin and RIvaroxaban after revascularIsation with angioplasTY) (Christopher Twine)
Chair: Mark Peters
Conflicts: Jo Dumville, Nick Francis, Athanasios Saratzis, Joyce Yeung, Hashim Ahmed, Julia Brown
Arrived at the meeting: Martin Dixon (observer)
Decision: Programme Oversight Committee to consider fund with changes

NIHR155220 - A double-blind randomised placebo-controlled trial to assess the effectiveness and cost-effectiveness of oral Corticosteroids in patients witH fibrOtic hypeRsensitivity pneUmonitiS (CHORUS) (Michael Gibbons)
Chair: Julia Brown
Conflicts: Ashley Agus. Victoria Goodwin, David Keene. Joanna Thompson-Coon, Athanasios Saratzis, Garry Barton, Thomas Hellyer
Arrived at the meeting: Sarah Markham
Left the meeting: Matthew Moore
Decision: Stage 2 resubmission

22/3 NIHR NICE Rolling Call (HTA Programme: Jan 22 - May 22)

NIHR152845 - SORTED Surgery Or Rehabilitation for Traumatic shouldEr Dislocations (Stephen Gwilym)
Chair: Julia Brown
Conflicts: David Keene, Hema Mistry, Andrew Farmer, Stephanie MacNeill, Laura Coates, Joyce Yeung, Simon Gates
Left the meeting: Stuart McIntosh
Decision: Stage 2 resubmission

NIHR152516 - ICS-RECODE: Predictors of treatment REsponse to inhaled corticosteroids (ICS) in COPD: randomised COntrolled trials individual participant Data re-Evaluation. (Alexander Mathioudakis)
Chair: Julia Brown
Conflicts: Jo Dumville, Abdullah Pandor 
Decision: Programme Oversight Committee to consider fund with changes

Stage 1 Applications

22/99 Clinical prediction models for early-onset neonatal infection

Chair: Julia Brown
Conflicts: Ashley Agus, Khalida Ismail, Hema Mistry, Andrew Farmer, Simon Gates, Mark Peters, Joyce Yeung
Arrived at the meeting: Marta Soares

NIHR154983 - Clinical pRediction model for eArlY-onset neOnatal iNfection: The CRAYON study. A cluster randomised trial and validation study of the Sepsis Risk Calculator with health economic and acceptability evaluations. (Sabita Uthaya)
Decision: Shortlist

NIHR156385 - Predicting Early Onset Neonatal Infection (PEONI): a multi centre, open label, superiority, cluster randomised controlled trial (Shalini Ojha)
Decision: Decline

22/97 Early detection of liver disease

Chair: Caroline Free
Conflicts: Nick Francis, Joanna Thompson-Coon, Victoria Goodwin, Simon Gates, David Keene, Stephanie MacNeill, Mark Peters, Andrew Farmer, Julia Brown, Hema Mistry, Athanasios Saratzis

NIHR155989 - DETECTOR: A cluster randomized trial of early detection of cirrhosis in primary care (John Dillon)
Decision: Decline Return to POC

NIHR157453 - Selecting people at risk of chronic liver disease in primary care for referral to secondary care - SEARCH (Ian Rowe)
Decision: Decline Return to POC

22/96 Urine sampling in children

NIHR156005 - Determining the feasibility of randomising children and young people to invasive and non-invasive urine sampling techniques. (Thomas Waterfield)
Chair: Julia Brown
Conflicts: Hema Mistry, Ashley Agus, Mark Peters
Left the meeting: Matthew Moore, Marta Soares, Martin Dixon (observer)
Decision: Stage 1 resubmission

22/98 Low-dose computed tomography for the diagnosis of lung cancer in symptomatic patients seen in primary care

Chair: Mark Peters
Conflicts: Julia Brown, David Keene, Joanna Thompson-Coon, Joyce Yeung, Andrew Farmer, Nick Francis
Arrived at the meeting: Matthew Moore

NIHR155952 - Methods of Early Detection of Lung cancEr in PrimarY Care (MEDLEY) (Matthew Callister) 
Decision: Shortlist

NIHR157368 - SHOuld CT scans replace CXRs for Primary Care ChEst Imaging. The HOPE trial (Fergus Gleeson) 
Decision: Shortlist

22/95 Chronic kidney disease education for patients, families and carers

Chair: Mark Peters
Conflicts: Abdullah Pandor, Athanasios Saratzis, Julia Brown, David Keene, Joanna Thompson-Coon, Hema Mistry, Victoria Goodwin
Arrived at the meeting: Martin Dixon (observer)

NIHR156249 - Interventions delivering chronic kidney disease information and education: evidence mapping, realist synthesis, and evaluation of clinical- and cost-effectiveness (Thomas Wilkinson)
Decision: Decline

NIHR157760 - Does current provision of information and education to patients, families and carers in the UK with CKD Stages 2-4 align with evidence on effectiveness and cost-effectiveness, and what factors tend to increase or decrease its use? (Peter Knapp)
Decision: Shortlist

NIHR157908 - Mixed Method Evidence Synthesis for Equity: to identify inclusive education and information interventions for all people managing early-stage chronic kidney disease (Paula Ormandy) 
Decision: Shortlist

22/100 Pain management for children and young people

NIHR157424 - The Analgesia Versus Intravenous Sedation for Fracture Reduction in Children (AVIS) Trial: A multi-centre prospective randomised trial comparing intravenous sedation with short-acting analgesia for closed reduction of paediatric fractures in the Emergency Department. (David Metcalfe)
Chair: Julia Brown
Conflicts: David Keene, Andrew Farmer, Laura Coates, Athanasios Saratzis
Decision: Decline

22/101 Management of bone metastasis and skeletal related events (SREs) in patients with advanced cancer

NIHR155305 - A randomised phase III trial evaluating the efficacy and cost-effectiveness of stereotactic radiotherapy compared with conventional radiotherapy for reducing pain associated with spinal metastases (SENSE) (Fay Cafferty)

Chair: Mark Peters
Conflicts: Hashim Ahmed, Julia Brown
Left the meeting: Matthew Moore
Decision: Decline

22/113 HTA Programme Researcher-led call Evidence Synthesis

NIHR156203 - Confirming the placement of nasogastric tubes: a systematic review and economic evaluation (Elizabeth Lightbody) 
Chair: Julia Brown
Conflicts: Jo Dumville
Arrived at the meeting: Matthew Moore
Decision: Shortlist

NIHR156881 - Expanding the eligibility criteria for a no-biopsy diagnosis for coeliac disease in adults and children: Individual participant data review and cost-effectiveness analysis. (Penny Whiting)
Chair: Julia Brown
Conflicts: Jo Dumville, Athanasios Saratzis, Nick Francis, Stephanie MacNeill, Abdullah Pandor
Left the meeting: Sarah Markham
Decision: Shortlist