Meeting
EME Funding Committee Meeting
Date
Tuesday 4th and Wednesday 5th July 2023
Place
Virtual Meeting
Present members
Danny McAuley - Programme Director - does not vote
John Norrie - Chair
Maya Buch - Deputy Chair
Victoria Allgar
James Burton
Tessa Cacciottolo - Committee Member Development Scheme
Vicky Coyle
Rob Forsyth
Daniel Freeman
Hayley Hall - Public Committee Member
George Hanna
Alastair Hay
Allen Knight - Public Committee Member
Gregory Lip
Ronan McMullan
Nuru Noor - Committee Member Development Scheme
Philip Pallmann
Manu Shankar-Hari
Don Sharkey
John Simpson
Deborah Stocken
Secretariat
Andrew Cook
Debbie Willis
Elena Harden
Helen Munday
Sam Newman
Caitlin Van Abeelen
Sue White
Apologies
Alun Bedding
Andrew Horne
David Jones
Patricia Limousin
Stuart Taylor
Masha Somi - MRFF (observer)
Observers/In Attendance
Sarah Brien - Research Design Service (RDS)
Janet Diffin - HSC R&D Division, Public Health Agency, Northern Ireland - joined at 2.20pm
Ruth Griffith - MRFF
Chandrika Kaviraj - new Public Committee Member - morning only
Gerry McCann - new Committee Member
Katie Stiles - NIHR CC
Dave Talbot - new Public Committee Member
Florence Theberge - Medical Research Council (MRC)
Stage 2 Proposals
22/110 Efficacy and Mechanism Evaluation Programme researcher-led
NIHR156651 - Kotecha
Bacterial mucosal immunotherapy for prevention of wheeze in preterm born infants (BALLOON Trial)
Chair: John Norrie
Declared a conflict and left the room: Philip Pallman, Rob Forsyth, David Jones (not present)
Decision: Recommended to Programme Director to consider Fund with Changes
NIHR156736 - Myers
Postnatal enalapril to Improve Cardiovascular fUnction and remodelling following hypertensive disorders of Pregnancy 2
Chair: John Norrie
Declared a conflict and left the room: Alastair Hay
Decision: Decline
NIHR155871 - Pavlides
Evaluation of non-contrast-enhanced Magnetic Resonance Imaging compared to standard of care ultrasound for hepatocellular cancer surveillance in patients with liver cirrhosis
Chair: John Norrie
Declared a conflict and left the room: Don Sharkey, Gerry McCann (Observer)
Decision: Recommended to Programme Director to consider Fund with Changes
NIHR156614 - El-Damanawi
Implementation of Metformin theraPy to Ease Decline of kidney function in Polycystic Kidney Disease (IMPEDE-PKD) Randomised Placebo-Controlled Trial
Chair: John Norrie
Declared a conflict and left the room: John Simpson, David Jones (not present)
Decision: Recommended to Programme Director to consider Fund with Changes
22/108 Pain management for children and young people (0-19 years)
NIHR156691 - Walker
NEUSTAC Trial: Neuropathic pain Stratification and Treatments in AdolesCents
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Decline
22/42 NIHR James Lind Alliance Priority Setting Partnerships rolling call (EME Programme: April 22 - August 22)
NIHR154244 - Crosbie
The Refining Adjuvant treatment IN endometrial cancer Based On molecular features (RAINBO) No Specific Molecular Profile (NSMP)-ORANGE Trial
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Recommended to Programme Director to consider Fund with Changes
21/609 Efficacy and Mechanism Evaluation Programme researcher-led
NIHR153014 - Griffith
INtravenous Iron and eryThropoietin to treat Anaemia following CriTical care-2 (INTACT-2): A multi-centre, randomised, parallel group, double blind, placebo controlled, clinical efficacy trial
Chair: Maya Buch
Declared a conflict and left the room: Alastair Hay, John Simpson, Ronan McMullan, John Norrie, Danny McAuley, Andrew Horne (not present), Philip Pallmann, Manu Shankar-Hari, Andrew Cook
Decision: Recommended to Programme Director to consider Fund with Changes
22/43 Efficacy and Mechanism Evaluation Programme researcher-led
NIHR153865 - Sturt
Efficacy and mechanisms evaluation of novel therapy vs waiting list control for Post-Traumatic Stress Disorder (PTSD) in UK military veterans
Chair: John Norrie
Declared a conflict and left the room: Danny McAuley, Vicky Coyle
Decision: Recommended to Programme Director to consider Fund with Changes
22/18 Applications with industry collaboration - The development and evaluation of predictive algorithms using Artificial Intelligence (AI)
NIHR153098 - Barrett
Multi-centre diagnostic accuracy study of artificial intelligence for magnetic resonance imaging (MRI) in prostate cancer diagnosis
Chair: John Norrie
Declared a conflict and left the room: Nuru Noor, George Hanna
Decision: Decline
Stage 1 Proposals
22/105 NIHR James Lind Alliance Priority Setting Partnerships rolling call (EME Programme: August 22 - December 22)
NIHR156754 - Pomeroy
