Meeting
EME Programme - Funding Committee Meeting
Date
Tuesday 25th February and Wednesday 26th February 2020
Place
Danubius Hotel, London
Present
Professor John Norrie (Programme Chair -does not vote)
Professor Eric Alton
Dr Matthew Ahearne
Dr Louise Brown
Dr Victoria Cornelius
Professor Bill Deakin
Ms Anne-Laure Donskoy (public contributor)
Professor Janet Dunn
Professor Jonathan Grigg
Professor Alastair Hay
Mr Allen Knight (public contributor)
Professor Gregory Lip
Professor Iain McInnes
Professor Michael Nicholson
Mr Richard Parnell (public contributor)
Dr Richard Peck
Professor John Petrie
Professor Ruth Plummer
Professor Rustam Salman
Professor Stuart Taylor
Professor Mark Thursz
Professor Chris Weir
Secretariat
Dr Andrew Cook
Dr Elena Harden
Miss Helen Munday
Dr Dani Preedy
Ms Susan Solomons
Dr Gemma Bashevoy
Apologies
Professor Danny McAuley (Programme Director)
Professor Ajit Lalvani (and did not contribute to this meeting)
Dr Amy Gillespie (and did not contribute to this meeting)
Professor Arrie Coomarasamy
Observers/In attendance
Dr Penny Morton, MRC
Professor Daniel Freeman
Sue Channon, RDS, Wales
Nicola Metrebian, RDS, London
Day 1
Stage 2 proposals
18/168 EME Precision Medicine
NIHR129268 Seligmann
A biomarker enrichment trial of anti-EGFR agents in patients with advanced colorectal cancer with wild-type RAS and right primary tumour location
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Christopher Weir, Dr Louise Brown, Professor Stuart Taylor, Sue Channon (observer)
Conflicted but not in attendance: Professor Arri Coomarasamy
Decision: Recommended to Programme Director to consider fund with changes
19/24 EME Researcher Led
NIHR130479 Costa
WHiTE-DeCI: World Hip Trauma Evaluation - Delirium and Cognitive Impairment
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Janet Dunn
Conflicted but not in attendance: Professor Arri Coomarasamy
Decision: Declined
NIHR130048 Papadopoulos
Duroplasty for Injured cervical Spinal Cord with Uncontrolled Swelling (DISCUS): a randomised controlled trial
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Alastair Hay, Professor Michael Nicholson
Decision: Recommended to Programme Director to consider fund with changes
NIHR130077 Rubia
Effects of external Trigeminal Nerve Stimulation in ADHD and mechanisms of action
Chair: Professor John Norrie
Declared a conflict and left the room: Dr Andrew Cook, Nicola Metrebian (observer)
Decision: Recommended to Programme Director to consider fund with changes
NIHR129875 Forsyth
Seizure control via pH manipulation: a phase II trial of inhaled carbogen as adjunctive treatment of paediatric convulsive status epilepticus
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Gregory Lip, Professor Ruth Plummer
Decision: Recommended to Programme Director to consider fund with changes
NIHR129910 Wilson
The efficacy and mechanisms of action of n-3 poly-unsaturated fatty acid supplementation in people with non-steroidal exacerbated airways disease and uncontrolled asthma
Chair: Dr Andrew Cook
Declared a conflict and left the room: Professor Christopher Weir, Professor John Norrie, Dr Louise Brown, Professor Michael Nicholson
Decision: Recommended to Programme Director to consider fund with changes
18/170 EME Researcher Led
NIHR128778 Grigg
Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis; a randomised placebo controlled trial (BLIPA; Bacterial Lysate in Preventing Asthma)
Chair: Dr Andrew Cook
Declared a conflict and left the room: Professor Christopher Weir, Professor Gregory Lip, Professor John Norrie, Professor Jonathan Grigg, Professor Rustam Salman
Decision: Declined - invited to resubmit
19/24 EME Researcher Led
NIHR129674 Price
The efficacy of feedback from a novel wristband accelerometer worn at home to enhance arm recovery after stroke: a multi-arm multi-stage randomised controlled trial
