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EME Funding Committee Minutes – 26th and 27th February 2019

 

Contents

 

Date 

Tuesday 26th February 2019 (Day 1) 

Venue

Danubius Hotel, Regents Park, London

Present members

Professor David Crossman (Interim Director and Chair)

Professor Eric Alton (Deputy Chair)

Dr Simon Bond

Dr Louise Brown

Professor Bill Deakin

Professor Janet Dunn

Mr Steve Edgar

Professor Carrol Gamble

Professor Paula Ghaneh

Professor Fiona Gilbert (Left at 3:50pm)

Professor Jonathan Grigg

Professor Ajit Lalvani (Left at 1:00pm)

Professor Iain McInnes

Professor Michael Nicholson

Mr Richard Parnell

Dr Richard Peck

Professor John Petrie

Professor RustamSalman

Professor Robert Storey

Professor Frank Sullivan (Left at 1:40pm)

Professor Mark Thursz

Professor Chris Weir

Co-Opted Committee

Members: Professor Carl Clarke (By telephone at 2:00pm)

Secretariat

Dr Andrew Cook

Mr Rod Delanougerede

Dr Elena Harden

Miss Helen Munday

Dr DaniPreedy

Ms Susan Solomons

Dr William Toff

Apologies

Professor Steve Thornton

Professor Ruth Plummer

Absent DCM comments were presented at the meeting

Observers/In attendance

Professor Danny McAuley, EME Programme Director, effective 1st March 2019

Dr Matthew Ahearne, future TCC Funding Committee member

Ting-Li Su, RDS-NW , Great Manchester office

 

Tuesday 26th February 2019 – Day 1 

Stage 2 Proposals

18/58: EME Researcher Led

NIHR127982: Catheter Against Urinary Tract Infection Trial: a randomised trial of antimicrobial-impregnated urinary catheters for long-term indwelling urinary catheter users (CAUTI Trial)

Professor Roger Bayston

Chair: David Crossman

Declared a conflict and left the room: None

Decision: Recommended to Programme Director to consider fund with changes

18/128: Mechanisms of Action of Health Interventions

NIHR128582: Investigating the mechanism of action of cannabidiol as an antipsychotic

Dr Sagnik Bhattacharyya

Chair: David Crossman

Declared a conflict and left the room: None

Decision: Declined

17/60: EME Researcher Led

17/60/67: Enceph-IG - Intravenous Immunoglobulin in Autoimmune Encephalitis in Adults: A Randomised Double-Blind Placebo-Controlled Trial

Professor Tom Solomon

Chair: David Crossman

Declared a conflict and left the room: Louise Brown, Carrol Gamble, Paula Ghaneh

Decision: Recommended to Programme Director to consider fund with changes

18/128: Mechanism of Action of Health Interventions

NIHR128374: The Role of Immunosuppression in an antibiotic Stewardship intervention and its association with Clinical outcomes and antibiotic use: RISC-sepsis

Dr Thomas Hellyer

Chair: David Crossman

Declared a conflict and left the room: Simon Bond, Bill Deakin, Janet Dunn, Rustam Salman, Chris Weir, Danny McAuley (observing), Ting-Li Su (observing)

Decision: Recommended to Programme Director to consider fund with changes

18/128: Mechanisms of Action of Health Interventions

NIHR128210: STudy Of Prevention by Aspirin anD EPA; kNowledge Of Mechanism of Action (STOP-ADENOMA) Professor Mark Hull

Chair: David Crossman

Declared a conflict and left the room: Louise Brown, Robert Storey Bill Deakin left the meeting prior to the discussion

Decision: Recommended to Programme Director to consider fund with changes

18/58: EME Researcher Led

NIHR127930: FUT U RE – GB Trial (Functional and Ultrasound guided Resection of Glioblastoma). A 2-Stage trial. Stage 1 Non-randomised learning phase evaluation of participating centres (an IDEAL study), followed by Stage 2 which is randomised,controlled Multicentre Phase III trial with 2 mechanistic substudies

Mr Puneet Plaha

Chair: David Crossman

Declared a conflict and left the room: Eric Alton, Carrol Gamble, Paula Ghaneh, AjitLalvani, Mark Thursz

Decision: Recommended to Programme Director to consider fund with changes

12/10: EME Researcher Led extension request

12/10/18: A randomised controlled trial of the ketogenic diet in the treatment of epilepsy in children under the age of two years

Professor Judith Helen Cross

Chair: David Crossman

Declared a conflict and left the room: Simon Bond, Louise Brown, Bill Deakin, Fiona Gilbert

Ajit Lalvani and Michael Nicholson left the meeting before the discussion

Decision: Approved

18/58: EME Researcher Led

NIHR127575: The efficacy and mechanism of trientine in patients with hypertrophic cardiomyopathy

