Meeting
EME Funding Committee July 2022
Date
Tuesday 5th and Wednesday 6th July 2022
Place
Virtual Meeting
Present - Day 1
Professor Danny McAuley (Programme Director - does not vote)
Professor John Norrie (Programme Chair - does not vote)
Professor John Petrie (Deputy Chair)
Professor Victoria Allgar
Professor Maya Buch
Dr Tessa Cacciottolo
Professor Janet Dunn
Professor Daniel Freeman
Mrs Hayley Hall (PPI)
Professor Andrew Horne
Professor Dave Jones
Professor Patricia Limousin
Professor Gregory Lip
Dr Ronan McMullan
Professor Ruth Plummer
Professor Manu Shankar-Hari
Professor Deborah Stocken
Professor Stuart Taylor
Professor Chris Weir
Secretariat
Dr Andrew Cook
Dr Juliana Callaghan
Ms Helen Munday
Dr Esther Sweeney
Ms Caitlin Van Abeelen
Apologies
Professor Jonathan Grigg
Professor Alastair Hay
Dr Puja Mehta
Professor Michael Nicholson
Professor John Simpson
Ms Nóirín O'Neill (PPI)
Observers/in attendance
Penny Morton, MRC
Stage 2 Proposals
21/545 Efficacy and Mechanism Evaluation Programme Researcher-led
NIHR151191 - Robson
Withdrawal of Immunosuppression in lupus Nephritis trial: the WIN trial
Chair: John Norrie
Declared a conflict and left the room: Michael Nicholson (not present), Tessa Cacciottolo, Maya Buch
Decision: Declined
NIHR151755 - Muir
NanO2 in Large VessEL Occlusion Stroke (NOVEL): a multicentre single-blind, randomised, placebo-controlled blinded end-point clinical trial evaluating the safety, tolerability and preliminary efficacy of perfluorocarbon in acute ischaemic stroke due to large vessel occlusion
Chair: John Norrie
Declared a conflict and left the room: John Petrie, John Simpson (not present)
Decision: Declined - invited to resubmit a Stage 2 application
NIHR151223 - Longden
A novel dialogical therapy (Talking With Voices) in comparison to treatment as usual in adults with distressing and persistent auditory hallucinations: A randomised controlled trial to investigate the efficacy of a treatment strategy targeted at trauma-related mechanisms
Chair: John Petrie
Declared a conflict and left the room: Chris Weir, Daniel Freeman, John Norrie
Decision: Recommended to the Programme Director to consider Fund with Changes
21/546 NIHR NICE Rolling Call (EME Programme: Aug 21 - Dec 21)
NIHR151274 - Torkington
The PICCOS Trial (PIPAC in Cancers of the Colon, Ovaries and Stomach): A randomised controlled phase II trial in Colorectal, Ovarian and Stomach cancers to define the efficacy of Pressurised IntraPeritoneal Aerosolised Chemotherapy (PIPAC) in the management of peritoneal metastases
Chair: John Norrie
Declared a conflict and left the room: Chris Weir, Deborah Stocken, Victoria Coyle (observer - not present), Alastair Hay (not present)
Decision: Recommended to the Programme Director to consider Fund with Changes
21/561 NIHR James Lind Alliance Priority Setting Partnerships Rolling Call (EME Programme: Sep 21 - Dec 21)
NIHR151282 - Robson
Paclitaxel or sirolimus coated balloons for ArterioVEnous fistulas (PAVE-2 trial)
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Recommended to Programme Director to consider Fund with Changes
21/544 EME Mechanisms of Action of Health Interventions (pilot call of expanded remit)
NIHR151210 - Mahil
Dissecting shared mechanisms of drug action and response within the BEACON eczema multi-arm clinical trial: a single-cell approach
Chair: John Norrie
Declared a conflict and left the room: John Simpson (not present)
Decision: Recommended to Programme Director to consider Straight Fund
NIHR151317 - Lundy
Elucidating the mechaNism of action of behavioural changes on Child tOoth decay in the Randomised controlled CHOICE trial – a role for salivary lactic Acid? (ENCOURAGE)
Chair: John Norrie
Declared a conflict and left the room: Ronan McMullan, Danny McAuley