Efficacy of mirror movement therapy for improved recovery of ankle neuromuscular control after stroke: MMT-ankle Trial
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Shortlist
NIHR156766 - Savaridas
Monitoring response to neoadjuvant chemotherapy - contrast enhanced mammography versus magnetic resonance imaging, a non-inferiority study
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Shortlist
Day 2 - 5 July
Present
Danny McAuley - Programme Director - does not vote
John Norrie - Chair
Maya Buch - Deputy Chair
Victoria Allgar
Alun Bedding - left at 11.30am
James Burton
Tessa Cacciottolo - Committee Member Development Scheme - left at 1pm and re-joined at 3:30pm
Vicky Coyle - left at 1pm
Rob Forsyth
Daniel Freeman
Hayley Hall - Public Committee Member
George Hanna
Alastair Hay
Allen Knight - Public Committee Member
Patricia Limousin
Gregory Lip - joined from 11.30am
Ronan McMullan - left at 11am
Nuru Noor - Committee Member Development Scheme
Philip Pallmann
Manu Shankar-Hari
Don Sharkey
John Simpson
Deborah Stocken
Secretariat
Andrew Cook
Debbie Willis
Elena Harden
Helen Munday
Sam Newman
Caitlin Van Abeelen
Apologies
Andrew Horne
David Jones
Gerry McCann - new Committee Member
Dave Talbot - new Public Committee Member
Stuart Taylor
Masha Somi, MRFF (observer)
Observers/In Attendance
Janet Diffin, HSC R&D Division, Public Health Agency, Northern Ireland - joined at 10.30am
Ruth Griffith, MRFF - joined at 10.00am
Chandrika Kaviraj - new Public Committee Member - morning only
Florence Theberge - MRC
Nicola Williams, RDS
Stage 1 Proposals
23/15 Precision medicine platform studies to efficiently evaluate the efficacy of interventions
NIHR158397 - Pratt
Rheumatoid Arthritis Prevention PlatfORm Trial (RAPPORT): A precision medicine collaborative for intercepting disease in at-risk populations
Chair: Andrew Cook
Declared a conflict and left the room: John Norrie, Deborah Stocken, Ronan McMullan, Maya Buch, Philip Pallmann, Nuru Noor, John Simpson, David Jones (not present)
Decision: Decline
NIHR158503 - O'Brien
Tackling HaRm from CIrrhosis and Ascites using a multi-arm platform for liVer disease (THRIVE LIVER)
Chair: Maya Buch
Declared a conflict and left the room: John Norrie, Deborah Stocken, Stuart Taylor (not present), Philip Pallmann, Nuru Noor
Decision: Decline
NIHR158411 - Modi
COLLABORATE: An international, precision-medicine, randomised, controlled, adaptive platform trial to evaluate the efficacy and mechanisms of action of interventions to prevent or treat neonatal necrotising enterocolitis, and provide ongoing infrastructure for future studies to improve newborn care
Chair: Maya Buch
Declared a conflict and left the room: John Simpson, Danny McAuley, Andrew Horne (not present), Tessa Cacciottolo, John Norrie, Ronan McMullan, Philip Pallman
Decision: Decline
NIHR159179 - Jenkins
A Randomized, Embedded, Multifactorial Adaptive Platform trial for Interstitial Lung Disease (REMAP-ILD)
Chair: Maya Buch
Declared a conflict and left the room: John Simpson, Ronan McMullan, Danny McAuley, John Norrie, George Hanna
Decision: Decline
NIHR158714 - McAuley
Precision medicine Adaptive Network platform Trial in Hypoxemic acutE respiratory failuRe (PANTHER)
Chair: Maya Buch
Declared a conflict and left the room: Alastair Hay, John Simpson, Manu Shankar-Hari, John Norrie, Andrew Horne (not present), Gerry McCann (observer - not present), Ronan McMullan, Vicky Coyle, Danny McAuley
Decision: Shortlist
NIHR158335 - Salman
Cavernous malformations A Randomised Efficacy MAster Protocol (CARE MAP) precision medicine platform study: application to establish infrastructure, UK recruitment to evaluate aspirin and propranolol, and preparation for international extension
Chair: Maya Buch
Declared a conflict and left the room: Andrew Horne (not preset), Philip Pallmann, John Norrie, Nuru Noor, Andrew Cook
Decision: Decline
23/16 A platform trial to evaluate potential interventions in dementia
NIHR159446 - Malhotra
A Multi-Arm, multi-Stage trial platform for dementia and mild cognitive impairment due to Alzheimer's Disease (MASTODON-AD)
Chair: Maya Buch
Declared a conflict and left the room: Daniel Freeman, John Norrie, Nuru Noor, David Jones (not present)
Decision: Shortlist
22/161 NIHR James Lind Alliance Priority Setting Partnerships Rolling Call (EME Programme: Dec 22 - Apr 23)
NIHR158499 - Mostafa
Evaluating the efficacy of a SleEp health intervention to reduce levels of glycated haeMoglobin, HbA1c, in people with PRE-diabetes and poor sleep health: a 36-month randomised controlled trIal (RCT) of intervention compared to usual care (control): the SEMPRE-FI trial
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Decline
