University Hospital Southampton NHS Foundation Trust; University of Southampton

University Hospital Southampton NHS Foundation Trust and the University of Southampton bring expertise in utilising stratified/personalised medicine to prevent disease progression and acute exacerbation in respiratory diseases. The centre is working on expanding its existing cohorts and establishing applicable tools for stratification of lung disease for the development of pharmacological and non-pharmacological treatments.

Capabilities     

This centre has directly contributed to the development of new drugs for asthma and idiopathic pulmonary fibrosis (IPF) and has informed national and international guidelines for the diagnosis and management of these diseases. The TRC centre hosts deeply-phenotyped cohorts of asthma, COPD and rare lung disease and leads on pioneering patient-focused research, including the EU (Innovative Medicines Initiative) respiratory disease stratification programme, U-BIOPRED (Unbiased Biomarkers Predictive of Respiratory Disease Outcomes).

This centre brings expertise in novel diagnostics including:

  • Mass spectrometry based analysis of lipids (lipidomics) and proteins (proteomics)
  • 3D histopathology to improve diagnostic accuracy and classification of ILD,
  • lung sound analysis as a tool for early diagnosis and monitoring of IPF (with the Institute of Sound and Vibration Research).

This centre has been a key contributor to the Respiratory TRC, leading on a £4m investigator-led project in collaboration with Novartis, which aims to optimise selection of patients for treatment with omalizumab (SoMOSA). This centre has also helped to develop the Refractory Asthma Stratification Programme (RASP) - UK, funded by a £4.7m MRC grant in response to a call from the MRC Stratified Medicine programme. Professor Djukanovic has led the set up (March 2017) of a European Severe Asthma Clinical Research Collaboration, an international network for the NIHR TRC to link to for key projects that require large registries of well characterised patients.

Leading academic expertise

Led by Professor Ratko Djukanovic, this centre has expertise in:

Respiratory cell biology - Professor Donna Davies

Severe asthma - Professor Ratko Djukanovic and Professor Peter Howarth

COPD - Professor Tom Wilkinson

Respiratory Allergy - Professor Hasan Arshad

Primary Ciliary Dyskinesia - Professor Jane Lucas

Tuberculosis - Professor Paul Elkington

Website

Southampton Biomedical Research Centre