Day 1: 26 February 2019, Danubius Hotel, Regents Park, London
Present
Members
- Professor David Crossman (Interim Director and Chair)
- Professor Eric Alton (Deputy Chair)
- Dr Simon Bond
- Dr Louise Brown
- Professor Bill Deakin
- Professor Janet Dunn
- Mr Steve Edgar
- Professor Carrol Gamble
- Professor Paula Ghaneh
- Professor Fiona Gilbert (Left at 3:50pm)
- Professor Jonathan Grigg
- Professor Ajit Lalvani (Left at 1:00pm)
- Professor Iain McInnes
- Professor Michael Nicholson
- Mr Richard Parnell
- Dr Richard Peck
- Professor John Petrie
- Professor RustamSalman
- Professor Robert Storey
- Professor Frank Sullivan (Left at 1:40pm)
- Professor Mark Thursz
- Professor Chris Weir
Co-Opted Committee Members: Professor Carl Clarke (By telephone at 2:00pm)
Secretariat
- Dr Andrew Cook
- Mr Rod Delanougerede
- Dr Elena Harden
- Miss Helen Munday
- Dr DaniPreedy
- Ms Susan Solomons
- Dr William Toff
Apologies
- Professor Steve Thornton
- Professor Ruth Plummer
- Absent DCM comments were presented at the meeting
Observers/In attendance
- Professor Danny McAuley, EME Programme Director, effective 1st March 2019
- Dr Matthew Ahearne, future TCC Funding Committee member
- Ting-Li Su, RDS-NW , Great Manchester office
Stage 2 Proposals
18/58: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: None
- NIHR127982: Catheter Against Urinary Tract Infection Trial: a randomised trial of antimicrobial-impregnated urinary catheters for long-term indwelling urinary catheter users (CAUTI Trial)
Professor Roger Bayston
Decision: Recommended to Programme Director to consider fund with changes
18/128: Mechanisms of Action of Health Interventions
Chair: David Crossman
Declared a conflict and left the room: None
- NIHR128582: Investigating the mechanism of action of cannabidiol as an antipsychotic
Dr Sagnik Bhattacharyya
Decision: Declined
17/60: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Louise Brown, Carrol Gamble, Paula Ghaneh
- 17/60/67: Enceph-IG - Intravenous Immunoglobulin in Autoimmune Encephalitis in Adults: A Randomised Double-Blind Placebo-Controlled Trial
Professor Tom Solomon
Decision: Recommended to Programme Director to consider fund with changes
18/128: Mechanism of Action of Health Interventions
Chair: David Crossman
Declared a conflict and left the room: Simon Bond, Bill Deakin, Janet Dunn, Rustam Salman, Chris Weir, Danny McAuley (observing), Ting-Li Su (observing)
- NIHR128374: The Role of Immunosuppression in an antibiotic Stewardship intervention and its association with Clinical outcomes and antibiotic use: RISC-sepsis
Dr Thomas Hellyer
Decision: Recommended to Programme Director to consider fund with changes
18/128: Mechanisms of Action of Health Interventions
Chair: David Crossman
Declared a conflict and left the room: Louise Brown, Robert Storey Bill Deakin left the meeting prior to the discussion
- NIHR128210: STudy Of Prevention by Aspirin anD EPA; kNowledge Of Mechanism of Action (STOP-ADENOMA)
Professor Mark Hull
Decision: Recommended to Programme Director to consider fund with changes
18/58: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Eric Alton, Carrol Gamble, Paula Ghaneh, AjitLalvani, Mark Thursz
- NIHR127930: FUT U RE – GB Trial (Functional and Ultrasound guided Resection of Glioblastoma). A 2-Stage trial. Stage 1 Non-randomised learning phase evaluation of participating centres (an IDEAL study), followed by Stage 2 which is randomised,controlled Multicentre Phase III trial with 2 mechanistic substudies
Mr Puneet Plaha
Decision: Recommended to Programme Director to consider fund with changes
12/10: EME Researcher Led extension request
Chair: David Crossman
Declared a conflict and left the room: Simon Bond, Louise Brown, Bill Deakin, Fiona Gilbert
Ajit Lalvani and Michael Nicholson left the meeting before the discussion
- 12/10/18: A randomised controlled trial of the ketogenic diet in the treatment of epilepsy in children under the age of two years
Professor Judith Helen Cross