22/159 EME Programme Researcher-led
NIHR159548 - Schache
Genomic (Personalised) Medicine for Head & Neck Cancer Patients - Assessing the Efficacy of the National Genomic Test Directory for Cancer as a Prognostic Tool for Patient Benefit
Chair: John Norrie
Declared a conflict and left the room: Rob Forsyth, Gregory Lip (not present)
Decision: Decline
NIHR158873 - Dillon
Targeted Therapy for Acute Myeloid Leukaemia in Molecular Relapse (TAMeR): a randomised phase 2 trial
Chair: John Norrie
Declared a conflict and left the room: Philip Pallmann
Decision: Shortlist
NIHR159180 - Galiza
Preg-CoV: Pregnancy Clinical trials Of Vaccines
Chair: John Norrie
Declared a conflict and left the room: Danny McAuley
Decision: Decline
NIHR158620 - Puthucheary
A randomised controlled trial of prevention of acute muscle wasting in critically ill adults with ketogenic feeding: the Alternative Substrates In the Critically Ill Subject II (ASICS-II)
Chair: John Norrie
Declared a conflict and left the room: Danny McAuley
Decision: Shortlist
NIHR157655 - Mosahebi
Microsurgical prophylactic lymphatic vessels anastomosis to reduce risk of lymphoedema (CRYPTIC trial)
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Shortlist
22/557 Palliative and End of Life Care (EME Programme)
NIHR159167 - Gillanders
A cluster randomized controlled trial of online Acceptance and Commitment Therapy training to improve mental wellbeing in staff caring for terminally ill people and their caregivers
Chair: Maya Buch
Declared a conflict and left the room: Alastair Hay, John Norrie, Andrew Horne (not present), Danny McAuley
Decision: Shortlist
22/159 EME Programme Researcher-led
NIHR158537 - Patel
Rest Or Moderate Mechanical Ventilation During ECMO Support - ROMEO
Chair: Maya Buch
Declared a conflict and left the room: Alastair Hay, John Simpson, Manu Shankar-Hari, Ronan McMullan (not present), Vicky Coyle (not present), John Norrie, Danny McAuley, George Hanna
Decision: Decline - invited to resubmit a Stage 1 application
NIHR159510 - Shah
Mechanisms for Platelets (M4P): understanding the mechanisms of action of platelet transfusions in critically ill patients
Chair: Maya Buch
Declared a conflict and left the room: Ronan McMullan (not present), John Norrie, Philip Pallmann, Manu Shankar-Hari, Danny McAuley, George Hanna
Decision: Decline
NIHR158535 - Ojha
DEXmedetomidine Trial of Adjunct Treatment with Morphine (DEXTA): a masked, randomised placebo-controlled trial
Chair: Maya Buch
Declared a conflict and left the room: Don Sharkey, John Norrie, Andrew Cook
Decision: Shortlist
NIHR158636 - Varese
Trauma-focused therapy in early psychosis: A randomised controlled trial assessing the efficacy and mechanisms of action of Eye Movement Desensitization and Reprocessing for psychosis (EMDRp) in comparison to treatment as usual in Early Intervention settings
Chair: Maya Buch
Declared a conflict and left the room: Daniel Freeman, John Norrie
Decision: Decline - invited to resubmit a Stage 1 application
NIHR159164 - Hafeez
Predicting treatment respOnse in bLadder cancer with MRI (POLAR) study
Chair: John Norrie
Declared a conflict and left the room: Vicky Coyle (not present), Allen Knight
Decision: Decline
22/162 Rehabilitation and care following stroke
NIHR158891 - Chatterjee
Virtual Reality based cognitive rehabilitation after a stroke: VIRTUE 2
Chair: John Norrie
Declared a conflict and left the room: Rob Forsyth, Gregory Lip
Decision: Decline
NIHR159047 - Rossit
Spatial Inattention Grasping Therapy (SIGHT) for rehabilitation of spatial neglect post-stroke: a randomised-control multicentre efficacy trial with embedded mechanistic study of determinants of therapy response
Chair: John Norrie
Declared a conflict and left the room: N/A
Decision: Shortlist
22/160 NIHR NICE Rolling Call (EME Programme: Dec 22 - Apr 23)
NIHR158852 - Burton
Investigating the efficacy of neuromuscular electrical stimulation as a therapy for sarcopenia in people on maintenance haemodialysis
Chair: John Norrie
Declared a conflict and left the room: James Burton, Gerry McCann (observer - not present)
Decision: Shortlist
NIHR158329 - Alam
Artificial Intelligence for the early Detection of diabEtic Neuropathy (AIDEN) study
Chair: John Norrie
Declared a conflict and left the room: Gregory Lip, Gerry McCann (observer - not present)
Decision: Decline
22/564 Evaluating the Efficacy of Metformin in Tuberous Sclerosis Complex
NIHR159386 - O'Callaghan
A double blind randomised placebo controlled trial of metformin in refractory epilepsies associated with tuberous sclerosis complex (MiTS2)
Chair: John Norrie
Declared a conflict and left the room: Patricia Limousin
Decision: Shortlist