Dr Christopher Alan Miller

Chair: David Crossman

Declared a conflict and left the room: Eric Alton, Carrol Gamble, Paula Ghaneh, Mark Thursz, Chris Weir, William Toff, Ting-Li Su

Conflicted but not in attendance: Bill Deakin, Ajit Lalvani

Frank Sullivan left the meeting prior to the discussion

Decision: Recommended to Programme Director to consider fund with changes

18/58: EME Researcher Led

NIHR127690: MAnnitol and/or Glibenclamide for reducing IntraCerebral oedema after stroke (MAGIC)

Professor Philip Michael Bath

Chair: David Crossman

Declared a conflict and left the room: Iain McInnes, John Petrie, Rustam Salman, Chris Weir

Decision: Declined

Stage 1 Proposals

18/125: EME Researcher Led

NIHR128397: Optical coherence tomography (OCT) for the management of retinoblastoma

Professor Irene Gottlob

Chair: David Crossman

Declared a conflict and left the room: Jonathan Grigg, Steve Thornton, William Toff and Matthew Ahearne (observing)

Bill Deakin returned to the meeting at the start of the discussion

Decision: Declined

18/126: Functional Imaging

NIHR128467: Computational AnalySiS of functionAl Neuroimaging and Drug Response in pAinful Diabetic Neuropathy (CASSANDRA-DN)

Dr Dinesh Selvarajah

Chair: David Crossman

Declared a conflict and left the room: Robert Storey, Chris Weir

Michael Nicholson returned for the meeting prior to the discussion

Decision: Declined - consider for development funding

18/126: Functional Imaging

NIHR128494: Application of multiparametric functional MRI to improve assessment of chronic kidney disease

Dr Nicholas Michael Selby

Chair: David Crossman

Declared a conflict and left the room: Simon Bond, Fiona Gilbert

Decision: Shortlisted

18/126: Functional Imaging

NIHR128538: 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography in Abdominal Aortic Aneurysms to Predict Growth, Rupture or Repair. The SoFIA3-PREDICT Study

Professor David E Newby

Chair: Eric Alton

Declared a conflict and left the room: David Crossman, Simon Bond, Fiona Gilbert, Iain McInnes, John Petrie, Rustam Salman, Frank Sullivan, Chris Weir, William Toff and Matthew Ahearne (observing)

Decision: Declined

18/131: Urothelial Cancers

NIHR128040: Biomarker Directed Radiotherapy for Bladder Cancer (DIRECT)

Professor Ananya Choudhury

Chair: David Crossman

Declared a conflict and left the room: : Louise Brown, Bill Deakin, Iain McInnes, John Petrie, Chris Weir, Ting-Li Su (observing)

Conflicted but not in attendance: Ruth Plummer

Decision: Declined - consider for development funding

18/131: Urothelial Cancers

NIHR128440: Testing Tests for the non-invasive diagnosis of recurrence during non-muscle-invasive bladder cancer Surveillance: “TT-Survey”

Mr Richard Bryan

Chair: David Crossman

Declared a conflict and left the room: Louise Brown

Decision: Declined

18/131: Urothelial Cancers

NIHR128103: Genotype of Urothelial cancer: Stratified Treatment and Oncological outcomes (GUSTO): Phase 2 study

Professor James William Catto

Chair: David Crossman

Declared a conflict and left the room: Robert Storey, Andrew Cook, Richard Peck

Fiona Gilbert left the meeting prior to the discussion

Decision: Shortlisted

18/127:Transplantation

NIHR128600: PROpHET - Perfusion and Recovery Of HEarts for Transplantation

Mr Pedro Catarino

Chair: David Crossman

Declared a conflict and left the room: Simon Bond, Bill Deakin, Fiona Gilbert, Chris Weir, Andrew Cook, William Toff, Ting-Li Su (observing)

Decision: Declined – invited to resubmit

18/127: Transplantation

NIHR128169: A randomised controlled trial assessing the benefits of screening for anti-HLA antibodies to optimise immunosuppressive therapy and improve chronic allograft damage in liver transplantation.

