Minutes for the Research for patient Benefit Programme Under-Represented Disciplines and Specialisms Highlight Notice: Methodologists Research Advisory Committee B Stage 2 Meeting

Minutes for the Research for Patient Benefit Programme Under-represented disciplines and specialisms highlight notice: Methodologists Research Advisory Committee B Stage 2 meeting 

Date and Location

Thursday 18 April 2024 Via Zoom Virtual Meeting

In attendance

Committee Members

Professor Christina Jones (Chair)
Professor Chris Gale (Deputy Chair)
Professor Peter Bower
Professor Sarah Byford
Professor Spiros Denaxas
Professor Robbie Foy
Rosemary Greenwood
Dr Hayley Jones
Professor Susan Mallett
Professor Tom Marshall
Professor Fliss Murtagh
Professor Stephen Morris
Professor Martin Orrell
Professor Katherine Payne
Dr Rachel Phillips
Mr John Roberts
Professor Caroline Sanders
Professor Rod Taylor
Ms Jane Whitehurst
Professor Paula Williamson
Mr Keith Wyncoll

Secretariat

Dr Kevin Munro, Programme Director RfPB
Dr Elisabeth Kugelberg (NIHRCC)
Mrs Zuzanna Tajchman (NIHRCC)
Mr Richard Foulsham (NIHRCC)
Dr Heather Ford (NIHRCC)
Mr Ian Beason (NIHRCC)
Ms Sarah Deria (NIHRCC)
Mr James Hurst (NIHRCC)
Mr Noor Akbar (NIHRCC)

Stage 2 applications considered

NIHR206873: Understanding the impact of single disease resolution in Multiple Long-Term Conditions (MLTC) on long-term trajectories towards hospitalisation and all-cause mortality: A cohort study
Conflicts: Professor Christina Jones, Dr Rachel Phillips, Professor Spiros Denaxas, Professor Jackie Sturt
Final outcome: Conditional support

NIHR206835: A Generic Standardised Item Set for remote assessments in people requiring specialist outpatient care: The GeneSIS Project
Conflicts: Professor Paula Williamson, Professor Caroline Sanders
Final outcome: Conditional support

NIHR206888: Assessing the effect of continuity of care on patient outcomes and hospital resourcing to improve efficiency and effectiveness of patient care
Conflicts: None
Final outcome: Conditional support

NIHR206858: Software to provide simulation-based minimum sample size calculations for prediction modelling
Conflicts: Professor Sarah Byford
Final outcome: Conditional support

NIHR206909:Temporal Recalibration for Up-to-date risk Estimates from Prognostic Models (TRUE-PM)
Conflicts: None
Final outcome: Conditional support

NIHR206847: Refining the usability and acceptability of reporting guidelines: a sequential feasibility study and parallel process evaluation.
Conflicts: Professor Spiros Denaxas, Professor Sue Mallett
Final outcome: Conditional support

NIHR206877: OpenPREGnosis: Developing an Open Algorithm to Identify Pregnancy Episodes and Outcomes in National Electronic Health Records (EHRs): A Comprehensive Methodological Approach
Conflicts: Professor Chris Gale, Professor Katherine Payne, Professor Robbie Foy, Professor Caroline Sanders, Professor Peter Bower, Professor Jackie Sturt
Final outcome: Conditional support

NIHR206833: Development of new reporting guidance for systematic reviews of health economic evaluations
Conflicts: Professor Peter Bower, Ms Jane Whitehurst, Professor Sue Mallett
Final outcome: Conditional support

NIHR206860: Combining treatment effects from clinical trial data and routinely collected healthcare data to answer important research questions
Conflicts: Professor Chris Gale, Dr Rachel Phillips
Final outcome: Conditional support

NIHR206837: Appropriateness of methodology and reporting in case-control studies in Electronic Health Records databases: methodological systematic review and simulations
Conflicts: Professor Stephen Morris, Professor Sue Mallett
Final outcome: Rejected

NIHR206879: Development of new methodology to frame and address the impact of poor-quality studies on meta-analysis
Conflicts: Dr Hayley Jones
Final outcome: Conditional support

NIHR206915: Target trial emulation in cystic fibrosis: optimising methods for evaluating antibiotic treatment using registry data
Conflicts: Professor Paula Williamson, Professor Spiros Denaxas, Professor Sue Mallett
Final outcome: Conditional support

NIHR206823: Health economic simulation modelling for cardiovascular assessment and intervention: development, validation, and application of a publicly available resource
Conflicts: Professor Spiros Denaxas, Professor Stephen Morris
Outcome: Rejected

NIHR206843: PREDICT: Pragmatic Recalibration and Evaluation of Drift In Clinical Tools
Conflicts: None
Final outcome: Conditional support

NIHR206850: Transitioning from Feasibility to Main trial: transparent Reporting of Modifications and Adaptations of Trial design Elements (TRANSFoRMATE)
Conflicts: Professor Sarah Byford, Dr Rachel Phillips, Professor Jackie Sturt
Final outcome: Conditional support

NIHR206813: Identifying methodological uncertainties in the design and analysis of trials in people living with multiple long-term conditions
Conflicts: Professor Spiros Denaxas, Professor Tom Marshall, Professor Jackie Sturt, Professor Martin Orrell, Professor Stephen Morris, Professor Rod Taylor, Professor Peter Bower
Final outcome: Conditional support

Outcomes Table

The table below displays the mean score for each application that was assessed in the research assessment committee meeting, and excludes applications which were rejected during the scrutiny and triage processes. The number of applications receiving each mean score are listed. The RfPB fundable range is 4-6, although a score of 4-6 does not guarantee funding. In exceptional circumstances and with approval from the Programme Director, applications may be funded which fall below the fundable range.
In exceptional circumstances, applications which fall below the fundable range may be recommended for funding by the Committee. The Programme Director reviews in detail any applications recommended for funding with a score below 4.

Stage 2