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Christopher Weir, Professor Ruth Plummer
Decision: Declined
NIHR130047 Corrie
A phase II study combining pembrolizumab with olaparib in metastatic pancreatic adenocarcinoma patients with high tumour mutation burden
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Iain McInnes, Professor Michael Nicholson
Decision: Declined - invited to resubmit
18/170 EME Researcher Led
NIHR129340 Limousin
Double blind comparison of optimised Deep Brain Stimulation for severe Tourette syndrome
Chair: Professor John Norrie
Declared a conflict and left the room: Dr Louise Brown, Professor Stuart Taylor
Decision: Recommended to Programme Director to consider fund with changes
NIHR129318 Armstrong
Home-based EXercise and motivAtional programme before and after Liver Transplantation: ExaLT trial
Chair: Professor John Norrie
Declared a conflict and left the room: Dr Louise Brown, Professor Stuart Taylor
Conflicted but not in attendance: Professor Arri Coomarasamy
Decision:Recommended to Programme Director to consider fund with changes
18/169 Resubmission: Mechanisms of Action of Health
NIHR129392 Rowland
“OSMOTIC Study” - Investigating the mechanisms of action of hyperosmolar therapy on neurological outcomes following acute severe traumatic brain injury
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Janet Dunn
Decision: Recommended to Programme Director to consider fund with changes
19/99 Mechanisms of Action of Health Interventions
NIHR130897 Ramchandani
Testing mechanisms of action of early intervention for enduring childhood behaviour problems
Chair: Dr Andrew Cook
Declared a conflict and left the room: Dr Victoria Cornelius, Professor Christopher Weir, Professor Eric Alton, Professor John Norrie, Professor Mark Thursz, Professor Michael Nicholson
Decision: Declined
NIHR130971 Peters
Therapeutic targets for the effective psychological treatment of trauma sequelae symptoms and psychosis in patients with comorbid Schizophrenia Spectrum Disorder and Post-Traumatic Stress Disorder: Psychological and neural mechanisms.
Chair: Professor Eric Alton
Declared a conflict and left the room: Professor Bill Deakin, Professor John Norrie, Dr Louise Brown, Professor Stuart Taylor
Decision: Recommended to Programme Director to consider fund with changes
12/206 Contract Extension: EME Researcher Led Call
12/206/52 Critchley
Ulipristal acetate versus conventional management of heavy menstrual bleeding (HMB; including uterine fibroids): a randomised controlled trial and exploration of mechanism of action (UCON trial)
Chair: Professor Eric Alton
Declared a conflict and left the room: Professor Christopher Weir, Professor Iain McInnes, Professor John Norrie, Professor John Petrie, Professor Rustam Salman
Conflicted but not in attendance: Professor Arri Coomarasamy
Decision: Recommended to Programme Director to consider fund with changes
14/48 Contract Extension: EME Researcher Led
14/48/53 Thursz
Nucleos(t)ide withdrawal in HBeAg negative hepatitis B virus infection to promote HBsAg clearance. (NUC-B)
Chair: Professor John Norrie
Declared a conflict and left the room: Dr Victoria Cornelius, Professor Eric Alton, Professor Jonathan Grigg, Dr Louise Brown, Professor Mark Thursz, Professor Stuart Taylor
Decision: Recommended to Programme Director to consider fund with changes
14/150 Contract Extension: EME Researcher Led
14/150/62 Jayne
IntAct: Intraoperative Fluorescence Angiography to Prevent Colorectal Anastomotic Leak
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Stuart Taylor
Decision: Recommended to Programme Director to consider fund with changes
Day 2
Present
Professor John Norrie (Programme Chair -does not vote)
Professor Eric Alton
Dr Matthew Ahearne
Dr Louise Brown
Professor Arri Coomarasamy
Dr Victoria Cornelius
Professor Bill Deakin
Ms Anne-Laure Donskoy (public contributor)
Professor Janet Dunn
Professor Jonathan Grigg
Professor Alastair Hay