Decision: Approved
18/58: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Eric Alton, Carrol Gamble, Paula Ghaneh, Mark Thursz, Chris Weir, William Toff, Ting-Li Su
Conflicted but not in attendance: Bill Deakin, Ajit Lalvani
Frank Sullivan left the meeting prior to the discussion
- NIHR127575: The efficacy and mechanism of trientine in patients with hypertrophic cardiomyopathy
Dr Christopher Alan Miller
Decision: Recommended to Programme Director to consider fund with changes
18/58: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Iain McInnes, John Petrie, Rustam Salman, Chris Weir
- NIHR127690: MAnnitol and/or Glibenclamide for reducing IntraCerebral oedema after stroke (MAGIC)
Professor Philip Michael Bath
Decision: Declined
Stage 1 Proposals
18/125: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Jonathan Grigg, Steve Thornton, William Toff and Matthew Ahearne (observing)
Bill Deakin returned to the meeting at the start of the discussion
- NIHR128397: Optical coherence tomography (OCT) for the management of retinoblastoma
Professor Irene Gottlob
Decision: Declined
18/126: Functional Imaging
Chair: David Crossman
Declared a conflict and left the room: Robert Storey, Chris Weir
Michael Nicholson returned for the meeting prior to the discussion
- NIHR128467: Computational AnalySiS of functionAl Neuroimaging and Drug Response in pAinful Diabetic Neuropathy (CASSANDRA-DN)
Dr Dinesh Selvarajah
Decision: Declined - consider for development funding
18/126: Functional Imaging
Chair: David Crossman
Declared a conflict and left the room: Simon Bond, Fiona Gilbert
- NIHR128494: Application of multiparametric functional MRI to improve assessment of chronic kidney disease
Dr Nicholas Michael Selby
Decision: Shortlisted
18/126: Functional Imaging
Chair: Eric Alton
Declared a conflict and left the room: David Crossman, Simon Bond, Fiona Gilbert, Iain McInnes, John Petrie, Rustam Salman, Frank Sullivan, Chris Weir, William Toff and Matthew Ahearne (observing)
- NIHR128538: 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography in Abdominal Aortic Aneurysms to Predict Growth, Rupture or Repair. The SoFIA3-PREDICT Study
Professor David E Newby
Decision: Declined
18/131: Urothelial Cancers
Chair: David Crossman
Declared a conflict and left the room: : Louise Brown, Bill Deakin, IainMcInnes, JohnPetrie, Chris Weir, Ting-Li Su (observing)
Conflicted but not in attendance: Ruth Plummer
- NIHR128040: Biomarker Directed Radiotherapy for Bladder Cancer (DIRECT)
Professor Ananya Choudhury
Decision: Declined - consider for development funding
18/131: Urothelial Cancers
Chair: David Crossman
Declared a conflict and left the room: Louise Brown
- NIHR128440: Testing Tests for the non-invasive diagnosis of recurrence during non-muscle-invasive bladder cancer Surveillance: “TT-Survey”
Mr Richard Bryan
Decision: Declined
18/131: Urothelial Cancers
Chair: David Crossman
Declared a conflict and left the room: Robert Storey, Andrew Cook, Richard Peck
Fiona Gilbert left the meeting prior to the discussion
- NIHR128103: Genotype of Urothelial cancer: Stratified Treatment and Oncological outcomes (GUSTO): Phase 2 study
Professor James William Catto
Decision: Shortlisted
18/127:Transplantation
Chair: David Crossman
Declared a conflict and left the room: Simon Bond, Bill Deakin, Fiona Gilbert, Chris Weir, Andrew Cook, William Toff, Ting-Li Su (observing)
- NIHR128600: PROpHET - Perfusion and Recovery Of HEarts for Transplantation
Mr Pedro Catarino
Decision: Declined – invited to resubmit
18/127: Transplantation
Chair: David Crossman
Declared a conflict and left the room: Simon Bond, Chris Weir
Conflicted but not in attendance: Fiona Gilbert
Frank Sullivan returned to the meeting prior to the discussion
- NIHR128169: A randomised controlled trial assessing the benefits of screening for anti-HLA antibodies to optimise immunosuppressive therapy and improve chronic allograft damage in liver transplantation.