Professor Alberto Sanchez-Fueyo

Chair: David Crossman

Declared a conflict and left the room: Simon Bond, Chris Weir

Conflicted but not in attendance: Fiona Gilbert

Frank Sullivan returned to the meeting prior to the discussion

Decision: Declined

18/127: Transplantation

NIHR128475: Early detection of post-transplant lung allograft dysfunction by monitoring of lung clearance index

Dr Alex Horsley

Chair: David Crossman

Declared a conflict and left the room: Bill Deakin, Robert Storey, Ting-Li Su (observing) Page 6 of 11 Funding Committee Minutes – February 2019

Eric Alton noted he had published with the lead applicant in 2013 or earlier and it was agreed for him to remain in the room

Decision: Shortlisted

18/127: Transplantation

NIHR128318: Randomised controlled trial of faecal microbiota transplantation in renal allograft recipients

Mr Reza Motallebzadeh

Chair: David Crossman

Declared a conflict and left the room: Eric Alton, Louise Brown, Ajit Lalvani, Mark Thursz

Decision: Declined

18/127: Transplantation

NIHR128565: The Effect of Normothermic Machine Preservation on Utilisation of High Risk Livers for Transplantation – A National Randomised Controlled Trial

Professor Peter Friend

Chair: David Crossman

Declared a conflict and left the room: Simon Bond, Fiona Gilbert, Rustam Salman, Chris Weir

Conflicted but not in attendance: Ajit Lalvani

Iain McInnes left the meeting prior to the discussion

Decision: Declined

18/125: EME Researcher Led

NIHR128445: Efficacy and mechanisms evaluation of a blood free (acellular) perfusion fluid for use in normothermic machine perfusion and transplantation of extended criteria donor livers

Professor Darius F Mirza

Chair: David Crossman

Declared a conflict and left the room: None

Iain McInnes returned to the meeting prior to the discussion

Decision: Shortlisted

18/85: EME End of Life Care

NIHR128366: Better treatment of symptoms for cancer patients at the end of life (BETTER-C): A Randomised Controlled Trial of a newly adapted pharmacological treatment for breathlessness and polysymptomatology in cancer patients at the end of life

Professor Irene Julie Higginson

Chair: David Crossman

Declared a conflict and left the room: None

Conflicted but not in attendance: Ruth Plummer

Mark Thursz left the meeting prior to the discussion

Decision: Declined

 

Date

Wednesday 27th February 2019 (Day 2)

Venue

Danubius Hotel, Regents Park, London

Present members

Professor David Crossman (Chair)

Professor Eric Alton (Deputy Chair)

Dr Simon Bond

Dr Louise Brown

Professor Bill Deakin

Professor Janet Dunn

Mr Steve Edgar

Professor Carrol Gamble

Professor Paula Ghaneh

Professor Jonathan Grigg

Professor AjitLalvani

Professor Iain McInnes

Mr Richard Parnell

Dr Richard Peck

Professor John Petrie

Professor RustamSalman

Professor Robert Storey

Professor Frank Sullivan

Professor Steve Thornton

Professor Mark Thursz

Professor Chris Weir

Secretariat

Miss Helen Munday

Dr Elena Harden

Ms Susan Solomons

Dr DaniPreedy

Dr Andrew Cook

Dr William Toff

Apologies

Professor Fiona Gilbert

Professor Ruth Plummer

Dr Michael Nicholson

Observers/In attendance

Professor Danny McAuley, EME Programme Director

Dr Penny Morton, MRC Dr Louise Jones, MRC

Louise Hayes, Senior Research Methodologist, RDS North East

 

Wednesday 27th February 2019 – Day 2 

Stage 1 Proposals

18/86: EME Precision Medicine

NIHR128529: Novel blood test to personalise Early Stage Colorectal Cancer treatment Professor David Cunningham

Chair: David Crossman

Declared a conflict and left the room: Richard Peck

Conflicted but not in attendance: Ruth Plummer

Decision: Shortlisted

18/86: EME Precision Medicine

NIHR128473: Etanercept as a disease-modifier in Alzheimer’s patients: a Phase II double-blind placebo controlled trial with a focus on neuro-inflammatory mechanisms

Professor Marios Politis

Chair: David Crossman

Declared a conflict and left the room: Steve Thornton

Decision: Declined

18/86: EME Precision Medicine

NIHR128465: Positioning Imatinib for Pulmonary Arterial Hypertension Professor Martin Wilkins

Chair: David Crossman

Declared a conflict and left the room: Eric Alton, Simon Bond, Fiona Gilbert, Ajit Lalvani, Robert Storey, Mark Thursz, Chris Weir

Decision: Shortlisted

18/180: EME Digital Technologies to Improve Health and Care

NIHR128345: Detection of residual leukaemia by integrated machine learning and label-free imaging cytometry

Professor Julie Anne Elizabeth Irving

Chair: David Crossman

Declared a conflict and left the room: None

Conflicted but not present: Ruth Plummer

Decision: Declined

18/125: EME Researcher Led

NIHR128346: A randomised control multicentre trial investigating efficacy and predictive markers of Spatial Inattention Grasping Home-based Therapy for spatial neglect recovery post-stroke (the predictiveSIGHT trial)

Dr Stephanie Rossit

Chair: Eric Alton

Declared a conflict and left the room: Simon Bond,Carrol Gamble, Paula Ghaneh, Fiona Gilbert, Iain McInnes, John Petrie, Chris Weir, David Crossman