Mr Allen Knight (public contributor)
Professor Gregory Lip
Professor Iain McInnes
Professor Michael Nicholson
Mr Richard Parnell (public contributor)
Dr Richard Peck (leaving at 3.30pm)
Professor John Petrie
Professor Ruth Plummer
Professor Rustam Salman
Professor Stuart Taylor
Professor Mark Thursz
Professor Chris Weir
Secretariat
Dr Andrew Cook
Mrs Julie Daniels
Dr Elena Harden
Dr Dani Preedy
Ms Susan Solomons
Apologies
Professor Danny McAuley (Programme Director)
Professor Ajit Lalvani
Dr Amy Gillespie
Observers/In attendance
Dr Penny Morton, MRC
Susan Smith, RDS, East of England
Lucy Chappell
John Simpson
Stage 2 Proposals
19/99 Mechanisms of Action of Health Interventions
NIHR130967 Pennington
Mechanisms of change underlying increased intelligibility for children with cerebral palsy following speech and language therapy focusing on breath support and speech rate
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Ruth Plummer
Decision: Recommended to Programme Director to consider fund with changes
NIHR130938 Turner
Crist: Airway microbiome driven mechanisms of improvement after optimised self management: Colour-COPD trial
Chair: Professor John Norrie
Declared a conflict and left the room: Dr Andrew Cook, Professor Arri Coomarasamy
Decision: Declined - invited to resubmit
Stage 1 Proposals
19/100 EME Researcher Led
NIHR131174 Rahman
Randomised Controlled Trial of Air Flow-Directed Management of Primary Spontaneous Pneumothorax
Chair: Professor John Norrie
Declared a conflict and left the room: N/A
Decision: Declined
NIHR130797 Pandit
Mechanically Aligned total knee Replacement Vs Kinematically Executed total Knee Replacement (MARKER)
Chair: Professor John Norrie
Declared a conflict and left the room: N/A
Decision: Shortlisted
NIHR130577 Dietrich
The efficacy of perioperative Vitamin C to reduce postoperative pain after wisdom tooth removal (VICTOR)
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Arri Coomarasamy, Professor Gregory Lip
Decision: Declined
19/24 Resubmission: EME Researcher Led
NIHR129819 Turner
SPIROMAC – SPIROmetry to Manage Asthma in Children
Chair: Dr Andrew Cook
Declared a conflict and left the room: Dr Matthew Ahearne, Professor Gregory Lip, Professor John Norrie
Decision: Shortlisted
18/170 Resubmission: EME Researcher Led
NIHR129265 Martins da Silva
Dietary antioxidant defence (DAD) study: a double blind randomised trial of Impryl® for male infertility to improve natural conception and live birth rate
Chair: Professor Eric Alton
Declared a conflict and left the room: Professor Arri Coomarasamy, Professor Christopher Weir, Professor Iain McInnes, Professor John Norrie, Professor John Petrie, Professor Rustam Salman
Decision: Declined
19/100 EME Researcher Led
NIHR131094 McAlonan
Cannabidiol in Adult Autism Trial (CANAT)
Chair: Professor Eric Alton
Declared a conflict and left the room: Professor Christopher Weir, Professor Iain McInnes, Professor John Norrie, Professor John Petrie, Professor Michael Nicholson
Decision: Declined
19/100 EME Researcher Led
NIHR131004 Jakovljevic
Cardiac Output Response to Stress (CORS) Test as an Additional Tool to Improve Diagnosis of Heart Failure in Primary Care
Chair: Professor Eric Alton
Declared a conflict and left the room:Dr Andrew Cook, Professor John Norrie, Professor Ruth Plummer
Decision: Declined
NIHR130772 Nyman
A randomised controlled trial to test the clinical efficacy and mechanism of effect of a Tai Chi exercise intervention for the prevention of falls among people with dementia
Chair: Professor Eric Alton
Declared a conflict and left the room: Professor John Norrie, Dr Louise Brown, Professor Stuart Taylor
Decision: Declined
NIHR130718 Field
Restoration of effective coagulation in aortic surgery: a comparison of autologous platelet rich plasma, fibrinogen concentrate and prothrombin complex concentrate to conventional allogenic blood product transfusion