Professor Alberto Sanchez-Fueyo
Decision: Declined
18/127: Transplantation
Chair: David Crossman
Declared a conflict and left the room: Bill Deakin, Robert Storey, Ting-Li Su (observing) Page 6 of 11 Funding Committee Minutes – February 2019
Eric Alton noted he had published with the lead applicant in 2013 or earlier and it was agreed for him to remain in the room
- NIHR128475: Early detection of post-transplant lung allograft dysfunction by monitoring of lung clearance index
Dr Alex Horsley
Decision: Shortlisted
18/127: Transplantation
Chair: David Crossman
Declared a conflict and left the room: Eric Alton, Louise Brown, Ajit Lalvani, Mark Thursz
- NIHR128318: Randomised controlled trial of faecal microbiota transplantation in renal allograft recipients
Mr Reza Motallebzadeh
Decision: Declined
18/127: Transplantation
Chair: David Crossman
Declared a conflict and left the room: Simon Bond, Fiona Gilbert,RustamSalman, Chris Weir
Conflicted but not in attendance: Ajit Lalvani
Iain McInnes left the meeting prior to the discussion
- NIHR128565: The Effect of Normothermic Machine Preservation on Utilisation of High Risk Livers for Transplantation – A National Randomised Controlled Trial
Professor Peter Friend
Decision: Declined
18/125: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: None
Iain McInnes returned to the meeting prior to the discussion
- NIHR128445: Efficacy and mechanisms evaluation of a blood free (acellular) perfusion fluid for use in normothermic machine perfusion and transplantation of extended criteria donor livers
Professor Darius F Mirza
Decision: Shortlisted
18/85: EME End of Life Care
Chair: David Crossman
Declared a conflict and left the room: None
Conflicted but not in attendance: Ruth Plummer
Mark Thursz left the meeting prior to the discussion
- NIHR128366: Better treatment of symptoms for cancer patients at the end of life (BETTER-C): A Randomised Controlled Trial of a newly adapted pharmacological treatment for breathlessness and polysymptomatology in cancer patients at the end of life
Professor Irene Julie Higginson
Decision: Declined
Day 2: 27 February 2019, Danubius Hotel, Regents Park, London
Present
Members
- Professor David Crossman (Chair)
- Professor Eric Alton (Deputy Chair)
- Dr Simon Bond
- Dr Louise Brown
- Professor Bill Deakin
- Professor Janet Dunn
- Mr Steve Edgar
- Professor Carrol Gamble
- Professor Paula Ghaneh
- Professor Jonathan Grigg
- Professor AjitLalvani
- Professor Iain McInnes
- Mr Richard Parnell
- Dr Richard Peck
- Professor John Petrie
- Professor RustamSalman
- Professor Robert Storey
- Professor Frank Sullivan
- Professor Steve Thornton
- Professor Mark Thursz
- Professor Chris Weir
Secretariat
- Miss Helen Munday
- Dr Elena Harden
- Ms Susan Solomons
- Dr Dani Preedy
- Dr Andrew Cook
- Dr William Toff
Apologies
- Professor Fiona Gilbert
- Professor Ruth Plummer
- Dr Michael Nicholson
Observers/In attendance
- Professor Danny McAuley, EME Programme Director
- Dr Penny Morton, MRC Dr Louise Jones, MRC
- Louise Hayes, Senior Research Methodologist, RDS North East
Stage 1 Proposals
18/86: EME Precision Medicine
Chair: David Crossman
Declared a conflict and left the room: Richard Peck
Conflicted but not in attendance: Ruth Plummer
- NIHR128529: Novel blood test to personalise Early Stage Colorectal Cancer treatment
Professor David Cunningham
Decision: Shortlisted
18/86: EME Precision Medicine
Chair: David Crossman
Declared a conflict and left the room: Steve Thornton
- NIHR128473: Etanercept as a disease-modifier in Alzheimer’s patients: a Phase II double-blind placebo controlled trial with a focus on neuro-inflammatory mechanisms
Professor Marios Politis
Decision: Declined
18/86: EME Precision Medicine
Chair: David Crossman
Declared a conflict and left the room: Eric Alton, Simon Bond, Fiona Gilbert, Ajit Lalvani, Robert Storey, Mark Thursz, Chris Weir
- NIHR128465: Positioning Imatinib for Pulmonary Arterial Hypertension
Professor Martin Wilkins
Decision: Shortlisted
18/180: EME Digital Technologies to Improve Health and Care
Chair: David Crossman
Declared a conflict and left the room: None
Conflicted but not present: Ruth Plummer
- NIHR128345: Detection of residual leukaemia by integrated machine learning and label-free imaging cytometry
Professor Julie Anne Elizabeth Irving
Decision: Declined
18/125: EME Researcher Led
Chair: Eric Alton