Decision: Recommended to Programme Director to consider Fund with Changes
NIHR151287 - Dushianthan
Oxidative stress, redox status and surfactant metabolism in mechanically ventilated patients receiving different approaches to oxygen therapy
Chair: John Petrie
Declared a conflict and left the room: Andrew Cook, Danny McAuley, Victoria Allgar, John Norrie
Decision: Recommended to the Programme Director to consider Fund with Changes
NIHR151302 - Lord
Trans-EndoNET: The influence of patient metabolism on the response to neoadjuvant endocrine therapy in post-menopausal women with oestrogen receptor positive breast cancer
Chair: John Petrie
Declared a conflict and left the room: Andrew Cook, Janet Dunn, John Norrie
Decision: Recommended to the Programme Director to consider Fund with Changes
Present - Day 2
Professor Danny McAuley (Programme Director - does not vote)
Professor John Norrie (Programme Chair - does not vote)
Professor John Petrie (Deputy Chair)
Professor Victoria Allgar
Professor Maya Buch
Dr Tessa Cacciottolo
Professor Janet Dunn
Professor Daniel Freeman
Mrs Hayley Hall (PPI)
Professor Andrew Horne
Professor Dave Jones
Professor Patricia Limousin
Professor Gregory Lip
Dr Ronan McMullan
Professor Michael Nicholson
Professor Ruth Plummer
Professor Manu Shankar-Hari
Professor John Simpson
Professor Deborah Stocken
Professor Stuart Taylor
Professor Chris Weir
Secretariat
Dr Andrew Cook
Dr Juliana Callaghan
Ms Helen Munday
Dr Esther Sweeney
Ms Caitlin van Abeelen
Apologies
Professor Jonathan Grigg
Professor Alastair Hay
Dr Puja Mehta
Ms Nóirín O'Neill (PPI)
Observers/in Attendance
Penny Morton, MRC
Dr Victoria Coyle, new DCM
Dr Beverly Shirkey, RDS
Stage 2 Proposals
21/506 EME Researcher Led
NIHR150502 - Jones
Diagnostic yield study to determine whether an abbreviated form of breast magnetic resonance imaging (FAST MRI) can detect breast cancers missed by screening mammography: for women at population risk of breast cancer with average mammographic density following their initial screening mammogram
Chair: John Norrie
Declared a conflict and left the room: Janet Dunn
Decision: Recommended to Programme Director to consider Fund with Changes
NIHR150098 - Turner
STABILISE: a multicentre, double blind, randomised, parallel group, superiority trial to investigate the use of BCG vaccine in altering immune response and exacerbation in chronic obstructive pulmonary disease (COPD)
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Recommended to Programme Director to consider Fund with Changes
Stage 1 Proposals
21/544 EME Mechanisms of Action of Health Interventions (pilot call of expanded remit)
NIHR151548 - Helmy
BIOmarkers Stratification of POst Traumatic Seizures Risk, BIOSPOTS-R
Chair: John Norrie
Declared a conflict and left the room: Michael Nicholson, Danny McAuley
Decision: Declined
21/545 Efficacy and Mechanism Evaluation Programme Researcher-led
NIHR151253 - Holmes
Oral flucloxacillin plus probenecid for the treatment of cellulitis: a double-blinded, randomised, placebo-controlled trial
Chair: John Norrie
Declared a conflict and left the room: Chris Weir
Decision: Declined
21/609 Efficacy and Mechanism Evaluation Programme researcher-led
NIHR153014 - Griffith
INtravenous iron and eryThropoietin to treat Anaemia following CriTical care-2 (INTACT-2): a randomised controlled trial
Chair: John Petrie
Declared a conflict and left the room: Andrew Cook, Janet Dunn, John Simpson, Ronan McMullan, John Norrie, Andrew Horne, Chris Weir, Manu Shankar-Hari, Danny McAuley
Decision: Shortlisted
NIHR152798 - Birchenall
PravastatIn tO preveNt prEtErm biRth (PIONEER): a parallel group randomised placebo-controlled trial
Chair: John Petrie
Declared a conflict and left the room: Chris Weir, Alastair Hay (not present), Andrew Horne, John Norrie, Beverly Shirkey (observer)
Decision: Shortlisted