The RESTORE Study
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Christopher Weir, Professor Gregory Lip, Professor Bill Deakin
Decision: Declined
NIHR130844 Dryden
The Tactical Trial
The clinicAl and resourCe impacT of reactIve oxygen gel® on wound infeCtion rAtes in patients undergoing surgicaL procedures – a randomised controlled trial (TACTICAL)
Chair: Professor John Norrie
Declared a conflict and left the room:Dr Andrew Cook, Professor Bill Deakin
Decision: Declined
NIHR131032 Gibbs
INTERvention with Cerebral Embolic Protection in TEVAR (INTERCEPT): A randomised controlled trial comparing carbon-dioxide flushing versus saline flushing to reduce neurological brain injury
Chair: Professor John Norrie
Declared a conflict and left the room:Dr Matthew Ahearne, Dr Victoria Cornelius, Professor Eric Alton, Professor Mark Thursz
Decision: Declined
NIHR130896 Goodman
Diagnostic Imaging in Staphylococcus aureus bacteraemia (DISARM)
Chair: Professor John Norrie
Declared a conflict and left the room:Professor Christopher Weir, Dr Louise Brown, Professor Stuart Taylor
Decision: Declined
NIHR131050 Shaw
RAPTOR: Randomised Controlled Trial of PENTOCLO in Mandibular Osteoradionecrosis
Chair: Professor John Norrie
Declared a conflict and left the room:Professor Gregory Lip, Professor Iain McInnes, Professor Stuart Taylor
Decision: Shortlisted
NIHR131120 Coles
PARABLE: Proton beAm theRApy in patients with Breast cancer: evaluating early and Late-Effects
Chair: Professor John Norrie
Declared a conflict and left the room:Professor Bill Deakin, Professor Michael Nicholson
Decision: Shortlisted
NIHR130628 Allen
Can the diagnostic accuracy of newborn eye screening for congenital cataract be improved with digital dual wavelength imaging? The Ophthalmoscope vs Imaging Device (OvID) study
Chair: Professor John Norrie
Declared a conflict and left the room:Professor Christopher Weir, Professor Michael Nicholson, Professor Stuart Taylor
Decision: Shortlisted
NIHR131157 Qurashi
GOTHIC2: A multi-centre randomised placebo-controlled trial of glycopyrrolate and hyoscine hydrobromide for the treatment of clozapine-induced hypersalivation
Chair: Professor John Norrie
Declared a conflict and left the room:Dr Amy Gillespie (absent), Professor Gregory Lip, Professor Bill Deakin
Left meeting: Lucy Chappell (observer)
Decision: Shortlisted
NIHR130966 Twelves
PROgesterone as a Steroid SParing agent against oEdema occurring during primary/secondary bRain cancer treatment
Chair: Professor John Norrie
Declared a conflict and left the room:N/A
Decision: Shortlisted
19/61 Resubmission: Mitigation of the adverse effects of health and social care interventions
NIHR130133 Leff
Primary Radiotherapy And DIEP Flap Reconstruction–II (PRADA-II)
Chair: Professor John Norrie
Declared a conflict and left the room:Dr Victoria Cornelius, Professor Eric Alton, Professor Mark Thursz
Decision: Shortlisted
NIHR130331 Drobniewski
PROtecting Hearing during Antimicrobial therapy using N-acetylcysteine - a double-blind randomised controlled trial (PROHAN)
Chair: Professor John Norrie
Declared a conflict and left the room:Dr Andrew Cook, Dr Victoria Cornelius, Professor Eric Alton, Professor Mark Thursz
Decision: Shortlisted
19/141 EME Liver Disease
NIHR130640 Trenell
Is a short very low calorie dietary intervention, followed by food reintroduction, effective at treating advanced non-alcoholic fatty liver disease (LO-CAL LIVER)?
Chair: Professor Eric Alton
Declared a conflict and left the room:Professor Christopher Weir, Professor John Norrie, Professor John Petrie, Professor Ruth Plummer
Conflicted and left the meeting: Professor Iain McInnes
Left meeting: Professor Bill Deakin
Decision: Declined
NIHR131085 Fallowfield
A randomised controlled trial to determine the effectiveness of increased coffee consumption as a treatment for adults with non-alcoholic fatty liver disease (NAFLD).