Decision: Declined – invited to resubmit

18/125: EME Researcher Led

NIHR128593: Valproic acid for delirium in subarachnoid bleed trial (VALID trial)

Dr Tonny Veenith

Chair: David Crossman

Declared a conflict and left the room: Chris Weir, Danny McAuley (observing)

Decision: Declined – invited to resubmit

18/125: EME Researcher Led

NIHR128516: The ATOMiC (Antioxidant Therapy of Male Infertility Collaboration) Trial

Dr Jackson C Kirkman-Brown

Chair: David Crossman

Declared a conflict and left the room: Bill Deakin, Danny McAuley (observing)

Decision: Declined

18/125: EME Researcher Led

NIHR128591: Improving Memory in Schizophrenia with PDE4 inibitor Roflumilast

Professor Mitul Ashok Mehta

Chair: David Crossman

Declared a conflict and left the room: Bill Deakin

Decision: Declined – invited to resubmit

18/125: EME Researcher Led

NIHR128499: Treatment with Azole Antifungals to Prevent Lung Function Decline in People with Cystic Fibrosis and Aspergillus Infection.

Professor Adilia Warris

Chair: Andrew Cook

Declared a conflict and left the room: Eric Alton, Bill Deakin, Ajit Lalvani, Mark Thursz, David Crossman

Danny McAuley left the meeting prior to the discussion

Decision: Declined 

18/125: EME Researcher Led

NIHR128104: Hereditary Sensory Neuropathy Serine trial (SENSE trial) Professor Mary Margaret Reilly

Chair: David Crossman

Declared a conflict and left the room: None

Bill Deakin and Mark Thursz left the meeting prior to the discussion

Decision: Shortlisted

18/125: EME Researcher Led

NIHR128602: Randomised Evaluation of the Effect of Atrial Fibrillation Targeted Treatment Strategies on Exercise Capacity in Heart Failure with Preserved Ejection Fraction (EASE-HFpEF) Trial

Dr Tom Wong

Chair: David Crossman

Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Iain McInnes, John Petrie, Mark Thursz, Andrew Cook, William Toff

Danny McAuley returned to the meeting prior to the discussion

Decision Declined – invited to resubmit

18/125: EME Researcher Led

NIHR128545: The efficacy of behavioural Support & low-energy TOtal diet rePlacement for Non-Alcoholic SteatoHepatitis: the STOP-NASH randomised controlled trial

Professor Paul Aveyard

Chair: David Crossman

Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Mark Thursz

Iain McInnes left the meeting prior to the discussion

Decision: Declined 

18/125: EME Researcher Led

NIHR128395: Alzheimer's Disease treatment with combined valacyclovir and celecoxib: A Novel Clinical Evaluation (ADVANCE)

Dr Naji Tabet

Chair: David Crossman

Declared a conflict and left the room: Eric Alton, Bill Deakin, Ajit Lalvani, Mark Thursz, Chris Weir

Decision: Declined

18/125: EME Researcher Led

NIHR128598: DIRECTION trial - A UK Multi-centre Randomised Controlled Trial of Distal Aortic Repair versus Conservative Surgery in Acute Type A Aortic Dissection

Mr Pedro Catarino

Chair: David Crossman

Declared a conflict and left the room: Simon Bond, Carrol Gamble, Paula Ghaneh, Fiona Gilbert, Chris Weir, Andrew Cook, William Toff

Decision: Declined

18/125: EME Researcher Led

NIHR128432: A randomised controlled trial to determine whether exercise preserves beta cell function in adults with newly diagnosed type 1 diabetes - The EXTOD2 trial

Dr Parth Narendran

Chair: David Crossman

Declared a conflict and left the room: Andrew Cook, William Toff

The Secretariat recorded that John Petrie has had a number of round table discussions about research strategy with co-applicant (Andrews) as they both chair a Diabetes UK Clinical Study Group. He has not been involved in any discussions about this application. It was agreed by the secretariat that there was not a direct link between the discussion with the co-applicants and the application topic under review

Decision: Declined 

18/125: EME Researcher Led

NIHR128240: Remote Ischaemic Conditioning After Stroke 3 (RECAST-3): A multicentre randomised controlled trial

Professor Timothy England

Chair: David Crossman

Declared a conflict and left the room: Iain McInnes, John Petrie

Decision: Shortlisted

18/58: EME Researcher Led

NIHR127461: SuSPeCT study (Stratification of Patients Suspected of Colorectal Cancer)

Professor Ramesh Arasaradnam

Chair: David Crossman

Declared a conflict and left the room: Janet Dunn, Steve Thornton, Matthew Ahearne (observing)

Simon Bond and Paula Ghaneh left the meeting prior to the discussion

Decision: Shortlisted