Declared a conflict and left the room: Simon Bond,Carrol Gamble, Paula Ghaneh, Fiona Gilbert, Iain McInnes, John Petrie, Chris Weir, David Crossman
- NIHR128346: A randomised control multicentre trial investigating efficacy and predictive markers of Spatial Inattention Grasping Home-based Therapy for spatial neglect recovery post-stroke (the predictiveSIGHT trial)
Dr Stephanie Rossit
Decision: Declined – invited to resubmit
18/125: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Chris Weir, Danny McAuley (observing)
- NIHR128593: Valproic acid for delirium in subarachnoid bleed trial (VALID trial)
Dr Tonny Veenith
Decision: Declined – invited to resubmit
18/125: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Bill Deakin, Danny McAuley (observing)
- NIHR128516: The ATOMiC (Antioxidant Therapy of Male Infertility Collaboration) Trial
Dr Jackson C Kirkman-Brown
Decision: Declined
18/125: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Bill Deakin
- NIHR128591: Improving Memory in Schizophrenia with PDE4 inibitor Roflumilast
Professor Mitul Ashok Mehta
Decision: Declined – invited to resubmit
18/125: EME Researcher Led
Chair: Andrew Cook
Declared a conflict and left the room: Eric Alton, Bill Deakin, Ajit Lalvani, Mark Thursz, David Crossman
Danny McAuley left the meeting prior to the discussion
- NIHR128499: Treatment with Azole Antifungals to Prevent Lung Function Decline in People with Cystic Fibrosis and Aspergillus Infection.
Professor Adilia Warris
Decision: Declined
18/125: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: None
Bill Deakin and Mark Thursz left the meeting prior to the discussion
- NIHR128104: Hereditary Sensory Neuropathy Serine trial (SENSE trial)
Professor Mary Margaret Reilly
Decision: Shortlisted
18/125: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Iain McInnes, John Petrie, Mark Thursz, Andrew Cook, William Toff
Danny McAuley returned to the meeting prior to the discussion
- NIHR128602: Randomised Evaluation of the Effect of Atrial Fibrillation Targeted Treatment Strategies on Exercise Capacity in Heart Failure with Preserved Ejection Fraction (EASE-HFpEF) Trial
Dr Tom Wong
Decision Declined – invited to resubmit
18/125: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Eric Alton, Ajit Lalvani, Mark Thursz
Iain McInnes left the meeting prior to the discussion
- NIHR128545: The efficacy of behavioural Support & low-energy TOtal diet rePlacement for Non-Alcoholic SteatoHepatitis: the STOP-NASH randomised controlled trial
Professor Paul Aveyard
Decision: Declined
18/125: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Eric Alton, Bill Deakin, Ajit Lalvani, Mark Thursz, Chris Weir
- NIHR128395: Alzheimer's Disease treatment with combined valacyclovir and celecoxib: A Novel Clinical Evaluation (ADVANCE)
Dr Naji Tabet
Decision: Declined
18/125: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Simon Bond, Carrol Gamble, Paula Ghaneh, Fiona Gilbert, Chris Weir, Andrew Cook, William Toff
- NIHR128598: DIRECTION trial - A UK Multi-centre Randomised Controlled Trial of Distal Aortic Repair versus Conservative Surgery in Acute Type A Aortic Dissection
Mr Pedro Catarino
Decision: Declined
18/125: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Andrew Cook, William Toff
The Secretariat recorded that John Petrie has had a number of round table discussions about research strategy with co-applicant (Andrews) as they both chair a Diabetes UK Clinical Study Group. He has not been involved in any discussions about this application. It was agreed by the secretariat that there was not a direct link between the discussion with the co-applicants and the application topic under review
- NIHR128432: A randomised controlled trial to determine whether exercise preserves beta cell function in adults with newly diagnosed type 1 diabetes - The EXTOD2 trial
Dr Parth Narendran
Decision: Declined
18/125: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Iain McInnes, John Petrie
- NIHR128240: Remote Ischaemic Conditioning After Stroke 3 (RECAST-3): A multicentre randomised controlled trial
Professor Timothy England
Decision: Shortlisted
18/58: EME Researcher Led
Chair: David Crossman
Declared a conflict and left the room: Janet Dunn, Steve Thornton, Matthew Ahearne (observing)
Simon Bond and Paula Ghaneh left the meeting prior to the discussion
- NIHR127461: SuSPeCT study (Stratification of Patients Suspected of Colorectal Cancer)
Professor Ramesh Arasaradnam
Decision: Shortlisted