Chair: Professor Eric Alton
Declared a conflict and left the room:Dr Andrew Cook, Professor Christopher Weir, Professor John Norrie, Professor Rustam Salman
Decision: Declined
NIHR130730 Shawcross
A PROspective double-blind placebo-controlled multicentre trial of Faecal MIcrobiota tranSplantation to improve outcomEs in patients with cirrhosis - PROMISE trial
Chair: Professor John Norrie
Declared a conflict and left the room:Dr Victoria Cornelius, Professor Eric Alton, Professor Mark Thursz
Left meeting: Dr Richard Peck
Decision: Shortlisted
NIHR131123 Rubino
MULTICENTRE SINGLE BLIND RANDOMIZED-TRIAL COMPARING ROUX-EN-Y GASTRIC BYPASS VS SEMAGLUTIDE VS STANDARD MEDICAL AND LIFESTYLE INTERVENTIONS FOR NON ALCOHOLIC STEATOHEPATITIS
Short title: Semaglutide and Metabolic Surgery in Non-Alcoholic Liver Disease. The SeMiNAL Tria
Chair: Professor John Norrie
Declared a conflict and left the room:Dr Victoria Cornelius, Professor Arri Coomarasamy, Professor Eric Alton, Professor Jonathan Grigg, Professor Mark Thursz, Professor Stuart Taylor
Left meeting: Professor Alastair Hay
Decision: Declined
NIHR131128 Jassem
Multicentre, randomised controlled trial to compare the efficiency of ischaemia-free with ex vivo normothermic machine perfusion in liver transplantation from deceased donors
Chair: Professor John Norrie
Declared a conflict and left the room:Professor Stuart Taylor
Decision: Declined
19/149 EME Solid Organ Replacement, Transplant And Donation
NIHR131163 Friend
Defatting of donor transplant livers during normothermic perfusion – a randomised pilot study
Chair: Professor John Norrie
Declared a conflict and left the room:Professor Michael Nicholson, Professor Stuart Taylor
Decision: Shortlisted
NIHR130975 Mirza
Normothermic mAchine Perfusion of the Liver to Enable transplantation in difficult recipientS 2 (NAPLES 2)
Chair: Professor John Norrie
Declared a conflict and left the room: Professor Ruth Plummer
Returned to the meeting: Professor Alastair Hay
Decision: Declined
NIHR130612 Fisher
Extracorporeal Photophoresis in the treatment of Chronic Lung Allograft Dysfunction: a randomised controlled trial (E-CLAD UK)
Chair: Professor John Norrie
Declared a conflict and left the room:Professor Christopher Weir, Professor Bill Deakin (absent), Professor Michael Nicholson, Professor Ruth Plummer
Decision: Shortlisted
NIHR130957 Marks
PRESOT
Predicting REjection in paediatric Solid Organ Transplant recipients using donor derived cell free DNA
Chair: Professor John Norrie
Declared a conflict and left the room:Dr Louise Brown, Professor Ruth Plummer, Professor Stuart Taylor
Decision: Declined
NIHR130899 Giele
Effectiveness and mechanism of sentinel skin flap monitoring of solid organ transplants
Chair: Professor John Norrie
Declared a conflict and left the room:Dr Victoria Cornelius, Professor Eric Alton, Professor Mark Thursz, Professor Michael Nicholson
Left meeting: Anne-Laure Donskoy, Professor Gregory Lip
Decision: Declined - invited to resubmit
19/144 EME Perinatal Mental Health
NIHR130608 Craig
Non Pharmacological Treatment for Antenatal Depression - A Multi-Centre Randomised Controlled Trial of Repetitive Transcranial Magnetic Stimulation (rTMS)
Chair:Dr Andrew Cook
Declared a conflict and left the room:Dr Victoria Cornelius, Professor Eric Alton, Professor Janet Dunn, Professor John Norrie, Professor Mark Thursz
Left meeting: Professor Alastair Hay
Decision: Declined
NIHR131161 Hirsch
A randomised controlled trial to evaluate the outcomes and mechanism of a web-based intervention to prevent perinatal anxiety
Chair: Professor Eric Alton
Declared a conflict and left the room:Professor Janet Dunn, Professor John Norrie
Left meeting: Professor John Simpson (observer)
Decision: Declined - invited to resubmit
NIHR131130 Waters
A pilot multi-site randomised controlled trial of group delivered Acceptance and Commitment Therapy (ACT) for pregnant women with moderate-to-severe depressive and/or anxiety disorders
Chair: Professor John Norrie
Declared a conflict and left the room:N/A
Decision: Declined
Outcomes Table
Stage 2 Proposals
The EME Funding Committee recommended the following Stage 2 proposals for either immediate funding or for funding subject to certain conditions
Commissioned
Project Reference | Lead Applicant | Institution | Project Title |
---|---|---|---|
NIHR129268 | Dr Jenny Seligmann | University of Leeds | ARIEL: A biomarker enrichment trial of anti-EGFR agents in patients with advanced colorectal cancer with wild-type RAS and right primary tumour location |
