University College London Hospitals NHS Foundation Trust; Royal Free Hampstead NHS Trust; University College London

Work in this TRC centre has a focus on understanding the mechanisms of inflammation, tissue fibrosis and repair in the context of respiratory disease. Translational research relating to: asthma; interstitial lung diseases (ILD); sarcoidosis; chronic obstructive pulmonary disease (COPD); bronchiectasis; pulmonary infections and acute respiratory distress syndrome (ARDS).  Focus of the work includes identification of novel targets for drug discovery; early phase studies in collaboration with our clinical research facility (CRF); patient stratification and novel biomarkers.

Capabilities     

Experimental respiratory medicine at UCL is coordinated through three collaborative centres, The Centre for Inflammation and Tissue Repair, The Centre for Respiratory Biology, and Lungs for Living Research Centre. These centres form a network of 70 clinical academics and scientists with a track record of translational research in respiratory medicine:

This centre, composed of members of the UCL Partners Academic Health Science network, serves 6 million people, (roughly 10% of the UK population). This network also includes an NHS England National Centres for ILD as well as specialist services in bronchiectasis difficult asthma and COPD.  The TRC centre itself hosts the largest number of bronchoscopic studies in the UK with eight bronchoscopy lists per week.

Other capabilities include:

Pioneering work in minimally invasive cryoscopic bronchoscope lung biopsy (CLB)

  • Novel nuclear medicine biomarker and cell trafficking facility (in association with institute of nuclear medicine)
  • Database of >1,400 ILD patients
  • 9000 COPD patient cohort
  • NIHR UCLH Clinical Research Facility able to support first in patient studies and overnight patient stays
  • Close interaction with the UCLH BRC (£111million for translational research)

Leading academic expertise

Led by Dr Joanna Porter, this centre’s expertise includes:

Asthma - Professor Douglas Robinson

Interstitial Lung Disease - Dr Joanna Porter

COPD including alpha-1 antitrypsin deficiency - Dr John Hurst and Professor David Lomas

Respiratory infection and bronchiectasis - Professor Jeremy Brown

Advanced bronchoscopy service - Dr Neal Navani

Website

UCL Hospitals Biomedical Research Centre