To find out more about current Stroke studies you can view a list of studies on the NIHR Clinical Research Network Portfolio Database.
The NIHR Clinical Research Network Stroke has been enormously successful in integrating clinical research into NHS clinical service provision, and both developing and delivering a large practice changing portfolio of clinical trials.
Read our Stroke Specialty Profile to find out more.
Clinical research into stroke takes place at every stage along the stroke patient pathway from prevention, to treatment and rehabilitation. Clinical studies also take place in diverse settings from specialist hospital units, to community rehabilitation centres and in patient’s homes.
We support a wide range of research, including:
Some currently active stroke studies focus on the following:
Where there are considerable overlaps with other specialty areas, for example with cardiovascular disease and in other care settings such as primary care, we work closely with our colleagues from across the Network to deliver high quality stroke research.
To find out more about current Stroke studies you can view a list on the UK Clinical Trials Gateway.
UK-led stroke research has made major contributions to developments in areas like anti-platelet agents, carotid endarterectomy, carotid stenting, surgical management of intracranial haemorrhage and rehabilitation in recent years.
UK research groups have contributed to national and international guidance on stroke care:
The aim of the GORE study was to investigate a percutaneous cardiac closure device for the secondary prevention of stroke in younger people. The NIHR Clinical Research Network supported recruitment of patients with ischaemic stroke secondary to an underlying cardiac defect from four stroke units across the UK.
Following identification and specialist stroke work up, eligible participants were randomised to either percutaneous closure device (or standard care) by the cardiologist. This trial was complex as it required collaboration between acute stroke services and cardiology, NIHR support for identification, enrolment and follow-up across both specialties was key in this study exceeding its target recruitment by 200 per cent.
Swallowing problems are common after stroke and a proportion of survivors are left dependent on feeding tubes. The STEPS study investigated electrical stimulation, applied to the pharynx by a device similar to a feeding tube. Assessment and treatment of swallowing is dependent on multi-disciplinary skills, including doctors nurses and speech and language therapists
The Network supported research staff from these multi-disciplinary teams to deliver the STEPS study in 11 stroke units across the UK, with 102 participants recruited over 26 months, making this the largest trial of its kind worldwide.
Immobile patients face a 10-20% risk of deep vein thrombosis (DVT) during the first month after stroke. The CLOTS – or ‘Clots in Legs Or sTockings after Stroke’ studies are testing graduated compression stockings for DVT prevention in acute stroke patients.
Findings from the CLOTS 1 trial were published in The Lancet in May 2009:
As a result, NICE revised its stroke guidelines in early 2010, and no longer recommend thigh-length GCS for stroke patients.