NIHR130971 | Dr Emmanuelle Peters | South London and Maudsley NHS Foundation Trust | Therapeutic targets for the effective psychological treatment of trauma sequelae symptoms and psychosis in patients with comorbid Schizophrenia Spectrum Disorder and Post-Traumatic Stress Disorder: Psychological and neural mechanisms |
NIHR129392 | Dr Matthew Rowland | University of Oxford | “OSMOTIC Study” - Investigating the mechanisms of action of hyperosmolar therapy on neurological outcomes following acute severe traumatic brain injury |
NIHR130967 | Dr Lindsay Pennington | University of Newcastle | Mechanisms of change underlying increased intelligibility for children with cerebral palsy following speech and language therapy focusing on breath support and speech rate |
Researcher Led
Project Reference | Lead Applicant | Institution | Project Title |
---|---|---|---|
NIHR130048 | Professor Marios Papadopoulos | University of London | Duroplasty for Injured cervical Spinal Cord with Uncontrolled Swelling (DISCUS): a randomised controlled trial |
NIHR129910 | Professor Andrew Wilson | University of East Anglia | The efficacy and mechanisms of action of n-3 poly-unsaturated fatty acid supplementation in people with non-steroidal exacerbated airways disease and uncontrolled asthma |
NIHR129340 | Professor Patricia Limousin | University College London | Double blind comparison of optimised Deep Brain Stimulation for severe Tourette syndrome |
NIHR129318 | Dr Matthew Armstrong | University of Birmingham | Home-based EXercise and motivAtional programme before and after Liver Transplantation: ExaLT trial |
NIHR130077 | Professor Katya Rubia | King's College London | Effects of external Trigeminal Nerve Stimulation in ADHD and mechanisms of action |
NIHR129875 | Dr Rob Forsyth | The Newcastle Upon Tyne Hospitals NHS Foundation Trust | Seizure control via pH manipulation: a phase II trial of inhaled carbogen as adjunctive treatment of paediatric convulsive status epilepticus |
Further information on the above projects will be provided on the EME website once the project has started.
Stage 1 Proposals
The following Stage 1 proposals have been shortlisted to submit a Stage 2 application for consideration by the EME Funding Committee at its next meeting
Researcher Led
Project Reference | Lead Applicant | Institution | Project Title |
---|---|---|---|
NIHR130797 | Professor Hemant Pandit | University of Leeds | Mechanically Aligned total knee Replacement Vs Kinematically Executed total Knee Replacement (MARKER) |
NIHR129819 | Professor Steve Turner | University of Aberdeen | SPIROMAC – SPIROmetry to Manage Asthma in Children |
NIHR131050 | Professor Richard Shaw | University of Liverpool | RAPTOR: Randomised Controlled Trial of PENTOCLO in Mandibular Osteoradionecrosis |
NIHR131120 | Professor Charlotte Coles | Institute of Cancer Research | PARABLE: Proton beAm theRApy in patients with Breast cancer: evaluating early and Late-Effects |
NIHR130628 | Dr Louise Allen | Cambridge University Hospitals NHS Foundation Trust | Can the diagnostic accuracy of newborn eye screening for congenital cataract be improved with digital dual wavelength imaging? The Ophthalmoscope vs Imaging Device (OvID) study |
NIHR131157 | Dr Inti Qurashi | Lancashire Care NHS Foundation Trust | GOTHIC2: A multi-centre randomised placebo-controlled trial of glycopyrrolate and hyoscine hydrobromide for the treatment of clozapine-induced hypersalivation |
NIHR130966 | Professor Chris Twelves | Common Services Agency | PROgesterone as a Steroid SParing agent against oEdema occurring during primary/secondary bRain cancer treatment |
Commissioned
Project Reference | Lead Applicant | Institution | Project Title |
---|---|---|---|
NIHR130331 | Professor Francis Drobniewski | Imperial College London | PROtecting Hearing during Antimicrobial therapy using N-acetylcysteine - a double-blind randomised controlled trial (PROHAN) |
NIHR130133 | Mr Daniel Leff | Imperial College London | Primary Radiotherapy And DIEP Flap Reconstruction–II (PRADA-II) |
NIHR130730 | Professor Debbie Shawcross | King's College London | A PROspective double-blind placebo-controlled multicentre trial of Faecal MIcrobiota tranSplantation to improve outcomEs in patients with cirrhosis - PROMISE tria |
NIHR131163 | Professor Peter Friend | University of Oxford | Defatting of donor transplant livers during normothermic perfusion – a randomised pilot study |
NIHR130612 | Professor Andrew Fisher | University of Newcastle upon Tyne | Extracorporeal Photophoresis in the treatment of Chronic Lung Allograft Dysfunction: a randomised controlled trial (E-CLAD UK) |