This site is optimised for modern browsers. For the best experience, please use Google Chrome, Mozilla Firefox, or Microsoft Edge.

Beta Site: This is a new site which is still under development. We welcome your feedback, which will help improve it.

Feedback form

International funding

The NIHR has a long established history of funding studies with an element of international collaboration. 

All NIHR-funded programmes will consider funding for international studies where the contract is held in the UK, but please contact individual programmes to check eligibility before applying.

Example of international collaboration: Joint NIHR Health Technology Assessment commissioned calls with Australian National Health Medical Research Council 

The NIHR Health Technology Assessment Programme has a long-standing collaboration with the Australian National Health Medical Research Council (NHMRC) and advertise joint commissioned calls inviting collaborative international research proposals to address shared research priorities. These collaborative commissioned calls are announced on the NIHR and NHMRC websites.

Collaborative proposals undergo a review by an NIHR HTA funding committee to assess UK costs and overall costs and value for money, shortlisted studies submit a more detailed full stage 2 proposal. All studies recommended for funding undergo an NHMRC financial review to ratify the Australian study costs.  For those studies formally approved for funding, each funder commits to fund the costs for research undertaken in their respective country.

Watch our video describing the different scenarios in which the NIHR will join international studies.

Contact us

 If you have a specific query in relation to the international element of your proposal please contact netsinternational@nihr.ac.uk. Otherwise for any other programme related queries applicants should refer to the programme contact information.

 

Funding: NIHR funding for recruitment is only applicable to research in UK institutions. International recruitment is funded from other sources

  • UK-based Chief Investigators and institutions must lead the UK aspects of any international studies to be funded by NIHR and the contract held by a UK organisation.
  • Modest allowances for the extra central UK administration associated with international recruitment and collaboration will be considered.
  • Applicants must demonstrate that they are seeking funding for recruitment at international centres from other sources when applying.
  • Applicants should identify how the project will mitigate or allow for delays to international centre funding with clear stop/go criteria for the funding of international centre(s) and contingency plans if international funding is not approved.
  • NIHR funding for recruitment is only applicable to research in UK institutions. International recruitment must be funded from other sources. There may be multiple funding sources for the international recruitment costs.
  •  Apart from the NIHR Global Health Programme it would be very unusual for NIHR programmes to fund recruitment internationally.

An international study will be considered where the study is relevant to and a priority for the UK population.

  • Applicants must provide the rationale for international collaboration, including justification for why the trial cannot be completed in the UK e.g. number of patients, recruitment, expertise etc. Applicants should demonstrate that UK opportunities for recruitment have been fully explored and that innovative study designs to deal with small study populations have been considered.
  • The project or proposed intervention must be deliverable and applicable to the UK population or clinical / health and social care settings.
  • International centres should usually be in countries with similar health contexts and settings generalisable to the UK.

 It is expected that the full international study will be able to determine whether there are statistically meaningful differences in outcomes.

Factors to take into account when considering whether an international collaboration is appropriate to include within a funding proposal:

  • The UK arm of the study is not expected to provide standalone statistical differences (or power).
  • The UK arms of international studies should have sufficient UK participants to have credibility in the UK clinical community and to answer UK specific questions as applicable.
  • NIHR programmes require at least 20% of all study participants to be in the UK arm and provide enough data for a health economic analysis to be done from a UK perspective.

What are the benefits of including an international element to a proposal?

  • Avoids early closure or significant delays for a project with recruitment issues.
  • Enables important projects in smaller UK patient group or with potential recruitment challenges to proceed.
  • Develops NIHR's international reputation and reach.
  • Pools international resources and provides opportunity for data analysis and learning.
  • Enables understanding of shared international priorities and opportunities.

What are the challenges to consider for proposals with international collaborations, these include, but are not limited to:

  • Establishing responsibility in terms of publication, copyright, and research governance issues etc.
  • Intellectual property issues and funders terms will need to be detailed through an agreement across contracting institutions.
  • Recognise where key element(s) of the study are not relevant to a UK setting.

Consider and mitigate any additional risks associated with the international collaboration element of a proposal.  Examples may include:

  • Complex funding arrangements, international protocols or recruitment issues may reduce the success of potentially important international studies at NIHR funding boards.
  • Challenging recruitment issues may increase risk of project failure and impact in NIHR reputation.
  • Responsibility for key issues including publication, copyright, intellectual property and research governance issues etc. should be defined up front and managed between contractors.
  • Ensuring NIHR specific requirements are are met eg cost effectiveness through a Memorandum of Understanding between funders and agreements between contractors.
  • Limited influence over study protocol for international led and funded studies.

Related pages