NIHR152443 - Crosbie
METformin as an Alternative to Progestin HORmonal treatment for endometrial hyperplasia - METAPHOR
Chair: Danny McAuley
Declared a conflict and left the room: Chris Weir, Andrew Horne, John Norrie
Decision: Declined
NIHR152450 - Mirza
Disease Modification in Epilepsy (DIME): Atorvastatin versus placebo following a first or second seizure
Chair: John Norrie
Declared a conflict and left the room: Chris Weir
Decision: Declined
NIHR152148 - Rosenberg
A randomised controlled trial of sofosbuvir, glecaprevir and pibrentasvir for 16 weeks in people with Hepatitis C virus infection who have failed two courses of treatment with direct acting antiviral therapy
Chair: John Norrie
Declared a conflict and left the room: Jonathan Grigg (not present), Patricia Limousin
Decision: Declined
NIHR152522 - Gray
Can krill oil supplementation improve functional abilities in older adults with low muscle strength? A double-blind, multi-centre, randomised controlled trial. Krill oIl musCle weaKness - KICK study
Chair: John Norrie
Declared a conflict and left the room: Andrew Cook, John Petrie
Decision: Declined
21/603 NIHR James Lind Alliance Priority Setting Partnerships rolling call (EME Programme: Dec 21 - Apr 22)
NIHR152053 - Bowling
PHANTOM: a placebo controlled, double-blind, randomised controlled trial with inbuilt feasibility to establish the efficacy of preventative (prophylactic) pregabalin for phantom limb pain
Chair: John Norrie
Declared a conflict and left the room: Chris Weir
Decision: Declined
NIHR152705 - Davies
Does stabilisation following posterior decompression in Degenerative Cervical Myelopathy, reduce mechanical stress and spinal cord damage? [DISTRESSED Study]
Chair: John Norrie
Declared a conflict and left the room: Chris Weir, Michael Nicholson
Decision: Shortlisted
22/18 Applications with industry collaboration - The development and evaluation of predictive algorithms using Artificial Intelligence (AI) (EME Programme)
NIHR204535 - Chauhan
Use of multicenter perioperative data to develop a patient led risk score for surgical outcomes using preoperative co-morbidities and self reported post operative 30 day outcomes from patients
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Declined
NIHR153098 - Barrett
Multi-centre diagnostic accuracy study of artificial intelligence for MRI in prostate cancer diagnosis
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Shortlisted
NIHR153598 - Hopkins
Clinical use and safety of multimodal AI in diagnosis and monitoring of prostate cancer
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Declined
NIHR153266 - Mills
Artificial Intelligence guided Diagnosis of acute Heart Failure (AID-HF): a randomised controlled trial
Chair: Andrew Cook
Declared a conflict and left the room: John Simpson, Ronan McMullan, Andrew Horne, Chris Weir, John Norrie, John Petrie, Danny McAuley, Manu Shankar-Hari
Decision: Shortlisted
NIHR153642 - Selvarajah
Towards an Artificial Intelligence Powered Neuroimaging Biomarker for Neuropathic Pain: A Multi-centre Study with Industry Partnership to Determine Proof of Clinical Efficacy.
Chair: John Norrie
Declared a conflict and left the room: Chris Weir, John Simpson
Decision: Declined
NIHR153320 - Harston
Prospective validation of e-Core for identification of stroke patients for mechanical thrombectomy
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Declined - invited to resubmit a Stage 1 application
21/609 Efficacy and Mechanism Evaluation Programme researcher-led
NIHR152268 - Markar
Double-blind randomised controlled trial for treatment of Gastro-Oesophageal reflux disease; Linx management system vs. Fundoplication (GOLF)
Chair: John Norrie
Declared a conflict and left the room: Andrew Cook, Beverly Shirkey (observer)
Decision: Shortlisted